{ "uniprot_canonical_ac": "A2AWP8-1", "uniprot_ac": "A2AWP8", "uniprot_id": "ARGAL_MOUSE", "mass": { "chemical_mass": 139987.0, "monoisotopic_mass": 139987.0 }, "refseq": { "ac": "NP_001106193", "name": "rho guanine nucleotide exchange factor 10-like protein isoform b", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193" }, "gene_names": [ { "name": "Arhgef10l", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8" }, { "name": "2810441C07Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193", "id": "NP_001106193" }, { "name": "Arhgef10l", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193", "id": "NP_001106193" }, { "name": "Kiaa1626", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8" } ], "protein_names": [ { "name": "Rho guanine nucleotide exchange factor 10-like protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AWP8#names_and_taxonomy", "id": "A2AWP8" }, { "name": "GrinchGEF", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AWP8#names_and_taxonomy", "id": "A2AWP8" }, { "name": "rho guanine nucleotide exchange factor 10-like protein isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193", "id": "NP_001106193" }, { "name": "rho guanine nucleotide exchange factor 10-like protein; GrinchGEF", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193", "id": "NP_001106193" } ], "function": [ { "annotation": "Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8#function" } ] } ], "disease": [ { "disease_id": "DOID:0050933", "recommended_name": { "id": "DOID:0050933", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050933", "name": "ovarian serous carcinoma", "description": "An ovarian carcinoma that has_material_basis_in the lining of the ovary and produces a serum-like fluid." }, "synonyms": [], "evidence": [ { "id": "0050933", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050933" } ] }, { "disease_id": "DOID:6212", "recommended_name": { "id": "DOID:6212", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6212", "name": "ovarian endometrial cancer", "description": "An ovary epithelial cancer that has_material_basis_in the endometrium and is located_in the ovary." }, "synonyms": [ { "id": "DOID:6212", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6212", "name": "endometrioid neoplasm of Ovary", "description": "" }, { "id": "DOID:6212", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6212", "name": "malignant ovarian endometrioid tumor", "description": "" }, { "id": "DOID:6212", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6212", "name": "ovarian endometrioid neoplasm", "description": "" } ], "evidence": [ { "id": "6212", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:6212" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Arhgef10l", "url": "https://www.uniprot.org/uniprot/A2AWP8", "locus": { "chromosome": "4", "start_pos": 140666012, "end_pos": 140514485, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000040964", "url": "https://www.ensembl.org/id/ENSMUSG00000040964" } ] } } ], "crossref": [ { "id": "ENSMUSG00000040964", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040964", "database": "Bgee" }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD" }, { "id": "72754", "url": "https://www.ncbi.nlm.nih.gov/gene/72754", "database": "GeneID" }, { "id": "A2AWP8", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AWP8*", "database": "IntAct" }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro" }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro" }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro" }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro" }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro" }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro" }, { "id": "IPR039919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039919", "database": "InterPro" }, { "id": "mmu:72754", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72754", "database": "KEGG Pathway" }, { "id": "1920004", "url": "http://www.informatics.jax.org/marker/MGI:1920004", "database": "MGI" }, { "id": "CGEDEGK", "url": "https://omabrowser.org/oma/group/CGEDEGK/", "database": "OMA" }, { "id": "67600at2759", "url": "http://www.orthodb.org/?query=67600at2759", "database": "OrthoDB" }, { "id": "PTHR12877", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12877", "database": "PANTHER" }, { "id": "PF00621", "url": "http://pfam.xfam.org/family/PF00621", "database": "Pfam" }, { "id": "PR_A2AWP8", "url": "http://purl.obolibrary.org/obo/PR_A2AWP8", "database": "PRO" }, { "id": "R-MMU-193648", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193648", "database": "Reactome" }, { "id": "R-MMU-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416482", "database": "Reactome" }, { "id": "R-MMU-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8980692", "database": "Reactome" }, { "id": "R-MMU-9013026", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013026", "database": "Reactome" }, { "id": "R-MMU-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013106", "database": "Reactome" }, { "id": "NP_001106193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193", "database": "RefSeq" }, { "id": "A2AWP4", "url": "https://www.uniprot.org/uniprot/A2AWP4", "database": "UniProtKB" }, { "id": "A2AWP4-1", "url": "https://www.uniprot.org/uniprot/A2AWP4-1", "database": "UniProtKB" }, { "id": "A2AWP6", "url": "https://www.uniprot.org/uniprot/A2AWP6", "database": "UniProtKB" }, { "id": "A2AWP6-1", "url": "https://www.uniprot.org/uniprot/A2AWP6-1", "database": "UniProtKB" }, { "id": "A2AWP7", "url": "https://www.uniprot.org/uniprot/A2AWP7", "database": "UniProtKB" }, { "id": "A2AWP7-1", "url": "https://www.uniprot.org/uniprot/A2AWP7-1", "database": "UniProtKB" }, { "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8", "database": "UniProtKB" }, { "id": "A2AWP8-1", "url": "https://www.uniprot.org/uniprot/A2AWP8-1", "database": "UniProtKB" }, { "id": "A2AWP8-2", "url": "https://www.uniprot.org/uniprot/A2AWP8-2", "database": "UniProtKB" }, { "id": "A2AWP8-3", "url": "https://www.uniprot.org/uniprot/A2AWP8-3", "database": "UniProtKB" }, { "id": "A2AWP8-4", "url": "https://www.uniprot.org/uniprot/A2AWP8-4", "database": "UniProtKB" }, { "id": "A2AWP8-5", "url": "https://www.uniprot.org/uniprot/A2AWP8-5", "database": "UniProtKB" }, { "id": "A8Y5U3", "url": "https://www.uniprot.org/uniprot/A8Y5U3", "database": "UniProtKB" }, { "id": "A8Y5U3-1", "url": "https://www.uniprot.org/uniprot/A8Y5U3-1", "database": "UniProtKB" }, { "id": "F6S3V7", "url": "https://www.uniprot.org/uniprot/F6S3V7", "database": "UniProtKB" }, { "id": "F6S3V7-1", "url": "https://www.uniprot.org/uniprot/F6S3V7-1", "database": "UniProtKB" }, { "id": "F6ZH54", "url": "https://www.uniprot.org/uniprot/F6ZH54", "database": "UniProtKB" }, { "id": "F6ZH54-1", "url": "https://www.uniprot.org/uniprot/F6ZH54-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKLSPDLTRLKERYVRTKRDILALRVGGRDMQELKLKCDCKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL", "length": 1280, "header": "sp|A2AWP8-1|ARGAL_MOUSE Isoform 1 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "isoforms": [ { "isoform_ac": "A2AWP4-1", "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP4-1", "sequence": { "sequence": "MLPSSSWGKRKPRSQRLGWVRCDARGNMWARQEGLRQPHPHPHALIRCPSSSSSSVSCSGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGH", "length": 261, "header": "tr|A2AWP4-1|A2AWP4_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=8 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140309094, "end_pos": 140302739, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000147426", "url": "https://www.ensembl.org/id/ENSMUST00000147426" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123642", "url": "https://www.ensembl.org/id/ENSMUSP00000123642" } ] } }, { "isoform_ac": "A2AWP6-1", "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP6-1", "sequence": { "sequence": "MTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL", "length": 1040, "header": "tr|A2AWP6-1|A2AWP6_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140311243, "end_pos": 140242304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000105798", "url": "https://www.ensembl.org/id/ENSMUST00000105798" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101424", "url": "https://www.ensembl.org/id/ENSMUSP00000101424" } ] } }, { "isoform_ac": "A2AWP7-1", "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP7-1", "sequence": { "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRE", "length": 163, "header": "tr|A2AWP7-1|A2AWP7_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140344260, "end_pos": 140319243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000143614", "url": "https://www.ensembl.org/id/ENSMUST00000143614" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000120437", "url": "https://www.ensembl.org/id/ENSMUSP00000120437" } ] } }, { "isoform_ac": "A2AWP8-1", "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-1", "sequence": { "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKLSPDLTRLKERYVRTKRDILALRVGGRDMQELKLKCDCKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL", "length": 1280, "header": "sp|A2AWP8-1|ARGAL_MOUSE Isoform 1 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140344260, "end_pos": 140242304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000105799", "url": "https://www.ensembl.org/id/ENSMUST00000105799" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101425", "url": "https://www.ensembl.org/id/ENSMUSP00000101425" } ] } }, { "isoform_ac": "A2AWP8-2", "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-2", "sequence": { "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL", "length": 1241, "header": "sp|A2AWP8-2|ARGAL_MOUSE Isoform 2 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140344260, "end_pos": 140242304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000069623", "url": "https://www.ensembl.org/id/ENSMUST00000069623" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000066249", "url": "https://www.ensembl.org/id/ENSMUSP00000066249" } ] } }, { "isoform_ac": "A2AWP8-3", "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-3", "sequence": { "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL", "length": 1236, "header": "sp|A2AWP8-3|ARGAL_MOUSE Isoform 3 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140344260, "end_pos": 140242304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000097820", "url": "https://www.ensembl.org/id/ENSMUST00000097820" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000095431", "url": "https://www.ensembl.org/id/ENSMUSP00000095431" } ] } }, { "isoform_ac": "A2AWP8-4", "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-4", "sequence": { "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKLSPDLTRLKERYVRTKRDILALRVGGRDMQELKLKCDCKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL", "length": 1275, "header": "sp|A2AWP8-4|ARGAL_MOUSE Isoform 4 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140344260, "end_pos": 140242304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000039204", "url": "https://www.ensembl.org/id/ENSMUST00000039204" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000040531", "url": "https://www.ensembl.org/id/ENSMUSP00000040531" } ] } }, { "isoform_ac": "A2AWP8-5", "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-5", "sequence": { "sequence": "MLPSSSWGKRKPRSQRLGWVRCDARGNMWARQEGLRQPHPHPHALIRCPSSSSSSVSCSGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL", "length": 988, "header": "sp|A2AWP8-5|ARGAL_MOUSE Isoform 5 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140309094, "end_pos": 140242304, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000105797", "url": "https://www.ensembl.org/id/ENSMUST00000105797" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101423", "url": "https://www.ensembl.org/id/ENSMUSP00000101423" } ] } }, { "isoform_ac": "A8Y5U3-1", "url": "https://www.uniprot.org/uniprot/A2AWP8#A8Y5U3-1", "sequence": { "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDR", "length": 119, "header": "tr|A8Y5U3-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140344260, "end_pos": 140320480, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000154979", "url": "https://www.ensembl.org/id/ENSMUST00000154979" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122667", "url": "https://www.ensembl.org/id/ENSMUSP00000122667" } ] } }, { "isoform_ac": "F6S3V7-1", "url": "https://www.uniprot.org/uniprot/A2AWP8#F6S3V7-1", "sequence": { "sequence": "XPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPDRSLIKCSPRA", "length": 611, "header": "tr|F6S3V7-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140304405, "end_pos": 140245039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000138493", "url": "https://www.ensembl.org/id/ENSMUST00000138493" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119471", "url": "https://www.ensembl.org/id/ENSMUSP00000119471" } ] } }, { "isoform_ac": "F6ZH54-1", "url": "https://www.uniprot.org/uniprot/A2AWP8#F6ZH54-1", "sequence": { "sequence": "HAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQMRTLSSGTGERAWDPAQINSRRSRAGWAVDWGAKS", "length": 205, "header": "tr|F6ZH54-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1" }, "locus": { "chromosome": "4", "start_pos": 140295692, "end_pos": 140279127, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000140403", "url": "https://www.ensembl.org/id/ENSMUST00000140403" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000117038", "url": "https://www.ensembl.org/id/ENSMUSP00000117038" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 131, "end_pos": 131, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Tyr", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" }, { "database": "iPTMnet", "id": "A2AWP8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AWP8" }, { "database": "PubMed", "id": "17947660", "url": "https://glygen.org/publication/PubMed/17947660" } ] }, { "start_pos": 131, "end_pos": 131, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" }, { "database": "PubMed", "id": "17947660", "url": "https://glygen.org/publication/PubMed/17947660" } ] }, { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Tyr", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" }, { "database": "iPTMnet", "id": "A2AWP8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AWP8" }, { "database": "PubMed", "id": "17947660", "url": "https://glygen.org/publication/PubMed/17947660" } ] }, { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" }, { "database": "PubMed", "id": "17947660", "url": "https://glygen.org/publication/PubMed/17947660" } ] }, { "start_pos": 279, "end_pos": 279, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ] }, { "start_pos": 40, "end_pos": 40, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2007", "authors": "Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" }, { "database": "UniProtKB", "id": "A2AWP7", "url": "https://www.uniprot.org/uniprot/A2AWP7" }, { "database": "iPTMnet", "id": "A2AWP8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AWP8" } ], "reference": [ { "type": "PubMed", "id": "17947660", "url": "https://glygen.org/publication/PubMed/17947660" } ] } ], "pathway": [ { "id": "mmu:72754", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72754", "resource": "KEGG Pathway" }, { "id": "R-MMU-193648", "name": "NRAGE signals death through JNK", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193648", "resource": "Reactome", "description": "NRAGE signals death through JNK" }, { "id": "R-MMU-416482", "name": "G alpha (12/13) signalling events", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-MMU-8980692", "name": "RHOA GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-MMU-9013026", "name": "RHOB GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013026", "resource": "Reactome", "description": "RHOB GTPase cycle" }, { "id": "R-MMU-9013106", "name": "RHOC GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9HCE6-1", "protein_name": "Rho guanine nucleotide exchange factor 10-like protein", "gene_name": "ARHGEF10L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSEDSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQAPCGETDSTLLIWQVPLML", "length": 1279 }, "evidence": [ { "id": "10017", "url": "http://www.informatics.jax.org/homology/10017", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ], "pmid": "21873635" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ], "pmid": "" }, { "name": "SREBP signaling pathway", "id": "GO:0032933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032933", "evidence": [ { "database": "UniProtKB", "id": "A2AWP8", "url": "https://www.uniprot.org/uniprot/A2AWP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 682, "end_pos": 684, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }