{
    "uniprot_canonical_ac": "A2AMM0-1",
    "uniprot_ac": "A2AMM0",
    "uniprot_id": "CAVN4_MOUSE",
    "mass": {
        "chemical_mass": 41008.0,
        "monoisotopic_mass": 41008.0
    },
    "refseq": {
        "ac": "NP_080785",
        "name": "caveolae-associated protein 4",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
    },
    "gene_names": [
        {
            "name": "Cavin4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AMM0",
            "id": "A2AMM0"
        },
        {
            "name": "2310039E09Rik; Murc",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "id": "NP_080785"
        },
        {
            "name": "Cavin4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "id": "NP_080785"
        },
        {
            "name": "Murc",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AMM0",
            "id": "A2AMM0"
        }
    ],
    "protein_names": [
        {
            "name": "Caveolae-associated protein 4",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AMM0#names_and_taxonomy",
            "id": "A2AMM0"
        },
        {
            "name": "Muscle-related coiled-coil protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AMM0#names_and_taxonomy",
            "id": "A2AMM0"
        },
        {
            "name": "Muscle-restricted coiled-coil protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AMM0#names_and_taxonomy",
            "id": "A2AMM0"
        },
        {
            "name": "caveolae-associated protein 4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "id": "NP_080785"
        },
        {
            "name": "muscle-restricted coiled-coil protein; cavin 4; muscle-related coiled-coil protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "id": "NP_080785"
        }
    ],
    "function": [
        {
            "annotation": "Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                },
                {
                    "database": "PubMed",
                    "id": "34633413",
                    "url": "https://glygen.org/publication/PubMed/34633413"
                }
            ]
        },
        {
            "annotation": "Data show that MURC/Cavin-4 forms a multiprotein complex that associates with caveolae, and identify Cavin-4 as a novel muscle disease candidate caveolar protein.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                },
                {
                    "database": "PubMed",
                    "id": "19546242",
                    "url": "https://glygen.org/publication/PubMed/19546242"
                }
            ]
        },
        {
            "annotation": "Findings suggest that MURC is involved in the skeletal myogenesis that results from modulation of myogenin expression and ERK activation; MURC may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                },
                {
                    "database": "PubMed",
                    "id": "18508909",
                    "url": "https://glygen.org/publication/PubMed/18508909"
                }
            ]
        },
        {
            "annotation": "MURC binds to Cav1 and inhibits the association of Cav1 with the active form of Galpha13, resulting in the facilitated association of the active form of Galpha13 with p115RhoGEF. These results reveal that MURC has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                },
                {
                    "database": "PubMed",
                    "id": "27546070",
                    "url": "https://glygen.org/publication/PubMed/27546070"
                }
            ]
        },
        {
            "annotation": "MURC modulates RhoA signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                },
                {
                    "database": "PubMed",
                    "id": "18332105",
                    "url": "https://glygen.org/publication/PubMed/18332105"
                }
            ]
        },
        {
            "annotation": "MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                },
                {
                    "database": "PubMed",
                    "id": "24567387",
                    "url": "https://glygen.org/publication/PubMed/24567387"
                }
            ]
        },
        {
            "annotation": "Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation (PubMed:24567387). Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (PubMed:26497963). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0#function"
                },
                {
                    "database": "PubMed",
                    "id": "18332105",
                    "url": "https://glygen.org/publication/PubMed/18332105"
                },
                {
                    "database": "PubMed",
                    "id": "26497963",
                    "url": "https://glygen.org/publication/PubMed/26497963"
                },
                {
                    "database": "PubMed",
                    "id": "24567387",
                    "url": "https://glygen.org/publication/PubMed/24567387"
                }
            ]
        },
        {
            "annotation": "Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin-4 Deletion Against Ischemia/Reperfusion Injury.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                },
                {
                    "database": "PubMed",
                    "id": "31364493",
                    "url": "https://glygen.org/publication/PubMed/31364493"
                }
            ]
        },
        {
            "annotation": "The MURC/Cavin-4 in vascular smooth muscle cells modulates abdominal aortic aneurysm (AAA) progression at the early stage via the activation of JNK and MMP-9. MURC/Cavin-4 is a potential therapeutic target against AAA progression.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                },
                {
                    "database": "PubMed",
                    "id": "28433630",
                    "url": "https://glygen.org/publication/PubMed/28433630"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:9884",
            "recommended_name": {
                "id": "DOID:9884",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9884",
                "name": "muscular dystrophy",
                "description": "A myopathy is characterized by progressive skeletal muscle weakness degeneration."
            },
            "synonyms": [
                {
                    "id": "MONDO:0010884",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010884",
                    "name": "muscular dystrophy, scapulohumeral",
                    "description": ""
                },
                {
                    "id": "MONDO:0010884",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010884",
                    "name": "muscular dystrophy, scapulohumeral",
                    "description": ""
                },
                {
                    "id": "MONDO:0010676",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010676",
                    "name": "muscular dystrophy, Hemizygous lethal type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010676",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010676",
                    "name": "muscular dystrophy, Hemizygous lethal type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010675",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010675",
                    "name": "muscular dystrophy, cardiac type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010675",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010675",
                    "name": "muscular dystrophy, cardiac type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010678",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010678",
                    "name": "muscular dystrophy, progressive Pectorodorsal",
                    "description": ""
                },
                {
                    "id": "MONDO:0010678",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010678",
                    "name": "muscular dystrophy, progressive Pectorodorsal",
                    "description": ""
                },
                {
                    "id": "MONDO:0010678",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010678",
                    "name": "muscular dystrophy, progressive, involving shoulder girdle and back",
                    "description": ""
                },
                {
                    "id": "MONDO:0010677",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010677",
                    "name": "muscular dystrophy, Mabry type",
                    "description": ""
                },
                {
                    "id": "MONDO:0010677",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010677",
                    "name": "muscular dystrophy, Mabry type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008028",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008028",
                    "name": "muscular dystrophy, Barnes type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008028",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008028",
                    "name": "muscular dystrophy, Barnes type",
                    "description": ""
                },
                {
                    "id": "MONDO:0008034",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008034",
                    "name": "muscular dystrophy, pseudohypertrophic, with Internalized capillaries",
                    "description": ""
                },
                {
                    "id": "MONDO:0008034",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008034",
                    "name": "muscular dystrophy, pseudohypertrophic, with Internalized capillaries",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "9884",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9884"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Cavin4",
            "url": "https://www.uniprot.org/uniprot/A2AMM0",
            "locus": {
                "chromosome": "4",
                "start_pos": 48663514,
                "end_pos": 48673502,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000028348",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000028348"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000028348",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028348",
            "database": "Bgee"
        },
        {
            "id": "68016",
            "url": "https://www.ncbi.nlm.nih.gov/gene/68016",
            "database": "GeneID"
        },
        {
            "id": "A2AMM0",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AMM0*",
            "database": "IntAct"
        },
        {
            "id": "IPR026752",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026752",
            "database": "InterPro"
        },
        {
            "id": "IPR033299",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033299",
            "database": "InterPro"
        },
        {
            "id": "mmu:68016",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68016",
            "database": "KEGG Pathway"
        },
        {
            "id": "1915266",
            "url": "http://www.informatics.jax.org/marker/MGI:1915266",
            "database": "MGI"
        },
        {
            "id": "GQEGIQE",
            "url": "https://omabrowser.org/oma/group/GQEGIQE/",
            "database": "OMA"
        },
        {
            "id": "991901at2759",
            "url": "http://www.orthodb.org/?query=991901at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR15240",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15240",
            "database": "PANTHER"
        },
        {
            "id": "PTHR15240:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15240:SF4",
            "database": "PANTHER"
        },
        {
            "id": "PF15237",
            "url": "http://pfam.xfam.org/family/PF15237",
            "database": "Pfam"
        },
        {
            "id": "PR_A2AMM0",
            "url": "http://purl.obolibrary.org/obo/PR_A2AMM0",
            "database": "PRO"
        },
        {
            "id": "NP_080785",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785",
            "database": "RefSeq"
        },
        {
            "id": "A2AMM0",
            "url": "https://www.uniprot.org/uniprot/A2AMM0",
            "database": "UniProtKB"
        },
        {
            "id": "A2AMM0-1",
            "url": "https://www.uniprot.org/uniprot/A2AMM0-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVASVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDIPCPASLSVVKDRSLPENQEEAEEVFDPPIELSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSRENMQKTRQTLDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISSAAPSKEAFKIRSLRKAKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDEFSETEKEVTKGGYSPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS",
        "length": 362,
        "header": "sp|A2AMM0-1|CAVN4_MOUSE Isoform 1 of Caveolae-associated protein 4  OS=Mus musculus OX=10090 GN=Cavin4 PE=1 SV=1 CANONICAL=A2AMM0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AMM0-1",
            "url": "https://www.uniprot.org/uniprot/A2AMM0#A2AMM0-1",
            "sequence": {
                "sequence": "MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVASVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDIPCPASLSVVKDRSLPENQEEAEEVFDPPIELSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSRENMQKTRQTLDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISSAAPSKEAFKIRSLRKAKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDEFSETEKEVTKGGYSPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS",
                "length": 362,
                "header": "sp|A2AMM0-1|CAVN4_MOUSE Isoform 1 of Caveolae-associated protein 4  OS=Mus musculus OX=10090 GN=Cavin4 PE=1 SV=1 CANONICAL=A2AMM0-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 48672642,
                "end_pos": 48663622,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000030033",
                        "url": "https://www.ensembl.org/id/ENSMUST00000030033"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000030033",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000030033"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 152,
            "end_pos": 152,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ]
        },
        {
            "start_pos": 171,
            "end_pos": 171,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ]
        },
        {
            "start_pos": 172,
            "end_pos": 172,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ]
        },
        {
            "start_pos": 324,
            "end_pos": 324,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AMM0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 324,
            "end_pos": 324,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 334,
            "end_pos": 334,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AMM0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 334,
            "end_pos": 334,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 353,
            "end_pos": 353,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AMM0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AMM0"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 353,
            "end_pos": 353,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
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                {
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                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
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                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.",
            "journal": "Mol. Cell. Biol.",
            "date": "2008",
            "authors": "Takahashi T., Ogata T., Oh H., Ueyama T., Harada K., Kawashima T., Isodono K., Matsubara H., Shioi T., Tagawa M., Takehara N.",
            "evidence": [
                {
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                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
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                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18332105",
                    "url": "https://glygen.org/publication/PubMed/18332105"
                }
            ]
        },
        {
            "title": "MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis.",
            "journal": "American journal of physiology. Cell physiology",
            "date": "2008",
            "authors": "Tagawa M, Ueyama T, Ogata T, Takehara N, Nakajima N, Isodono K, Asada S, Takahashi T, Matsubara H, Oh H",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18508909",
                    "url": "https://glygen.org/publication/PubMed/18508909"
                }
            ]
        },
        {
            "title": "MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes.",
            "journal": "J. Cell Biol.",
            "date": "2009",
            "authors": "Gygi S.P., Liu L., North K.N., Parton R.G., Hill M.M., Abankwa D., Bastiani M., Hancock J.F., Luetterforst R., Nixon S.J., Pilch P.F., Jedrychowski M.P., Breen M.R., Fernandez-Rojo M., Lo H.P., Vinten J., Walser P.J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
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                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19546242",
                    "url": "https://glygen.org/publication/PubMed/19546242"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AMM0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AMM0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "title": "MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2014",
            "authors": "Yamada H., Taniguchi T., Hamaoka T., Hayashi Y.K., Ikeda K., Maruyama N., Matoba S., Miyagawa K., Naito D., Nakanishi N., Ogata T., Oh H., Ueyama T.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24567387",
                    "url": "https://glygen.org/publication/PubMed/24567387"
                }
            ]
        },
        {
            "title": "The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes.",
            "journal": "Am. J. Physiol.",
            "date": "2015",
            "authors": "Taniguchi T., Hamaoka T., Maruyama N., Matoba S., Miyagawa K., Naito D., Nakanishi N., Ogata T., Ueyama T., Nishi M., Kasahara T.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AMM0",
                    "url": "https://www.uniprot.org/uniprot/A2AMM0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26497963",
                    "url": "https://glygen.org/publication/PubMed/26497963"
                }
            ]
        },
        {
            "title": "MURC deficiency in smooth muscle attenuates pulmonary hypertension.",
            "journal": "Nature communications",
            "date": "2016",
            "authors": "Nakanishi N, Ogata T, Naito D, Miyagawa K, Taniguchi T, Hamaoka T, Maruyama N, Kasahara T, Nishi M, Matoba S, Ueyama T",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27546070",
                    "url": "https://glygen.org/publication/PubMed/27546070"
                }
            ]
        },
        {
            "title": "Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm.",
            "journal": "Biochemical and biophysical research communications",
            "date": "2017",
            "authors": "Miyagawa K, Ogata T, Ueyama T, Kasahara T, Nakanishi N, Naito D, Taniguchi T, Hamaoka T, Maruyama N, Nishi M, Kimura T, Yamada H, Aoki H, Matoba S",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28433630",
                    "url": "https://glygen.org/publication/PubMed/28433630"
                }
            ]
        },
        {
            "title": "Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin-4 Deletion Against Ischemia/Reperfusion Injury.",
            "journal": "Journal of the American Heart Association",
            "date": "2019",
            "authors": "Nishi M, Ogata T, Cannistraci CV, Ciucci S, Nakanishi N, Higuchi Y, Sakamoto A, Tsuji Y, Mizushima K, Matoba S",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "31364493",
                    "url": "https://glygen.org/publication/PubMed/31364493"
                }
            ]
        },
        {
            "title": "Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle.",
            "journal": "The Journal of cell biology",
            "date": "2021",
            "authors": "Lo HP, Lim YW, Xiong Z, Martel N, Ferguson C, Ariotti N, Giacomotto J, Rae J, Floetenmeyer M, Moradi SV, Gao Y, Tillu VA, Xia D, Wang H, Rahnama S, Nixon SJ, Bastiani M, Day RD, Smith KA, Palpant NJ, Johnston WA, Alexandrov K, Collins BM, Hall TE, Parton RG",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080785",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080785"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "34633413",
                    "url": "https://glygen.org/publication/PubMed/34633413"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:68016",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68016",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "B1PRL5-1",
            "protein_name": "Caveolae-associated protein 4",
            "gene_name": "Cavin4",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVATVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDVPCPASLSVVKDRSLPENEEEAEEVFDPPIDLSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSKENMQKTRQNFDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNATPSKEAFKIRSLRKPKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDGFSETEKEVTKVGYIPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS",
                "length": 362
            },
            "evidence": [
                {
                    "id": "12224",
                    "url": "http://www.informatics.jax.org/homology/12224",
                    "database": "MGI"
                },
                {
                    "id": "A2AMM0",
                    "url": "https://omabrowser.org/oma/group/A2AMM0/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q5BKX8-1",
            "protein_name": "Caveolae-associated protein 4",
            "gene_name": "CAVIN4",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEHNGSASNADKIHQNRLSSVTEDEDQDAALTIVTVLDKVASIVDSVQASQKRIEERHREMENAIKSVQIDLLKLSQSHSNTGHIINKLFEKTRKVSAHIKDVKARVEKQQIHVKKVEVKQEEIMKKNKFRVVIFQEKFRCPTSLSVVKDRNLTENQEEDDDDIFDPPVDLSSDEEYYVEESRSARLRKSGKEHIDNIKKAFSKENMQKTRQNLDKKVNRIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNAAPSKEAFKMRSLRKGKDRTVAEGEECAREMGVDIIARSESLGPISELYSDELSEPEHEAARPVYPPHEGREIPTPEPLKVTFKSQVKVEDDESLLLDLKHSS",
                "length": 364
            },
            "evidence": [
                {
                    "id": "12224",
                    "url": "http://www.informatics.jax.org/homology/12224",
                    "database": "MGI"
                },
                {
                    "id": "A2AMM0",
                    "url": "https://omabrowser.org/oma/group/A2AMM0/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "GTPase activator activity",
                        "id": "GO:0005096",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
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                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
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                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "26497963"
                    },
                    {
                        "name": "caveola",
                        "id": "GO:0005901",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005901",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "24567387"
                    },
                    {
                        "name": "sarcolemma",
                        "id": "GO:0042383",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Z disc",
                        "id": "GO:0030018",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    },
                    {
                        "name": "Rho protein signal transduction",
                        "id": "GO:0007266",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007266",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    },
                    {
                        "name": "muscle organ development",
                        "id": "GO:0007517",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of Rho protein signal transduction",
                        "id": "GO:0035023",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cardiac myofibril assembly",
                        "id": "GO:0055003",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055003",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": "18332105"
                    },
                    {
                        "name": "regulation of gene expression",
                        "id": "GO:0010468",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AMM0",
                                "url": "https://www.uniprot.org/uniprot/A2AMM0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 4,
            "end_pos": 6,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}