{ "uniprot_canonical_ac": "A2AWT3-1", "uniprot_ac": "A2AWT3", "uniprot_id": "AT7L3_MOUSE", "mass": { "chemical_mass": 38594.0, "monoisotopic_mass": 38594.0 }, "refseq": { "ac": "NP_001092306", "name": "ataxin-7-like protein 3 isoform a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306" }, "gene_names": [ { "name": "Atxn7l3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AWT3", "id": "A2AWT3" }, { "name": "Atxn7l3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306", "id": "NP_001092306" }, { "name": "E030022H21Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306", "id": "NP_001092306" } ], "protein_names": [ { "name": "Ataxin-7-like protein 3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AWT3#names_and_taxonomy", "id": "A2AWT3" }, { "name": "SAGA-associated factor 11 homolog; ataxin-7-like protein 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306", "id": "NP_001092306" }, { "name": "SAGA-associated factor 11 homolog", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AWT3#names_and_taxonomy", "id": "A2AWT3" }, { "name": "ataxin-7-like protein 3 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306", "id": "NP_001092306" } ], "function": [ { "annotation": "Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3#function" }, { "database": "PubMed", "id": "MF_03047", "url": "https://glygen.org/publication/PubMed/MF_03047" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Atxn7l3", "url": "https://www.uniprot.org/uniprot/A2AWT3", "locus": { "chromosome": "11", "start_pos": 102296631, "end_pos": 102289300, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000059995", "url": "https://www.ensembl.org/id/ENSMUSG00000059995" } ] } } ], "crossref": [ { "id": "ENSMUSG00000059995", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000059995", "database": "Bgee" }, { "id": "217218", "url": "https://www.ncbi.nlm.nih.gov/gene/217218", "database": "GeneID" }, { "id": "A2AWT3", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AWT3*", "database": "IntAct" }, { "id": "IPR013243", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013243", "database": "InterPro" }, { "id": "IPR013246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013246", "database": "InterPro" }, { "id": "mmu:217218", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217218", "database": "KEGG Pathway" }, { "id": "3036270", "url": "http://www.informatics.jax.org/marker/MGI:3036270", "database": "MGI" }, { "id": "PSNYENM", "url": "https://omabrowser.org/oma/group/PSNYENM/", "database": "OMA" }, { "id": "1244885at2759", "url": "http://www.orthodb.org/?query=1244885at2759", "database": "OrthoDB" }, { "id": "PF08209", "url": "http://pfam.xfam.org/family/PF08209", "database": "Pfam" }, { "id": "PF08313", "url": "http://pfam.xfam.org/family/PF08313", "database": "Pfam" }, { "id": "PR_A2AWT3", "url": "http://purl.obolibrary.org/obo/PR_A2AWT3", "database": "PRO" }, { "id": "NP_001092306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092306", "database": "RefSeq" }, { "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3", "database": "UniProtKB" }, { "id": "A2AWT3-1", "url": "https://www.uniprot.org/uniprot/A2AWT3-1", "database": "UniProtKB" }, { "id": "A2AWT3-2", "url": "https://www.uniprot.org/uniprot/A2AWT3-2", "database": "UniProtKB" }, { "id": "F6RCN9", "url": "https://www.uniprot.org/uniprot/F6RCN9", "database": "UniProtKB" }, { "id": "F6RCN9-1", "url": "https://www.uniprot.org/uniprot/F6RCN9-1", "database": "UniProtKB" }, { "id": "Z4YN62", "url": "https://www.uniprot.org/uniprot/Z4YN62", "database": "UniProtKB" }, { "id": "Z4YN62-1", "url": "https://www.uniprot.org/uniprot/Z4YN62-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN", "length": 347, "header": "sp|A2AWT3-1|AT7L3_MOUSE Isoform 1 of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1" }, "isoforms": [ { "isoform_ac": "A2AWT3-1", "url": "https://www.uniprot.org/uniprot/A2AWT3#A2AWT3-1", "sequence": { "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN", "length": 347, "header": "sp|A2AWT3-1|AT7L3_MOUSE Isoform 1 of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1" }, "locus": { "chromosome": "11", "start_pos": 102185825, "end_pos": 102182484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000073234", "url": "https://www.ensembl.org/id/ENSMUST00000073234" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000072967", "url": "https://www.ensembl.org/id/ENSMUSP00000072967" } ] } }, { "isoform_ac": "A2AWT3-2", "url": "https://www.uniprot.org/uniprot/A2AWT3#A2AWT3-2", "sequence": { "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKLWYLPFQNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN", "length": 354, "header": "sp|A2AWT3-2|AT7L3_MOUSE Isoform 2 of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1" }, "locus": { "chromosome": "11", "start_pos": 102185825, "end_pos": 102182484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000107132", "url": "https://www.ensembl.org/id/ENSMUST00000107132" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102750", "url": "https://www.ensembl.org/id/ENSMUSP00000102750" } ] } }, { "isoform_ac": "F6RCN9-1", "url": "https://www.uniprot.org/uniprot/A2AWT3#F6RCN9-1", "sequence": { "sequence": "XRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGFSVCTSASNTLPLLFSSSGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN", "length": 258, "header": "tr|F6RCN9-1|AT7L3_MOUSE Computationally mapped isoform of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1" }, "locus": { "chromosome": "11", "start_pos": 102184989, "end_pos": 102182482, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000141516", "url": "https://www.ensembl.org/id/ENSMUST00000141516" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000121917", "url": "https://www.ensembl.org/id/ENSMUSP00000121917" } ] } }, { "isoform_ac": "Z4YN62-1", "url": "https://www.uniprot.org/uniprot/A2AWT3#Z4YN62-1", "sequence": { "sequence": "EMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKLWYLPFQNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN", "length": 350, "header": "tr|Z4YN62-1|Z4YN62_MOUSE Computationally mapped isoform of Ataxin-7-like protein 3 OS=Mus musculus OX=10090 GN=Atxn7l3 PE=1 SV=1 CANONICAL=A2AWT3-1" }, "locus": { "chromosome": "11", "start_pos": 102185813, "end_pos": 102182484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000137387", "url": "https://www.ensembl.org/id/ENSMUST00000137387" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122610", "url": "https://www.ensembl.org/id/ENSMUSP00000122610" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 129, "end_pos": 129, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ] }, { "start_pos": 131, "end_pos": 131, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ] }, { "start_pos": 278, "end_pos": 278, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ] }, { "start_pos": 281, "end_pos": 281, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" }, { "database": "iPTMnet", "id": "A2AWT3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AWT3" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 281, "end_pos": 281, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 326, "end_pos": 326, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" }, { "database": "iPTMnet", "id": "A2AWT3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AWT3" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "pathway": [ { "id": "mmu:217218", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217218", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A5H7-1", "protein_name": "Ataxin-7-like protein 3", "gene_name": "Atxn7l3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYSNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDGFDMTDSQALLSRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPAPSIYEDIN", "length": 347 }, "evidence": [ { "id": "35401", "url": "http://www.informatics.jax.org/homology/35401", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14CW9-1", "protein_name": "Ataxin-7-like protein 3", "gene_name": "ATXN7L3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKMEEMSLSGLDNSKLEAIAQEIYADLVEDSCLGFCFEVHRAVKCGYFFLDDTDPDSMKDFEIVDQPGLDIFGQVFNQWKSKECVCPNCSRSIAASRFAPHLEKCLGMGRNSSRIANRRIANSNNMNKSESDQEDNDDINDNDWSYGSEKKAKKRKSDKNPNSPRRSKSLKHKNGELSNSDPFKYNNSTGISYETLGPEELRSLLTTQCGVISEHTKKMCTRSLRCPQHTDEQRRTVRIYFLGPSAVLPEVESSLDNDSFDMTDSQALISRLQWDGSSDLSPSDSGSSKTSENQGWGLGTNSSESRKTKKKKSHLSLVGTASGLGSNKKKKPKPPAPPTPSIYDDIN", "length": 347 }, "evidence": [ { "id": "35401", "url": "http://www.informatics.jax.org/homology/35401", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" }, { "name": "nuclear receptor coactivator activity", "id": "GO:0030374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030374", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" }, { "name": "DUBm complex", "id": "GO:0071819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071819", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" }, { "name": "SAGA complex", "id": "GO:0000124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "21873635" }, { "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" }, { "name": "histone deubiquitination", "id": "GO:0016578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016578", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" }, { "name": "histone monoubiquitination", "id": "GO:0010390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010390", "evidence": [ { "database": "UniProtKB", "id": "A2AWT3", "url": "https://www.uniprot.org/uniprot/A2AWT3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 301, "end_pos": 303, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }