{ "uniprot_canonical_ac": "A2AVZ9-1", "uniprot_ac": "A2AVZ9", "uniprot_id": "S43A3_MOUSE", "mass": { "chemical_mass": 56034.0, "monoisotopic_mass": 56034.0 }, "refseq": { "ac": "NP_067373", "name": "solute carrier family 43 member 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373" }, "gene_names": [ { "name": "Slc43a3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AVZ9", "id": "A2AVZ9" }, { "name": "Eeg1; SEEEG-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373", "id": "NP_067373" }, { "name": "Eeg1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AVZ9", "id": "A2AVZ9" }, { "name": "Slc43a3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373", "id": "NP_067373" } ], "protein_names": [ { "name": "Solute carrier family 43 member 3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AVZ9#names_and_taxonomy", "id": "A2AVZ9" }, { "name": "Embryonic epithelia gene 1 protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AVZ9#names_and_taxonomy", "id": "A2AVZ9" }, { "name": "embryonic epithelial gene 1; selectively expressed in embryonic epithelia protein-1; embryonic epithelia gene 1 protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373", "id": "NP_067373" }, { "name": "solute carrier family 43 member 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373", "id": "NP_067373" } ], "function": [ { "annotation": "Putative transporter.", "evidence": [ { "database": "UniProtKB", "id": "A2AVZ9", "url": "https://www.uniprot.org/uniprot/A2AVZ9#function" } ] }, { "annotation": "SLC43A3 is an equilibrative nucleobase transporter involved in purine salvage in mammals. Erratum:[Sci Rep. 2016;6:22175. PMID: 26940463] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_067373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373" }, { "database": "PubMed", "id": "26455426", "url": "https://glygen.org/publication/PubMed/26455426" } ] }, { "annotation": "Slc43a3 is a regulator of free fatty acid flux.", "evidence": [ { "database": "RefSeq", "id": "NP_067373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373" }, { "database": "PubMed", "id": "32217606", "url": "https://glygen.org/publication/PubMed/32217606" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AVZ9", "url": "https://www.uniprot.org/uniprot/A2AVZ9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Slc43a3", "url": "https://www.uniprot.org/uniprot/A2AVZ9", "locus": { "chromosome": "2", "start_pos": 84936579, "end_pos": 84958509, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000027074", "url": "https://www.ensembl.org/id/ENSMUSG00000027074" } ] } } ], "crossref": [ { "id": "ENSMUSG00000027074", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027074", "database": "Bgee" }, { "id": "58207", "url": "https://www.ncbi.nlm.nih.gov/gene/58207", "database": "GeneID" }, { "id": "GPDB0001734", "url": "https://acgg.asia/gpdb2/GPDB0001734", "database": "GlycoProtDB" }, { "id": "GPDB0001735", "url": "https://acgg.asia/gpdb2/GPDB0001735", "database": "GlycoProtDB" }, { "id": "GPDB0001807", "url": "https://acgg.asia/gpdb2/GPDB0001807", "database": "GlycoProtDB" }, { "id": "GPDB0007945", "url": "https://acgg.asia/gpdb2/GPDB0007945", "database": "GlycoProtDB" }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro" }, { "id": "IPR027197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027197", "database": "InterPro" }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro" }, { "id": "mmu:58207", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:58207", "database": "KEGG Pathway" }, { "id": "1931054", "url": "http://www.informatics.jax.org/marker/MGI:1931054", "database": "MGI" }, { "id": "TVVQMTR", "url": "https://omabrowser.org/oma/group/TVVQMTR/", "database": "OMA" }, { "id": "639867at2759", "url": "http://www.orthodb.org/?query=639867at2759", "database": "OrthoDB" }, { "id": "PTHR20765", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20765", "database": "PANTHER" }, { "id": "PF07690", "url": "http://pfam.xfam.org/family/PF07690", "database": "Pfam" }, { "id": "PR_A2AVZ9", "url": "http://purl.obolibrary.org/obo/PR_A2AVZ9", "database": "PRO" }, { "id": "NP_067373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373", "database": "RefSeq" }, { "id": "A2AVZ9", "url": "https://www.uniprot.org/uniprot/A2AVZ9", "database": "UniProtKB" }, { "id": "A2AVZ9-1", "url": "https://www.uniprot.org/uniprot/A2AVZ9-1", "database": "UniProtKB" }, { "id": "A2AVZ9-2", "url": "https://www.uniprot.org/uniprot/A2AVZ9-2", "database": "UniProtKB" }, { "id": "A6PWZ8", "url": "https://www.uniprot.org/uniprot/A6PWZ8", "database": "UniProtKB" }, { "id": "A6PWZ8-1", "url": "https://www.uniprot.org/uniprot/A6PWZ8-1", "database": "UniProtKB" }, { "id": "A6PWZ9", "url": "https://www.uniprot.org/uniprot/A6PWZ9", "database": "UniProtKB" }, { "id": "A6PWZ9-1", "url": "https://www.uniprot.org/uniprot/A6PWZ9-1", "database": "UniProtKB" }, { "id": "Z4YM12", "url": "https://www.uniprot.org/uniprot/Z4YM12", "database": "UniProtKB" }, { "id": "Z4YM12-1", "url": "https://www.uniprot.org/uniprot/Z4YM12-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MASKGLPLYLATLLTGLLECIGFAGVLFGWTSLLFVFKAENYFSEPCEQDCLLQSNVTGPSDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTCATIIIAFTSANTAMLLFLAMPMLAVGGILFLITNLQIGNLFGKHRSTIITLYNGAFDSSSAVFLVIKLLYEQGISLRSSFIFMSVCSVWHIARTFLLMPKGHIPYPLPPNYSYGLCSRFGASKKENKAAEHETKELRSKECLPPKEENSGPEQQQQQEQQQQQQQQQEQHEQHSFRRCALSRRFILHVVWLSIIQLWHYLFIGTLNSLLTKLSGGDKVEVSAYTNAFAITQFFGVLCAPWNGLLMDRLKQKYQKAAKRTGSSSEAVALCSMVPSLALTSLLSLGFALCASIPVMQLQYATFILQVVSRSFLYGCNAAFLTLAFPSEHFGKLFGLVMALSAIVSLLQFPLFKVSPESNAVYVSMGLAIFLTLVHPFLVYRECRAEKTKSSVDA", "length": 502, "header": "sp|A2AVZ9-1|S43A3_MOUSE Isoform 1 of Solute carrier family 43 member 3 OS=Mus musculus OX=10090 GN=Slc43a3 PE=1 SV=1 CANONICAL=A2AVZ9-1" }, "isoforms": [ { "isoform_ac": "A2AVZ9-1", "url": "https://www.uniprot.org/uniprot/A2AVZ9#A2AVZ9-1", "sequence": { "sequence": "MASKGLPLYLATLLTGLLECIGFAGVLFGWTSLLFVFKAENYFSEPCEQDCLLQSNVTGPSDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTCATIIIAFTSANTAMLLFLAMPMLAVGGILFLITNLQIGNLFGKHRSTIITLYNGAFDSSSAVFLVIKLLYEQGISLRSSFIFMSVCSVWHIARTFLLMPKGHIPYPLPPNYSYGLCSRFGASKKENKAAEHETKELRSKECLPPKEENSGPEQQQQQEQQQQQQQQQEQHEQHSFRRCALSRRFILHVVWLSIIQLWHYLFIGTLNSLLTKLSGGDKVEVSAYTNAFAITQFFGVLCAPWNGLLMDRLKQKYQKAAKRTGSSSEAVALCSMVPSLALTSLLSLGFALCASIPVMQLQYATFILQVVSRSFLYGCNAAFLTLAFPSEHFGKLFGLVMALSAIVSLLQFPLFKVSPESNAVYVSMGLAIFLTLVHPFLVYRECRAEKTKSSVDA", "length": 502, "header": "sp|A2AVZ9-1|S43A3_MOUSE Isoform 1 of Solute carrier family 43 member 3 OS=Mus musculus OX=10090 GN=Slc43a3 PE=1 SV=1 CANONICAL=A2AVZ9-1" }, "locus": { "chromosome": "2", "start_pos": 84788125, "end_pos": 84768030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000090726", "url": "https://www.ensembl.org/id/ENSMUST00000090726" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000088227", "url": "https://www.ensembl.org/id/ENSMUSP00000088227" } ] } }, { "isoform_ac": "A2AVZ9-2", "url": "https://www.uniprot.org/uniprot/A2AVZ9#A2AVZ9-2", "sequence": { "sequence": "MASKGLPLYLATLLTGLLECIGFAGVLFGWTSLLFVFKAENYFSEPCEQDCLLQSNVTGPSDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTCATIIIAFTSANTAMLLFLAMPMLAVGGILFLITNLQIGNLFGKHRSTIITLYNGAFDSSSAVFLVIKLLYEQGISLRSSFIFMSVCSVWHIARTFLLMPKGHIPYPLPPNYSYG", "length": 224, "header": "sp|A2AVZ9-2|S43A3_MOUSE Isoform 2 of Solute carrier family 43 member 3 OS=Mus musculus OX=10090 GN=Slc43a3 PE=1 SV=1 CANONICAL=A2AVZ9-1" }, "locus": {} }, { "isoform_ac": "A6PWZ8-1", "url": "https://www.uniprot.org/uniprot/A2AVZ9#A6PWZ8-1", "sequence": { "sequence": "MASKGLPLYLATLLTGLLECIGFAGVLFGWTSLLFVFKAENYFSEPCEQ", "length": 49, "header": "tr|A6PWZ8-1|S43A3_MOUSE Computationally mapped isoform of Solute carrier family 43 member 3 OS=Mus musculus OX=10090 GN=Slc43a3 PE=1 SV=1 CANONICAL=A2AVZ9-1" }, "locus": { "chromosome": "2", "start_pos": 84768176, "end_pos": 84768030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000130278", "url": "https://www.ensembl.org/id/ENSMUST00000130278" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119122", "url": "https://www.ensembl.org/id/ENSMUSP00000119122" } ] } }, { "isoform_ac": "A6PWZ9-1", "url": "https://www.uniprot.org/uniprot/A2AVZ9#A6PWZ9-1", "sequence": { "sequence": "MASKGLPLYLATLLTGLLECIGFAGVLFGWTSLLFVFKAENYFSEPCEQDCLLQSNVTGPSDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKT", "length": 97, "header": "tr|A6PWZ9-1|S43A3_MOUSE Computationally mapped isoform of Solute carrier family 43 member 3 OS=Mus musculus OX=10090 GN=Slc43a3 PE=1 SV=1 CANONICAL=A2AVZ9-1" }, "locus": { "chromosome": "2", "start_pos": 84768673, "end_pos": 84768030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000138719", "url": "https://www.ensembl.org/id/ENSMUST00000138719" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000121959", "url": "https://www.ensembl.org/id/ENSMUSP00000121959" } ] } }, { "isoform_ac": "Z4YM12-1", "url": "https://www.uniprot.org/uniprot/A2AVZ9#Z4YM12-1", "sequence": { "sequence": "MASKGLPLYLATLLTGLLECIGFAGVLFGWTSLLFVFKAENYFSEPCEQDCLLQSNVTGPSDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTCATIIIAFTSANTAMLLFLAMPMLAVGGILFLITNLQIGNLFGKHRSTIITLYNGAFDSS", "length": 169, "header": "tr|Z4YM12-1|S43A3_MOUSE Computationally mapped isoform of Solute carrier family 43 member 3 OS=Mus musculus OX=10090 GN=Slc43a3 PE=1 SV=1 CANONICAL=A2AVZ9-1" }, "locus": { "chromosome": "2", "start_pos": 84774930, "end_pos": 84768030, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000141650", "url": "https://www.ensembl.org/id/ENSMUST00000141650" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116513", "url": "https://www.ensembl.org/id/ENSMUSP00000116513" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 220, "start_aa": "Asn", "end_pos": 220, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2AVZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AVZ9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 56, "start_aa": "Asn", "end_pos": 56, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2AVZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AVZ9#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis.", "journal": "Am. J. Physiol.", "date": "2001", "authors": "Li Z., Nigam S.K., Stuart R.O., Beier D., Krijanovski Y., Pavlova A.", "evidence": [ { "database": "UniProtKB", "id": "A2AVZ9", "url": "https://www.uniprot.org/uniprot/A2AVZ9" } ], "reference": [ { "type": "PubMed", "id": "11704567", "url": "https://glygen.org/publication/PubMed/11704567" } ] }, { "title": "Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals.", "journal": "Scientific reports", "date": "2015", "authors": "Furukawa J, Inoue K, Maeda J, Yasujima T, Ohta K, Kanai Y, Takada T, Matsuo H, Yuasa H", "evidence": [ { "database": "RefSeq", "id": "NP_067373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373" } ], "reference": [ { "type": "PubMed", "id": "26455426", "url": "https://glygen.org/publication/PubMed/26455426" } ] }, { "title": "Slc43a3 is a regulator of free fatty acid flux.", "journal": "Journal of lipid research", "date": "2020", "authors": "Hasbargen KB, Shen WJ, Zhang Y, Hou X, Wang W, Shuo Q, Bernlohr DA, Azhar S, Kraemer FB", "evidence": [ { "database": "RefSeq", "id": "NP_067373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067373" } ], "reference": [ { "type": "PubMed", "id": "32217606", "url": "https://glygen.org/publication/PubMed/32217606" } ] } ], "pathway": [ { "id": "mmu:58207", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:58207", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A832-1", "protein_name": "Solute carrier family 43, member 3", "gene_name": "Slc43a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASQLPLYLATFLTGLLECIGFAGVLFGWTSLLFVFKAENYFLKPCEQDCVLGGNTTGLPDLKAQDEKFSLIFTLASFMNNFMTFPTGYIFDRFKTAVARLLAIFFYTCATLIIAFTSADTAMLLFLAMPMLAVGGILFLITNLQIGNLFGKHRSTIITFYNGAFDSSSAVFLIIKLLYEQGISLRHSFIFLSVCSAWHVGRTFLLMPRGHIPYPLPPNYSYGLCSRFCTRKEENEAAEHETKELQSRECQSPKEENSGPEQQQQQQQQQQQQQQQQQQHSFRRCVFSHRFILHVVWLSIIQLWHYLFIGTLNSLLTKLAGEDSVKVSAYTNAFAITQFFGVLCAPWNGLLMDCLKQKYQKEAKRTGLSSEAVALCSMVPSLALTSLLSLGFTLCASIPVIELQYATFILQVVSRSFLYGCNAAFLTLAFPSEHFGKLFGLVMALSAIVSLLQFPLFKVSPESKAVYVSMGLAIFLTLVHPFLVYRECRVEKTKPSVDA", "length": 499 }, "evidence": [ { "id": "40925", "url": "http://www.informatics.jax.org/homology/40925", "database": "MGI" }, { "id": "A2AVZ9", "url": "https://omabrowser.org/oma/group/A2AVZ9/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NBI5-1", "protein_name": "Solute carrier family 43 member 3", "gene_name": "SLC43A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGQGLPLHVATLLTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNATGQADCKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTTATLIIAFTSAGSAVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLYEKGISLRASFIFISVCSTWHVARTFLLMPRGHIPYPLPPNYSYGLCPGNGTTKEEKETAEHENRELQSKEFLSAKEETPGAGQKQELRSFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTLNSLLTNMAGGDMARVSTYTNAFAFTQFGVLCAPWNGLLMDRLKQKYQKEARKTGSSTLAVALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSEHFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLAILLTFFHPFLVYRECRTWKESPSAIA", "length": 491 }, "evidence": [ { "id": "40925", "url": "http://www.informatics.jax.org/homology/40925", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A2AVZ9", "url": "https://www.uniprot.org/uniprot/A2AVZ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A2AVZ9", "url": "https://www.uniprot.org/uniprot/A2AVZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }