{ "uniprot_canonical_ac": "A2AX52-1", "uniprot_ac": "A2AX52", "uniprot_id": "CO6A4_MOUSE", "mass": { "chemical_mass": 250798.0, "monoisotopic_mass": 250798.0 }, "refseq": { "ac": "NP_081039", "name": "collagen alpha-4(VI) chain precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" }, "gene_names": [ { "name": "Col6a4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52" }, { "name": "1110001D15Rik; AI413310; AU023415; Dvwa; EG235580; Vwa6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039", "id": "NP_081039" }, { "name": "Col6a4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039", "id": "NP_081039" }, { "name": "Dvwa", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AX52", "id": "A2AX52" } ], "protein_names": [ { "name": "Collagen alpha-4(VI) chain", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AX52#names_and_taxonomy", "id": "A2AX52" }, { "name": "collagen alpha-4(VI) chain precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039", "id": "NP_081039" }, { "name": "collagen alpha-4(VI) chain; double von Willebrand factor A domains; dual von Willebrand factor A domains", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039", "id": "NP_081039" } ], "function": [ { "annotation": "Analysis of collagen VI chains alpha4, alpha5, and alpha6with high homology to the alpha3 chain", "evidence": [ { "database": "RefSeq", "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" }, { "database": "PubMed", "id": "18276594", "url": "https://glygen.org/publication/PubMed/18276594" } ] }, { "annotation": "Collagen VI acts as a cell-binding protein.", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52#function" } ] }, { "annotation": "DVWA is evolutionally very unique, which, together with its specific expression in articular cartilage, suggests its specific role in human cartilage metabolism.", "evidence": [ { "database": "RefSeq", "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" }, { "database": "PubMed", "id": "21057832", "url": "https://glygen.org/publication/PubMed/21057832" } ] }, { "annotation": "Discovery of three additional collagen VI chains doubles the collagen VI family and adds a layer of complexity to collagen VI assembly and function in the extracellular matrix", "evidence": [ { "database": "RefSeq", "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" }, { "database": "PubMed", "id": "18400749", "url": "https://glygen.org/publication/PubMed/18400749" } ] }, { "annotation": "The collagen VI alpha 4 chain is strongly expressed in the intestinal smooth muscle, surrounding the follicles in ovary, and in testis", "evidence": [ { "database": "RefSeq", "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" }, { "database": "PubMed", "id": "21477648", "url": "https://glygen.org/publication/PubMed/21477648" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs36435239", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs36435239" }, { "id": "rs36435239", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs36435239" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1281, "end_pos": 1281, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DET->NET).", "chr_id": "9", "chr_pos": "105940088C>", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs29838304", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs29838304" }, { "id": "rs29838304", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs29838304" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 425, "end_pos": 425, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TKT->NKT).", "chr_id": "9", "chr_pos": "105952623G>", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Col6a4", "url": "https://www.uniprot.org/uniprot/A2AX52", "locus": { "chromosome": "9", "start_pos": 106096783, "end_pos": 105989454, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000032572", "url": "https://www.ensembl.org/id/ENSMUSG00000032572" } ] } } ], "crossref": [ { "id": "ENSMUSG00000032572", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000032572", "database": "Bgee" }, { "id": "68553", "url": "https://www.ncbi.nlm.nih.gov/gene/68553", "database": "GeneID" }, { "id": "GPDB0001740", "url": "https://acgg.asia/gpdb2/GPDB0001740", "database": "GlycoProtDB" }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro" }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro" }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro" }, { "id": "mmu:68553", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68553", "database": "KEGG Pathway" }, { "id": "1915803", "url": "http://www.informatics.jax.org/marker/MGI:1915803", "database": "MGI" }, { "id": "YPPWKHA", "url": "https://omabrowser.org/oma/group/YPPWKHA/", "database": "OMA" }, { "id": "1049829at2759", "url": "http://www.orthodb.org/?query=1049829at2759", "database": "OrthoDB" }, { "id": "PF00092", "url": "http://pfam.xfam.org/family/PF00092", "database": "Pfam" }, { "id": "PF01391", "url": "http://pfam.xfam.org/family/PF01391", "database": "Pfam" }, { "id": "PR_A2AX52", "url": "http://purl.obolibrary.org/obo/PR_A2AX52", "database": "PRO" }, { "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039", "database": "RefSeq" }, { "id": "A0A1W2P6K8", "url": "https://www.uniprot.org/uniprot/A0A1W2P6K8", "database": "UniProtKB" }, { "id": "A0A1W2P6K8-1", "url": "https://www.uniprot.org/uniprot/A0A1W2P6K8-1", "database": "UniProtKB" }, { "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52", "database": "UniProtKB" }, { "id": "A2AX52-1", "url": "https://www.uniprot.org/uniprot/A2AX52-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MGTWKTFWLIISLAAGLGFVKSQRIVCREASVGDIVFLVHNSINPQHAHSVRNFLYILANSLQVGRDNIRVGLAQYSDTPTSEFLLSVYHRKGDVLKHIRGLQFKPGGNRMGQALQFILEHHFREGAGSRASQGVPQVAVVVSSGLTEDHIREPAEALRRAGILVYAIGVKDASQAELREISSSPKDNFTFFVPNFPGLPGLAQKLRPELCSTLGKAAQYTERESPACSEASPADIVFLVDSSTSIGLQNFQKVKHFLHSVVSGLDVRSDQVQVGLVQYSDNIYPAFPLKQSSLKSAVLDRIRNLPYSMGGTSTGSALEFIRANSLTEMSGSRAKDGVPQIVVLVTDGESSDEVQDVADQLKRDGVFVFVVGINIQDVQELQKIANEPFEEFLFTTENFSILQALSGTLLQALCSTVERQMKKSTKTYADVVFLIDTSQGTSQASFQWMQNFISRIIGILEVGQDKYQIGLAQYSDQGHTEFLFNTHKTRNEMVAHIHELLVFQGGSRKTGQGLRFLHRTFFQEAAGSRLLQGVPQYVVVITSGKSEDEVGEVAQILRKRGVDIVSVGLQDFDRAELEGIGPVVLVSDLQGEDRIRQLMLDVNMFIQGSPKPPRVMTDVAKDAVEECLVPVPADLVFLVEDFSSARQPNFQRVVHFLTTTVHSLNIHPDTTRVSLVFYSEKPRLEFSLDMYQSAAQVLRHLDRLTFRARRGRAKAGAALDFLRKEVFLPEKGSRPHRGVQQIAVVIIESPSLDNVSTPASYLRRAGVTIYAAGTQPASESKDLEKIVTYPPWKHAIRLESFLQLSVVGNKLKKKLCPEMLSGMPPLMSFIPESTRQSTQEGCESVEKADIYFLIDGSGSIKPNDFIEMKDFMKEVIKMFHIGPDRVRFGVVQYSDKIISQFFLTQYASMAGLSAAIDNIQQVGGGTTTGKALSKMVPVFQNTARIDVARYLIVITDGQSTDPVAEAAQGLRDIGVNIYAIGVRDANTTELEEIASKKMFFIYEFDSLKSIHQEVIRDICSSENCKSQKADIIFLIDGSESIAPKDFEKMKDFMERMVNQSNIGADEIQIGLLQFSSNPQEEFRLNRYSSKVDMCRAILSVQQMSDGTHTGKALNFTLPFFDSSRGGRPRVHQYLIVITDGVSQDNVAPPAKALRDRNIIIFAIGVGNVQRAQLLEITNDQDKVFQEENFESLQSLEKEILSEVCSSQGCNIDLSVGVDTSTSSERAQQELRRLLPELMQQLAFLSNISCEAPGQMEPRFRYVVPGSSDQPVFDSGFEKYSDETIQKFLVHQGSVNNRMDVDFLQSLGETAIHLSLAKVKVLLVFTDGLDEDLERLRRTSEFLRSRGLSGLLLIGLGGAHKLEELQELEFGRGFAYRQPLSSSLPSLPSVLLKQLDTIVERTCCNMYAKCYGDDGIRGEPGSRGEQGERGLDGLPGHPGEEGDHGQRGPRGLPGLRGEEGCPGVRGPKGARGFSGEKGNPGEEGVGGLDGEQGDRGAAGPSGEKGSSGSRGLTGLPGPAGPRGEPGLRGDPGDPGIDNLIQGPKGEKGRRGHQGSPGFHGPLGEAGSVGPRGSLGRHGLPGLKGVLGETGELGSRGEPGHPGPQGPRGRQGPPGFFGQKGDPGTQGNPGLPGPSGSKGPDGPRGLKGEVGPAGERGPRGQQGPRGQPGLFGPDGHGYPGRKGRKGEPGFPGYPGVQGEDGNPGRGGEKGAKGIRGKRGNSGFPGLAGTPGDQGPPGKMGTKGSKGLADRTPCEIVDFVRGNCPCSTGISRCPAFPTEVVFTLDMSNDVAPSDFERMRNILLSLLMKLEMCESNCPTGARVAIVSYNTRTDYLVRLSDHRGKAALLQAVRKIPLERSSGSRNLGATMRFVARHVFKRVRSGLLVRKVAVFFQAGRNYDTASVSTATLELHAADIATAVVTFTEEHNLPEAGLVDGPNEFHLFTWETEGQQDVERLASCTLCYDKCRPALGCQLRAPGPQKLDMDLVFLVDSSQGVSRDIYLGALRLVDSVLKDLEVAAQPGTSWHGARAALLTHTTPGFWPGVDQAPVLEYFHLTSHGHRTEMQRQIREAASGLLQGGPALGHALEWTLENVLLTAVLPRRSRVLYAIVASETSIWDREKLRTLSQEAKCKGIALFVLAVGPGVGAQELAELAKVASAPWEQHLLRLEGVSEAEVAYASRFTEAFLNLLNSGINQYPPPELVKECGGPNRGDTLLHFFTSAKRFSRSQSGTSAAFANDSEALKSQGIFLGERKSRVASVALQEALGSHGKDRADTEDIDQETPAKGRHLGPTHGPCPMGPEEGECLNYVLK", "length": 2309, "header": "sp|A2AX52-1|CO6A4_MOUSE Isoform 1 of Collagen alpha-4(VI) chain OS=Mus musculus OX=10090 GN=Col6a4 PE=1 SV=2 CANONICAL=A2AX52-1" }, "isoforms": [ { "isoform_ac": "A0A1W2P6K8-1", "url": "https://www.uniprot.org/uniprot/A2AX52#A0A1W2P6K8-1", "sequence": { "sequence": "XKVAVFFQAGRNYDTASVSTATLELHAADIATAVVTFTEEHNLPEAGLVDGPNEFHLFTWETEGQQDVERLASCTLCYDKCRPALGCQLRAPGPQKLDMDLCALGAAPATPRGCLRGRGGLCQQIHGGLPEPSK", "length": 134, "header": "tr|A0A1W2P6K8-1|A0A1W2P6K8_MOUSE Computationally mapped isoform of Collagen alpha-4(VI) chain OS=Mus musculus OX=10090 GN=Col6a4 PE=4 SV=1 CANONICAL=A2AX52-1" }, "locus": { "chromosome": "9", "start_pos": 105890645, "end_pos": 105877411, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000218471", "url": "https://www.ensembl.org/id/ENSMUST00000218471" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000151299", "url": "https://www.ensembl.org/id/ENSMUSP00000151299" } ] } }, { "isoform_ac": "A2AX52-1", "url": "https://www.uniprot.org/uniprot/A2AX52#A2AX52-1", "sequence": { "sequence": "MGTWKTFWLIISLAAGLGFVKSQRIVCREASVGDIVFLVHNSINPQHAHSVRNFLYILANSLQVGRDNIRVGLAQYSDTPTSEFLLSVYHRKGDVLKHIRGLQFKPGGNRMGQALQFILEHHFREGAGSRASQGVPQVAVVVSSGLTEDHIREPAEALRRAGILVYAIGVKDASQAELREISSSPKDNFTFFVPNFPGLPGLAQKLRPELCSTLGKAAQYTERESPACSEASPADIVFLVDSSTSIGLQNFQKVKHFLHSVVSGLDVRSDQVQVGLVQYSDNIYPAFPLKQSSLKSAVLDRIRNLPYSMGGTSTGSALEFIRANSLTEMSGSRAKDGVPQIVVLVTDGESSDEVQDVADQLKRDGVFVFVVGINIQDVQELQKIANEPFEEFLFTTENFSILQALSGTLLQALCSTVERQMKKSTKTYADVVFLIDTSQGTSQASFQWMQNFISRIIGILEVGQDKYQIGLAQYSDQGHTEFLFNTHKTRNEMVAHIHELLVFQGGSRKTGQGLRFLHRTFFQEAAGSRLLQGVPQYVVVITSGKSEDEVGEVAQILRKRGVDIVSVGLQDFDRAELEGIGPVVLVSDLQGEDRIRQLMLDVNMFIQGSPKPPRVMTDVAKDAVEECLVPVPADLVFLVEDFSSARQPNFQRVVHFLTTTVHSLNIHPDTTRVSLVFYSEKPRLEFSLDMYQSAAQVLRHLDRLTFRARRGRAKAGAALDFLRKEVFLPEKGSRPHRGVQQIAVVIIESPSLDNVSTPASYLRRAGVTIYAAGTQPASESKDLEKIVTYPPWKHAIRLESFLQLSVVGNKLKKKLCPEMLSGMPPLMSFIPESTRQSTQEGCESVEKADIYFLIDGSGSIKPNDFIEMKDFMKEVIKMFHIGPDRVRFGVVQYSDKIISQFFLTQYASMAGLSAAIDNIQQVGGGTTTGKALSKMVPVFQNTARIDVARYLIVITDGQSTDPVAEAAQGLRDIGVNIYAIGVRDANTTELEEIASKKMFFIYEFDSLKSIHQEVIRDICSSENCKSQKADIIFLIDGSESIAPKDFEKMKDFMERMVNQSNIGADEIQIGLLQFSSNPQEEFRLNRYSSKVDMCRAILSVQQMSDGTHTGKALNFTLPFFDSSRGGRPRVHQYLIVITDGVSQDNVAPPAKALRDRNIIIFAIGVGNVQRAQLLEITNDQDKVFQEENFESLQSLEKEILSEVCSSQGCNIDLSVGVDTSTSSERAQQELRRLLPELMQQLAFLSNISCEAPGQMEPRFRYVVPGSSDQPVFDSGFEKYSDETIQKFLVHQGSVNNRMDVDFLQSLGETAIHLSLAKVKVLLVFTDGLDEDLERLRRTSEFLRSRGLSGLLLIGLGGAHKLEELQELEFGRGFAYRQPLSSSLPSLPSVLLKQLDTIVERTCCNMYAKCYGDDGIRGEPGSRGEQGERGLDGLPGHPGEEGDHGQRGPRGLPGLRGEEGCPGVRGPKGARGFSGEKGNPGEEGVGGLDGEQGDRGAAGPSGEKGSSGSRGLTGLPGPAGPRGEPGLRGDPGDPGIDNLIQGPKGEKGRRGHQGSPGFHGPLGEAGSVGPRGSLGRHGLPGLKGVLGETGELGSRGEPGHPGPQGPRGRQGPPGFFGQKGDPGTQGNPGLPGPSGSKGPDGPRGLKGEVGPAGERGPRGQQGPRGQPGLFGPDGHGYPGRKGRKGEPGFPGYPGVQGEDGNPGRGGEKGAKGIRGKRGNSGFPGLAGTPGDQGPPGKMGTKGSKGLADRTPCEIVDFVRGNCPCSTGISRCPAFPTEVVFTLDMSNDVAPSDFERMRNILLSLLMKLEMCESNCPTGARVAIVSYNTRTDYLVRLSDHRGKAALLQAVRKIPLERSSGSRNLGATMRFVARHVFKRVRSGLLVRKVAVFFQAGRNYDTASVSTATLELHAADIATAVVTFTEEHNLPEAGLVDGPNEFHLFTWETEGQQDVERLASCTLCYDKCRPALGCQLRAPGPQKLDMDLVFLVDSSQGVSRDIYLGALRLVDSVLKDLEVAAQPGTSWHGARAALLTHTTPGFWPGVDQAPVLEYFHLTSHGHRTEMQRQIREAASGLLQGGPALGHALEWTLENVLLTAVLPRRSRVLYAIVASETSIWDREKLRTLSQEAKCKGIALFVLAVGPGVGAQELAELAKVASAPWEQHLLRLEGVSEAEVAYASRFTEAFLNLLNSGINQYPPPELVKECGGPNRGDTLLHFFTSAKRFSRSQSGTSAAFANDSEALKSQGIFLGERKSRVASVALQEALGSHGKDRADTEDIDQETPAKGRHLGPTHGPCPMGPEEGECLNYVLK", "length": 2309, "header": "sp|A2AX52-1|CO6A4_MOUSE Isoform 1 of Collagen alpha-4(VI) chain OS=Mus musculus OX=10090 GN=Col6a4 PE=1 SV=2 CANONICAL=A2AX52-1" }, "locus": { "chromosome": "9", "start_pos": 105960141, "end_pos": 105867981, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000121963", "url": "https://www.ensembl.org/id/ENSMUST00000121963" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000112472", "url": "https://www.ensembl.org/id/ENSMUSP00000112472" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1114, "start_aa": "Asn", "end_pos": 1114, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2AX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AX52#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 188, "start_aa": "Asn", "end_pos": 188, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2AX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AX52#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 754, "start_aa": "Asn", "end_pos": 754, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2AX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AX52#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Three novel collagen VI chains with high homology to the alpha 3 chain.", "journal": "J. Biol. Chem.", "date": "2008", "authors": "Koch M., Wagener R., Bonaldo P., Grumati P., Urciuolo A., Paulsson M., Gara S.K., Kobbe B.", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" }, { "database": "RefSeq", "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" } ], "reference": [ { "type": "PubMed", "id": "18276594", "url": "https://glygen.org/publication/PubMed/18276594" } ] }, { "title": "Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI).", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Fitzgerald J, Rich C, Zhou FH, Hansen U", "evidence": [ { "database": "RefSeq", "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" } ], "reference": [ { "type": "PubMed", "id": "18400749", "url": "https://glygen.org/publication/PubMed/18400749" } ] }, { "title": "Cloning and characterization of the osteoarthritis-associated gene DVWA.", "journal": "Journal of bone and mineral metabolism", "date": "2011", "authors": "Nakajima M, Miyamoto Y, Ikegawa S", "evidence": [ { "database": "RefSeq", "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" } ], "reference": [ { "type": "PubMed", "id": "21057832", "url": "https://glygen.org/publication/PubMed/21057832" } ] }, { "title": "Differential and restricted expression of novel collagen VI chains in mouse.", "journal": "Matrix biology : journal of the International Society for Matrix Biology", "date": "2011", "authors": "Gara SK, Grumati P, Squarzoni S, Sabatelli P, Urciuolo A, Bonaldo P, Paulsson M, Wagener R", "evidence": [ { "database": "RefSeq", "id": "NP_081039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081039" } ], "reference": [ { "type": "PubMed", "id": "21477648", "url": "https://glygen.org/publication/PubMed/21477648" } ] } ], "pathway": [ { "id": "mmu:68553", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68553", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1M6H4-1", "protein_name": "Collagen, type VI, alpha 4", "gene_name": "Col6a4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTWKTLWLIISFAAGLGFIKSQRTVCREASVGDIVFLVHTNIDPQHAQSVRNFLYILANSLQVGGDNIRVSLALYGDTPTTEFLLSAYPRKGDVLKHIRGLQFKPGGNRMGQSLQFILEHHFPEGAGSRASQGVPQVALVMSTGVAEDHFREPAEALKREGILLYAIGVKDAAQAELREIASSPKDNFTFFVPNFSGLPGLAQKLRPELCTTLAKVVQHTEQGSPACTEAFLADIVFLVDSSTSIGLQNFQKVKNFLHSIVSGLDVRSDQVQVGLVQYSDNIYPAFQLKQSSLKSVVLEQIRNLPYNMGSTNTGSALEFIRANYLTEMSGSRAKDGVPQIVILVTDGESNDEVQDAADQLKRDGVFVYVVGINIQDVQELQKIASEPFEEFLFTTENFNILQELSGSLSQAVCSTVEREMKKCLAPIPTDLVFLVEEFTSAGQPNFQQVIKLLKTTVHSLNIHPDIVRVSLVFYSEKPQLKFSLNTFQNAAQVLTSLDQLTFRARRGRTKAGAALDFLRKEVFLPEKGSRSIWGVQQIAVIIMESPSLDNVSTPASHLRRTGVTIYAVGIQSASESKDLEKIATYPPGKHTIHLESFLQLDVVRKILNKKLCPETLGKMPPVGSMPPGAEMPPGAEMPPGGKMPPLTGCTPQSMQKVCTHVEKADIYFLIDGSGSISPKDFTEMKEFMKDVIKMFHIGPDGVRFGVVQYSDKIISQFLLTQYTSMEKLGTAIGNIQQGGGGTTTGELSKMALVFRNTARTNVAQYLIVITDGQSSDPVADAAQGLRDTGINIYAIGVRDANTTELEEIANNRVFFTDDFHFLKSIHQEVVRDICSFENCRSQKADIIFLIDGSESISSEDFEKIKDFVKRMVNQSNIGADKIQIGLLQFSSTPREEFTLKNNYSSKDEMCRAISNVTQINSGTETGKALNFTLPFFDISQGGRPGVHQYLIVITDGDSHDDIVSPAKALRDRNIIIFAIGVGKIQRAQLLAITNDQDKVYHEENFESLQNLEKEILYEVCTSQGCSMDLSVGVDTSTSSGRAQQELGRFLPGLLQQLALLSNISCEAPGQMEPRFRYVVPGSSSRPVFDSGFEKYNDETVQKFLVQQGSANNRLNVDFLKSLGETAIHSSSANVKVLLVFTDGLDEDLERLRRTSELLRSGGLSGLLVIGLGGAHKLEELQELEFGKGFAYRQPLSSSLPSLPSVLLKQLDTIVEKACCYVCAKCYGDDGVRGDPGSLGKEGERGLDGLPGHPGEDGDHGPRGPRGLPGLRGEEGCPGVRGPKGARGFSGEKGNPGDEGVEGLDGEQGDRGAAGSSGEKGSRGSQGLTGLPGPAGSRGEPGLRGDPGDPGIDNFIQGPKGEKGRRGRQGSSGFHGLLGETGSVGPWGSLGRRGLPGLKGVLGEAGELGYQGEPGYPGPQGPRGRQGPPGSFGQKGDAGAQGNPGPPGPNGSRGTDGPRGLKGELGHTGERGPRGQQGSRGQPGRFGLDGYGHPGRKGKKGEPGFPGYPGLQGEDGNPGRGGEKGAKGIRGKRGSSGFPGFAGTPGDQGPPGKMGIKGPKGLADRTPCEIVDFVRGNCPPCQGISRCPAFPTEVVFALDMSNDVSQSDFERMRNILLSLLMKLEMSESNCPTGARVAIVSYNMRTDYLVRLSDHRGKATLLQAVRKIPLERSSGFRNLGATMKFVARHVFKRVRSGFLVRKVAVFFQVGGNYDATSVNTAMLELHAANIVTAVVTFTEDHNLPDALLVDGLNTFHLFTWETEHQQDVERLVSCTLCYDKCRPAPGCRVESPRPQELDMDLVFLVDSSQGVSRDIYLGALRLVDSVLKDLEVAAQPGTSWHGARVALLTHTTPGFWPGVGQDPVLEYFHLTSHGHRTQMQRQIQEAASGLLQGAPALGHALEWTLEKVLLAAILPRRSQVLFAIVASETSIWDRETLRALSLEAKCKGITLFVLAVGPGVGAQELTELANVASAPSEQHLLRLEGVSEAEVAYASRFTEAFLNLLKSGINQYPPPELNEECGGPNRGDTLLQFFTSAKRLSKPRFGTSAATGYDSGAPKPQDSFLRGKRKIRTLSVAQQETLGSLGRDRADAEETPAKGRRSGAAHGEIPNLVL", "length": 2113 }, "evidence": [ { "id": "A2AX52", "url": "https://omabrowser.org/oma/group/A2AX52/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "pmid": "18400749" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "pmid": "26571399" }, { "name": "collagen trimer", "id": "GO:0005581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005581", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "pmid": "18400749" }, { "name": "collagen-containing extracellular matrix", "id": "GO:0062023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "pmid": "22159717" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "pmid": "26571399" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "A2AX52", "url": "https://www.uniprot.org/uniprot/A2AX52" } ], "pmid": "18400749" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1058, "end_pos": 1060, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1114, "end_pos": 1116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1246, "end_pos": 1248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2235, "end_pos": 2237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 398, "end_pos": 400, "annotation": "n_glycosylation_sequon" }, { "start_pos": 754, "end_pos": 756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 986, "end_pos": 988, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }