{
    "uniprot_canonical_ac": "A2AMW3-1",
    "uniprot_ac": "A2AMW3",
    "uniprot_id": "A2AMW3_MOUSE",
    "mass": {
        "chemical_mass": 104508.0,
        "monoisotopic_mass": 104508.0
    },
    "refseq": {
        "ac": "NP_059065",
        "name": "gamma-aminobutyric acid receptor subunit epsilon precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059065"
    },
    "gene_names": [
        {
            "name": "Gabre",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AMW3",
            "id": "A2AMW3"
        },
        {
            "name": "Gabre",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059065",
            "id": "NP_059065"
        }
    ],
    "protein_names": [
        {
            "name": "Gamma-aminobutyric acid (GABA) A receptor, subunit epsilon",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AMW3#names_and_taxonomy",
            "id": "A2AMW3"
        },
        {
            "name": "gamma-aminobutyric acid receptor subunit epsilon precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059065",
            "id": "NP_059065"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMW3",
                    "url": "https://www.uniprot.org/uniprot/A2AMW3"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Gabre",
            "url": "https://www.uniprot.org/uniprot/A2AMW3",
            "locus": {
                "chromosome": "X",
                "start_pos": 72274803,
                "end_pos": 72255999,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000031340",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000031340"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000031340",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031340",
            "database": "Bgee"
        },
        {
            "id": "CHEMBL2094133",
            "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2094133",
            "database": "ChEMBL"
        },
        {
            "id": "14404",
            "url": "https://www.ncbi.nlm.nih.gov/gene/14404",
            "database": "GeneID"
        },
        {
            "id": "IPR006028",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006028",
            "database": "InterPro"
        },
        {
            "id": "IPR006029",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006029",
            "database": "InterPro"
        },
        {
            "id": "IPR006201",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006201",
            "database": "InterPro"
        },
        {
            "id": "IPR006202",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006202",
            "database": "InterPro"
        },
        {
            "id": "IPR008099",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008099",
            "database": "InterPro"
        },
        {
            "id": "IPR018000",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018000",
            "database": "InterPro"
        },
        {
            "id": "IPR036719",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036719",
            "database": "InterPro"
        },
        {
            "id": "IPR036734",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036734",
            "database": "InterPro"
        },
        {
            "id": "mmu:14404",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14404",
            "database": "KEGG Pathway"
        },
        {
            "id": "1330235",
            "url": "http://www.informatics.jax.org/marker/MGI:1330235",
            "database": "MGI"
        },
        {
            "id": "QWRVGPH",
            "url": "https://omabrowser.org/oma/group/QWRVGPH/",
            "database": "OMA"
        },
        {
            "id": "1057372at2759",
            "url": "http://www.orthodb.org/?query=1057372at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR18945",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945",
            "database": "PANTHER"
        },
        {
            "id": "PF02931",
            "url": "http://pfam.xfam.org/family/PF02931",
            "database": "Pfam"
        },
        {
            "id": "PF02932",
            "url": "http://pfam.xfam.org/family/PF02932",
            "database": "Pfam"
        },
        {
            "id": "NP_059065",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059065",
            "database": "RefSeq"
        },
        {
            "id": "A2AMW3",
            "url": "https://www.uniprot.org/uniprot/A2AMW3",
            "database": "UniProtKB"
        },
        {
            "id": "A2AMW3-1",
            "url": "https://www.uniprot.org/uniprot/A2AMW3-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MLPKVLLMLLNMFLALQWRVGPHVNLENKPPAQDKVVFGPQPQPVPQPLTPPESPAGDTVVFGPQPQPQAESPGHDDVVFSSQPQPMPQPQPMPEPQPQPEPEPEPQPQPQPQPLAGRQPLPQPLPWPMPQPQPEPEPEPEPEPEPEPEPEPEPEPEPEPQPEPQPQPLAGRQPLPQPLPWPLPLPLPEPQPEPQPDPQPEPQPEPQPEPQPEPQPEPQTPGQVQAGRQPRPRPQPEPQPQPEPQPEPQPEPQPQPEPEPEPQPEPEPQPEPEPQPEPQPEPQPEPKPEPEPQPEPEPQPEPQPEPQPEPQPEPKPEPEPQPEPKPEPEPQPEPEPEPEPEPEPQPEPEPKPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPESESELDLEPEPEPHPHPHPHPHPHPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEMKSEPQSQLEPQPSGKKLPAKEPELTVDCMTERPGGKLTRASRILNTILSNYDHKLRPGIGEKPTVVTVEVIVNSLGPISTPDMEYSIDIIFHQTWYDERLRYNDTFETLILHGNVVSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKVLYSVRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYDDSEMIYKWENFKLEINAKNTWKLLEFDFTGVNNKTEIISTPFGDFMVMTFFFNVSRRFGFIVFQNYVPSSVTTMLSWVSFWIKIEAAAARASVGVSSVLTMATLGTLSCKNFPRVSYLTALDFYIAICFVLCFCTLLEFAVLNFLTYNNIKRQASLKVYQLPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSPRSRRPQCPWRRCGRSYVCFRVLRKYFCMAPGCEGGSWQRGRICIHVYRLDNYSRVLFPITFFFFNVLYWLICLNL",
        "length": 916,
        "header": "tr|A2AMW3-1|A2AMW3_MOUSE Isoform 1 of Gamma-aminobutyric acid (GABA) A receptor, subunit epsilon  OS=Mus musculus OX=10090 GN=Gabre PE=3 SV=1 CANONICAL=A2AMW3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AMW3-1",
            "url": "https://www.uniprot.org/uniprot/A2AMW3#A2AMW3-1",
            "sequence": {
                "sequence": "MLPKVLLMLLNMFLALQWRVGPHVNLENKPPAQDKVVFGPQPQPVPQPLTPPESPAGDTVVFGPQPQPQAESPGHDDVVFSSQPQPMPQPQPMPEPQPQPEPEPEPQPQPQPQPLAGRQPLPQPLPWPMPQPQPEPEPEPEPEPEPEPEPEPEPEPEPEPQPEPQPQPLAGRQPLPQPLPWPLPLPLPEPQPEPQPDPQPEPQPEPQPEPQPEPQPEPQTPGQVQAGRQPRPRPQPEPQPQPEPQPEPQPEPQPQPEPEPEPQPEPEPQPEPEPQPEPQPEPQPEPKPEPEPQPEPEPQPEPQPEPQPEPQPEPKPEPEPQPEPKPEPEPQPEPEPEPEPEPEPQPEPEPKPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPESESELDLEPEPEPHPHPHPHPHPHPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEMKSEPQSQLEPQPSGKKLPAKEPELTVDCMTERPGGKLTRASRILNTILSNYDHKLRPGIGEKPTVVTVEVIVNSLGPISTPDMEYSIDIIFHQTWYDERLRYNDTFETLILHGNVVSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKVLYSVRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYDDSEMIYKWENFKLEINAKNTWKLLEFDFTGVNNKTEIISTPFGDFMVMTFFFNVSRRFGFIVFQNYVPSSVTTMLSWVSFWIKIEAAAARASVGVSSVLTMATLGTLSCKNFPRVSYLTALDFYIAICFVLCFCTLLEFAVLNFLTYNNIKRQASLKVYQLPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSPRSRRPQCPWRRCGRSYVCFRVLRKYFCMAPGCEGGSWQRGRICIHVYRLDNYSRVLFPITFFFFNVLYWLICLNL",
                "length": 916,
                "header": "tr|A2AMW3-1|A2AMW3_MOUSE Isoform 1 of Gamma-aminobutyric acid (GABA) A receptor, subunit epsilon  OS=Mus musculus OX=10090 GN=Gabre PE=3 SV=1 CANONICAL=A2AMW3-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 71318307,
                "end_pos": 71301061,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000064780",
                        "url": "https://www.ensembl.org/id/ENSMUST00000064780"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000066543",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000066543"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:14404",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14404",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 8,
                "go_terms": [
                    {
                        "name": "integral component of plasma membrane",
                        "id": "GO:0005887",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "10804200"
                    },
                    {
                        "name": "synapse",
                        "id": "GO:0045202",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "postsynaptic membrane",
                        "id": "GO:0045211",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "postsynapse",
                        "id": "GO:0098794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "neuron projection",
                        "id": "GO:0043005",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "chloride channel complex",
                        "id": "GO:0034707",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034707",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite membrane",
                        "id": "GO:0032590",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032590",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "GABA-A receptor complex",
                        "id": "GO:1902711",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902711",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 10,
                "go_terms": [
                    {
                        "name": "signal transduction",
                        "id": "GO:0007165",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "regulation of membrane potential",
                        "id": "GO:0042391",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "gamma-aminobutyric acid signaling pathway",
                        "id": "GO:0007214",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007214",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "10804200"
                    },
                    {
                        "name": "chemical synaptic transmission",
                        "id": "GO:0007268",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "ion transmembrane transport",
                        "id": "GO:0034220",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034220",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "nervous system process",
                        "id": "GO:0050877",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050877",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "chloride transport",
                        "id": "GO:0006821",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006821",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "10804200"
                    },
                    {
                        "name": "chloride transmembrane transport",
                        "id": "GO:1902476",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "synaptic transmission, GABAergic",
                        "id": "GO:0051932",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051932",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "regulation of postsynaptic membrane potential",
                        "id": "GO:0060078",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060078",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "neurotransmitter receptor activity",
                        "id": "GO:0030594",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030594",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "GABA-A receptor activity",
                        "id": "GO:0004890",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004890",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "10804200"
                    },
                    {
                        "name": "inhibitory extracellular ligand-gated ion channel activity",
                        "id": "GO:0005237",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005237",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "GABA-gated chloride ion channel activity",
                        "id": "GO:0022851",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022851",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential",
                        "id": "GO:1904315",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904315",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMW3",
                                "url": "https://www.uniprot.org/uniprot/A2AMW3"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 545,
            "end_pos": 547,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 663,
            "end_pos": 665,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 683,
            "end_pos": 685,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 892,
            "end_pos": 894,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": []
}