{ "uniprot_canonical_ac": "A2ALV5-1", "uniprot_ac": "A2ALV5", "uniprot_id": "SHOC1_MOUSE", "mass": { "chemical_mass": 168065.0, "monoisotopic_mass": 168065.0 }, "refseq": {}, "gene_names": [ { "name": "Shoc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ALV5", "id": "A2ALV5" }, { "name": "Zip2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALV5", "id": "A2ALV5" } ], "protein_names": [ { "name": "Protein shortage in chiasmata 1 ortholog", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ALV5#names_and_taxonomy", "id": "A2ALV5" }, { "name": "3.6.-.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALV5#names_and_taxonomy", "id": "A2ALV5" }, { "name": "MZip2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALV5#names_and_taxonomy", "id": "A2ALV5" }, { "name": "Protein ZIP2 homolog", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALV5#names_and_taxonomy", "id": "A2ALV5" } ], "function": [ { "annotation": "ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (PubMed:30272023). Required for recruitment of TEX11 and MSH4 to recombination intermediates (PubMed:30272023).", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5#function" }, { "database": "PubMed", "id": "Q5VXU9", "url": "https://glygen.org/publication/PubMed/Q5VXU9" }, { "database": "PubMed", "id": "30272023", "url": "https://glygen.org/publication/PubMed/30272023" }, { "database": "PubMed", "id": "29742103", "url": "https://glygen.org/publication/PubMed/29742103" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Shoc1", "url": "https://www.uniprot.org/uniprot/A2ALV5", "locus": {} } ], "crossref": [ { "id": "ENSMUSG00000038598", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038598", "database": "Bgee" }, { "id": "IPR039991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039991", "database": "InterPro" }, { "id": "2140313", "url": "http://www.informatics.jax.org/marker/MGI:2140313", "database": "MGI" }, { "id": "TNDEREM", "url": "https://omabrowser.org/oma/group/TNDEREM/", "database": "OMA" }, { "id": "60413at2759", "url": "http://www.orthodb.org/?query=60413at2759", "database": "OrthoDB" }, { "id": "PTHR35668", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35668", "database": "PANTHER" }, { "id": "PF17825", "url": "http://pfam.xfam.org/family/PF17825", "database": "Pfam" }, { "id": "PR_A2ALV5", "url": "http://purl.obolibrary.org/obo/PR_A2ALV5", "database": "PRO" }, { "id": "XP_017175979", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017175979", "database": "RefSeq" }, { "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5", "database": "UniProtKB" }, { "id": "A2ALV5-1", "url": "https://www.uniprot.org/uniprot/A2ALV5-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MALNGRTMFPAFKYYAIDYLQEDIIKERLYRDALLLQIPSCLNQDKNIIDDKYRTPWTRAIPVQEMEDNSVLEQWRTRFCVEGVPEKKTVTGVMINGTFEEIVPSSNPNSPPGIENDKLFPSKDYVDDFIPVKCSLYYPGVKAEHQGLLIDEEMIFMNKAMDNHLPTVNGLLSRLKLYLVKDPFLDFKEELSGKDNFTEYFSVQECSEPFVRDFHMAEETFCKKKLPSVFPSGFKSLISTNPKQEILILPPSKLKKPLNSIPKIMDSVDESECFKGDITSKHEFDTEDIKCNSTENLTFASLCEPECSEPGDLEMPPTHLILPRQHSAVSSLHMGFQTFPFSATCKINLLSAGESANKYCMLWQLGGCRNSWVSFLLTVPRFQEPSSQYSLADMRNIFSVKGDSLVINPAKAKGWRQARLHPIMAETLAHLKAYLCHNGLSSQETKLEIFLPTKVFQLESWLELKSRPLPIVPISEKSTDVHQLHPQKRPIPSSEKEVPHLCLSGESISVKKSKVEANPKNDQEPEARIMQKPENSCVGLGCSSQVPSAESASSSQIQASYDKKQDDLDLLSEFIILRSKHQTFPSEADVDVKSHDHDQNNEFQDKEKYSLTLQEESLVASNSKAPEERCEERTDGVIEIPASDTQCQAYCLLEATANPILKELVCLCTYPAANWKFATVNFDQTRFFLKEQEKKINDATHPDKNDDRKMTFRHAALLHLLITIRDVLLTCNLDTALGYLSNAKDIYKSVLDSRLDNIWRQLKILQFIKEKRPKSNYKIQELQCQILSRLQNQQQMKVLIIIRMDSDGEKHLLIKTLKKIEGLTMTVLRSNDRKKILETTSILKGTNACVVVHNHSIGADFPWSSFSLVVEYNHVGHSCWAEHCQLLDIPFLAFKVAVPDTALQRDALLDGFGGFLLKIPIPYVFFASEGLLNTPEILRLLESNYNITLVERCCCGSLKLFGSTECYVVVTVDEHTAIVVQDLEELHHEKASDNIIMRLMALSFQYSCCWIILYSKETLNSQYHLTEETLRHLAQVYAALVSSGLKSEELDVKLIIAPGVEETALIIRQIADHNLMTSTRDPHEWLDKSWVEVSPSKEEMSLLDFPCINPLVAQLMLHRAPSLHWLLIATPAELQELLPQVPGKVLKHFCSITSLFKISSPSMTKSSQISSLQEDMNQTDLFISQSSAPIIQEQEEYYPYEDSEGTSSSPVELRATPCMLPSAAPHSQRGCWEDPSCGPDPVQNNPSLMNAESKKVTWPSVPSWSDSESDVFSLARTQVSCEPIMTLTDSQRRGTNGFVNCPEAKGPRNMQVSTPVFLPENSQSHLHWDFKKNSCRKQIYSFNPSCGTEQTTYNKWYSWKDDFSSNQPECLWDEMEDVTYRNANAGTRETFWRELPAVPSWDSPCASDSNANQRGFKGLDFCQRAGNYLGQRSLPVSSSNWGDYKTPTDLMYSQVPQPKKRRLMYEKVPGRVDGQTRLKFL", "length": 1481, "header": "sp|A2ALV5-1|SHOC1_MOUSE Isoform 1 of Protein shortage in chiasmata 1 ortholog OS=Mus musculus OX=10090 GN=Shoc1 PE=1 SV=1 CANONICAL=A2ALV5-1" }, "isoforms": [ { "isoform_ac": "A2ALV5-1", "url": "https://www.uniprot.org/uniprot/A2ALV5#A2ALV5-1", "sequence": { "sequence": "MALNGRTMFPAFKYYAIDYLQEDIIKERLYRDALLLQIPSCLNQDKNIIDDKYRTPWTRAIPVQEMEDNSVLEQWRTRFCVEGVPEKKTVTGVMINGTFEEIVPSSNPNSPPGIENDKLFPSKDYVDDFIPVKCSLYYPGVKAEHQGLLIDEEMIFMNKAMDNHLPTVNGLLSRLKLYLVKDPFLDFKEELSGKDNFTEYFSVQECSEPFVRDFHMAEETFCKKKLPSVFPSGFKSLISTNPKQEILILPPSKLKKPLNSIPKIMDSVDESECFKGDITSKHEFDTEDIKCNSTENLTFASLCEPECSEPGDLEMPPTHLILPRQHSAVSSLHMGFQTFPFSATCKINLLSAGESANKYCMLWQLGGCRNSWVSFLLTVPRFQEPSSQYSLADMRNIFSVKGDSLVINPAKAKGWRQARLHPIMAETLAHLKAYLCHNGLSSQETKLEIFLPTKVFQLESWLELKSRPLPIVPISEKSTDVHQLHPQKRPIPSSEKEVPHLCLSGESISVKKSKVEANPKNDQEPEARIMQKPENSCVGLGCSSQVPSAESASSSQIQASYDKKQDDLDLLSEFIILRSKHQTFPSEADVDVKSHDHDQNNEFQDKEKYSLTLQEESLVASNSKAPEERCEERTDGVIEIPASDTQCQAYCLLEATANPILKELVCLCTYPAANWKFATVNFDQTRFFLKEQEKKINDATHPDKNDDRKMTFRHAALLHLLITIRDVLLTCNLDTALGYLSNAKDIYKSVLDSRLDNIWRQLKILQFIKEKRPKSNYKIQELQCQILSRLQNQQQMKVLIIIRMDSDGEKHLLIKTLKKIEGLTMTVLRSNDRKKILETTSILKGTNACVVVHNHSIGADFPWSSFSLVVEYNHVGHSCWAEHCQLLDIPFLAFKVAVPDTALQRDALLDGFGGFLLKIPIPYVFFASEGLLNTPEILRLLESNYNITLVERCCCGSLKLFGSTECYVVVTVDEHTAIVVQDLEELHHEKASDNIIMRLMALSFQYSCCWIILYSKETLNSQYHLTEETLRHLAQVYAALVSSGLKSEELDVKLIIAPGVEETALIIRQIADHNLMTSTRDPHEWLDKSWVEVSPSKEEMSLLDFPCINPLVAQLMLHRAPSLHWLLIATPAELQELLPQVPGKVLKHFCSITSLFKISSPSMTKSSQISSLQEDMNQTDLFISQSSAPIIQEQEEYYPYEDSEGTSSSPVELRATPCMLPSAAPHSQRGCWEDPSCGPDPVQNNPSLMNAESKKVTWPSVPSWSDSESDVFSLARTQVSCEPIMTLTDSQRRGTNGFVNCPEAKGPRNMQVSTPVFLPENSQSHLHWDFKKNSCRKQIYSFNPSCGTEQTTYNKWYSWKDDFSSNQPECLWDEMEDVTYRNANAGTRETFWRELPAVPSWDSPCASDSNANQRGFKGLDFCQRAGNYLGQRSLPVSSSNWGDYKTPTDLMYSQVPQPKKRRLMYEKVPGRVDGQTRLKFL", "length": 1481, "header": "sp|A2ALV5-1|SHOC1_MOUSE Isoform 1 of Protein shortage in chiasmata 1 ortholog OS=Mus musculus OX=10090 GN=Shoc1 PE=1 SV=1 CANONICAL=A2ALV5-1" }, "locus": { "chromosome": "4", "start_pos": 59113963, "end_pos": 59043870, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000107547", "url": "https://www.ensembl.org/id/ENSMUST00000107547" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000103171", "url": "https://www.ensembl.org/id/ENSMUSP00000103171" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis.", "journal": "PLoS Genet.", "date": "2018", "authors": "Pezza R.J., Guiraldelli M.F., Almeida L.P., Felberg A., Parikh A., de Castro R.O.", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "reference": [ { "type": "PubMed", "id": "29742103", "url": "https://glygen.org/publication/PubMed/29742103" } ] }, { "title": "Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.", "journal": "Commun. Biol.", "date": "2018", "authors": "Zhang Q., Yu C., Shao J., Fan H.Y.", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "reference": [ { "type": "PubMed", "id": "30272023", "url": "https://glygen.org/publication/PubMed/30272023" } ] }, { "title": "SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.", "journal": "Sci. Adv.", "date": "2019", "authors": "Zhang Q., Yu C., Ji S.Y., Busayavalasa K.", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "reference": [ { "type": "PubMed", "id": "30746471", "url": "https://glygen.org/publication/PubMed/30746471" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q5VXU9-1", "protein_name": "Protein shortage in chiasmata 1 ortholog", "gene_name": "SHOC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDTSVLDQWKASFFVEDFLEKKTITRMVTQINCEFEEVVPSSNPDSQIEVEEVSLYTHMDYNEVFTPVSCLEKCSALQNQNQDLFIDDKGILFVSSRKHLPTLPTLLSRLKLFLVKDPLLDFKGQIFTEANFSRECFSLQETLEAFVKEDFCMDKVNFCQEKLEDTICLNEPSSFLIEYEFLIPPSLKPEIDIPSLSELKELLNPVPEIINYVDEKEKLFERDLTNKHGIEDIGDIKFSSTEILTIQSQSEPEECSKPGELEMPLTPLFLTCQHSSVNSLRTELQTFPLSPVCKINLLTAEESANEYYMMWQLERCRSPLNPFLLTVPRIQEPHSQYSVTDLKKIFSVKEESLVINLEKAEWWKQAGLNLKMMETLEHLNTYLCHDNLSSNDTKIEIFLPTKVLQLESCLEHKSHSSPIALIDEKSTNAHLSLPQKSPSLAKEVPDLCFSDDYFSDKGAAKEEKPKNDQEPVNRIIQKKENNDHFELDCTGPSIKSPSSSIIKKASFEHGKKQENDLDLLSDFIMLRNKYKTCTSKTEVTNSDEKHDKEACSLTLQEESPIVHINKTLEEINQERGTDSVIEIQASDSQCQAFCLLEAAASPILKNLVSLCTLPTANWKFATVIFDQTRFLLKEQEKVVSDAVRQGTIDEREMTFKHAALLHLLVTIRDVLLTCSLDTALGYLSKAKDIYNSILGPYLGDIWRQLEIVQFIRGKKPETNYKIQELQCQILSWMQSQQQIKVLIIIRMDSDGEKHFLIKILNKIEGLTLTVLHSNERKDFLESEGVLRGTSSCVVVHNQYIGADFPWSNFSFVVEYNYVEDSCWTKHCKELNIPYMAFKVILPDTVLERSTLLDRFGGFLLEIQIPYVFFASEGLLNTPDILQLLESNYNISLVERGCSESLKLFGSSECYVVVTIDEHTAIILQDLEELNYEKASDNIIMRLMALSLQYRYCWIILYTKETLNSEYLLTEKTLHHLALIYAALVSFGLNSEELDVKLIIAPGVEATALIIRQIADHSLMTSKRDPHEWLDKSWLKVSPSEEEMYLLDFPCINPLVAQLMLNKGPSLHWILLATLCQLQELLPEVPEKVLKHFCSITSLFKIGSSSITKSPQISSPQENRNQISTLSSQSSASDLDSVIQEHNEYYQYLGLGETVQEDKTTILNDNSSIMELKEISSFLPPVTSYNQTSYWKDSSCKSNIGQNTPFLINIESRRPAYNSFLNHSDSESDVFSLGLTQMNCETIKSPTDTQKRVSVVPRFINSQKRRTHEAKGFINKDVSDPIFSLEGTQSPLHWNFKKNIWEQENHPFNLQYGAQQTACNKLYSQKGNLFTDQQKCLSDESEGLTCESSKDETFWRELPSVPSLDLFRASDSNANQKEFNSLYFYQRAGKSLGQKRHHESSFNSGDKESLTGFMCSQLPQFKKRRLAYEKVPGRVDGQTRLRFF", "length": 1444 }, "evidence": [ { "id": "A2ALV5", "url": "https://omabrowser.org/oma/group/A2ALV5/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "resolution of meiotic recombination intermediates", "id": "GO:0000712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000712", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "pmid": "29742103" }, { "name": "reciprocal meiotic recombination", "id": "GO:0007131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "pmid": "30272023" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "condensed nuclear chromosome", "id": "GO:0000794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "pmid": "29742103" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "pmid": "30272023" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0140603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140603", "evidence": [ { "database": "UniProtKB", "id": "A2ALV5", "url": "https://www.uniprot.org/uniprot/A2ALV5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1177, "end_pos": 1179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 854, "end_pos": 856, "annotation": "n_glycosylation_sequon" }, { "start_pos": 946, "end_pos": 948, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ] }