{ "uniprot_canonical_ac": "A2BFL2-1", "uniprot_ac": "A2BFL2", "uniprot_id": "ZY11A_MOUSE", "mass": { "chemical_mass": 70404.0, "monoisotopic_mass": 70404.0 }, "refseq": { "ac": "XP_006503039", "name": "protein zyg-11 homolog A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006503039" }, "gene_names": [ { "name": "Zyg11a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2BFL2", "id": "A2BFL2" }, { "name": "BC022150", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161408", "id": "NP_001161408" }, { "name": "Zyg11a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161408", "id": "NP_001161408" } ], "protein_names": [ { "name": "Protein zyg-11 homolog A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2BFL2#names_and_taxonomy", "id": "A2BFL2" }, { "name": "protein zyg-11 homolog A isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006503039", "id": "XP_006503039" }, { "name": "protein zyg-11 homolog A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161408", "id": "NP_001161408" }, { "name": "zyg-11 homolog A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161408", "id": "NP_001161408" } ], "function": [ { "annotation": "Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.", "evidence": [ { "database": "UniProtKB", "id": "A2BFL2", "url": "https://www.uniprot.org/uniprot/A2BFL2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2BFL2", "url": "https://www.uniprot.org/uniprot/A2BFL2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Zyg11a", "url": "https://www.uniprot.org/uniprot/A2BFL2", "locus": { "chromosome": "4", "start_pos": 108218048, "end_pos": 108181738, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000034645", "url": "https://www.ensembl.org/id/ENSMUSG00000034645" } ] } } ], "crossref": [ { "id": "ENSMUSG00000034645", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034645", "database": "Bgee" }, { "id": "230590", "url": "https://www.ncbi.nlm.nih.gov/gene/230590", "database": "GeneID" }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro" }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro" }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro" }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro" }, { "id": "mmu:230590", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230590", "database": "KEGG Pathway" }, { "id": "2446208", "url": "http://www.informatics.jax.org/marker/MGI:2446208", "database": "MGI" }, { "id": "ACLYHLC", "url": "https://omabrowser.org/oma/group/ACLYHLC/", "database": "OMA" }, { "id": "374821at2759", "url": "http://www.orthodb.org/?query=374821at2759", "database": "OrthoDB" }, { "id": "PR_A2BFL2", "url": "http://purl.obolibrary.org/obo/PR_A2BFL2", "database": "PRO" }, { "id": "NP_001161408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161408", "database": "RefSeq" }, { "id": "XP_006503039", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006503039", "database": "RefSeq" }, { "id": "A0A1Y7VNL1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VNL1", "database": "UniProtKB" }, { "id": "A0A1Y7VNL1-1", "url": "https://www.uniprot.org/uniprot/A0A1Y7VNL1-1", "database": "UniProtKB" }, { "id": "A0A217FL76", "url": "https://www.uniprot.org/uniprot/A0A217FL76", "database": "UniProtKB" }, { "id": "A0A217FL76-1", "url": "https://www.uniprot.org/uniprot/A0A217FL76-1", "database": "UniProtKB" }, { "id": "A2BFL2", "url": "https://www.uniprot.org/uniprot/A2BFL2", "database": "UniProtKB" }, { "id": "A2BFL2-1", "url": "https://www.uniprot.org/uniprot/A2BFL2-1", "database": "UniProtKB" }, { "id": "F8WHU3", "url": "https://www.uniprot.org/uniprot/F8WHU3", "database": "UniProtKB" }, { "id": "F8WHU3-1", "url": "https://www.uniprot.org/uniprot/F8WHU3-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MAWQGKLTDRTASIFQGKQMSLKLINIPRVKLSAAAFTKAFCHHKLIEVNATSVDSELLAPDIIHALQSSAWIQKNLQCLVLDSVSIPPNSGLVALSHFTGLHTLSVANVSFCNEDLVSVSQLPNLGSLDISNTLVTNISALLSCKNRLRSLTMHYLKCLAMNSPQVLAVIRQLKCLLHLDISDHQQLRSDLAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFLQHRPAMRFVGLLYTDAGYSDFFTAKQGLKVAGGANMSQISEALSRYRNRSCFVKEALFRLFTETLSLRAVLPVMLKLVAIGMRNHPLDLPVQFTASACALNLTRQELARGMPVRLLAEITDLLFKATKNFPYYQQLQKNCLLSLTSSRILMDVPFDRFDAAKLALRWVCRRESPKLRTMAVSITSILALKLSPEEMGQLQEELIMAIKELLTIIRQKLAENLDDVTFLFTLKALWNLTDECPLACKYFMENEGLATVIRVLETFSISVIQSKVLGLLNNVAEVRELSSKLVTEDVIERIISLLHSSNLEVSFLAAGVLAHLTCDRQHWLSRDLQRTDLLRYLHLAIQNWPSSRCDMSVLVTYRSFKAFSPLLVNFSQPEVQRWALWAIHHVCSKNPRPKDV", "length": 627, "header": "sp|A2BFL2-1|ZY11A_MOUSE Isoform 1 of Protein zyg-11 homolog A OS=Mus musculus OX=10090 GN=Zyg11a PE=2 SV=1 CANONICAL=A2BFL2-1" }, "isoforms": [ { "isoform_ac": "A0A1Y7VNL1-1", "url": "https://www.uniprot.org/uniprot/A2BFL2#A0A1Y7VNL1-1", "sequence": { "sequence": "MVHFLHPLLWPRALVLPDAQQDAQGHCLVQEEASPYSLVNICLDVLIAELDKWCSKRPDGTLCLPEHWYFPHEIADKFLERMAWQGKLTDRTASIFQGKQMSLKLINIPRVKLSAAAFTKAFCHHKLIEVNATSVDSELLAPDIIHALQSSAWIQKNLQCLVLDSVSIPPNSGLVALSHFTGLHTLSVANVSFCNEDLVSVSQLPNLGSLDISNTLVTNISALLSCKNRLRSLTMHYLKCLAMNSPQVLAVIRQLKCLLHLDISDHQQLRSDLAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFLQHRPAMRFVGLLYTDAGYSDFFTAKQGLKVAGGANMSQISEALSRYRNRSCFVKEALFRLFTETLSLRAVLPVMLKLVAIGMRNHPLDLPVQFTASACALNLTRQELARGMPVRLLAEITDLLFKATKNFPYYQQLQKNCLLSLTSSRILMDVPFDRFDAAKLALRWVCRRESPKLRTMAVSITSILALKLSPEEMGQLQEELIMAIKELLTIIRQKLAENLDDVTFLFTLKALWNLTDECPLACKYFMENEGLATVIRVLETFSISVIQSKVLGLLNNVAEVRELSSKLVTEDVIERIISLLHSSNLEVSFLAAGVLAHLTCDRQHWLSRDLQRTDLLRYLHLAIQNWPSSRCDMSVLVTYRSFKAFSPLLVNFSQPEVQRWALWAIHHVCSKNPSKYCQLLVEGGGLQLMYDIQEHGQASAQVRQMVSSILEEFRMHFTSDRRPPQPQGPL", "length": 760, "header": "tr|A0A1Y7VNL1-1|A0A1Y7VNL1_MOUSE Computationally mapped isoform of Protein zyg-11 homolog A OS=Mus musculus OX=10090 GN=Zyg11a PE=3 SV=1 CANONICAL=A2BFL2-1" }, "locus": { "chromosome": "4", "start_pos": 108075119, "end_pos": 108038938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000223127", "url": "https://www.ensembl.org/id/ENSMUST00000223127" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000152477", "url": "https://www.ensembl.org/id/ENSMUSP00000152477" } ] } }, { "isoform_ac": "A0A217FL76-1", "url": "https://www.uniprot.org/uniprot/A2BFL2#A0A217FL76-1", "sequence": { "sequence": "MVHFLHPLLWPRALVLPDAQQDAQGHCLVQEEASPYSLVNICLDVLIAELDKWCSKRPDGTLCLPEHWYFPHEIADKFLERMAWQGKLTDRTASIFQGKQMSLKLINIPRVKLSAAAFTKAFCHHKLIEVNATSVDSELLAPDIIHALQSSAWIQKNLQCLVLDSVSIPPNSGLVALSHFTGLHTLSVANVSFCNEDLVSVSQLPNLGSLDISNTLVTNISALLSCKNRLRSLTMHYLKCLAMNSPQVLAVIRQLKCLLHLDISDHQQLRSDLAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFLQHRPAMRFVGLLYTDAGYSDFFTAKQGLKVAGGANMSQISEALSRYRNRSCFVKEALFRLFTETLSLRAVLPVMLKLVAIGMRNHPLDLPVQFTASACALNLTRQELARGMPVRLLAEITDLLFKATKNFPYYQQLQKNCLLSLTSSRILMDVPFDRFDAAKLALRWVCRRESPKLRTMAVSITSILALKLSPEEMGQLQEELIMAIKELLTIIRQKLAENLDDVTFLFTLKALWNLTDECPLACKYFMENEGLATVIRVLETFSISVIQSKVLGLLNNVAEVRELSSKLVTEDVIERIISLLHSSNLEVSFLAAGVLAHLTCDRQHWLSRDLQRTDLLRYLHLAIQNWPSSRCDMSVLVTYRSFKAFSPLLVNFSQPEVQRWALWAIHHVCSKNPRPKDV", "length": 708, "header": "tr|A0A217FL76-1|ZY11A_MOUSE Computationally mapped isoform of Protein zyg-11 homolog A OS=Mus musculus OX=10090 GN=Zyg11a PE=2 SV=1 CANONICAL=A2BFL2-1" }, "locus": { "chromosome": "4", "start_pos": 108075119, "end_pos": 108039302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106690", "url": "https://www.ensembl.org/id/ENSMUST00000106690" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102301", "url": "https://www.ensembl.org/id/ENSMUSP00000102301" } ] } }, { "isoform_ac": "A2BFL2-1", "url": "https://www.uniprot.org/uniprot/A2BFL2#A2BFL2-1", "sequence": { "sequence": "MAWQGKLTDRTASIFQGKQMSLKLINIPRVKLSAAAFTKAFCHHKLIEVNATSVDSELLAPDIIHALQSSAWIQKNLQCLVLDSVSIPPNSGLVALSHFTGLHTLSVANVSFCNEDLVSVSQLPNLGSLDISNTLVTNISALLSCKNRLRSLTMHYLKCLAMNSPQVLAVIRQLKCLLHLDISDHQQLRSDLAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFLQHRPAMRFVGLLYTDAGYSDFFTAKQGLKVAGGANMSQISEALSRYRNRSCFVKEALFRLFTETLSLRAVLPVMLKLVAIGMRNHPLDLPVQFTASACALNLTRQELARGMPVRLLAEITDLLFKATKNFPYYQQLQKNCLLSLTSSRILMDVPFDRFDAAKLALRWVCRRESPKLRTMAVSITSILALKLSPEEMGQLQEELIMAIKELLTIIRQKLAENLDDVTFLFTLKALWNLTDECPLACKYFMENEGLATVIRVLETFSISVIQSKVLGLLNNVAEVRELSSKLVTEDVIERIISLLHSSNLEVSFLAAGVLAHLTCDRQHWLSRDLQRTDLLRYLHLAIQNWPSSRCDMSVLVTYRSFKAFSPLLVNFSQPEVQRWALWAIHHVCSKNPRPKDV", "length": 627, "header": "sp|A2BFL2-1|ZY11A_MOUSE Isoform 1 of Protein zyg-11 homolog A OS=Mus musculus OX=10090 GN=Zyg11a PE=2 SV=1 CANONICAL=A2BFL2-1" }, "locus": {} }, { "isoform_ac": "F8WHU3-1", "url": "https://www.uniprot.org/uniprot/A2BFL2#F8WHU3-1", "sequence": { "sequence": "MVHFLHPLLWPRALVLPDAQQDAQGHCLEEASPYSLVNICLDVLIAELDKWCSKRPDGTLCLPEHWYFPHEIADKFLERMAWQGKLTDRTASIFQGKQMSLKLINIPRVKLSAAAFTKAFCHHKLIEVNATSVDSELLAPDIIHALQSSAWIQKNLQCLVLDSVSIPPNSGLVALSHFTGLHTLSVANVSFCNEDLVSVSQLPNLGSLDISNTLVTNISALLSCKNRLRSLTMHYLKCLAMNSPQVLAVIRQLKCLLHLDISDHQQLRSDLAFYLLQQKDILPNLTSLDISGGTDVTDQAVESFLQHRPAMRFVGLLYTDAGYSDFFTAKQGLKVAGGANMSQISEALSRYRNRSCFVKEALFRLFTETLSLRAVLPVMLKLVAIGMRNHPLDLPVQFTASACALNLTRQELARGMPVRLLAEITDLLFKATKNFPYYQQLQKNCLLSLTSSRILMDVPFDRFDAAKLALRWVCRRESPKLRTMAVSITSILALKLSPEEMGQLQEELIMAIKELLTIIRQKLAENLDDVTFLFTLKALWNLTDECPLACKYFMENEGLATVIRVLETFSISVIQSKVLGLLNNVAEVRELSSKLVTEDVIERIISLLHSSNLEVSFLAAGVLAHLTCDRQHWLSRDLQRTDLLRYLHLAIQNWPSSRCDMSVLVTYRSFKAFSPLLVNFSQPEVQRWALWAIHHVCSKNPRPKDV", "length": 706, "header": "tr|F8WHU3-1|F8WHU3_MOUSE Computationally mapped isoform of Protein zyg-11 homolog A OS=Mus musculus OX=10090 GN=Zyg11a PE=3 SV=1 CANONICAL=A2BFL2-1" }, "locus": { "chromosome": "4", "start_pos": 108075119, "end_pos": 108039302, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000043793", "url": "https://www.ensembl.org/id/ENSMUST00000043793" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000038478", "url": "https://www.ensembl.org/id/ENSMUSP00000038478" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:230590", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230590", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6WRX3-1", "protein_name": "Protein zyg-11 homolog A", "gene_name": "ZYG11A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVHFLHPGHTPRNIVPPDAQKDALGCCVVQEEASPYTLVNICLNVLIANLEKLCSERPDGTLCLPEHWSFPQEVAERFLRVMTWQGKLTDRTASIFRGNQMKLKLVNIQKAKISTAAFIKAFCRHKLIELNATAVHADLPVPDIISGLCSNRWIQQNLQCLLLDSTSIPQNSRLLFFSQLTGLRILSVFNVCFHTEDLANVSQLPRLESLDISNTLVTDISALLTCKDRLKSLTMHYLKCLAMTKSQILAVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVELFIRLRPAMQFVGLLATDAGSSDFFTTKQGLRVAGGASMSQISEALSRYRNRSCFVKEALHRLFTETFSMEVTMPAILKLVAIGMRNHPLDLRVQFTASACALNLTRQGLAKGMPVRLLSEVTCLLFKALKNFPHYQQLQKNCLLSLTNSRILVDVPFDRFDAAKFVMRWLCKHENPKMQTMAVSVTSILALQLSPEQTAQLEELFMAVKELLAIVKQKTTENLDDVTFLFTLKALWNLTDGSPAACKHFIENQGLQIFIQVLETFSESAIQSKVLGLLNNIAEVRELSSKLVTEDVLKHINSLLCSREMEVSYFAAGIIAHLTSDRQLWISRDFQRRTLLQDLHATIQNWPSSSCKMTALVTYRSFKTFFPLLGNFSQPEVQLWALWAMYHVCSKNPSKYCKMLVEEEGLQLLCDIQEHSEATPKAQQIAASILDDFRMHFMNYQRPTLCQMPF", "length": 759 }, "evidence": [ { "id": "66294", "url": "http://www.informatics.jax.org/homology/66294", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cul2-RING ubiquitin ligase complex", "id": "GO:0031462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031462", "evidence": [ { "database": "UniProtKB", "id": "A2BFL2", "url": "https://www.uniprot.org/uniprot/A2BFL2" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }