{
    "uniprot_canonical_ac": "A2APB8-1",
    "uniprot_ac": "A2APB8",
    "uniprot_id": "TPX2_MOUSE",
    "mass": {
        "chemical_mass": 85894.0,
        "monoisotopic_mass": 85894.0
    },
    "refseq": {
        "ac": "NP_001135447",
        "name": "targeting protein for Xklp2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447"
    },
    "gene_names": [
        {
            "name": "Tpx2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2APB8",
            "id": "A2APB8"
        },
        {
            "name": "2610005B21Rik; DIL2; p100; REPP86",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447",
            "id": "NP_001135447"
        },
        {
            "name": "Tpx2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447",
            "id": "NP_001135447"
        }
    ],
    "protein_names": [
        {
            "name": "Targeting protein for Xklp2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2APB8#names_and_taxonomy",
            "id": "A2APB8"
        },
        {
            "name": "TPX2, microtubule-associated protein homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447",
            "id": "NP_001135447"
        },
        {
            "name": "targeting protein for Xklp2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447",
            "id": "NP_001135447"
        }
    ],
    "function": [
        {
            "annotation": "Depleting TPX2 decreases microtubule formation frequency specifically at the tip and the base of the neurite, and these correlate precisely with the regions where active GTP-bound Ran proteins are enriched. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001135447",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447"
                },
                {
                    "database": "PubMed",
                    "id": "28205572",
                    "url": "https://glygen.org/publication/PubMed/28205572"
                }
            ]
        },
        {
            "annotation": "Inhibition of interleukin-1beta plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001135447",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447"
                },
                {
                    "database": "PubMed",
                    "id": "33892301",
                    "url": "https://glygen.org/publication/PubMed/33892301"
                }
            ]
        },
        {
            "annotation": "Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8#function"
                },
                {
                    "database": "PubMed",
                    "id": "Q9ULW0",
                    "url": "https://glygen.org/publication/PubMed/Q9ULW0"
                },
                {
                    "database": "PubMed",
                    "id": "18663142",
                    "url": "https://glygen.org/publication/PubMed/18663142"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 8,
            "end_pos": 11,
            "sequence_org": "YSFD",
            "sequence_mut": "ASAA",
            "comment": "Abolishes interaction with AURKA.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "PubMed",
                    "id": "18663142",
                    "url": "https://glygen.org/publication/PubMed/18663142"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Tpx2",
            "url": "https://www.uniprot.org/uniprot/A2APB8",
            "locus": {
                "chromosome": "2",
                "start_pos": 152847964,
                "end_pos": 152895321,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000027469",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000027469"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000027469",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027469",
            "database": "Bgee"
        },
        {
            "id": "72119",
            "url": "https://www.ncbi.nlm.nih.gov/gene/72119",
            "database": "GeneID"
        },
        {
            "id": "A2APB8",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2APB8*",
            "database": "IntAct"
        },
        {
            "id": "IPR009675",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009675",
            "database": "InterPro"
        },
        {
            "id": "IPR015128",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015128",
            "database": "InterPro"
        },
        {
            "id": "IPR027329",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027329",
            "database": "InterPro"
        },
        {
            "id": "IPR027330",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027330",
            "database": "InterPro"
        },
        {
            "id": "mmu:72119",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72119",
            "database": "KEGG Pathway"
        },
        {
            "id": "1919369",
            "url": "http://www.informatics.jax.org/marker/MGI:1919369",
            "database": "MGI"
        },
        {
            "id": "AREWQEY",
            "url": "https://omabrowser.org/oma/group/AREWQEY/",
            "database": "OMA"
        },
        {
            "id": "1390734at2759",
            "url": "http://www.orthodb.org/?query=1390734at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR14326",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14326",
            "database": "PANTHER"
        },
        {
            "id": "PF06886",
            "url": "http://pfam.xfam.org/family/PF06886",
            "database": "Pfam"
        },
        {
            "id": "PF09041",
            "url": "http://pfam.xfam.org/family/PF09041",
            "database": "Pfam"
        },
        {
            "id": "PF12214",
            "url": "http://pfam.xfam.org/family/PF12214",
            "database": "Pfam"
        },
        {
            "id": "PR_A2APB8",
            "url": "http://purl.obolibrary.org/obo/PR_A2APB8",
            "database": "PRO"
        },
        {
            "id": "R-MMU-6804756",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804756",
            "database": "Reactome"
        },
        {
            "id": "R-MMU-8854518",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518",
            "database": "Reactome"
        },
        {
            "id": "NP_001135447",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447",
            "database": "RefSeq"
        },
        {
            "id": "A2APB8",
            "url": "https://www.uniprot.org/uniprot/A2APB8",
            "database": "UniProtKB"
        },
        {
            "id": "A2APB8-1",
            "url": "https://www.uniprot.org/uniprot/A2APB8-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQGFVTPLKAVDNTYHKETEKENLQKQSIPSNDCSSLDAKRAVSGNTPVQPQRRSIRLSAQKDLEQKEKNHVASVEMKAKRCVAPATDCPPQKRMKVSHKKKLEEEEEGSAPATSRKNERETLEKAKGKHTVPGVPPAREKVLKSTEEQEIEKRLRMQQEVVELRRKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKNQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKSVNKIARDPQTPILQTKYRTRAVTCKSTAEQEAEELEKLQQYKFKARELDPRIFESGPILPKRAPVKPPTQPVGFDLEIEKRIHERESKKKTEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPIKDEEEEKPVVIKAQPVPHYGVPYKPHIAEARNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNVTQAEPFSLETDKRGAYKAEMWKHQLEEEQKQQKDAACFKARPNTVIFQEPFVPKKEKKSLAENPSGSLVQEPFQLATERRAKERQELEKKMAEVEAWKLQQLEEVRQQEEEQQKEELARLRKELVHKANPIRKYAAVEVKSSELPLTVPVSPKFSTRFQ",
        "length": 745,
        "header": "sp|A2APB8-1|TPX2_MOUSE Isoform 1 of Targeting protein for Xklp2  OS=Mus musculus OX=10090 GN=Tpx2 PE=1 SV=1 CANONICAL=A2APB8-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2APB8-1",
            "url": "https://www.uniprot.org/uniprot/A2APB8#A2APB8-1",
            "sequence": {
                "sequence": "MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQGFVTPLKAVDNTYHKETEKENLQKQSIPSNDCSSLDAKRAVSGNTPVQPQRRSIRLSAQKDLEQKEKNHVASVEMKAKRCVAPATDCPPQKRMKVSHKKKLEEEEEGSAPATSRKNERETLEKAKGKHTVPGVPPAREKVLKSTEEQEIEKRLRMQQEVVELRRKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKNQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKSVNKIARDPQTPILQTKYRTRAVTCKSTAEQEAEELEKLQQYKFKARELDPRIFESGPILPKRAPVKPPTQPVGFDLEIEKRIHERESKKKTEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPIKDEEEEKPVVIKAQPVPHYGVPYKPHIAEARNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNVTQAEPFSLETDKRGAYKAEMWKHQLEEEQKQQKDAACFKARPNTVIFQEPFVPKKEKKSLAENPSGSLVQEPFQLATERRAKERQELEKKMAEVEAWKLQQLEEVRQQEEEQQKEELARLRKELVHKANPIRKYAAVEVKSSELPLTVPVSPKFSTRFQ",
                "length": 745,
                "header": "sp|A2APB8-1|TPX2_MOUSE Isoform 1 of Targeting protein for Xklp2  OS=Mus musculus OX=10090 GN=Tpx2 PE=1 SV=1 CANONICAL=A2APB8-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 152735608,
                "end_pos": 152709172,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000028969",
                        "url": "https://www.ensembl.org/id/ENSMUST00000028969"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000028969",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000028969"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 121,
            "end_pos": 121,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ]
        },
        {
            "start_pos": 125,
            "end_pos": 125,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ]
        },
        {
            "start_pos": 294,
            "end_pos": 294,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ]
        },
        {
            "start_pos": 312,
            "end_pos": 312,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ]
        },
        {
            "start_pos": 340,
            "end_pos": 340,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ]
        },
        {
            "start_pos": 359,
            "end_pos": 359,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ]
        },
        {
            "start_pos": 369,
            "end_pos": 369,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ]
        },
        {
            "start_pos": 486,
            "end_pos": 486,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2APB8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2APB8"
                },
                {
                    "database": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 486,
            "end_pos": 486,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 72,
            "end_pos": 72,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2APB8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2APB8"
                },
                {
                    "database": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                }
            ]
        },
        {
            "start_pos": 72,
            "end_pos": 72,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                }
            ]
        },
        {
            "start_pos": 737,
            "end_pos": 737,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2APB8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2APB8"
                },
                {
                    "database": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 737,
            "end_pos": 737,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                }
            ]
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Large-scale phosphorylation analysis of mouse liver.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2007",
            "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2APB8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2APB8"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                }
            ]
        },
        {
            "title": "Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.",
            "journal": "J. Cell Biol.",
            "date": "2008",
            "authors": "Hyman A.A., Bird A.W.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18663142",
                    "url": "https://glygen.org/publication/PubMed/18663142"
                }
            ]
        },
        {
            "title": "The phagosomal proteome in interferon-gamma-activated macrophages.",
            "journal": "Immunity",
            "date": "2009",
            "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2APB8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2APB8"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19144319",
                    "url": "https://glygen.org/publication/PubMed/19144319"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2APB8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2APB8"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.",
            "journal": "Mol. Cell",
            "date": "2013",
            "authors": "Chen Y., Park J., Zhang Y., Zhao Y., Peng C., Tan M., Xie Z., Zwaans B.M., Lombard D.B., Dai L., Tishkoff D.X., Skinner M.E.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2APB8",
                    "url": "https://www.uniprot.org/uniprot/A2APB8"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23806337",
                    "url": "https://glygen.org/publication/PubMed/23806337"
                }
            ]
        },
        {
            "title": "Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons.",
            "journal": "Scientific reports",
            "date": "2017",
            "authors": "Chen WS, Chen YJ, Huang YA, Hsieh BY, Chiu HC, Kao PY, Chao CY, Hwang E",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001135447",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28205572",
                    "url": "https://glygen.org/publication/PubMed/28205572"
                }
            ]
        },
        {
            "title": "Inhibition of interleukin-1beta plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2.",
            "journal": "International immunopharmacology",
            "date": "2021",
            "authors": "Zhang YY, Dong LX, Bao HL, Liu Y, An FM, Zhang GW",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001135447",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33892301",
                    "url": "https://glygen.org/publication/PubMed/33892301"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:72119",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72119",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-6804756",
            "name": "Regulation of TP53 Activity through Phosphorylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804756",
            "resource": "Reactome",
            "description": "Regulation of TP53 Activity through Phosphorylation"
        },
        {
            "id": "R-MMU-8854518",
            "name": "AURKA Activation by TPX2",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518",
            "resource": "Reactome",
            "description": "AURKA Activation by TPX2"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZA78-1",
            "protein_name": "TPX2, microtubule nucleation factor",
            "gene_name": "Tpx2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAQVPTAYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQSGIGEPFQGKTSLRKAKLQQGCVTPLKAVDNTYYKETEKENLQKQSIPSNDCPSLNAKRAVTGTTPIQPQRRSVRLSAQKDLEQKEKNHVASVEMKAKRCTAPTTDYPPNKKMKVSHKKKPEEEEEGSAPATSRKDETLERAKGKHTVPAVPPAREKTVKSTEEQELEKSLRMQQEVVEMRKKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKSQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKPVNKIVRDPQTPILQTKYRARAVTCKSAAEKEAEELEKLQQYKFKARELDPRIFESGPILPKRPPVKPPTQPVGFDLEIEKRIHERESKKKPEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPVKEDEEEEKPVVIKAQPVPHYGVPYKPPIPETRNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNATQAEPFSLETDKRGAYKAEIWKHQLEEEQKQQKEAACFKARPNTVIFQEPFVPKKEKKSAAENPSGSLVQEPFQLATEKRAKERQELEKKMAEMEAWKLQQLAEVRQQEEEQQKEELARLRKELVHKANPIRKYSAVEVKSSELPLTVPVSPKFSTRFQ",
                "length": 744
            },
            "evidence": [
                {
                    "id": "8107",
                    "url": "http://www.informatics.jax.org/homology/8107",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9ULW0-1",
            "protein_name": "Targeting protein for Xklp2",
            "gene_name": "TPX2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPKFSTRFHC",
                "length": 747
            },
            "evidence": [
                {
                    "id": "8107",
                    "url": "http://www.informatics.jax.org/homology/8107",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "importin-alpha family protein binding",
                        "id": "GO:0061676",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061676",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "26165940"
                    },
                    {
                        "name": "microtubule binding",
                        "id": "GO:0008017",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "protein kinase binding",
                        "id": "GO:0019901",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "18663142"
                    },
                    {
                        "name": "protein kinase activator activity",
                        "id": "GO:0030295",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030295",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 11,
                "go_terms": [
                    {
                        "name": "spindle pole",
                        "id": "GO:0000922",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "spindle",
                        "id": "GO:0005819",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "18663142"
                    },
                    {
                        "name": "microtubule cytoskeleton",
                        "id": "GO:0015630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intercellular bridge",
                        "id": "GO:0045171",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "axon hillock",
                        "id": "GO:0043203",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043203",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "19668197"
                    },
                    {
                        "name": "mitotic spindle",
                        "id": "GO:0072686",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "aster",
                        "id": "GO:0005818",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005818",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear microtubule",
                        "id": "GO:0005880",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005880",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 8,
                "go_terms": [
                    {
                        "name": "cell division",
                        "id": "GO:0051301",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitotic spindle assembly",
                        "id": "GO:0090307",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090307",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "26165940"
                    },
                    {
                        "name": "apoptotic process",
                        "id": "GO:0006915",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "activation of protein kinase activity",
                        "id": "GO:0032147",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032147",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule nucleation",
                        "id": "GO:0007020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of microtubule depolymerization",
                        "id": "GO:0007026",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007026",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of mitotic spindle organization",
                        "id": "GO:0060236",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060236",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": "18663142"
                    },
                    {
                        "name": "spindle assembly",
                        "id": "GO:0051225",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051225",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2APB8",
                                "url": "https://www.uniprot.org/uniprot/A2APB8"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 18,
            "end_pos": 20,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 310,
            "end_pos": 312,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 585,
            "end_pos": 587,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}