{ "uniprot_canonical_ac": "A2AP18-1", "uniprot_ac": "A2AP18", "uniprot_id": "PLCH2_MOUSE", "mass": { "chemical_mass": 164297.0, "monoisotopic_mass": 164297.0 }, "refseq": { "ac": "NP_780765", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" }, "gene_names": [ { "name": "Plch2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18" }, { "name": "A930027K05Rik; Plc-eta2; PLCeta2; Plcl4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831", "id": "NP_001106831" }, { "name": "Plch2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831", "id": "NP_001106831" }, { "name": "Plcl4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18" } ], "protein_names": [ { "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "id": "A2AP18" }, { "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765", "id": "NP_780765" }, { "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831", "id": "NP_001106831" }, { "name": "3.1.4.11", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "id": "A2AP18" }, { "name": "PLC-L4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "id": "A2AP18" }, { "name": "PLC-eta2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "id": "A2AP18" }, { "name": "Phosphoinositide phospholipase C-eta-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "id": "A2AP18" }, { "name": "Phosphoinositide phospholipase C-like 4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "id": "A2AP18" }, { "name": "Phospholipase C-eta-2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "id": "A2AP18" }, { "name": "Phospholipase C-like protein 4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "id": "A2AP18" }, { "name": "phospholipase C-like protein 4; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765", "id": "NP_780765" } ], "function": [ { "annotation": "Molecular cloning of PLC-eta1 and PLC-eta2.", "evidence": [ { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" }, { "database": "PubMed", "id": "15583837", "url": "https://glygen.org/publication/PubMed/15583837" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" } ] }, { "annotation": "PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain", "evidence": [ { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" }, { "database": "PubMed", "id": "15899900", "url": "https://glygen.org/publication/PubMed/15899900" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" } ] }, { "annotation": "PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina.", "evidence": [ { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" }, { "database": "PubMed", "id": "20060933", "url": "https://glygen.org/publication/PubMed/20060933" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" } ] }, { "annotation": "The molecular cloning and sequencing of phospholipase C eta2 are reported.", "evidence": [ { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" }, { "database": "PubMed", "id": "16107206", "url": "https://glygen.org/publication/PubMed/16107206" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" } ] }, { "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18#function" }, { "database": "PubMed", "id": "16107206", "url": "https://glygen.org/publication/PubMed/16107206" }, { "database": "PubMed", "id": "15899900", "url": "https://glygen.org/publication/PubMed/15899900" } ] }, { "annotation": "The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation", "evidence": [ { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" }, { "database": "PubMed", "id": "23237262", "url": "https://glygen.org/publication/PubMed/23237262" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 415, "end_pos": 415, "sequence_org": "H", "sequence_mut": "A", "comment": "Inhibition of activity.", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "PubMed", "id": "15899900", "url": "https://glygen.org/publication/PubMed/15899900" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Plch2", "url": "https://www.uniprot.org/uniprot/A2AP18", "locus": { "chromosome": "4", "start_pos": 155056784, "end_pos": 154983115, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000029055", "url": "https://www.ensembl.org/id/ENSMUSG00000029055" } ] } } ], "crossref": [ { "id": "ENSMUSG00000029055", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029055", "database": "Bgee" }, { "id": "3.1.4.11", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.11&UniProtAcc=A2AP18", "database": "BRENDA" }, { "id": "269615", "url": "https://www.ncbi.nlm.nih.gov/gene/269615", "database": "GeneID" }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro" }, { "id": "IPR000909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909", "database": "InterPro" }, { "id": "IPR001192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001192", "database": "InterPro" }, { "id": "IPR001711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001711", "database": "InterPro" }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro" }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro" }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro" }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro" }, { "id": "IPR015359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015359", "database": "InterPro" }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro" }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro" }, { "id": "IPR028393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028393", "database": "InterPro" }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro" }, { "id": "mmu:269615", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269615", "database": "KEGG Pathway" }, { "id": "2443078", "url": "http://www.informatics.jax.org/marker/MGI:2443078", "database": "MGI" }, { "id": "CVIGSKE", "url": "https://omabrowser.org/oma/group/CVIGSKE/", "database": "OMA" }, { "id": "368239at2759", "url": "http://www.orthodb.org/?query=368239at2759", "database": "OrthoDB" }, { "id": "PTHR10336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336", "database": "PANTHER" }, { "id": "PTHR10336:SF166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF166", "database": "PANTHER" }, { "id": "PF00168", "url": "http://pfam.xfam.org/family/PF00168", "database": "Pfam" }, { "id": "PF00387", "url": "http://pfam.xfam.org/family/PF00387", "database": "Pfam" }, { "id": "PF00388", "url": "http://pfam.xfam.org/family/PF00388", "database": "Pfam" }, { "id": "PF09279", "url": "http://pfam.xfam.org/family/PF09279", "database": "Pfam" }, { "id": "PF16457", "url": "http://pfam.xfam.org/family/PF16457", "database": "Pfam" }, { "id": "PR_A2AP18", "url": "http://purl.obolibrary.org/obo/PR_A2AP18", "database": "PRO" }, { "id": "R-MMU-1855204", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "database": "Reactome" }, { "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831", "database": "RefSeq" }, { "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765", "database": "RefSeq" }, { "id": "33179", "url": "https://www.rhea-db.org/rhea/33179", "database": "Rhea" }, { "id": "A0A087WSR3", "url": "https://www.uniprot.org/uniprot/A0A087WSR3", "database": "UniProtKB" }, { "id": "A0A087WSR3-1", "url": "https://www.uniprot.org/uniprot/A0A087WSR3-1", "database": "UniProtKB" }, { "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18", "database": "UniProtKB" }, { "id": "A2AP18-1", "url": "https://www.uniprot.org/uniprot/A2AP18-1", "database": "UniProtKB" }, { "id": "A2AP18-2", "url": "https://www.uniprot.org/uniprot/A2AP18-2", "database": "UniProtKB" }, { "id": "A2AP18-3", "url": "https://www.uniprot.org/uniprot/A2AP18-3", "database": "UniProtKB" }, { "id": "A2AP18-4", "url": "https://www.uniprot.org/uniprot/A2AP18-4", "database": "UniProtKB" }, { "id": "A2AP18-5", "url": "https://www.uniprot.org/uniprot/A2AP18-5", "database": "UniProtKB" }, { "id": "A6PWW4", "url": "https://www.uniprot.org/uniprot/A6PWW4", "database": "UniProtKB" }, { "id": "A6PWW4-1", "url": "https://www.uniprot.org/uniprot/A6PWW4-1", "database": "UniProtKB" }, { "id": "F6UKG4", "url": "https://www.uniprot.org/uniprot/F6UKG4", "database": "UniProtKB" }, { "id": "F6UKG4-1", "url": "https://www.uniprot.org/uniprot/F6UKG4-1", "database": "UniProtKB" }, { "id": "F7C3A0", "url": "https://www.uniprot.org/uniprot/F7C3A0", "database": "UniProtKB" }, { "id": "F7C3A0-1", "url": "https://www.uniprot.org/uniprot/F7C3A0-1", "database": "UniProtKB" }, { "id": "F7C512", "url": "https://www.uniprot.org/uniprot/F7C512", "database": "UniProtKB" }, { "id": "F7C512-1", "url": "https://www.uniprot.org/uniprot/F7C512-1", "database": "UniProtKB" }, { "id": "H3BIW6", "url": "https://www.uniprot.org/uniprot/H3BIW6", "database": "UniProtKB" }, { "id": "H3BIW6-1", "url": "https://www.uniprot.org/uniprot/H3BIW6-1", "database": "UniProtKB" }, { "id": "H3BK11", "url": "https://www.uniprot.org/uniprot/H3BK11", "database": "UniProtKB" }, { "id": "H3BK11-1", "url": "https://www.uniprot.org/uniprot/H3BK11-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL", "length": 1501, "header": "sp|A2AP18-1|PLCH2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1" }, "isoforms": [ { "isoform_ac": "A0A087WSR3-1", "url": "https://www.uniprot.org/uniprot/A2AP18#A0A087WSR3-1", "sequence": { "sequence": "MDSSIGPASLPEDPGPDLGSRWLFLSANVLPVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTGKACRSAASHALYTWHA", "length": 493, "header": "tr|A0A087WSR3-1|A0A087WSR3_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155139035, "end_pos": 155070622, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000186598", "url": "https://www.ensembl.org/id/ENSMUST00000186598" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000141152", "url": "https://www.ensembl.org/id/ENSMUSP00000141152" } ] } }, { "isoform_ac": "A2AP18-1", "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-1", "sequence": { "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL", "length": 1501, "header": "sp|A2AP18-1|PLCH2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155095441, "end_pos": 155068122, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000105631", "url": "https://www.ensembl.org/id/ENSMUST00000105631" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101256", "url": "https://www.ensembl.org/id/ENSMUSP00000101256" } ] } }, { "isoform_ac": "A2AP18-2", "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-2", "sequence": { "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLRREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD", "length": 1238, "header": "sp|A2AP18-2|PLCH2_MOUSE Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1" }, "locus": {} }, { "isoform_ac": "A2AP18-3", "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-3", "sequence": { "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTGKACRSAASHALYTWHA", "length": 1252, "header": "sp|A2AP18-3|PLCH2_MOUSE Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1" }, "locus": {} }, { "isoform_ac": "A2AP18-4", "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-4", "sequence": { "sequence": "MDAGAAPQKHMERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL", "length": 1396, "header": "sp|A2AP18-4|PLCH2_MOUSE Isoform 4 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155127453, "end_pos": 155068122, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000135665", "url": "https://www.ensembl.org/id/ENSMUST00000135665" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118292", "url": "https://www.ensembl.org/id/ENSMUSP00000118292" } ] } }, { "isoform_ac": "A2AP18-5", "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-5", "sequence": { "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDVSGSPGSACREPGVGPQHPRPILSTKGIYLPQRERGQGVRDKDRRWRVREKGKGTREGARGICPGGRGDKGLPLDREETDRQTWPIGKWWFTNVKK", "length": 599, "header": "sp|A2AP18-5|PLCH2_MOUSE Isoform 5 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155095441, "end_pos": 155082622, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000145662", "url": "https://www.ensembl.org/id/ENSMUST00000145662" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119864", "url": "https://www.ensembl.org/id/ENSMUSP00000119864" } ] } }, { "isoform_ac": "A6PWW4-1", "url": "https://www.uniprot.org/uniprot/A2AP18#A6PWW4-1", "sequence": { "sequence": "MPTLQEGSEVLFCRVRCSCPAATVPDFKSNPGDVWRRVERCMSAMQEGTQMVKLRGS", "length": 57, "header": "tr|A6PWW4-1|A6PWW4_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=8 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155103482, "end_pos": 155093536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000126098", "url": "https://www.ensembl.org/id/ENSMUST00000126098" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115440", "url": "https://www.ensembl.org/id/ENSMUSP00000115440" } ] } }, { "isoform_ac": "F6UKG4-1", "url": "https://www.uniprot.org/uniprot/A2AP18#F6UKG4-1", "sequence": { "sequence": "MDSSIGPASLPEDPGPDLGSRWLFLSANVLPVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNC", "length": 111, "header": "tr|F6UKG4-1|F6UKG4_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155139035, "end_pos": 155091530, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000131173", "url": "https://www.ensembl.org/id/ENSMUST00000131173" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118629", "url": "https://www.ensembl.org/id/ENSMUSP00000118629" } ] } }, { "isoform_ac": "F7C3A0-1", "url": "https://www.uniprot.org/uniprot/A2AP18#F7C3A0-1", "sequence": { "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD", "length": 1238, "header": "tr|F7C3A0-1|F7C3A0_MOUSE Computationally mapped isoform of Phosphoinositide phospholipase C OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155095441, "end_pos": 155069842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000139976", "url": "https://www.ensembl.org/id/ENSMUST00000139976" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122704", "url": "https://www.ensembl.org/id/ENSMUSP00000122704" } ] } }, { "isoform_ac": "F7C512-1", "url": "https://www.uniprot.org/uniprot/A2AP18#F7C512-1", "sequence": { "sequence": "XEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRVRD", "length": 199, "header": "tr|F7C512-1|F7C512_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155074248, "end_pos": 155069840, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000124517", "url": "https://www.ensembl.org/id/ENSMUST00000124517" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122139", "url": "https://www.ensembl.org/id/ENSMUSP00000122139" } ] } }, { "isoform_ac": "H3BIW6-1", "url": "https://www.uniprot.org/uniprot/A2AP18#H3BIW6-1", "sequence": { "sequence": "MEEPGPPGGLSQDQVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD", "length": 1137, "header": "tr|H3BIW6-1|H3BIW6_MOUSE Computationally mapped isoform of Phosphoinositide phospholipase C OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155103699, "end_pos": 155069842, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000176194", "url": "https://www.ensembl.org/id/ENSMUST00000176194" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134750", "url": "https://www.ensembl.org/id/ENSMUSP00000134750" } ] } }, { "isoform_ac": "H3BK11-1", "url": "https://www.uniprot.org/uniprot/A2AP18#H3BK11-1", "sequence": { "sequence": "XARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL", "length": 1250, "header": "tr|H3BK11-1|H3BK11_MOUSE Computationally mapped isoform of Phosphoinositide phospholipase C OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1" }, "locus": { "chromosome": "4", "start_pos": 155091464, "end_pos": 155068120, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000175982", "url": "https://www.ensembl.org/id/ENSMUST00000175982" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000135209", "url": "https://www.ensembl.org/id/ENSMUSP00000135209" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 561, "end_pos": 561, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "iPTMnet", "id": "A2AP18", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AP18" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 561, "end_pos": 561, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 565, "end_pos": 565, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "iPTMnet", "id": "A2AP18", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AP18" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 565, "end_pos": 565, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 676, "end_pos": 676, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "iPTMnet", "id": "A2AP18", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AP18" }, { "database": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 676, "end_pos": 676, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 686, "end_pos": 686, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "iPTMnet", "id": "A2AP18", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AP18" }, { "database": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 686, "end_pos": 686, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Phosphoproteomic analysis of the developing mouse brain.", "journal": "Molecular & cellular proteomics : MCP", "date": "2004", "authors": "Ballif BA, Villen J, Beausoleil SA, Schwartz D, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "UniProtKB", "id": "F7C3A0", "url": "https://www.uniprot.org/uniprot/F7C3A0" }, { "database": "UniProtKB", "id": "H3BK11", "url": "https://www.uniprot.org/uniprot/H3BK11" }, { "database": "UniProtKB", "id": "H3BIW6", "url": "https://www.uniprot.org/uniprot/H3BIW6" }, { "database": "iPTMnet", "id": "A2AP18", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AP18" } ], "reference": [ { "type": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" } ] }, { "title": "Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.", "journal": "International journal of molecular medicine", "date": "2005", "authors": "Stewart AJ, Mukherjee J, Roberts SJ, Lester D, Farquharson C", "evidence": [ { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" } ], "reference": [ { "type": "PubMed", "id": "15583837", "url": "https://glygen.org/publication/PubMed/15583837" } ] }, { "title": "A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Nakamura Y., Morita M., Fukami K., Nakahara M., Kudo Y., Irino Y., Shimozawa M.", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" } ], "reference": [ { "type": "PubMed", "id": "15899900", "url": "https://glygen.org/publication/PubMed/15899900" } ] }, { "title": "Molecular cloning and characterization of PLC-eta2.", "journal": "Biochem. J.", "date": "2005", "authors": "Zhou Y., Sondek J., Harden T.K., Wing M.R.", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" }, { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" } ], "reference": [ { "type": "PubMed", "id": "16107206", "url": "https://glygen.org/publication/PubMed/16107206" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Mol. Cell. Proteomics", "date": "2007", "authors": "Gehrig P., Gerrits B., Mansuy I.M., Longo D., Schlapbach R., Livingstone-Zatchej M., Munton R.P., Panse C., Potthast F., Rutishauser D., Tweedie-Cullen R., Waidelich M., Weinandy F.", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "UniProtKB", "id": "F7C3A0", "url": "https://www.uniprot.org/uniprot/F7C3A0" }, { "database": "UniProtKB", "id": "H3BK11", "url": "https://www.uniprot.org/uniprot/H3BK11" }, { "database": "UniProtKB", "id": "H3BIW6", "url": "https://www.uniprot.org/uniprot/H3BIW6" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Phospholipase C-eta2 is highly expressed in the habenula and retina.", "journal": "Gene expression patterns : GEP", "date": "2010", "authors": "Kanemaru K, Nakahara M, Nakamura Y, Hashiguchi Y, Kouchi Z, Yamaguchi H, Oshima N, Kiyonari H, Fukami K", "evidence": [ { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" }, { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" } ], "reference": [ { "type": "PubMed", "id": "20060933", "url": "https://glygen.org/publication/PubMed/20060933" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" }, { "database": "iPTMnet", "id": "A2AP18", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AP18" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Phospholipase C-eta2 is required for retinoic acid-stimulated neurite growth.", "journal": "Journal of neurochemistry", "date": "2013", "authors": "Popovics P, Gray A, Arastoo M, Finelli DK, Tan AJ, Stewart AJ", "evidence": [ { "database": "RefSeq", "id": "NP_780765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765" }, { "database": "RefSeq", "id": "NP_001106831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831" } ], "reference": [ { "type": "PubMed", "id": "23237262", "url": "https://glygen.org/publication/PubMed/23237262" } ] } ], "pathway": [ { "id": "mmu:269615", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269615", "resource": "KEGG Pathway" }, { "id": "R-MMU-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "resource": "Reactome", "description": "Synthesis of IP3 and IP4 in the cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "O75038-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2", "gene_name": "PLCH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL", "length": 1416 }, "evidence": [ { "id": "85172", "url": "http://www.informatics.jax.org/homology/85172", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "phosphatidylinositol phospholipase C activity", "id": "GO:0004435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "" }, { "name": "phospholipase C activity", "id": "GO:0004629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004629", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "15899900" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "15899900" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "" }, { "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "" }, { "name": "phosphatidylinositol metabolic process", "id": "GO:0046488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "15899900" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A2AP18", "url": "https://www.uniprot.org/uniprot/A2AP18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1237, "end_pos": 1239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 381, "end_pos": 383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33179", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10687-1", "A0A096MJW8-1", "D4AAX6-1", "P24135-1", "O89040-1", "Q62688-1", "Q9QW07-1", "Q62711-1", "D4A978-1", "F1M324-1", "Q99JE6-1", "P10686-1", "P10688-1", "Q99P84-1", "Q5FX52-1", "Q8WTR4-1", "Q8N3E9-1", "O75038-1", "P19174-1", "Q86YW0-1", "Q9NQ66-1", "P16885-1", "Q9UPR0-1", "Q9BRC7-1", "Q15111-1", "Q4KWH8-1", "Q9P212-1", "Q01970-1", "P51178-1", "Q15147-1", "Q00722-1", "Q91UZ1-1", "Q8K2J0-1", "P51432-1", "Q8K4D7-1", "Q4KWH5-1", "A2AP18-1", "Q62077-1", "Q640M6-1", "Q8K4S1-1", "A3KGF7-1", "Q8R3B1-1", "Q9Z1B3-1", "Q8K3R3-1", "Q8CIH5-1", "P13217-1", "P25455-3", "Q9VXH3-1" ], "evidence": [ { "id": "33179", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33179" } ] }, { "id": "R-MMU-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2AP18-1", "Q8K4S1-1", "Q8R3B1-1", "Q62077-1", "Q8CIH5-1", "Q4KWH5-1", "Q8K2J0-1" ], "evidence": [ { "id": "R-MMU-1855221", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855221" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJW8", "gene_name": "Plch1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "A0A096MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJW8" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A096MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJW8" } ] } ] }, { "uniprot_ac": "A2AP18", "gene_name": "Plch2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "A2AP18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AP18" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A2AP18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AP18" } ] } ] }, { "uniprot_ac": "A3KGF7", "gene_name": "Plcb2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "A3KGF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A3KGF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KGF7" } ] } ] }, { "uniprot_ac": "D4A978", "gene_name": "Plcd3", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "D4A978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A978" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "D4A978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A978" } ] } ] }, { "uniprot_ac": "D4AAX6", "gene_name": "Plch2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "D4AAX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAX6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "D4AAX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAX6" } ] } ] }, { "uniprot_ac": "F1M324", "gene_name": "Plcl2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "F1M324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M324" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "F1M324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M324" } ] } ] }, { "uniprot_ac": "O75038", "gene_name": "PLCH2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "O75038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75038" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "O75038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75038" } ] } ] }, { "uniprot_ac": "O89040", "gene_name": "Plcb2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "O89040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89040" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "O89040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89040" } ] } ] }, { "uniprot_ac": "P10686", "gene_name": "Plcg1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P10686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10686" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10686" } ] } ] }, { "uniprot_ac": "P10687", "gene_name": "Plcb1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P10687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10687" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10687" } ] } ] }, { "uniprot_ac": "P10688", "gene_name": "Plcd1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P10688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10688" } ] } ] }, { "uniprot_ac": "P13217", "gene_name": "norpA", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P13217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13217" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P13217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13217" } ] } ] }, { "uniprot_ac": "P16885", "gene_name": "PLCG2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P16885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16885" } ] } ] }, { "uniprot_ac": "P19174", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P19174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19174" } ] } ] }, { "uniprot_ac": "P24135", "gene_name": "Plcg2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P24135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24135" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P24135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24135" } ] } ] }, { "uniprot_ac": "P25455", "gene_name": "Plc21C", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P25455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25455" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P25455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25455" } ] } ] }, { "uniprot_ac": "P51178", "gene_name": "PLCD1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P51178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51178" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P51178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51178" } ] } ] }, { "uniprot_ac": "P51432", "gene_name": "Plcb3", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "P51432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51432" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "P51432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51432" } ] } ] }, { "uniprot_ac": "Q00722", "gene_name": "PLCB2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q00722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00722" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q00722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00722" } ] } ] }, { "uniprot_ac": "Q01970", "gene_name": "PLCB3", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q01970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01970" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q01970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01970" } ] } ] }, { "uniprot_ac": "Q15111", "gene_name": "PLCL1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q15111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15111" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q15111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15111" } ] } ] }, { "uniprot_ac": "Q15147", "gene_name": "PLCB4", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q15147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15147" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q15147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15147" } ] } ] }, { "uniprot_ac": "Q4KWH5", "gene_name": "Plch1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q4KWH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q4KWH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH5" } ] } ] }, { "uniprot_ac": "Q4KWH8", "gene_name": "PLCH1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q4KWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH8" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q4KWH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KWH8" } ] } ] }, { "uniprot_ac": "Q5FX52", "gene_name": "Plcz1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q5FX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FX52" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q5FX52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FX52" } ] } ] }, { "uniprot_ac": "Q62077", "gene_name": "Plcg1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q62077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62077" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62077" } ] } ] }, { "uniprot_ac": "Q62688", "gene_name": "Plcl1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q62688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62688" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62688" } ] } ] }, { "uniprot_ac": "Q62711", "gene_name": "Plcd4", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q62711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62711" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q62711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62711" } ] } ] }, { "uniprot_ac": "Q640M6", "gene_name": "Gdpd5", "activity": [ { "ec_number": "3.1.4.2", "activity": "sn-glycero-3-phosphocholine + H(2)O = choline + sn-glycerol 3-phosphate.", "evidence": [ { "id": "Q640M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q640M6" } ] }, { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q640M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q640M6" } ] } ] }, { "uniprot_ac": "Q86YW0", "gene_name": "PLCZ1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q86YW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86YW0" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q86YW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86YW0" } ] } ] }, { "uniprot_ac": "Q8CIH5", "gene_name": "Plcg2", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q8CIH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIH5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q8CIH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIH5" } ] } ] }, { "uniprot_ac": "Q8K2J0", "gene_name": "Plcd3", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q8K2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2J0" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q8K2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2J0" } ] } ] }, { "uniprot_ac": "Q8K3R3", "gene_name": "Plcd4", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q8K3R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K3R3" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q8K3R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K3R3" } ] } ] }, { "uniprot_ac": "Q8K4D7", "gene_name": "Plcz1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q8K4D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4D7" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q8K4D7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4D7" } ] } ] }, { "uniprot_ac": "Q8K4S1", "gene_name": "Plce1", "activity": [ { "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.", "evidence": [ { "id": "Q8K4S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4S1" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "Q8K4S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4S1" } ] } ] }, { "uniprot_ac": "Q8N3E9", "gene_name": "PLCD3", "activity": [ { "ec_number": "3.1.4.11", "activity": 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