{ "uniprot_canonical_ac": "A2ATD1-1", "uniprot_ac": "A2ATD1", "uniprot_id": "ISM1_MOUSE", "mass": { "chemical_mass": 51145.0, "monoisotopic_mass": 51145.0 }, "refseq": { "ac": "NP_001263418", "name": "isthmin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418" }, "gene_names": [ { "name": "Ism1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ATD1", "id": "A2ATD1" }, { "name": "5430433G21Rik; Ism", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418", "id": "NP_001263418" }, { "name": "Ism1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418", "id": "NP_001263418" }, { "name": "Ism", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ATD1", "id": "A2ATD1" } ], "protein_names": [ { "name": "Isthmin-1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ATD1#names_and_taxonomy", "id": "A2ATD1" }, { "name": "isthmin 1 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418", "id": "NP_001263418" }, { "name": "isthmin-1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418", "id": "NP_001263418" } ], "function": [ { "annotation": "Acts as an angiogenesis inhibitor.", "evidence": [ { "database": "UniProtKB", "id": "A2ATD1", "url": "https://www.uniprot.org/uniprot/A2ATD1#function" }, { "database": "PubMed", "id": "19874420", "url": "https://glygen.org/publication/PubMed/19874420" } ] }, { "annotation": "ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation as well as induction of apoptosis", "evidence": [ { "database": "RefSeq", "id": "NP_001263418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418" }, { "database": "PubMed", "id": "25952901", "url": "https://glygen.org/publication/PubMed/25952901" } ] }, { "annotation": "Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers.", "evidence": [ { "database": "RefSeq", "id": "NP_001263418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418" }, { "database": "PubMed", "id": "34469202", "url": "https://glygen.org/publication/PubMed/34469202" } ] }, { "annotation": "Results demonstrate that Isthmin is a novel endogenous angiogenesis inhibitor with functions likely in physiological as well as pathological angiogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_001263418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418" }, { "database": "PubMed", "id": "19874420", "url": "https://glygen.org/publication/PubMed/19874420" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ATD1", "url": "https://www.uniprot.org/uniprot/A2ATD1" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ism1", "url": "https://www.uniprot.org/uniprot/A2ATD1", "locus": { "chromosome": "2", "start_pos": 139678178, "end_pos": 139758581, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000074766", "url": "https://www.ensembl.org/id/ENSMUSG00000074766" } ] } } ], "crossref": [ { "id": "ENSMUSG00000074766", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074766", "database": "Bgee" }, { "id": "319909", "url": "https://www.ncbi.nlm.nih.gov/gene/319909", "database": "GeneID" }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro" }, { "id": "IPR005533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005533", "database": "InterPro" }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro" }, { "id": "IPR042413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042413", "database": "InterPro" }, { "id": "mmu:319909", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319909", "database": "KEGG Pathway" }, { "id": "2442963", "url": "http://www.informatics.jax.org/marker/MGI:2442963", "database": "MGI" }, { "id": "QRFRQEN", "url": "https://omabrowser.org/oma/group/QRFRQEN/", "database": "OMA" }, { "id": "876510at2759", "url": "http://www.orthodb.org/?query=876510at2759", "database": "OrthoDB" }, { "id": "PTHR10239:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10239:SF30", "database": "PANTHER" }, { "id": "PF00090", "url": "http://pfam.xfam.org/family/PF00090", "database": "Pfam" }, { "id": "PF03782", "url": "http://pfam.xfam.org/family/PF03782", "database": "Pfam" }, { "id": "PR_A2ATD1", "url": "http://purl.obolibrary.org/obo/PR_A2ATD1", "database": "PRO" }, { "id": "NP_001263418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418", "database": "RefSeq" }, { "id": "A2ATD1", "url": "https://www.uniprot.org/uniprot/A2ATD1", "database": "UniProtKB" }, { "id": "A2ATD1-1", "url": "https://www.uniprot.org/uniprot/A2ATD1-1", "database": "UniProtKB" }, { "id": "V9GXR4", "url": "https://www.uniprot.org/uniprot/V9GXR4", "database": "UniProtKB" }, { "id": "V9GXR4-1", "url": "https://www.uniprot.org/uniprot/V9GXR4-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY", "length": 454, "header": "sp|A2ATD1-1|ISM1_MOUSE Isoform 1 of Isthmin-1 OS=Mus musculus OX=10090 GN=Ism1 PE=1 SV=1 CANONICAL=A2ATD1-1" }, "isoforms": [ { "isoform_ac": "A2ATD1-1", "url": "https://www.uniprot.org/uniprot/A2ATD1#A2ATD1-1", "sequence": { "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY", "length": 454, "header": "sp|A2ATD1-1|ISM1_MOUSE Isoform 1 of Isthmin-1 OS=Mus musculus OX=10090 GN=Ism1 PE=1 SV=1 CANONICAL=A2ATD1-1" }, "locus": { "chromosome": "2", "start_pos": 139599411, "end_pos": 139520590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000099307", "url": "https://www.ensembl.org/id/ENSMUST00000099307" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000096910", "url": "https://www.ensembl.org/id/ENSMUSP00000096910" } ] } }, { "isoform_ac": "V9GXR4-1", "url": "https://www.uniprot.org/uniprot/A2ATD1#V9GXR4-1", "sequence": { "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNVSGSQLQNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY", "length": 461, "header": "tr|V9GXR4-1|V9GXR4_MOUSE Computationally mapped isoform of Isthmin-1 OS=Mus musculus OX=10090 GN=Ism1 PE=3 SV=1 CANONICAL=A2ATD1-1" }, "locus": { "chromosome": "2", "start_pos": 139599411, "end_pos": 139520590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000184404", "url": "https://www.ensembl.org/id/ENSMUST00000184404" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000139280", "url": "https://www.ensembl.org/id/ENSMUSP00000139280" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer.", "journal": "Mech. Dev.", "date": "2002", "authors": "Kim J.I., De Robertis E.M., Li S.-Y., Brechner M., Martinez S.L., Pera E.M., Wessely O.", "evidence": [ { "database": "UniProtKB", "id": "A2ATD1", "url": "https://www.uniprot.org/uniprot/A2ATD1" } ], "reference": [ { "type": "PubMed", "id": "12128218", "url": "https://glygen.org/publication/PubMed/12128218" } ] }, { "title": "Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice.", "journal": "J. Cell. Mol. Med.", "date": "2011", "authors": "Wang J., Wang Z., Yang H., Zhang Y., Irwan I.D., Ge R., Xiang W., Ke Z., Cheng G.H., Kini R.M., Potturi P., Sulochana K.N., Zhuo L.", "evidence": [ { "database": "UniProtKB", "id": "A2ATD1", "url": "https://www.uniprot.org/uniprot/A2ATD1" }, { "database": "RefSeq", "id": "NP_001263418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418" } ], "reference": [ { "type": "PubMed", "id": "19874420", "url": "https://glygen.org/publication/PubMed/19874420" } ] }, { "title": "Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation.", "journal": "Cardiovascular research", "date": "2015", "authors": "Venugopal S, Chen M, Liao W, Er SY, Wong WS, Ge R", "evidence": [ { "database": "RefSeq", "id": "NP_001263418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418" } ], "reference": [ { "type": "PubMed", "id": "25952901", "url": "https://glygen.org/publication/PubMed/25952901" } ] }, { "title": "Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers.", "journal": "American journal of physiology. Cell physiology", "date": "2021", "authors": "Li J, Xia Y, Huang Z, Zhao Y, Xiong R, Li X, Huang Q, Shan F", "evidence": [ { "database": "RefSeq", "id": "NP_001263418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418" } ], "reference": [ { "type": "PubMed", "id": "34469202", "url": "https://glygen.org/publication/PubMed/34469202" } ] } ], "pathway": [ { "id": "mmu:319909", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319909", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B1AKI9-1", "protein_name": "Isthmin-1", "gene_name": "ISM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGAADGPDAAAGNASQAQLQNNLNVGSDTTSETSFSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERWMSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY", "length": 464 }, "evidence": [ { "id": "19061", "url": "http://www.informatics.jax.org/homology/19061", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A2ATD1", "url": "https://www.uniprot.org/uniprot/A2ATD1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of angiogenesis", "id": "GO:0016525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", "evidence": [ { "database": "UniProtKB", "id": "A2ATD1", "url": "https://www.uniprot.org/uniprot/A2ATD1" } ], "pmid": "19874420" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }