{ "uniprot_canonical_ac": "A2ART8-1", "uniprot_ac": "A2ART8", "uniprot_id": "A2ART8_MOUSE", "mass": { "chemical_mass": 79847.0, "monoisotopic_mass": 79847.0 }, "refseq": { "ac": "NP_001153896", "name": "protein-glutamine gamma-glutamyltransferase Z", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153896" }, "gene_names": [ { "name": "Tgm7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ART8", "id": "A2ART8" }, { "name": "TGMZ; TGz", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153896", "id": "NP_001153896" }, { "name": "Tgm7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153896", "id": "NP_001153896" } ], "protein_names": [ { "name": "Transglutaminase 7", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ART8#names_and_taxonomy", "id": "A2ART8" }, { "name": "protein-glutamine gamma-glutamyltransferase Z", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153896", "id": "NP_001153896" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ART8", "url": "https://www.uniprot.org/uniprot/A2ART8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Tgm7", "url": "https://www.uniprot.org/uniprot/A2ART8", "locus": { "chromosome": "2", "start_pos": 121109795, "end_pos": 121093565, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000079103", "url": "https://www.ensembl.org/id/ENSMUSG00000079103" } ] } } ], "crossref": [ { "id": "ENSMUSG00000079103", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000079103", "database": "Bgee" }, { "id": "640543", "url": "https://www.ncbi.nlm.nih.gov/gene/640543", "database": "GeneID" }, { "id": "IPR001102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001102", "database": "InterPro" }, { "id": "IPR002931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002931", "database": "InterPro" }, { "id": "IPR008958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008958", "database": "InterPro" }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro" }, { "id": "IPR013808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013808", "database": "InterPro" }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro" }, { "id": "IPR023608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023608", "database": "InterPro" }, { "id": "IPR036238", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036238", "database": "InterPro" }, { "id": "IPR036985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036985", "database": "InterPro" }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro" }, { "id": "mmu:640543", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:640543", "database": "KEGG Pathway" }, { "id": "2151164", "url": "http://www.informatics.jax.org/marker/MGI:2151164", "database": "MGI" }, { "id": "ALSNCTM", "url": "https://omabrowser.org/oma/group/ALSNCTM/", "database": "OMA" }, { "id": "PF00868", "url": "http://pfam.xfam.org/family/PF00868", "database": "Pfam" }, { "id": "PF00927", "url": "http://pfam.xfam.org/family/PF00927", "database": "Pfam" }, { "id": "PF01841", "url": "http://pfam.xfam.org/family/PF01841", "database": "Pfam" }, { "id": "NP_001153896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153896", "database": "RefSeq" }, { "id": "A0A571BDB6", "url": "https://www.uniprot.org/uniprot/A0A571BDB6", "database": "UniProtKB" }, { "id": "A0A571BDB6-1", "url": "https://www.uniprot.org/uniprot/A0A571BDB6-1", "database": "UniProtKB" }, { "id": "A2ART8", "url": "https://www.uniprot.org/uniprot/A2ART8", "database": "UniProtKB" }, { "id": "A2ART8-1", "url": "https://www.uniprot.org/uniprot/A2ART8-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MDPVAALELRSVELQIPRNNKDHHTEDLGLSKLILRRGQIFILTIVFSRPFQPQKDHLTFVAETGPEPTELLGTRATFFLAQTRPENVWSASDFMIDSNSLQVSIFSPASAVIGHYTLKLEISQGQGPGVTYPLGNFILLFNPWSTEDDVYLPSETLLREYIMSDYGFIYKGQTNSITSRPWNYGQFEEDIVDICFEILNKSLYFLKNPSKDHSQRNNVVYVCRVVSAMINSNDDSGVLQGNWGEDYSQGTSPLEWNGSVAILRQWSAKGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFHSAHNTDGNLTIDTYYDRTAEMLTAQRPDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIKEGDVQLPYDTPFVYAEVNADEVVWLFEGGQVQEILAHNTSYIGKAISTKMVGSDERLDITSSYKYPEGSSEERSAFIKASWKLLEPRRNASSLLDLLGSENLKAKPVRLQLHLVRAPMWGQDLPLMLYVQRVPVRDHVQGSVGLTVRFCAQALLHGGGTRKPFWRHIVHLNVDFEKELQWPFLLPYSSYRDKLTDERLIRVAGIAEVEETGQFILVLKDFSLEPPHLSIEVFERAEVGKALDIHITLTNTLMVPLNNCTMVLEGSGLINGQMTKDLGTLMAGHTIRIHLELYPIKAGPHQLQVLISSSEVKEIKGYKDILVAAAPAS", "length": 710, "header": "tr|A2ART8-1|A2ART8_MOUSE Isoform 1 of Transglutaminase 7 OS=Mus musculus OX=10090 GN=Tgm7 PE=3 SV=2 CANONICAL=A2ART8-1" }, "isoforms": [ { "isoform_ac": "A0A571BDB6-1", "url": "https://www.uniprot.org/uniprot/A2ART8#A0A571BDB6-1", "sequence": { "sequence": "VAALELRSVELQIPRNNKDHHTEDLGLSKLILRRGQIFILTIVFSRPFQPQKDHLTFVAETGPEPTELLGTRATFFLAQTRPENVWSASDFMIDSNSLQVSIFSPASAVIGHYTLKLEISQGQGPGVTYPLGNFILLFNPWSTEDDVYLPSETLLREYIMSDYGFIYKGQTNSITSRPWNYGQFEEDIVDICFEILNKSLYFLKNPSKDHSQRNNVVYVCRVVSAMINSNDDSGVLQGNWGEDYSQGTSPLEWNGSVAILRQWSAKGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFHSAHNTDGNLTIDTYYDRTAEMLTAQRPDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIKEGDVQLPYDTPFVYAEVNADEVVWLFEGGQVQEILAHNTSYIGKAISTKMVGSDERLDITSSYKYPEGSSEERSAFIKASWKLLEPRRNASSLLDLLGSENLKAKPVRLQLHLVRAPMWGQDLPLMLYVQRVPVRDHVQGSVGLTVRFCAQALLHGGGTRKPFWRHIVHLNVDFEKELQWPFLLPYSSYRDKLTDERLIRVAGIAEVEETGQFILVLKDFSLEPPHLSIEVFERAEVGKALDIHITLTNTLMVPLNNCTMVLEGSGLINGQMTKDLGTLMAGHTIRIHLELYPIKAGPHQLQVLISSSEVKEIKGYKDILVAAAPAS", "length": 707, "header": "tr|A0A571BDB6-1|A0A571BDB6_MOUSE Computationally mapped isoform of Transglutaminase 7 OS=Mus musculus OX=10090 GN=Tgm7 PE=3 SV=1 CANONICAL=A2ART8-1" }, "locus": { "chromosome": "2", "start_pos": 120940273, "end_pos": 120924073, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238428", "url": "https://www.ensembl.org/id/ENSMUST00000238428" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158669", "url": "https://www.ensembl.org/id/ENSMUSP00000158669" } ] } }, { "isoform_ac": "A2ART8-1", "url": "https://www.uniprot.org/uniprot/A2ART8#A2ART8-1", "sequence": { "sequence": "MDPVAALELRSVELQIPRNNKDHHTEDLGLSKLILRRGQIFILTIVFSRPFQPQKDHLTFVAETGPEPTELLGTRATFFLAQTRPENVWSASDFMIDSNSLQVSIFSPASAVIGHYTLKLEISQGQGPGVTYPLGNFILLFNPWSTEDDVYLPSETLLREYIMSDYGFIYKGQTNSITSRPWNYGQFEEDIVDICFEILNKSLYFLKNPSKDHSQRNNVVYVCRVVSAMINSNDDSGVLQGNWGEDYSQGTSPLEWNGSVAILRQWSAKGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFHSAHNTDGNLTIDTYYDRTAEMLTAQRPDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIKEGDVQLPYDTPFVYAEVNADEVVWLFEGGQVQEILAHNTSYIGKAISTKMVGSDERLDITSSYKYPEGSSEERSAFIKASWKLLEPRRNASSLLDLLGSENLKAKPVRLQLHLVRAPMWGQDLPLMLYVQRVPVRDHVQGSVGLTVRFCAQALLHGGGTRKPFWRHIVHLNVDFEKELQWPFLLPYSSYRDKLTDERLIRVAGIAEVEETGQFILVLKDFSLEPPHLSIEVFERAEVGKALDIHITLTNTLMVPLNNCTMVLEGSGLINGQMTKDLGTLMAGHTIRIHLELYPIKAGPHQLQVLISSSEVKEIKGYKDILVAAAPAS", "length": 710, "header": "tr|A2ART8-1|A2ART8_MOUSE Isoform 1 of Transglutaminase 7 OS=Mus musculus OX=10090 GN=Tgm7 PE=3 SV=2 CANONICAL=A2ART8-1" }, "locus": { "chromosome": "2", "start_pos": 120946877, "end_pos": 120924073, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110675", "url": "https://www.ensembl.org/id/ENSMUST00000110675" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106303", "url": "https://www.ensembl.org/id/ENSMUSP00000106303" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:640543", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:640543", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LZP5-1", "protein_name": "Protein-glutamine gamma-glutamyltransferase", "gene_name": "Tgm7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "PQVAALELRSVELQIPRNNKDHHTQDLGSSKLILRRGQIFILTIVFSRPFQPQKDHLTFVAETGPEPTELLGTRATFFLVQTRPENVWSASDFVIDSNSLQVSIFSPASAVIGHYTLKLEISRDQGPGVTYPLGNFILLFNPWSTEDDVYLPSEALLREYIMCDYGFVYKGQANSITSRPWNYGQFEEDIVDICFEILNKSLYFLKNPSKDHSQRNDVVYVCRVVSAMINSNDDSGVLQGNWGEDYSQGTSPLEWNGSVAILRQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFHSAHNTDGNLTIDTYYDRTAEMLPAQRPDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIKEGDVQLPYDTPFVYAEVNADEVVWLFEGGQVQEILAHNISYIGKAISTKMVGSDERLDITSSYKYPEGSSEERSVFIKASWKLLEPRRNSSSLLDLLGSENFKDKPVQLQLHLARAPMWGQDVLLMLLVRRVPVRDHVQGPVGLTVRFCAQALLHGGGTRKPFWRHVVHLNVDSEKELQWPLLLPYSNYRDKLTDENLIHVSGIAEVEETGQFILVLKEFSLEPPYLSIEVFEKAEVGKALNIHITLTNTLMVPLNNCTMVLEGSGLINGQMTKDLGTLMAGHTIRIQLELYPIKAGRHQLQVLISSSEVKEIKGYKDIFIAAAPAS", "length": 709 }, "evidence": [ { "id": "A2ART8", "url": "https://omabrowser.org/oma/group/A2ART8/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96PF1-1", "protein_name": "Protein-glutamine gamma-glutamyltransferase Z", "gene_name": "TGM7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITFVAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLLESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGGGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP", "length": 710 }, "evidence": [ { "id": "14192", "url": "http://www.informatics.jax.org/homology/14192", "database": "MGI" }, { "id": "A2ART8", "url": "https://omabrowser.org/oma/group/A2ART8/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A2ART8", "url": "https://www.uniprot.org/uniprot/A2ART8" } ], "pmid": "" }, { "name": "protein-glutamine gamma-glutamyltransferase activity", "id": "GO:0003810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003810", "evidence": [ { "database": "UniProtKB", "id": "A2ART8", "url": "https://www.uniprot.org/uniprot/A2ART8" } ], "pmid": "21873635" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "peptide cross-linking", "id": "GO:0018149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018149", "evidence": [ { "database": "UniProtKB", "id": "A2ART8", "url": "https://www.uniprot.org/uniprot/A2ART8" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" }, { "start_pos": 640, "end_pos": 642, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }