{ "uniprot_canonical_ac": "A2AR95-1", "uniprot_ac": "A2AR95", "uniprot_id": "LRAD3_MOUSE", "mass": { "chemical_mass": 37467.0, "monoisotopic_mass": 37467.0 }, "refseq": { "ac": "NP_001277713", "name": "low-density lipoprotein receptor class A domain-containing protein 3 isoform b precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277713" }, "gene_names": [ { "name": "Ldlrad3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AR95", "id": "A2AR95" }, { "name": "6430500P08; AI194318; Lrad3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277713", "id": "NP_001277713" }, { "name": "Ldlrad3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277713", "id": "NP_001277713" } ], "protein_names": [ { "name": "Low-density lipoprotein receptor class A domain-containing protein 3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AR95#names_and_taxonomy", "id": "A2AR95" }, { "name": "low-density lipoprotein receptor class A domain-containing protein 3 isoform b precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277713", "id": "NP_001277713" }, { "name": "low-density lipoprotein receptor class A domain-containing protein 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277713", "id": "NP_001277713" } ], "function": [ { "annotation": "LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.", "evidence": [ { "database": "RefSeq", "id": "NP_001277713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277713" }, { "database": "PubMed", "id": "33208938", "url": "https://glygen.org/publication/PubMed/33208938" } ] }, { "annotation": "May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.", "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95#function" }, { "database": "PubMed", "id": "21795536", "url": "https://glygen.org/publication/PubMed/21795536" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ldlrad3", "url": "https://www.uniprot.org/uniprot/A2AR95", "locus": { "chromosome": "2", "start_pos": 102186385, "end_pos": 101950203, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000048058", "url": "https://www.ensembl.org/id/ENSMUSG00000048058" } ] } } ], "crossref": [ { "id": "ENSMUSG00000048058", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048058", "database": "Bgee" }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD" }, { "id": "241576", "url": "https://www.ncbi.nlm.nih.gov/gene/241576", "database": "GeneID" }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro" }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro" }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro" }, { "id": "mmu:241576", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241576", "database": "KEGG Pathway" }, { "id": "2138856", "url": "http://www.informatics.jax.org/marker/MGI:2138856", "database": "MGI" }, { "id": "LPDCFDD", "url": "https://omabrowser.org/oma/group/LPDCFDD/", "database": "OMA" }, { "id": "PF00057", "url": "http://pfam.xfam.org/family/PF00057", "database": "Pfam" }, { "id": "PR_A2AR95", "url": "http://purl.obolibrary.org/obo/PR_A2AR95", "database": "PRO" }, { "id": "NP_001277713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277713", "database": "RefSeq" }, { "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95", "database": "UniProtKB" }, { "id": "A2AR95-1", "url": "https://www.uniprot.org/uniprot/A2AR95-1", "database": "UniProtKB" }, { "id": "A2AR95-2", "url": "https://www.uniprot.org/uniprot/A2AR95-2", "database": "UniProtKB" }, { "id": "A2AR95-3", "url": "https://www.uniprot.org/uniprot/A2AR95-3", "database": "UniProtKB" } ], "sequence": { "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEASSHNPEQPGSPEGSAEPRDSVPSQGTEEV", "length": 345, "header": "sp|A2AR95-1|LRAD3_MOUSE Isoform 1 of Low-density lipoprotein receptor class A domain-containing protein 3 OS=Mus musculus OX=10090 GN=Ldlrad3 PE=1 SV=1 CANONICAL=A2AR95-1" }, "isoforms": [ { "isoform_ac": "A2AR95-1", "url": "https://www.uniprot.org/uniprot/A2AR95#A2AR95-1", "sequence": { "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEASSHNPEQPGSPEGSAEPRDSVPSQGTEEV", "length": 345, "header": "sp|A2AR95-1|LRAD3_MOUSE Isoform 1 of Low-density lipoprotein receptor class A domain-containing protein 3 OS=Mus musculus OX=10090 GN=Ldlrad3 PE=1 SV=1 CANONICAL=A2AR95-1" }, "locus": { "chromosome": "2", "start_pos": 102016670, "end_pos": 101783286, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000058790", "url": "https://www.ensembl.org/id/ENSMUST00000058790" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000054134", "url": "https://www.ensembl.org/id/ENSMUSP00000054134" } ] } }, { "isoform_ac": "A2AR95-2", "url": "https://www.uniprot.org/uniprot/A2AR95#A2AR95-2", "sequence": { "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASLPRSQQPPECGSQQPQPRAAWLSRGLC", "length": 331, "header": "sp|A2AR95-2|LRAD3_MOUSE Isoform 2 of Low-density lipoprotein receptor class A domain-containing protein 3 OS=Mus musculus OX=10090 GN=Ldlrad3 PE=1 SV=1 CANONICAL=A2AR95-1" }, "locus": {} }, { "isoform_ac": "A2AR95-3", "url": "https://www.uniprot.org/uniprot/A2AR95#A2AR95-3", "sequence": { "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPAKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEASSHNPEQPGSPEGSAEPRDSVPSQGTEEV", "length": 313, "header": "sp|A2AR95-3|LRAD3_MOUSE Isoform 3 of Low-density lipoprotein receptor class A domain-containing protein 3 OS=Mus musculus OX=10090 GN=Ldlrad3 PE=1 SV=1 CANONICAL=A2AR95-1" }, "locus": { "chromosome": "2", "start_pos": 102016670, "end_pos": 101783286, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000111222", "url": "https://www.ensembl.org/id/ENSMUST00000111222" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106853", "url": "https://www.ensembl.org/id/ENSMUSP00000106853" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 24, "start_aa": "Asn", "end_pos": 24, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2AR95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AR95#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.", "journal": "J. Neurosci.", "date": "2011", "authors": "Hyman B.T., Yepes M., Migliorini M., Mikhailenko I., Strickland D.K., Smith E., Ranganathan S., Battey F.D., Noyes N.C., Winkles J.A.", "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95" } ], "reference": [ { "type": "PubMed", "id": "21795536", "url": "https://glygen.org/publication/PubMed/21795536" } ] }, { "title": "LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.", "journal": "Nature", "date": "2020", "authors": "Ma H, Kim AS, Kafai NM, Earnest JT, Shah AP, Case JB, Basore K, Gilliland TC, Sun C, Nelson CA, Thackray LB, Klimstra WB, Fremont DH, Diamond MS", "evidence": [ { "database": "RefSeq", "id": "NP_001277713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277713" } ], "reference": [ { "type": "PubMed", "id": "33208938", "url": "https://glygen.org/publication/PubMed/33208938" } ] } ], "pathway": [ { "id": "mmu:241576", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241576", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LXB2-1", "protein_name": "Low density lipoprotein receptor class A domain-containing 3", "gene_name": "Ldlrad3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLLGPLCLLLSSTAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCRNGLCIDKSFICDGQNNCQDNSDEESCESSLEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGVQYVATQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSAYSASSQAASSLLSVEGSSHSPEQPGPAESTSEPRDSVPSQGTEEV", "length": 345 }, "evidence": [ { "id": "18377", "url": "http://www.informatics.jax.org/homology/18377", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86YD5-1", "protein_name": "Low-density lipoprotein receptor class A domain-containing protein 3", "gene_name": "LDLRAD3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV", "length": 345 }, "evidence": [ { "id": "18377", "url": "http://www.informatics.jax.org/homology/18377", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95" } ], "pmid": "21795536" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95" } ], "pmid": "21795536" }, { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "amyloid-beta binding", "id": "GO:0001540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95" } ], "pmid": "21795536" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95" } ], "pmid": "21795536" }, { "name": "regulation of protein processing", "id": "GO:0070613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070613", "evidence": [ { "database": "UniProtKB", "id": "A2AR95", "url": "https://www.uniprot.org/uniprot/A2AR95" } ], "pmid": "21795536" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }