{ "uniprot_canonical_ac": "A2ARA8-1", "uniprot_ac": "A2ARA8", "uniprot_id": "ITA8_MOUSE", "mass": { "chemical_mass": 117556.0, "monoisotopic_mass": 117556.0 }, "refseq": { "ac": "NP_001001309", "name": "integrin alpha-8 preproprotein", "summary": "This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309" }, "gene_names": [ { "name": "Itga8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ARA8", "id": "A2ARA8" }, { "name": "AI447669", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309", "id": "NP_001001309" }, { "name": "Itga8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309", "id": "NP_001001309" } ], "protein_names": [ { "name": "Integrin alpha-8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ARA8#names_and_taxonomy", "id": "A2ARA8" }, { "name": "integrin alpha-8 preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309", "id": "NP_001001309" } ], "function": [ { "annotation": "Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8#function" }, { "database": "PubMed", "id": "11470831", "url": "https://glygen.org/publication/PubMed/11470831" }, { "database": "PubMed", "id": "17537792", "url": "https://glygen.org/publication/PubMed/17537792" }, { "database": "PubMed", "id": "10742111", "url": "https://glygen.org/publication/PubMed/10742111" }, { "database": "PubMed", "id": "12787402", "url": "https://glygen.org/publication/PubMed/12787402" }, { "database": "PubMed", "id": "9548928", "url": "https://glygen.org/publication/PubMed/9548928" }, { "database": "PubMed", "id": "11891185", "url": "https://glygen.org/publication/PubMed/11891185" }, { "database": "PubMed", "id": "9614184", "url": "https://glygen.org/publication/PubMed/9614184" }, { "database": "PubMed", "id": "9054500", "url": "https://glygen.org/publication/PubMed/9054500" } ] }, { "annotation": "Role of integrin alpha8 in murine model of lung fibrosis Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001001309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309" }, { "database": "PubMed", "id": "29813125", "url": "https://glygen.org/publication/PubMed/29813125" } ] }, { "annotation": "This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_001001309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309" } ] } ], "disease": [ { "disease_id": "DOID:14766", "recommended_name": { "id": "DOID:14766", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14766", "name": "renal agenesis", "description": "A renal disease that is characterized by the failure of one or both kidneys to develop." }, "synonyms": [ { "id": "DOID:14766", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14766", "name": "hereditary renal aplasia", "description": "" }, { "id": "DOID:14766", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14766", "name": "hereditary urogenital adysplasia", "description": "" }, { "id": "DOID:14766", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14766", "name": "renal adysplasia", "description": "" }, { "id": "DOID:14766", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14766", "name": "renal aplasia", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "renal hypodysplasia/aplasia 1", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "renal agenesis", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "renal aplasia", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "renal adysplasia", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "Selig Benacerraf Greene syndrome", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "renal dysplasia, megalocystis, and sirenomelia", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "renal hypodysplasia/aplasia 1; RHDA1", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "hereditary renal aplasia", "description": "" }, { "id": "MONDO:0024519", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024519", "name": "RHDA1", "description": "" }, { "id": "MIM:191830", "resource": "MIM", "url": "https://www.omim.org/entry/191830", "name": "Renal hypodysplasia/aplasia 1", "description": "Renal hypodysplasia/aplasia 1" } ], "evidence": [ { "id": "14766", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:14766" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1; OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, NOS", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ], "evidence": [ { "id": "2394", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2394" } ] }, { "disease_id": "DOID:4783", "recommended_name": { "id": "DOID:4783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4783", "name": "mesangial proliferative glomerulonephritis", "description": "" }, "synonyms": [], "evidence": [ { "id": "4783", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4783" } ] }, { "disease_id": "DOID:5419", "recommended_name": { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness." }, "synonyms": [ { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia (disease)", "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality." }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia with or without an affective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "SCZD", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia; SCZD", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizoaffective disorder", "description": "" }, { "id": "MIM:181500", "resource": "MIM", "url": "https://www.omim.org/entry/181500", "name": "Schizophrenia", "description": "Schizophrenia" } ], "evidence": [ { "id": "5419", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ] }, { "disease_id": "DOID:783", "recommended_name": { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end stage renal disease", "description": "A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease." }, "synonyms": [ { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end stage renal failure", "description": "" }, { "id": "DOID:783", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:783", "name": "end-stage kidney disease", "description": "" } ], "evidence": [ { "id": "783", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:783" } ] }, { "disease_id": "DOID:898", "recommended_name": { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "autosomal dominant polycystic kidney disease", "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal dominant fashion." }, "synonyms": [ { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "Congenital biliary ectasias", "description": "" }, { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1", "description": "" } ], "evidence": [ { "id": "898", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:898" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Itga8", "url": "https://www.uniprot.org/uniprot/A2ARA8", "locus": { "chromosome": "2", "start_pos": 12301922, "end_pos": 12106632, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000026768", "url": "https://www.ensembl.org/id/ENSMUSG00000026768" } ] } } ], "crossref": [ { "id": "ENSMUSG00000026768", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026768", "database": "Bgee" }, { "id": "241226", "url": "https://www.ncbi.nlm.nih.gov/gene/241226", "database": "GeneID" }, { "id": "GPDB0001717", "url": "https://acgg.asia/gpdb2/GPDB0001717", "database": "GlycoProtDB" }, { "id": "GPDB0001718", "url": "https://acgg.asia/gpdb2/GPDB0001718", "database": "GlycoProtDB" }, { "id": "GPDB0002862", "url": "https://acgg.asia/gpdb2/GPDB0002862", "database": "GlycoProtDB" }, { "id": "IPR000413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000413", "database": "InterPro" }, { "id": "IPR013517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013517", "database": "InterPro" }, { "id": "IPR013519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013519", "database": "InterPro" }, { "id": "IPR013649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013649", "database": "InterPro" }, { "id": "IPR018184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018184", "database": "InterPro" }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro" }, { "id": "IPR032695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032695", "database": "InterPro" }, { "id": "mmu:241226", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241226", "database": "KEGG Pathway" }, { "id": "109442", "url": "http://www.informatics.jax.org/marker/MGI:109442", "database": "MGI" }, { "id": "MVAGTNF", "url": "https://omabrowser.org/oma/group/MVAGTNF/", "database": "OMA" }, { "id": "743479at2759", "url": "http://www.orthodb.org/?query=743479at2759", "database": "OrthoDB" }, { "id": "PF00357", "url": "http://pfam.xfam.org/family/PF00357", "database": "Pfam" }, { "id": "PF01839", "url": "http://pfam.xfam.org/family/PF01839", "database": "Pfam" }, { "id": "PF08441", "url": "http://pfam.xfam.org/family/PF08441", "database": "Pfam" }, { "id": "PR_A2ARA8", "url": "http://purl.obolibrary.org/obo/PR_A2ARA8", "database": "PRO" }, { "id": "R-MMU-2129379", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2129379", "database": "Reactome" }, { "id": "R-MMU-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", "database": "Reactome" }, { "id": "R-MMU-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", "database": "Reactome" }, { "id": "NP_001001309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309", "database": "RefSeq" }, { "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8", "database": "UniProtKB" }, { "id": "A2ARA8-1", "url": "https://www.uniprot.org/uniprot/A2ARA8-1", "database": "UniProtKB" }, { "id": "A2ARA8-2", "url": "https://www.uniprot.org/uniprot/A2ARA8-2", "database": "UniProtKB" }, { "id": "G3UYN5", "url": "https://www.uniprot.org/uniprot/G3UYN5", "database": "UniProtKB" }, { "id": "G3UYN5-1", "url": "https://www.uniprot.org/uniprot/G3UYN5-1", "database": "UniProtKB" }, { "id": "G3UYV5", "url": "https://www.uniprot.org/uniprot/G3UYV5", "database": "UniProtKB" }, { "id": "G3UYV5-1", "url": "https://www.uniprot.org/uniprot/G3UYV5-1", "database": "UniProtKB" } ], "sequence": { "sequence": 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OX=10090 GN=Itga8 PE=1 SV=1 CANONICAL=A2ARA8-1" }, "locus": {} }, { "isoform_ac": "G3UYN5-1", "url": "https://www.uniprot.org/uniprot/A2ARA8#G3UYN5-1", "sequence": { "sequence": "MSAGTHCGPPGNRAPPFARLCCVSAALGMLWSPACLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPSERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSIADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQASALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNPRGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSVRVCASIAGQSISNTIALLAEVQLDFLKQKGAIKRTLFLHNHQSHFTFPFVMKQQKSLHCQDFMVYLRTLA", "length": 590, "header": "tr|G3UYN5-1|ITA8_MOUSE Computationally mapped isoform of Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1 CANONICAL=A2ARA8-1" }, "locus": { "chromosome": "2", "start_pos": 12306593, "end_pos": 12198085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000172791", "url": "https://www.ensembl.org/id/ENSMUST00000172791" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134154", "url": "https://www.ensembl.org/id/ENSMUSP00000134154" } ] } }, { "isoform_ac": "G3UYV5-1", "url": "https://www.uniprot.org/uniprot/A2ARA8#G3UYV5-1", "sequence": { "sequence": "NCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLKRKNDHYALASLVSFEVKKMPYKEQPAKLPAGSTAVKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKLVFLFSSVDSLIEQDLLRMK", "length": 133, "header": "tr|G3UYV5-1|ITA8_MOUSE Computationally mapped isoform of Integrin alpha-8 OS=Mus musculus OX=10090 GN=Itga8 PE=1 SV=1 CANONICAL=A2ARA8-1" }, "locus": { "chromosome": "2", "start_pos": 12137363, "end_pos": 12113973, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000148055", "url": "https://www.ensembl.org/id/ENSMUST00000148055" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134238", "url": "https://www.ensembl.org/id/ENSMUSP00000134238" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1004, "start_aa": "Asn", "end_pos": 1004, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 121, "start_aa": "Asn", "end_pos": 121, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", 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"https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 310, "start_aa": "Asn", "end_pos": 310, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 503, "start_aa": "Asn", "end_pos": 503, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 600, "start_aa": "Asn", "end_pos": 600, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 604, "start_aa": "Asn", "end_pos": 604, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 718, "start_aa": "Asn", "end_pos": 718, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 736, "start_aa": "Asn", "end_pos": 736, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 752, "start_aa": "Asn", "end_pos": 752, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 779, "start_aa": "Asn", "end_pos": 779, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 80, "start_aa": "Asn", "end_pos": 80, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 895, "start_aa": "Asn", "end_pos": 895, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 922, "start_aa": "Asn", "end_pos": 922, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2ARA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ARA8#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Integrin subunit gene expression is regionally differentiated in adult brain.", "journal": "J. Neurosci.", "date": "1999", "authors": "Detterich J., Gall C., Lynch G., Pinkstaff J.K.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "10024342", "url": "https://glygen.org/publication/PubMed/10024342" } ] }, { "title": "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.", "journal": "Kidney Int.", "date": "1999", "authors": "Mueller U., Hartner A., Proels F., Schoecklmann H., Sterzel R.B.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "10504498", "url": "https://glygen.org/publication/PubMed/10504498" } ] }, { "title": "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1.", "journal": "Nat. Genet.", "date": "2000", "authors": "Mueller U., Littlewood Evans A.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "10742111", "url": "https://glygen.org/publication/PubMed/10742111" } ] }, { "title": "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney.", "journal": "J. Cell Biol.", "date": "2001", "authors": "Wang D., Mueller U., Brandenberger R., Schmidt A., Reichardt L.F., Linton J., Backus C., Denda S.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "11470831", "url": "https://glygen.org/publication/PubMed/11470831" } ] }, { "title": "The alpha8 integrin chain affords mechanical stability to the glomerular capillary tuft in hypertensive glomerular disease.", "journal": "Am. J. Pathol.", "date": "2002", "authors": "Mueller U., Hartner A., Sterzel R.B., Cordasic N., Hilgers K.F., Klanke B.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "11891185", "url": "https://glygen.org/publication/PubMed/11891185" } ] }, { "title": "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.", "journal": "Kidney Int.", "date": "2003", "authors": "Spessotto P., Colombatti A., Hartner A., Jahn A., Bieritz B., Prols F.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "12787402", "url": "https://glygen.org/publication/PubMed/12787402" } ] }, { "title": "Expression of the integrin subunit alpha8 in murine lung development.", "journal": "J. Histochem. Cytochem.", "date": "2003", "authors": "Schnapp L.M., Frevert C.W., Herzog E.L., Wagner T.E.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "14500699", "url": "https://glygen.org/publication/PubMed/14500699" } ] }, { "title": "The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression.", "journal": "Development", "date": "2007", "authors": "Reichardt L.F., Martin G.R., Linton J.M.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "17537792", "url": "https://glygen.org/publication/PubMed/17537792" } ] }, { "title": "Role of integrin alpha8 in murine model of lung fibrosis.", "journal": "PloS one", "date": "2018", "authors": "Hung CF, Wilson CL, Chow YH, Schnapp LM", "evidence": [ { "database": "RefSeq", "id": "NP_001001309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001309" } ], "reference": [ { "type": "PubMed", "id": "29813125", "url": "https://glygen.org/publication/PubMed/29813125" } ] }, { "title": "Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis.", "journal": "Cell", "date": "1997", "authors": "Wang D., Mueller U., Reichardt L.F., Pedersen R.A., Denda S., Meneses J.J.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "9054500", "url": "https://glygen.org/publication/PubMed/9054500" } ] }, { "title": "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.", "journal": "Biochemistry", "date": "1998", "authors": "Mueller U., Reichardt L.F., Erickson H.P., Crossin K.L., Denda S.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "9548928", "url": "https://glygen.org/publication/PubMed/9548928" } ] }, { "title": "Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis.", "journal": "Mol. Biol. Cell", "date": "1998", "authors": "Mueller U., Reichardt L.F., Denda S.", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "reference": [ { "type": "PubMed", "id": "9614184", "url": "https://glygen.org/publication/PubMed/9614184" } ] } ], "pathway": [ { "id": "mmu:241226", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241226", "resource": "KEGG Pathway" }, { "id": "R-MMU-2129379", "name": "Molecules associated with elastic fibres", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2129379", "resource": "Reactome", "description": "Molecules associated with elastic fibres" }, { "id": "R-MMU-216083", "name": "Integrin cell surface interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-MMU-3000178", "name": "ECM proteoglycans", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", "resource": "Reactome", "description": "ECM proteoglycans" } ], "orthologs": [ { "uniprot_canonical_ac": "B5DEG1-1", "protein_name": "RGD1564327 protein", "gene_name": "Itga8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSARTHRGPPENWAPPFACLCCVSAVLGMLWSPVSLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKPNPAKDPVGTCYVAIQNFSAYAEHSPCRNSNVDPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFTGDSLQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQVSALLFQDPQVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPSQVLQGIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGEGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQIPEFPTPVACFSLRVCASIAGQSISNTVALMAEVQLDFLKQKGAIKRTLFLHNHQSHLIFPFVMRQQKSLHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTFEDGLEVKPILNHYRENVVTEQAHILVDCGEDNLCVPDLRLSARPDKQEIIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGLRLLSCEYKMENVTRMVVCDLGNPMVTGTNFSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSVQINVTAVAQVEIRGVSHPPQIVLPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPSTISDSILEVGWPFSAREEFLLYVFHLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQPHRQSPAKILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA", "length": 1062 }, "evidence": [ { "id": "37396", "url": "http://www.informatics.jax.org/homology/37396", "database": "MGI" }, { "id": "A2ARA8", "url": "https://omabrowser.org/oma/group/A2ARA8/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P53708-1", "protein_name": "Integrin alpha-8", "gene_name": "ITGA8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFHIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVKAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAGEKQTEVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNKDGLNTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTNDKTPEA", "length": 1063 }, "evidence": [ { "id": "37396", "url": "http://www.informatics.jax.org/homology/37396", "database": "MGI" }, { "id": "A2ARA8", "url": "https://omabrowser.org/oma/group/A2ARA8/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "10742111" }, { "name": "dendritic spine membrane", "id": "GO:0032591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032591", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "integrin complex", "id": "GO:0008305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008305", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "12904471" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "10742111" }, { "name": "inner ear morphogenesis", "id": "GO:0042472", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042472", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "10742111" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "substrate adhesion-dependent cell spreading", "id": "GO:0034446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034446", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" }, { "name": "establishment of protein localization", "id": "GO:0045184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "21335239" }, { "name": "positive regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030511", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "17537792" }, { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "10742111" }, { "name": "metanephros development", "id": "GO:0001656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001656", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "17537792" }, { "name": "smooth muscle tissue development", "id": "GO:0048745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048745", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "21335239" }, { "name": "positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation", "id": "GO:2000721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000721", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "21335239" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A2ARA8", "url": "https://www.uniprot.org/uniprot/A2ARA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1004, "end_pos": 1006, "annotation": "n_glycosylation_sequon" }, { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 301, "end_pos": 303, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 718, "end_pos": 720, "annotation": "n_glycosylation_sequon" }, { "start_pos": 736, "end_pos": 738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" }, { "start_pos": 779, "end_pos": 781, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" }, { "start_pos": 895, "end_pos": 897, "annotation": "n_glycosylation_sequon" }, { "start_pos": 922, "end_pos": 924, "annotation": 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