{ "uniprot_canonical_ac": "A2APC3-1", "uniprot_ac": "A2APC3", "uniprot_id": "TTLL9_MOUSE", "mass": { "chemical_mass": 54107.0, "monoisotopic_mass": 54107.0 }, "refseq": { "ac": "NP_001077087", "name": "probable tubulin polyglutamylase TTLL9 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087" }, "gene_names": [ { "name": "Ttll9", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2APC3", "id": "A2APC3" }, { "name": "1700016F23Rik; 4930509O20Rik; AW046572", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087", "id": "NP_001077087" }, { "name": "Ttll9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087", "id": "NP_001077087" } ], "protein_names": [ { "name": "Probable tubulin polyglutamylase TTLL9", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2APC3#names_and_taxonomy", "id": "A2APC3" }, { "name": "6.3.2.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2APC3#names_and_taxonomy", "id": "A2APC3" }, { "name": "Tubulin--tyrosine ligase-like protein 9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2APC3#names_and_taxonomy", "id": "A2APC3" }, { "name": "probable tubulin polyglutamylase TTLL9 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087", "id": "NP_001077087" }, { "name": "tubulin tyrosine ligase like family 9; probable tubulin polyglutamylase TTLL9; putative polyglutamylase; tubulin--tyrosine ligase-like protein 9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087", "id": "NP_001077087" } ], "function": [ { "annotation": "Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (PubMed:27257088). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (Probable). Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern (PubMed:27257088).", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3#function" }, { "database": "PubMed", "id": "27257088", "url": "https://glygen.org/publication/PubMed/27257088" }, { "database": "PubMed", "id": "17499049", "url": "https://glygen.org/publication/PubMed/17499049" } ] }, { "annotation": "Ttll9 plays essential roles in maintaining the normal structure and beating pattern of sperm flagella by establishing normal heterogeneous polyglutamylation patterns.", "evidence": [ { "database": "RefSeq", "id": "NP_001077087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087" }, { "database": "PubMed", "id": "27257088", "url": "https://glygen.org/publication/PubMed/27257088" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ttll9", "url": "https://www.uniprot.org/uniprot/A2APC3", "locus": { "chromosome": "2", "start_pos": 152962485, "end_pos": 153008482, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000074673", "url": "https://www.ensembl.org/id/ENSMUSG00000074673" } ] } } ], "crossref": [ { "id": "ENSMUSG00000074673", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074673", "database": "Bgee" }, { "id": "74711", "url": "https://www.ncbi.nlm.nih.gov/gene/74711", "database": "GeneID" }, { "id": "IPR004344", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", "database": "InterPro" }, { "id": "IPR013815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "database": "InterPro" }, { "id": "IPR027751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027751", "database": "InterPro" }, { "id": "mmu:74711", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:74711", "database": "KEGG Pathway" }, { "id": "1913589", "url": "http://www.informatics.jax.org/marker/MGI:1913589", "database": "MGI" }, { "id": "LIWANGP", "url": "https://omabrowser.org/oma/group/LIWANGP/", "database": "OMA" }, { "id": "584228at2759", "url": "http://www.orthodb.org/?query=584228at2759", "database": "OrthoDB" }, { "id": "PTHR12241:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12241:SF39", "database": "PANTHER" }, { "id": "PF03133", "url": "http://pfam.xfam.org/family/PF03133", "database": "Pfam" }, { "id": "PR_A2APC3", "url": "http://purl.obolibrary.org/obo/PR_A2APC3", "database": "PRO" }, { "id": "R-MMU-8955332", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "database": "Reactome" }, { "id": "NP_001077087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087", "database": "RefSeq" }, { "id": "60148", "url": "https://www.rhea-db.org/rhea/60148", "database": "Rhea" }, { "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3", "database": "UniProtKB" }, { "id": "A2APC3-1", "url": "https://www.uniprot.org/uniprot/A2APC3-1", "database": "UniProtKB" }, { "id": "A2APC3-2", "url": "https://www.uniprot.org/uniprot/A2APC3-2", "database": "UniProtKB" }, { "id": "D6RCJ6", "url": "https://www.uniprot.org/uniprot/D6RCJ6", "database": "UniProtKB" }, { "id": "D6RCJ6-1", "url": "https://www.uniprot.org/uniprot/D6RCJ6-1", "database": "UniProtKB" }, { "id": "D6RG93", "url": "https://www.uniprot.org/uniprot/D6RG93", "database": "UniProtKB" }, { "id": "D6RG93-1", "url": "https://www.uniprot.org/uniprot/D6RG93-1", "database": "UniProtKB" }, { "id": "E9PUG4", "url": "https://www.uniprot.org/uniprot/E9PUG4", "database": "UniProtKB" }, { "id": "E9PUG4-1", "url": "https://www.uniprot.org/uniprot/E9PUG4-1", "database": "UniProtKB" }, { "id": "F6ZRM1", "url": "https://www.uniprot.org/uniprot/F6ZRM1", "database": "UniProtKB" }, { "id": "F6ZRM1-1", "url": "https://www.uniprot.org/uniprot/F6ZRM1-1", "database": "UniProtKB" }, { "id": "Z4YLM0", "url": "https://www.uniprot.org/uniprot/Z4YLM0", "database": "UniProtKB" }, { "id": "Z4YLM0-1", "url": "https://www.uniprot.org/uniprot/Z4YLM0-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSRQKNQNSKGHGVSKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKYLERESGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKGTSGKKPTGVETQPARANMNPSGSHDTRSSDDQKDDLPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDHYVHLTNVAVQKTSPDYHLKKGCKWMLQRFRQYLASKHGPKAVETLFSDMDNIFIKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGKEKRVGGFDLMWNDGPVSREDGPSDLSGMGNFVTNTHLGCVNDRKEQLRQLFRSLQAQRKAPS", "length": 461, "header": "sp|A2APC3-1|TTLL9_MOUSE Isoform 1 of Probable tubulin polyglutamylase TTLL9 OS=Mus musculus OX=10090 GN=Ttll9 PE=1 SV=2 CANONICAL=A2APC3-1" }, "isoforms": [ { "isoform_ac": "A2APC3-1", "url": "https://www.uniprot.org/uniprot/A2APC3#A2APC3-1", "sequence": { "sequence": "MSRQKNQNSKGHGVSKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKYLERESGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKGTSGKKPTGVETQPARANMNPSGSHDTRSSDDQKDDLPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDHYVHLTNVAVQKTSPDYHLKKGCKWMLQRFRQYLASKHGPKAVETLFSDMDNIFIKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGKEKRVGGFDLMWNDGPVSREDGPSDLSGMGNFVTNTHLGCVNDRKEQLRQLFRSLQAQRKAPS", "length": 461, "header": "sp|A2APC3-1|TTLL9_MOUSE Isoform 1 of Probable tubulin polyglutamylase TTLL9 OS=Mus musculus OX=10090 GN=Ttll9 PE=1 SV=2 CANONICAL=A2APC3-1" }, "locus": { "chromosome": "2", "start_pos": 152848902, "end_pos": 152804461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000099197", "url": "https://www.ensembl.org/id/ENSMUST00000099197" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000096803", "url": "https://www.ensembl.org/id/ENSMUSP00000096803" } ] } }, { "isoform_ac": "A2APC3-2", "url": "https://www.uniprot.org/uniprot/A2APC3#A2APC3-2", "sequence": { "sequence": "MSRQKNQNSKGHGVSKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKYLERESGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKGTSGKKPTGVETQPARANMNPSGSHDTRSSDDQKDDLPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDHYVHLTNVAVQKTSPDYHLKKGCKWMLQRFRQYLASKHGPKAVETLFSDMDNIFIKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGKEKRVGGFDLMWNDGPVSREDGPSDLSGMGNFVTNTHLGTLSQTGSEWERNIIGSGGGLGPLGRAV", "length": 464, "header": "sp|A2APC3-2|TTLL9_MOUSE Isoform 2 of Probable tubulin polyglutamylase TTLL9 OS=Mus musculus OX=10090 GN=Ttll9 PE=1 SV=2 CANONICAL=A2APC3-1" }, "locus": { "chromosome": "2", "start_pos": 152845025, "end_pos": 152804461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000103155", "url": "https://www.ensembl.org/id/ENSMUST00000103155" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000099444", "url": "https://www.ensembl.org/id/ENSMUSP00000099444" } ] } }, { "isoform_ac": "D6RCJ6-1", "url": "https://www.uniprot.org/uniprot/A2APC3#D6RCJ6-1", "sequence": { "sequence": "MSRQKRAENLNPLQDHPHEHTHGCSAPQARMGGSQR", "length": 36, "header": "tr|D6RCJ6-1|D6RCJ6_MOUSE Computationally mapped isoform of Probable tubulin polyglutamylase TTLL9 OS=Mus musculus OX=10090 GN=Ttll9 PE=4 SV=1 CANONICAL=A2APC3-1" }, "locus": { "chromosome": "2", "start_pos": 152818163, "end_pos": 152804461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000146626", "url": "https://www.ensembl.org/id/ENSMUST00000146626" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000121434", "url": "https://www.ensembl.org/id/ENSMUSP00000121434" } ] } }, { "isoform_ac": "D6RG93-1", "url": "https://www.uniprot.org/uniprot/A2APC3#D6RG93-1", "sequence": { "sequence": "MSRQKNQNSKGHGVSKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYEKWARQGTEGSPSALPCCLAYQEKLHGKEPEALPEVPGA", "length": 126, "header": "tr|D6RG93-1|D6RG93_MOUSE Computationally mapped isoform of Probable tubulin polyglutamylase TTLL9 OS=Mus musculus OX=10090 GN=Ttll9 PE=3 SV=1 CANONICAL=A2APC3-1" }, "locus": { "chromosome": "2", "start_pos": 152826114, "end_pos": 152804461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000152158", "url": "https://www.ensembl.org/id/ENSMUST00000152158" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122494", "url": "https://www.ensembl.org/id/ENSMUSP00000122494" } ] } }, { "isoform_ac": "E9PUG4-1", "url": "https://www.uniprot.org/uniprot/A2APC3#E9PUG4-1", "sequence": { "sequence": "MSRQKNQNSKGHGVSKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKYLERESGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKDTRSSDDQKDDLPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSMFTSPMLLCRRHRLTTT", "length": 234, "header": "tr|E9PUG4-1|E9PUG4_MOUSE Computationally mapped isoform of Tubulin--tyrosine ligase-like protein 9 OS=Mus musculus OX=10090 GN=Ttll9 PE=3 SV=1 CANONICAL=A2APC3-1" }, "locus": { "chromosome": "2", "start_pos": 152841269, "end_pos": 152804461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000109801", "url": "https://www.ensembl.org/id/ENSMUST00000109801" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000105426", "url": "https://www.ensembl.org/id/ENSMUSP00000105426" } ] } }, { "isoform_ac": "F6ZRM1-1", "url": "https://www.uniprot.org/uniprot/A2APC3#F6ZRM1-1", "sequence": { "sequence": "NQNSKGHGVSKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKETQGVLMTRKMTSRWRTTWLSVTWKTPT", "length": 73, "header": "tr|F6ZRM1-1|TTLL9_MOUSE Computationally mapped isoform of Probable tubulin polyglutamylase TTLL9 OS=Mus musculus OX=10090 GN=Ttll9 PE=1 SV=1 CANONICAL=A2APC3-1" }, "locus": { "chromosome": "2", "start_pos": 152833579, "end_pos": 152814208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000165343", "url": "https://www.ensembl.org/id/ENSMUST00000165343" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000131839", "url": "https://www.ensembl.org/id/ENSMUSP00000131839" } ] } }, { "isoform_ac": "Z4YLM0-1", "url": "https://www.uniprot.org/uniprot/A2APC3#Z4YLM0-1", "sequence": { "sequence": "MTCDPRGSKEQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKYLERESGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKP", "length": 139, "header": "tr|Z4YLM0-1|Z4YLM0_MOUSE Computationally mapped isoform of Tubulin--tyrosine ligase-like protein 9 OS=Mus musculus OX=10090 GN=Ttll9 PE=3 SV=1 CANONICAL=A2APC3-1" }, "locus": { "chromosome": "2", "start_pos": 152826241, "end_pos": 152815499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000155631", "url": "https://www.ensembl.org/id/ENSMUST00000155631" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000114786", "url": "https://www.ensembl.org/id/ENSMUSP00000114786" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "A targeted multienzyme mechanism for selective microtubule polyglutamylation.", "journal": "Mol. Cell", "date": "2007", "authors": "Janke C., Lacroix B., Rogowski K., van Dijk J., Miro J., Edde B.", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "reference": [ { "type": "PubMed", "id": "17499049", "url": "https://glygen.org/publication/PubMed/17499049" } ] }, { "title": "Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.", "journal": "J. Cell Biol.", "date": "2013", "authors": "Giordano T., Spassky N., Janke C., Rocha C., Magiera M.M., Bosch Grau M., Marques Sousa P., Gonzalez Curto G.", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "reference": [ { "type": "PubMed", "id": "23897886", "url": "https://glygen.org/publication/PubMed/23897886" } ] }, { "title": "Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating.", "journal": "J. Cell Sci.", "date": "2016", "authors": "Abe M., Yamazaki M., Shiba K., Setou M., Yao I., Ikegami K., Yang H.J., Konishi Y., Inaba K., Sakimura K., Konno A.", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" }, { "database": "RefSeq", "id": "NP_001077087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087" } ], "reference": [ { "type": "PubMed", "id": "27257088", "url": "https://glygen.org/publication/PubMed/27257088" } ] } ], "pathway": [ { "id": "mmu:74711", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:74711", "resource": "KEGG Pathway" }, { "id": "R-MMU-8955332", "name": "Carboxyterminal post-translational modifications of tubulin", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "resource": "Reactome", "description": "Carboxyterminal post-translational modifications of tubulin" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3SXZ7-1", "protein_name": "Probable tubulin polyglutamylase TTLL9", "gene_name": "TTLL9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVPSREALLGPGTTAIRCPKKLQNQNYKGHGLSKGKEREQRASIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVYVLVMSVFAECLLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDNIFVKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGREKRVGGFDLMWNDGPVSREEGAPDLSGMGNFVTNTHLGCVNDRKKQLRQLFCSLQVQKKASS", "length": 439 }, "evidence": [ { "id": "41769", "url": "http://www.informatics.jax.org/homology/41769", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q641W7-1", "protein_name": "Probable tubulin polyglutamylase TTLL9", "gene_name": "Ttll9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRQKSQTSKGHGASKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKQLEREAGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKGTAGKKVTSVETQATRANVNPSGSHDTRSSDDQKDDIPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDHYVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPKAVETLFSDMDNIFIKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGKEKRVGGFDLMWNDGPVSREEGPCDLSGMGNFVTNTHLGCINDRKEQLRQLFRSLQVQKKASS", "length": 461 }, "evidence": [ { "id": "41769", "url": "http://www.informatics.jax.org/homology/41769", "database": "MGI" }, { "id": "A2APC3", "url": "https://omabrowser.org/oma/group/A2APC3/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "" }, { "name": "tubulin-glutamic acid ligase activity", "id": "GO:0070740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070740", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "21873635" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "21873635" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cellular protein modification process", "id": "GO:0006464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006464", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "27257088" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "21873635" }, { "name": "protein polyglutamylation", "id": "GO:0018095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018095", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "27257088" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "21873635" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A2APC3", "url": "https://www.uniprot.org/uniprot/A2APC3" } ], "pmid": "17499049" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "60148", "name": "", "equation": "(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5PPI9-1", "Q641W7-1", "Q6ZT98-1", "O95922-1", "A6NNM8-1", "Q3SXZ7-1", "Q8N841-1", "Q6EMB2-1", "Q8NHH1-1", "A4Q9F4-1", "A2APC3-1", "A4Q9F6-1", "Q8CHB8-1", "A4Q9E8-1", "Q91V51-1", "A4Q9F0-1" ], "evidence": [ { "id": "60148", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60148" } ] }, { "id": "R-MMU-8865774", "name": "TTLLs polyglutamylate tubulin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4Q9E4-1", "Q80UG8-1", "A2APC3-1", "A4Q9E8-1", "A4Q9F0-1", "Q8CHB8-1", "A4Q9F4-1", "A4Q9F6-1" ], "evidence": [ { "id": "R-MMU-8865774", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8865774" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2APC3", "gene_name": "Ttll9", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "A2APC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2APC3" } ] } ] }, { "uniprot_ac": "A4Q9E4", "gene_name": "Ttll2", "activity": [ { "ec_number": "6.-.-.-", "activity": "", "evidence": [ { "id": "A4Q9E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4Q9E4" } ] } ] }, { "uniprot_ac": "A4Q9E8", "gene_name": "Ttll6", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "A4Q9E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4Q9E8" } ] } ] }, { "uniprot_ac": "A4Q9F0", "gene_name": "Ttll7", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "A4Q9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4Q9F0" } ] } ] }, { "uniprot_ac": "A4Q9F4", "gene_name": "Ttll11", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "A4Q9F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4Q9F4" } ] } ] }, { "uniprot_ac": "A4Q9F6", "gene_name": "Ttll13", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "A4Q9F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4Q9F6" } ] } ] }, { "uniprot_ac": "A6NNM8", "gene_name": "TTLL13P", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "A6NNM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NNM8" } ] } ] }, { "uniprot_ac": "O95922", "gene_name": "TTLL1", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "O95922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95922" } ] } ] }, { "uniprot_ac": "Q3SXZ7", "gene_name": "TTLL9", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q3SXZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3SXZ7" } ] } ] }, { "uniprot_ac": "Q5PPI9", "gene_name": "Ttll1", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q5PPI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PPI9" } ] } ] }, { "uniprot_ac": "Q641W7", "gene_name": "Ttll9", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q641W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641W7" } ] } ] }, { "uniprot_ac": "Q6EMB2", "gene_name": "TTLL5", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q6EMB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6EMB2" } ] } ] }, { "uniprot_ac": "Q6ZT98", "gene_name": "TTLL7", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q6ZT98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZT98" } ] } ] }, { "uniprot_ac": "Q80UG8", "gene_name": "Ttll4", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q80UG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UG8" } ] } ] }, { "uniprot_ac": "Q8CHB8", "gene_name": "Ttll5", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q8CHB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHB8" } ] } ] }, { "uniprot_ac": "Q8N841", "gene_name": "TTLL6", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q8N841", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N841" } ] } ] }, { "uniprot_ac": "Q8NHH1", "gene_name": "TTLL11", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q8NHH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NHH1" } ] } ] }, { "uniprot_ac": "Q91V51", "gene_name": "Ttll1", "activity": [ { "ec_number": "6.3.2.-", "activity": "", "evidence": [ { "id": "Q91V51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V51" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }