{ "uniprot_canonical_ac": "A2AT37-1", "uniprot_ac": "A2AT37", "uniprot_id": "RENT2_MOUSE", "mass": { "chemical_mass": 147553.0, "monoisotopic_mass": 147553.0 }, "refseq": { "ac": "NP_001074601", "name": "regulator of nonsense transcripts 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" }, "gene_names": [ { "name": "Upf2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37" }, { "name": "Upf2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601", "id": "NP_001074601" } ], "protein_names": [ { "name": "Regulator of nonsense transcripts 2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AT37#names_and_taxonomy", "id": "A2AT37" }, { "name": "Nonsense mRNA reducing factor 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AT37#names_and_taxonomy", "id": "A2AT37" }, { "name": "Up-frameshift suppressor 2 homolog", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AT37#names_and_taxonomy", "id": "A2AT37" }, { "name": "Upf2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AT37#names_and_taxonomy", "id": "A2AT37" }, { "name": "nonsense mRNA reducing factor 2; up-frameshift suppressor 2 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601", "id": "NP_001074601" }, { "name": "regulator of nonsense transcripts 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601", "id": "NP_001074601" } ], "function": [ { "annotation": "Hematopoietic-specific deletion of Upf2, a core NMD factor, led to the rapid, complete, and lasting cell-autonomous extinction of all hematopoietic stem and progenitor populations.", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" }, { "database": "PubMed", "id": "18483223", "url": "https://glygen.org/publication/PubMed/18483223" } ] }, { "annotation": "Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown.", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" }, { "database": "PubMed", "id": "33627408", "url": "https://glygen.org/publication/PubMed/33627408" } ] }, { "annotation": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37#function" }, { "database": "PubMed", "id": "Q9HAU5", "url": "https://glygen.org/publication/PubMed/Q9HAU5" } ] }, { "annotation": "Our findings indicate that impaired UPF2-dependent nonsense-mediated decay leads to neurodevelopmental dysfunction", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" }, { "database": "PubMed", "id": "31585809", "url": "https://glygen.org/publication/PubMed/31585809" } ] }, { "annotation": "Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" }, { "database": "PubMed", "id": "20657840", "url": "https://glygen.org/publication/PubMed/20657840" } ] }, { "annotation": "UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function.", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" }, { "database": "PubMed", "id": "31636381", "url": "https://glygen.org/publication/PubMed/31636381" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Upf2", "url": "https://www.uniprot.org/uniprot/A2AT37", "locus": { "chromosome": "2", "start_pos": 5951469, "end_pos": 6056703, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000043241", "url": "https://www.ensembl.org/id/ENSMUSG00000043241" } ] } } ], "crossref": [ { "id": "ENSMUSG00000043241", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000043241", "database": "Bgee" }, { "id": "326622", "url": "https://www.ncbi.nlm.nih.gov/gene/326622", "database": "GeneID" }, { "id": "A2AT37", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AT37*", "database": "IntAct" }, { "id": "IPR003890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003890", "database": "InterPro" }, { "id": "IPR007193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007193", "database": "InterPro" }, { "id": "IPR016021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016021", "database": "InterPro" }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro" }, { "id": "IPR039762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039762", "database": "InterPro" }, { "id": "mmu:326622", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:326622", "database": "KEGG Pathway" }, { "id": "2449307", "url": "http://www.informatics.jax.org/marker/MGI:2449307", "database": "MGI" }, { "id": "IFDTMYK", "url": "https://omabrowser.org/oma/group/IFDTMYK/", "database": "OMA" }, { "id": "653534at2759", "url": "http://www.orthodb.org/?query=653534at2759", "database": "OrthoDB" }, { "id": "PTHR12839", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12839", "database": "PANTHER" }, { "id": "PF02854", "url": "http://pfam.xfam.org/family/PF02854", "database": "Pfam" }, { "id": "PF04050", "url": "http://pfam.xfam.org/family/PF04050", "database": "Pfam" }, { "id": "PR_A2AT37", "url": "http://purl.obolibrary.org/obo/PR_A2AT37", "database": "PRO" }, { "id": "R-MMU-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975957", "database": "Reactome" }, { "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601", "database": "RefSeq" }, { "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37", "database": "UniProtKB" }, { "id": "A2AT37-1", "url": "https://www.uniprot.org/uniprot/A2AT37-1", "database": "UniProtKB" }, { "id": "F6Q3G7", "url": "https://www.uniprot.org/uniprot/F6Q3G7", "database": "UniProtKB" }, { "id": "F6Q3G7-1", "url": "https://www.uniprot.org/uniprot/F6Q3G7-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKPRDDLKVTAKKEVSKVPEDKKKRLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKLSDVNCAAHLCSLFHQRYSDFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSNKDDSKEAKEPKDNKEASSPDDLELELENLEINDDTLELEGADEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR", "length": 1269, "header": "sp|A2AT37-1|RENT2_MOUSE Isoform 1 of Regulator of nonsense transcripts 2 OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1" }, "isoforms": [ { "isoform_ac": "A2AT37-1", "url": "https://www.uniprot.org/uniprot/A2AT37#A2AT37-1", "sequence": { "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKPRDDLKVTAKKEVSKVPEDKKKRLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKLSDVNCAAHLCSLFHQRYSDFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSNKDDSKEAKEPKDNKEASSPDDLELELENLEINDDTLELEGADEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR", "length": 1269, "header": "sp|A2AT37-1|RENT2_MOUSE Isoform 1 of Regulator of nonsense transcripts 2 OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1" }, "locus": { "chromosome": "2", "start_pos": 6060250, "end_pos": 5962300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000060092", "url": "https://www.ensembl.org/id/ENSMUST00000060092" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000058375", "url": "https://www.ensembl.org/id/ENSMUSP00000058375" } ] } }, { "isoform_ac": "F6Q3G7-1", "url": "https://www.uniprot.org/uniprot/A2AT37#F6Q3G7-1", "sequence": { "sequence": "XVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR", "length": 523, "header": "tr|F6Q3G7-1|RENT2_MOUSE Computationally mapped isoform of Regulator of nonsense transcripts 2 OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1" }, "locus": { "chromosome": "2", "start_pos": 6060252, "end_pos": 6028150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000128200", "url": "https://www.ensembl.org/id/ENSMUST00000128200" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119348", "url": "https://www.ensembl.org/id/ENSMUSP00000119348" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1085, "end_pos": 1085, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.", "journal": "Genes & development", "date": "2008", "authors": "Weischenfeldt J, Damgaard I, Bryder D, Theilgaard-Monch K, Thoren LA, Nielsen FC, Jacobsen SE, Nerlov C, Porse BT", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" } ], "reference": [ { "type": "PubMed", "id": "18483223", "url": "https://glygen.org/publication/PubMed/18483223" } ] }, { "title": "UPF2 is a critical regulator of liver development, function and regeneration.", "journal": "PLoS ONE", "date": "2010", "authors": "Borup R., Blom A.M., Bisgaard H.C., Porse B.T., Bergstroem F.C., Damgaard I., Jakobsen J.S., Noergaard G.A., Thoren L.A., Waage J., Weischenfeldt J.", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" }, { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" } ], "reference": [ { "type": "PubMed", "id": "20657840", "url": "https://glygen.org/publication/PubMed/20657840" } ] }, { "title": "Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.", "journal": "PLoS Genet.", "date": "2016", "authors": "Dahl A., Jessberger R., Akpinar M., Fanourgakis G., Lesche M.", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "reference": [ { "type": "PubMed", "id": "27149095", "url": "https://glygen.org/publication/PubMed/27149095" } ] }, { "title": "Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response.", "journal": "Neuron", "date": "2019", "authors": "Johnson JL, Stoica L, Liu Y, Zhu PJ, Bhattacharya A, Buffington SA, Huq R, Eissa NT, Larsson O, Porse BT, Domingo D, Nawaz U, Carroll R, Jolly L, Scerri TS, Kim HG, Brignell A, Coleman MJ, Braden R, Kini U, Jackson V, Baxter A, Bahlo M, Scheffer IE, Amor DJ, Hildebrand MS, Bonnen PE, Beeton C, Gecz J, Morgan AT, Costa-Mattioli M", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" } ], "reference": [ { "type": "PubMed", "id": "31585809", "url": "https://glygen.org/publication/PubMed/31585809" } ] }, { "title": "UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function.", "journal": "Molecular psychiatry", "date": "2020", "authors": "Notaras M, Allen M, Longo F, Volk N, Toth M, Li Jeon N, Klann E, Colak D", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" } ], "reference": [ { "type": "PubMed", "id": "31636381", "url": "https://glygen.org/publication/PubMed/31636381" } ] }, { "title": "Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2021", "authors": "Zhang Y, Xie X, Yeganeh PN, Lee DJ, Valle-Garcia D, Meza-Sosa KF, Junqueira C, Su J, Luo HR, Hide W, Lieberman J", "evidence": [ { "database": "RefSeq", "id": "NP_001074601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601" } ], "reference": [ { "type": "PubMed", "id": "33627408", "url": "https://glygen.org/publication/PubMed/33627408" } ] } ], "pathway": [ { "id": "mmu:326622", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:326622", "resource": "KEGG Pathway" }, { "id": "R-MMU-975957", "name": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZT03-1", "protein_name": "UPF2, regulator of nonsense mediated mRNA decay", "gene_name": "Upf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKSKDDLKITAKKEVSKVPEDKKKKLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLNFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSSKDDSKETGGYEPRNWRNRENENELMLEFESFLRATSTVHYTSSALEKGKRKKRRDEREQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRRKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDDEDEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQFNSGKVEKISELGTPFNVNLESTFHVKPQLRHGERNTRESTDTNIPLYVLSQEHNKKKMFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGR", "length": 1272 }, "evidence": [ { "id": "A2AT37", "url": "https://omabrowser.org/oma/group/A2AT37/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9HAU5-1", "protein_name": "Regulator of nonsense transcripts 2", "gene_name": "UPF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKENKEVSSPDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLTDSNKENETDEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR", "length": 1272 }, "evidence": [ { "id": "6101", "url": "http://www.informatics.jax.org/homology/6101", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" }, { "name": "telomeric DNA binding", "id": "GO:0042162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042162", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" }, { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" }, { "name": "polysome", "id": "GO:0005844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005844", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "21873635" }, { "name": "exon-exon junction complex", "id": "GO:0035145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035145", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" }, { "name": "liver development", "id": "GO:0001889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001889", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "20657840" }, { "name": "animal organ regeneration", "id": "GO:0031100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031100", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "20657840" }, { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "A2AT37", "url": "https://www.uniprot.org/uniprot/A2AT37" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1046, "end_pos": 1048, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1083, "end_pos": 1085, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 662, "end_pos": 664, "annotation": "n_glycosylation_sequon" }, { "start_pos": 680, "end_pos": 682, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }