{ "uniprot_canonical_ac": "A2BFE8-1", "uniprot_ac": "A2BFE8", "uniprot_id": "A2BFE8_MOUSE", "mass": { "chemical_mass": 25060.0, "monoisotopic_mass": 25060.0 }, "refseq": { "ac": "NP_001157747", "name": "transmembrane gamma-carboxyglutamic acid protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157747" }, "gene_names": [ { "name": "Prrg1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2BFE8", "id": "A2BFE8" }, { "name": "2010007L08Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157747", "id": "NP_001157747" }, { "name": "Prrg1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157747", "id": "NP_001157747" } ], "protein_names": [ { "name": "Proline-rich Gla (G-carboxyglutamic acid) 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2BFE8#names_and_taxonomy", "id": "A2BFE8" }, { "name": "ortholog of proline rich Gla (G-carboxyglutamic acid) 1 PRRG1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157747", "id": "NP_001157747" }, { "name": "transmembrane gamma-carboxyglutamic acid protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157747", "id": "NP_001157747" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2BFE8", "url": "https://www.uniprot.org/uniprot/A2BFE8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Prrg1", "url": "https://www.uniprot.org/uniprot/A2BFE8", "locus": { "chromosome": "X", "start_pos": 78583896, "end_pos": 78449613, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000047996", "url": "https://www.ensembl.org/id/ENSMUSG00000047996" } ] } } ], "crossref": [ { "id": "ENSMUSG00000047996", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000047996", "database": "Bgee" }, { "id": "546336", "url": "https://www.ncbi.nlm.nih.gov/gene/546336", "database": "GeneID" }, { "id": "IPR000294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000294", "database": "InterPro" }, { "id": "IPR017857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017857", "database": "InterPro" }, { "id": "IPR035972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035972", "database": "InterPro" }, { "id": "mmu:546336", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:546336", "database": "KEGG Pathway" }, { "id": "1917364", "url": "http://www.informatics.jax.org/marker/MGI:1917364", "database": "MGI" }, { "id": "YPRANTF", "url": "https://omabrowser.org/oma/group/YPRANTF/", "database": "OMA" }, { "id": "1305760at2759", "url": "http://www.orthodb.org/?query=1305760at2759", "database": "OrthoDB" }, { "id": "PF00594", "url": "http://pfam.xfam.org/family/PF00594", "database": "Pfam" }, { "id": "NP_001157747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157747", "database": "RefSeq" }, { "id": "A2BFE8", "url": "https://www.uniprot.org/uniprot/A2BFE8", "database": "UniProtKB" }, { "id": "A2BFE8-1", "url": "https://www.uniprot.org/uniprot/A2BFE8-1", "database": "UniProtKB" }, { "id": "A2BFE9", "url": "https://www.uniprot.org/uniprot/A2BFE9", "database": "UniProtKB" }, { "id": "A2BFE9-1", "url": "https://www.uniprot.org/uniprot/A2BFE9-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MGRVFLTEEKANSVLKRYPRANGLFEEIRQGNIERECREEICTYEEAREAFENHEKTKEFWSTYTKAQQGETNRGSDWFQFYLTFPLIFGLFIILLVIFLIWRCFLRNKTRRQTVTESHIPFPQQLNIITPPPPPDEVFDSSALSPGFLEYVVGRSDSVSTRLSNCDPPPTYEEATGQVNLRRSETEPPLDPPPEYEDIVNSSSASAIAMVPVVTTIK", "length": 218, "header": "tr|A2BFE8-1|A2BFE8_MOUSE Isoform 1 of Proline-rich Gla (G-carboxyglutamic acid) 1 OS=Mus musculus OX=10090 GN=Prrg1 PE=4 SV=1 CANONICAL=A2BFE8-1" }, "isoforms": [ { "isoform_ac": "A2BFE8-1", "url": "https://www.uniprot.org/uniprot/A2BFE8#A2BFE8-1", "sequence": { "sequence": "MGRVFLTEEKANSVLKRYPRANGLFEEIRQGNIERECREEICTYEEAREAFENHEKTKEFWSTYTKAQQGETNRGSDWFQFYLTFPLIFGLFIILLVIFLIWRCFLRNKTRRQTVTESHIPFPQQLNIITPPPPPDEVFDSSALSPGFLEYVVGRSDSVSTRLSNCDPPPTYEEATGQVNLRRSETEPPLDPPPEYEDIVNSSSASAIAMVPVVTTIK", "length": 218, "header": "tr|A2BFE8-1|A2BFE8_MOUSE Isoform 1 of Proline-rich Gla (G-carboxyglutamic acid) 1 OS=Mus musculus OX=10090 GN=Prrg1 PE=4 SV=1 CANONICAL=A2BFE8-1" }, "locus": { "chromosome": "X", "start_pos": 77564386, "end_pos": 77496296, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114025", "url": "https://www.ensembl.org/id/ENSMUST00000114025" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000109659", "url": "https://www.ensembl.org/id/ENSMUSP00000109659" } ] } }, { "isoform_ac": "A2BFE9-1", "url": "https://www.uniprot.org/uniprot/A2BFE8#A2BFE9-1", "sequence": { "sequence": "MGRVFLTEEKANSVLKRYPRANGLFEEIRQGNIERECR", "length": 38, "header": "tr|A2BFE9-1|A2BFE8_MOUSE Computationally mapped isoform of Proline-rich Gla (G-carboxyglutamic acid) 1 OS=Mus musculus OX=10090 GN=Prrg1 PE=4 SV=1 CANONICAL=A2BFE8-1" }, "locus": { "chromosome": "X", "start_pos": 77564386, "end_pos": 77527414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000134602", "url": "https://www.ensembl.org/id/ENSMUST00000134602" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000117104", "url": "https://www.ensembl.org/id/ENSMUSP00000117104" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:546336", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:546336", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZUF5-1", "protein_name": "Proline-rich and Gla domain 1", "gene_name": "Prrg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHVFLTGEKANSVLKRYPRANGLFEEIRQGNIERECREEVCTYEEAREAFENHEKTKEFWSTYTKAQQGETNRGSDWFQFYLTFPLIFGLFIILLVIFLIWRCFLRNKTRRQTVTESHIPFPQHLNIITPPPPPDEVFDSSGLSPGFLEYVVGRSDSVSTRLSNCDPPPTYEEATGQVNLRRSETEPHLDPPPEYEDIVNSSSASAIAMVPVVTTIK", "length": 217 }, "evidence": [ { "id": "734", "url": "http://www.informatics.jax.org/homology/734", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O14668-1", "protein_name": "Transmembrane gamma-carboxyglutamic acid protein 1", "gene_name": "PRRG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRVFLTGEKANSILKRYPRANGFFEEIRQGNIERECKEEFCTFEEAREAFENNEKTKEFWSTYTKAQQGESNRGSDWFQFYLTFPLIFGLFIILLVIFLIWRCFLRNKTRRQTVTEGHIPFPQHLNIITPPPPPDEVFDSSGLSPGFLGYVVGRSDSVSTRLSNCDPPPTYEEATGQVNLQRSETEPHLDPPPEYEDIVNSNSASAIPMVPVVTTIK", "length": 218 }, "evidence": [ { "id": "734", "url": "http://www.informatics.jax.org/homology/734", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A2BFE8", "url": "https://www.uniprot.org/uniprot/A2BFE8" } ], "pmid": "" }, { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A2BFE8", "url": "https://www.uniprot.org/uniprot/A2BFE8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A2BFE8", "url": "https://www.uniprot.org/uniprot/A2BFE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }