{ "uniprot_canonical_ac": "A2ALU4-1", "uniprot_ac": "A2ALU4", "uniprot_id": "SHRM2_MOUSE", "mass": { "chemical_mass": 164703.0, "monoisotopic_mass": 164703.0 }, "refseq": { "ac": "NP_001277613", "name": "protein Shroom2 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613" }, "gene_names": [ { "name": "Shroom2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4" }, { "name": "4832440C16; Apxl; C630003H05Rik; Shrm2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613", "id": "NP_001277613" }, { "name": "Apxl", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4" }, { "name": "Shroom2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613", "id": "NP_001277613" } ], "protein_names": [ { "name": "Protein Shroom2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ALU4#names_and_taxonomy", "id": "A2ALU4" }, { "name": "Protein Apxl", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALU4#names_and_taxonomy", "id": "A2ALU4" }, { "name": "protein Shroom2 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766029", "id": "NP_766029" }, { "name": "protein Shroom2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613", "id": "NP_001277613" }, { "name": "protein Shroom2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766029", "id": "NP_766029" } ], "function": [ { "annotation": "Data suggest that Shroom2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_001277613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613" }, { "database": "PubMed", "id": "21248203", "url": "https://glygen.org/publication/PubMed/21248203" }, { "database": "RefSeq", "id": "NP_766029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766029" } ] }, { "annotation": "May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution.", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4#function" }, { "database": "PubMed", "id": "16684770", "url": "https://glygen.org/publication/PubMed/16684770" }, { "database": "PubMed", "id": "16987870", "url": "https://glygen.org/publication/PubMed/16987870" } ] }, { "annotation": "Shroom2 and ZO-1 form a tight-junction-associated scaffolding complex, possibly linked to myosin VIIa, that bridges the junctional membrane to the underlying cytoskeleton, thereby contributing to the stabilization of these junctions.", "evidence": [ { "database": "RefSeq", "id": "NP_001277613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613" }, { "database": "PubMed", "id": "17666436", "url": "https://glygen.org/publication/PubMed/17666436" }, { "database": "RefSeq", "id": "NP_766029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766029" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Shroom2", "url": "https://www.uniprot.org/uniprot/A2ALU4", "locus": { "chromosome": "X", "start_pos": 152769465, "end_pos": 152609509, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000045180", "url": "https://www.ensembl.org/id/ENSMUSG00000045180" } ] } } ], "crossref": [ { "id": "ENSMUSG00000045180", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000045180", "database": "Bgee" }, { "id": "110380", "url": "https://www.ncbi.nlm.nih.gov/gene/110380", "database": "GeneID" }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro" }, { "id": "IPR014799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014799", "database": "InterPro" }, { "id": "IPR014800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014800", "database": "InterPro" }, { "id": "IPR027685", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027685", "database": "InterPro" }, { "id": "IPR027686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027686", "database": "InterPro" }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro" }, { "id": "mmu:110380", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110380", "database": "KEGG Pathway" }, { "id": "107194", "url": "http://www.informatics.jax.org/marker/MGI:107194", "database": "MGI" }, { "id": "PFDAHVG", "url": "https://omabrowser.org/oma/group/PFDAHVG/", "database": "OMA" }, { "id": "29607at2759", "url": "http://www.orthodb.org/?query=29607at2759", "database": "OrthoDB" }, { "id": "PTHR15012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15012", "database": "PANTHER" }, { "id": "PTHR15012:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15012:SF8", "database": "PANTHER" }, { "id": "PF00595", "url": "http://pfam.xfam.org/family/PF00595", "database": "Pfam" }, { "id": "PF08687", "url": "http://pfam.xfam.org/family/PF08687", "database": "Pfam" }, { "id": "PF08688", "url": "http://pfam.xfam.org/family/PF08688", "database": "Pfam" }, { "id": "PR_A2ALU4", "url": "http://purl.obolibrary.org/obo/PR_A2ALU4", "database": "PRO" }, { "id": "NP_001277613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613", "database": "RefSeq" }, { "id": "NP_766029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766029", "database": "RefSeq" }, { "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4", "database": "UniProtKB" }, { "id": "A2ALU4-1", "url": "https://www.uniprot.org/uniprot/A2ALU4-1", "database": "UniProtKB" }, { "id": "A2ALU4-2", "url": "https://www.uniprot.org/uniprot/A2ALU4-2", "database": "UniProtKB" }, { "id": "A7TU71", "url": "https://www.uniprot.org/uniprot/A7TU71", "database": "UniProtKB" }, { "id": "A7TU71-1", "url": "https://www.uniprot.org/uniprot/A7TU71-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MEGAEPRARPERLAEAEAPATDGVRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHATKYFDVHPEPAASLFLNTSGSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFSVAARGHEKARGPPFSDLASMQHFITLPHVQPRGDHRMETTDRQWKLTHLSSGKEIGNVGYQSEGHLDCRWLCSDDRAGRPSGPPGRLQFSDVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITPGGGLQEPPEPSQDDNPTQVRWPGSAHQKLDDRGRSHYFPGSLRQPVQGSAQVVIPRGDYWHSDTTPVDLEYPLLRPVGQRTYLQQHEETPASHEKEGYHQLNAGIEGCCSGIQEPPRASRTVRTGLQCPSNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRADVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGLAKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVGTFADRWKFFEETSKSLLQKAGHRQVHCGLPREKAERPQTGHHECESTEPWFQKRSLATSCGEILSDRKVEKASEKLNPPRRLGTFAEYQASWKEQKKPLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGDHKEAILCTLQAEEGCSAPSAQPQDSQHVNEDTTFPQPETQLSSKCQHLQTSAMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK", "length": 1481, "header": "sp|A2ALU4-1|SHRM2_MOUSE Isoform 1 of Protein Shroom2 OS=Mus musculus OX=10090 GN=Shroom2 PE=1 SV=1 CANONICAL=A2ALU4-1" }, "isoforms": [ { "isoform_ac": "A2ALU4-1", "url": "https://www.uniprot.org/uniprot/A2ALU4#A2ALU4-1", "sequence": { "sequence": "MEGAEPRARPERLAEAEAPATDGVRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHATKYFDVHPEPAASLFLNTSGSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFSVAARGHEKARGPPFSDLASMQHFITLPHVQPRGDHRMETTDRQWKLTHLSSGKEIGNVGYQSEGHLDCRWLCSDDRAGRPSGPPGRLQFSDVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITPGGGLQEPPEPSQDDNPTQVRWPGSAHQKLDDRGRSHYFPGSLRQPVQGSAQVVIPRGDYWHSDTTPVDLEYPLLRPVGQRTYLQQHEETPASHEKEGYHQLNAGIEGCCSGIQEPPRASRTVRTGLQCPSNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRADVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGLAKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVGTFADRWKFFEETSKSLLQKAGHRQVHCGLPREKAERPQTGHHECESTEPWFQKRSLATSCGEILSDRKVEKASEKLNPPRRLGTFAEYQASWKEQKKPLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGDHKEAILCTLQAEEGCSAPSAQPQDSQHVNEDTTFPQPETQLSSKCQHLQTSAMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK", "length": 1481, "header": "sp|A2ALU4-1|SHRM2_MOUSE Isoform 1 of Protein Shroom2 OS=Mus musculus OX=10090 GN=Shroom2 PE=1 SV=1 CANONICAL=A2ALU4-1" }, "locus": { "chromosome": "X", "start_pos": 151552446, "end_pos": 151395527, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000062317", "url": "https://www.ensembl.org/id/ENSMUST00000062317" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000057500", "url": "https://www.ensembl.org/id/ENSMUSP00000057500" } ] } }, { "isoform_ac": "A2ALU4-2", "url": "https://www.uniprot.org/uniprot/A2ALU4#A2ALU4-2", "sequence": { "sequence": "METSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK", "length": 446, "header": "sp|A2ALU4-2|SHRM2_MOUSE Isoform 2 of Protein Shroom2 OS=Mus musculus OX=10090 GN=Shroom2 PE=1 SV=1 CANONICAL=A2ALU4-1" }, "locus": {} }, { "isoform_ac": "A7TU71-1", "url": "https://www.uniprot.org/uniprot/A2ALU4#A7TU71-1", "sequence": { "sequence": "MEGAEPRARPERLAEAEAPATDGVRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHATKYFDVHPEPAASLFLNTSGSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFSVAARGHEKARGPPFSDLASMQHFITLPHVQPRGDHRMETTDRQWKLTHLSSGKEIGNVGYQSEGHLDCRWLCSDDRAGRPSGPPGRLQFSDVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITPGGGLQEPPEPSQDDNPTQVRWPGSAHQKLDDRGRSHYFPGSLRQPVQGSAQVVIPRGDYWHSDTTPVDLEYPLLRPVGQRTYLQQHEETPASHEKEGYHQLNAGIEGCCSGIQEPPRASRTVRTGLQCPSNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRADVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGLAKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVGTFADRWKFFEETSKSLLQKAGHRQVHCGLPREKAERPQTGHHECESTEPWFQKRSLATSCGEILSDRKVEKASEKLNPPRRLGTFAEYQASWKEQKKPLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGDHKEAILCTLQAEEGCSAPSSSVLSSAQPQDSQHVNEDTTFPQPETQLSSKCQHLQTSAMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK", "length": 1487, "header": "tr|A7TU71-1|A7TU71_MOUSE Computationally mapped isoform of Protein Shroom2 OS=Mus musculus OX=10090 GN=Shroom2 PE=1 SV=1 CANONICAL=A2ALU4-1" }, "locus": { "chromosome": "X", "start_pos": 151552446, "end_pos": 151395527, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000101141", "url": "https://www.ensembl.org/id/ENSMUST00000101141" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000098701", "url": "https://www.ensembl.org/id/ENSMUSP00000098701" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1041, "end_pos": 1041, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ] }, { "start_pos": 1043, "end_pos": 1043, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ] }, { "start_pos": 1165, "end_pos": 1165, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "A2ALU4", "url": "http://phospho.elm.eu.org/byAccession/A2ALU4.html" }, { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1165, "end_pos": 1165, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 236, "end_pos": 236, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 236, "end_pos": 236, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 318, "end_pos": 318, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 318, "end_pos": 318, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 330, "end_pos": 330, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 330, "end_pos": 330, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 933, "end_pos": 933, "kinase_uniprot_canonical_ac": "Q3UD01-1", 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"Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 959, "end_pos": 959, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 959, "end_pos": 959, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": 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"https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 963, "end_pos": 963, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Thr", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 963, "end_pos": 963, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "A new standard nomenclature for proteins related to Apx and Shroom.", "journal": "BMC Cell Biol.", "date": "2006", "authors": "Ballabio A., Kalscheuer V., Staub O., Schiaffino M.V., Smith P., Wallingford J.B., Hagens O., Hildebrand J.D., Kraehenbuhl J.-P.", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "reference": [ { "type": "PubMed", "id": "16615870", "url": "https://glygen.org/publication/PubMed/16615870" } ] }, { "title": "Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins.", "journal": "J. Biol. Chem.", "date": "2006", "authors": "Bernaciak T.M., Dietz M.L., Hildebrand J.D., Kielec J.M., Vendetti F.", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "reference": [ { "type": "PubMed", "id": "16684770", "url": "https://glygen.org/publication/PubMed/16684770" } ] }, { "title": "Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium.", "journal": "Development", "date": "2006", "authors": "Lee C., Wallingford J.B., Ellis A., Hildebrand J.D., Fairbank P.D., Gross J.M.", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "reference": [ { "type": "PubMed", "id": "16987870", "url": "https://glygen.org/publication/PubMed/16987870" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "UniProtKB", "id": "A7TU71", "url": "https://www.uniprot.org/uniprot/A7TU71" }, { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions.", "journal": "J. Cell Sci.", "date": "2007", "authors": "Legrain P., Petit C., El-Amraoui A., Perfettini I., Zwaenepoel I., Etournay R.", "evidence": [ { "database": "UniProtKB", "id": "A7TU71", "url": "https://www.uniprot.org/uniprot/A7TU71" }, { "database": "RefSeq", "id": "NP_001277613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613" }, { "database": "RefSeq", "id": "NP_766029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766029" } ], "reference": [ { "type": "PubMed", "id": "17666436", "url": "https://glygen.org/publication/PubMed/17666436" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" }, { "database": "iPTMnet", "id": "A2ALU4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALU4" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Shroom2 regulates contractility to control endothelial morphogenesis.", "journal": "Molecular biology of the cell", "date": "2011", "authors": "Farber MJ, Rizaldy R, Hildebrand JD", "evidence": [ { "database": "RefSeq", "id": "NP_001277613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613" }, { "database": "RefSeq", "id": "NP_766029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766029" } ], "reference": [ { "type": "PubMed", "id": "21248203", "url": "https://glygen.org/publication/PubMed/21248203" } ] } ], "pathway": [ { "id": "mmu:110380", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110380", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13796-1", "protein_name": "Protein Shroom2", "gene_name": "SHROOM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK", "length": 1616 }, "evidence": [ { "id": "84697", "url": "http://www.informatics.jax.org/homology/84697", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TP36-1", "protein_name": "Protein Shroom2", "gene_name": "Shroom2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1423 }, "evidence": [ { "id": "84697", "url": "http://www.informatics.jax.org/homology/84697", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "negative regulation of actin filament depolymerization", "id": "GO:0030835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030835", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "pmid": "17666436" }, { "name": "eye pigment granule organization", "id": "GO:0008057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008057", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "pmid": "16987870" }, { "name": "cellular pigment accumulation", "id": "GO:0043482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043482", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "pmid": "16987870" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "pmid": "21873635" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "pmid": "16684770" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": "https://www.uniprot.org/uniprot/A2ALU4" } ], "pmid": "16987870" }, { "name": "melanosome organization", "id": "GO:0032438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032438", "evidence": [ { "database": "UniProtKB", "id": "A2ALU4", "url": 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