{
    "uniprot_canonical_ac": "A2BDX3-1",
    "uniprot_ac": "A2BDX3",
    "uniprot_id": "MOCS3_MOUSE",
    "mass": {
        "chemical_mass": 49375.0,
        "monoisotopic_mass": 49375.0
    },
    "refseq": {
        "ac": "NP_001153802",
        "name": "adenylyltransferase and sulfurtransferase MOCS3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153802"
    },
    "gene_names": [
        {
            "name": "Mocs3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2BDX3",
            "id": "A2BDX3"
        },
        {
            "name": "1700020H17Rik; Uba4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153802",
            "id": "NP_001153802"
        },
        {
            "name": "Mocs3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153802",
            "id": "NP_001153802"
        },
        {
            "name": "Uba4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2BDX3",
            "id": "A2BDX3"
        }
    ],
    "protein_names": [
        {
            "name": "Adenylyltransferase and sulfurtransferase MOCS3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2BDX3#names_and_taxonomy",
            "id": "A2BDX3"
        },
        {
            "name": "Adenylyltransferase MOCS3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2BDX3#names_and_taxonomy",
            "id": "A2BDX3"
        },
        {
            "name": "MPT synthase sulfurylase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153802",
            "id": "NP_001153802"
        },
        {
            "name": "Molybdenum cofactor synthesis protein 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2BDX3#names_and_taxonomy",
            "id": "A2BDX3"
        },
        {
            "name": "Sulfur carrier protein MOCS2A adenylyltransferase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2BDX3#names_and_taxonomy",
            "id": "A2BDX3"
        },
        {
            "name": "Sulfur carrier protein MOCS2A sulfurtransferase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2BDX3#names_and_taxonomy",
            "id": "A2BDX3"
        },
        {
            "name": "Sulfurtransferase MOCS3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2BDX3#names_and_taxonomy",
            "id": "A2BDX3"
        },
        {
            "name": "adenylyltransferase and sulfurtransferase MOCS3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153802",
            "id": "NP_001153802"
        }
    ],
    "function": [
        {
            "annotation": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2BDX3",
                    "url": "https://www.uniprot.org/uniprot/A2BDX3#function"
                },
                {
                    "database": "PubMed",
                    "id": "MF_03049",
                    "url": "https://glygen.org/publication/PubMed/MF_03049"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2BDX3",
                    "url": "https://www.uniprot.org/uniprot/A2BDX3"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Mocs3",
            "url": "https://www.uniprot.org/uniprot/A2BDX3",
            "locus": {
                "chromosome": "2",
                "start_pos": 168230622,
                "end_pos": 168232594,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000074576",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000074576"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000074576",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074576",
            "database": "Bgee"
        },
        {
            "id": "69372",
            "url": "https://www.ncbi.nlm.nih.gov/gene/69372",
            "database": "GeneID"
        },
        {
            "id": "A2BDX3",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2BDX3*",
            "database": "IntAct"
        },
        {
            "id": "IPR000594",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000594",
            "database": "InterPro"
        },
        {
            "id": "IPR001763",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001763",
            "database": "InterPro"
        },
        {
            "id": "IPR028885",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028885",
            "database": "InterPro"
        },
        {
            "id": "IPR035985",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035985",
            "database": "InterPro"
        },
        {
            "id": "IPR036873",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036873",
            "database": "InterPro"
        },
        {
            "id": "mmu:69372",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69372",
            "database": "KEGG Pathway"
        },
        {
            "id": "1916622",
            "url": "http://www.informatics.jax.org/marker/MGI:1916622",
            "database": "MGI"
        },
        {
            "id": "GTIGAMQ",
            "url": "https://omabrowser.org/oma/group/GTIGAMQ/",
            "database": "OMA"
        },
        {
            "id": "1445129at2759",
            "url": "http://www.orthodb.org/?query=1445129at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00581",
            "url": "http://pfam.xfam.org/family/PF00581",
            "database": "Pfam"
        },
        {
            "id": "PF00899",
            "url": "http://pfam.xfam.org/family/PF00899",
            "database": "Pfam"
        },
        {
            "id": "PR_A2BDX3",
            "url": "http://purl.obolibrary.org/obo/PR_A2BDX3",
            "database": "PRO"
        },
        {
            "id": "R-MMU-947581",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-947581",
            "database": "Reactome"
        },
        {
            "id": "NP_001153802",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153802",
            "database": "RefSeq"
        },
        {
            "id": "43616",
            "url": "https://www.rhea-db.org/rhea/43616",
            "database": "Rhea"
        },
        {
            "id": "48612",
            "url": "https://www.rhea-db.org/rhea/48612",
            "database": "Rhea"
        },
        {
            "id": "A2BDX3",
            "url": "https://www.uniprot.org/uniprot/A2BDX3",
            "database": "UniProtKB"
        },
        {
            "id": "A2BDX3-1",
            "url": "https://www.uniprot.org/uniprot/A2BDX3-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MAAPEDVAALQAEITRREEELASLKRRLAAALTAEPEPERPLRVPPPPLAPRAALSRDEILRYSRQLLLPELGVRGQLRLAAAAVLVVGCGGLGCPLAQYLAAAGVGRLGLVDHDVVETSNLARQVLHGEAQAGESKARSAAAALRRLNSAVECVAYPRALAEDWALDLVRGYDVVADCCDNVPTRYLVNDACVLAGRPLVSASALRFEGQMTVYHHDGGPCYRCVFPRPPPPETVTNCADGGVLGAVPGVLGCAQALEVLKIAAGLGSSYSGSMLLFDGLGGHFRRIRLRRRRPDCVVCGQQPTVTRLQDYEAFCGSSATDKCRALKLLCPEERISVTDYKRLLDSGAPHVLLDVRPQVEVDICRLPHSLHIPLSQLERRDADSLKLLGAALRKGKQESQEGVALPVYVICKLGNDSQKAVKVLQSLTAVPELDSLTVQDIVGGLMAWAAKIDGTFPQY",
        "length": 460,
        "header": "sp|A2BDX3-1|MOCS3_MOUSE Isoform 1 of Adenylyltransferase and sulfurtransferase MOCS3  OS=Mus musculus OX=10090 GN=Mocs3 PE=1 SV=1 CANONICAL=A2BDX3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2BDX3-1",
            "url": "https://www.uniprot.org/uniprot/A2BDX3#A2BDX3-1",
            "sequence": {
                "sequence": "MAAPEDVAALQAEITRREEELASLKRRLAAALTAEPEPERPLRVPPPPLAPRAALSRDEILRYSRQLLLPELGVRGQLRLAAAAVLVVGCGGLGCPLAQYLAAAGVGRLGLVDHDVVETSNLARQVLHGEAQAGESKARSAAAALRRLNSAVECVAYPRALAEDWALDLVRGYDVVADCCDNVPTRYLVNDACVLAGRPLVSASALRFEGQMTVYHHDGGPCYRCVFPRPPPPETVTNCADGGVLGAVPGVLGCAQALEVLKIAAGLGSSYSGSMLLFDGLGGHFRRIRLRRRRPDCVVCGQQPTVTRLQDYEAFCGSSATDKCRALKLLCPEERISVTDYKRLLDSGAPHVLLDVRPQVEVDICRLPHSLHIPLSQLERRDADSLKLLGAALRKGKQESQEGVALPVYVICKLGNDSQKAVKVLQSLTAVPELDSLTVQDIVGGLMAWAAKIDGTFPQY",
                "length": 460,
                "header": "sp|A2BDX3-1|MOCS3_MOUSE Isoform 1 of Adenylyltransferase and sulfurtransferase MOCS3  OS=Mus musculus OX=10090 GN=Mocs3 PE=1 SV=1 CANONICAL=A2BDX3-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 168073934,
                "end_pos": 168072555,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000099071",
                        "url": "https://www.ensembl.org/id/ENSMUST00000099071"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000096670",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000096670"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:69372",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69372",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-947581",
            "name": "Molybdenum cofactor biosynthesis",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-947581",
            "resource": "Reactome",
            "description": "Molybdenum cofactor biosynthesis"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A8L5-1",
            "protein_name": "Adenylyltransferase and sulfurtransferase MOCS3",
            "gene_name": "Mocs3",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAAPEDVAALQDEIARREEELASLKQRLAAALAVEPEPERPIPVMPLPSRAALSRDEILRYSRQLLLPELGVRGQLRLAAASVLVVGCGGLGCPLAQYLAAAGVGRLGLVDHDVVETSNLARQVLHGEAQAGHAKAWSAAAALRRLNSAVEYVPYARALSEAWALDLVRGYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQMTVYHYDDGPCYRCVFPRPPPAETVTNCADGGVLGVVPGVLGCVQALEVLKIAAGLGTTYSGSMLLFDGLGGHFRRIRLRRRRPDCVVCGQQPTVTCLKNYEAFCGSSATDKCRSLKLLSPEERISVTDYKRLLDSGVPHVLLDVRPQVEVDICRLQHSLHIPLSLLERRDADSLKLLGAALQEEKRNSQEGAALAVYVICKLGNDSQKAVRVLQSLTAVPELDSLKVQDISGGLMAWAAKIDGTFPQY",
                "length": 458
            },
            "evidence": [
                {
                    "id": "6108",
                    "url": "http://www.informatics.jax.org/homology/6108",
                    "database": "MGI"
                },
                {
                    "id": "A2BDX3",
                    "url": "https://omabrowser.org/oma/group/A2BDX3/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "O95396-1",
            "protein_name": "Adenylyltransferase and sulfurtransferase MOCS3",
            "gene_name": "MOCS3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MASREEVLALQAEVAQREEELNSLKQKLASALLAEQEPQPERLVPVSPLPPKAALSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNCADGGVLGVVTGVLGCLQALEVLKIAAGLGPSYSGSLLLFDALRGHFRSIRLRSRRLDCAACGERPTVTDLLDYEAFCGSSATDKCRSLQLLSPEERVSVTDYKRLLDSGAFHLLLDVRPQVEVDICRLPHALHIPLKHLERRDAESLKLLKEAIWEEKQGTQEGAAVPIYVICKLGNDSQKAVKILQSLSAAQELDPLTVRDVVGGLMAWAAKIDGTFPQY",
                "length": 460
            },
            "evidence": [
                {
                    "id": "6108",
                    "url": "http://www.informatics.jax.org/homology/6108",
                    "database": "MGI"
                },
                {
                    "id": "A2BDX3",
                    "url": "https://omabrowser.org/oma/group/A2BDX3/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "tRNA wobble position uridine thiolation",
                        "id": "GO:0002143",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002143",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "tRNA thio-modification",
                        "id": "GO:0034227",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034227",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "tRNA wobble uridine modification",
                        "id": "GO:0002098",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002098",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Mo-molybdopterin cofactor biosynthetic process",
                        "id": "GO:0006777",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006777",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein urmylation",
                        "id": "GO:0032447",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032447",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 8,
                "go_terms": [
                    {
                        "name": "sulfurtransferase activity",
                        "id": "GO:0016783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleotidyltransferase activity",
                        "id": "GO:0016779",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016779",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "thiosulfate sulfurtransferase activity",
                        "id": "GO:0004792",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004792",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "URM1 activating enzyme activity",
                        "id": "GO:0042292",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042292",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "molybdopterin-synthase sulfurtransferase activity",
                        "id": "GO:0061604",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061604",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "molybdopterin-synthase adenylyltransferase activity",
                        "id": "GO:0061605",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061605",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2BDX3",
                                "url": "https://www.uniprot.org/uniprot/A2BDX3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 416,
            "end_pos": 418,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "43616",
            "name": "",
            "equation": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "D4A8L5-1",
                "O95396-1",
                "A2BDX3-1",
                "Q9VLJ8-1"
            ],
            "evidence": [
                {
                    "id": "43616",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/43616"
                }
            ]
        },
        {
            "id": "48612",
            "name": "",
            "equation": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "D4A8L5-1",
                "O95396-1",
                "A2BDX3-1",
                "Q9VLJ8-1"
            ],
            "evidence": [
                {
                    "id": "48612",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/48612"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A2BDX3",
            "gene_name": "Mocs3",
            "activity": [
                {
                    "ec_number": "2.7.7.80",
                    "activity": "ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.",
                    "evidence": [
                        {
                            "id": "A2BDX3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2BDX3"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.1.11",
                    "activity": "[Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + [cysteine desulfurase] + oxidized acceptor.",
                    "evidence": [
                        {
                            "id": "A2BDX3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2BDX3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "D4A8L5",
            "gene_name": "Mocs3",
            "activity": [
                {
                    "ec_number": "2.7.7.80",
                    "activity": "ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.",
                    "evidence": [
                        {
                            "id": "D4A8L5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D4A8L5"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.1.11",
                    "activity": "[Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + [cysteine desulfurase] + oxidized acceptor.",
                    "evidence": [
                        {
                            "id": "D4A8L5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D4A8L5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O95396",
            "gene_name": "MOCS3",
            "activity": [
                {
                    "ec_number": "2.7.7.80",
                    "activity": "ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.",
                    "evidence": [
                        {
                            "id": "O95396",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O95396"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.1.11",
                    "activity": "[Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + [cysteine desulfurase] + oxidized acceptor.",
                    "evidence": [
                        {
                            "id": "O95396",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O95396"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9VLJ8",
            "gene_name": "Uba4",
            "activity": [
                {
                    "ec_number": "2.7.7.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9VLJ8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9VLJ8"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.1.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9VLJ8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9VLJ8"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.7.80",
                    "activity": "ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.",
                    "evidence": [
                        {
                            "id": "Q9VLJ8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9VLJ8"
                        }
                    ]
                },
                {
                    "ec_number": "2.8.1.11",
                    "activity": "[Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + [cysteine desulfurase] + oxidized acceptor.",
                    "evidence": [
                        {
                            "id": "Q9VLJ8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9VLJ8"
                        }
                    ]
                }
            ]
        }
    ],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}