{ "uniprot_canonical_ac": "A2ALS5-1", "uniprot_ac": "A2ALS5", "uniprot_id": "RPGP1_MOUSE", "mass": { "chemical_mass": 73433.0, "monoisotopic_mass": 73433.0 }, "refseq": { "ac": "NP_001074624", "name": "rap1 GTPase-activating protein 1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" }, "gene_names": [ { "name": "Rap1gap", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5" }, { "name": "1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; Gap; Rap1ga1; Rap1GAP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624", "id": "NP_001074624" }, { "name": "Kiaa0474", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5" }, { "name": "Rap1ga1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5" }, { "name": "Rap1gap", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624", "id": "NP_001074624" } ], "protein_names": [ { "name": "Rap1 GTPase-activating protein 1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ALS5#names_and_taxonomy", "id": "A2ALS5" }, { "name": "ARPP-90", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALS5#names_and_taxonomy", "id": "A2ALS5" }, { "name": "Rap1GAP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALS5#names_and_taxonomy", "id": "A2ALS5" }, { "name": "Rap1GAP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ALS5#names_and_taxonomy", "id": "A2ALS5" }, { "name": "rap1 GTPase-activating protein 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624", "id": "NP_001074624" }, { "name": "rap1 GTPase-activating protein 1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147", "id": "NP_001243147" }, { "name": "rap1 GTPase-activating protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147", "id": "NP_001243147" } ], "function": [ { "annotation": "ERK activation by cAMP does not require RAP1", "evidence": [ { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" }, { "database": "PubMed", "id": "12082090", "url": "https://glygen.org/publication/PubMed/12082090" }, { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" } ] }, { "annotation": "Evidence of differential Krit1 and Rap1A expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1, not restricted to vascular endothelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" }, { "database": "PubMed", "id": "12172908", "url": "https://glygen.org/publication/PubMed/12172908" }, { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" } ] }, { "annotation": "Expression studies show that mr-gef is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).", "evidence": [ { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" }, { "database": "PubMed", "id": "14643017", "url": "https://glygen.org/publication/PubMed/14643017" }, { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" } ] }, { "annotation": "GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5#function" } ] }, { "annotation": "Increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin", "evidence": [ { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" }, { "database": "PubMed", "id": "24642466", "url": "https://glygen.org/publication/PubMed/24642466" }, { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" } ] }, { "annotation": "Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.", "evidence": [ { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" }, { "database": "PubMed", "id": "12873387", "url": "https://glygen.org/publication/PubMed/12873387" }, { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" } ] } ], "disease": [ { "disease_id": "DOID:0050908", "recommended_name": { "id": "DOID:0050908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050908", "name": "myelodysplastic syndrome", "description": "A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets." }, "synonyms": [ { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome", "description": "A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome, NOS", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic neoplasm", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplasia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "smoldering leukemia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome/neoplasm", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "preleukemia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "oligoblastic leukemia", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome, susceptibility to", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndromes", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "MDS", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "hematopoeitic - myelodysplastic syndrome (MDS)", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "dysmyelopoietic syndrome", "description": "" }, { "id": "MONDO:0018881", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0018881", "name": "myelodysplastic syndrome; MDS", "description": "" }, { "id": "MIM:614286", "resource": "MIM", "url": "https://www.omim.org/entry/614286", "name": "Myelodysplastic syndrome", "description": "Myelodysplastic syndrome" } ], "evidence": [ { "id": "0050908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050908" } ] }, { "disease_id": "DOID:1312", "recommended_name": { "id": "DOID:1312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1312", "name": "focal segmental glomerulosclerosis", "description": "" }, "synonyms": [ { "id": "DOID:1312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1312", "name": "FGS", "description": "" }, { "id": "DOID:1312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1312", "name": "FSGS", "description": "" }, { "id": "DOID:1312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1312", "name": "focal glomerular sclerosis", "description": "" }, { "id": "DOID:1312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1312", "name": "focal glomerulosclerosis", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "focal segmental glomerulosclerosis 1", "description": "Any focal segmental glomerulosclerosis in which the cause of the disease is a mutation in the ACTN4 gene." }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "focal segmental glomerulosclerosis caused by mutation in ACTN4", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "glomerulosclerosis, focal segmental, 1", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "focal segmental glomerulosclerosis 1", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "familial idiopathic steroid-resistant nephrotic syndrome with focal segmental glomerulosclerosis", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "focal segmental glomerulosclerosis 1; FSGS1", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "ACTN4 focal segmental glomerulosclerosis", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "FSGS1", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis", "description": "" }, { "id": "MONDO:0011303", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011303", "name": "focal segmental glomerulosclerosis type 1", "description": "" }, { "id": "MIM:603278", "resource": "MIM", "url": "https://www.omim.org/entry/603278", "name": "Focal segmental glomerulosclerosis 1", "description": "Focal segmental glomerulosclerosis 1" } ], "evidence": [ { "id": "1312", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1312" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "evidence": [ { "id": "1793", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:1909", "recommended_name": { "id": "DOID:1909", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1909", "name": "melanoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye." }, "synonyms": [ { "id": "DOID:1909", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1909", "name": "Naevocarcinoma", "description": "" }, { "id": "DOID:1909", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1909", "name": "malignant melanoma", "description": "" } ], "evidence": [ { "id": "1909", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1909" } ] }, { "disease_id": "DOID:3312", "recommended_name": { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar disorder", "description": "A mood disorder that involves alternating periods of mania and depression." }, "synonyms": [ { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic Bipolar Affective disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic Depressive disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic bipolar I disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar depression", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar disorder manic phase", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "manic depression", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "manic disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "mixed bipolar disorder", "description": "" } ], "evidence": [ { "id": "3312", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3312" } ] }, { "disease_id": "DOID:3969", "recommended_name": { "id": "DOID:3969", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3969", "name": "thyroid gland papillary carcinoma", "description": "A differentiated thyroid gland carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer abd arises from the follicular cells of the thyroid gland." }, "synonyms": [ { "id": "DOID:3969", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3969", "name": "Papillary carcinoma of the Thyroid gland", "description": "" }, { "id": "MONDO:0008567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008567", "name": "thyroid cancer, nonmedullary, 1", "description": "" }, { "id": "MONDO:0008567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008567", "name": "thyroid cancer, nonmedullary, type 1", "description": "" }, { "id": "MONDO:0008567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008567", "name": "NMTC1", "description": "" }, { "id": "MONDO:0008567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008567", "name": "nonmedullary Thyroid carcinoma, papillary", "description": "" }, { "id": "MONDO:0008567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008567", "name": "familial nonmedullary Thyroid cancer, papillary", "description": "" }, { "id": "MONDO:0008567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008567", "name": "thyroid cancer, nonmedullary, 1; NMTC1", "description": "" }, { "id": "MONDO:0008567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008567", "name": "papillary carcinoma of Thyroid", "description": "" }, { "id": "MONDO:0008567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008567", "name": "thyroid cancer, nonmedullary, 1", "description": "" }, { "id": "MIM:188550", "resource": "MIM", "url": "https://www.omim.org/entry/188550", "name": "Thyroid cancer, non-medullary, 1", "description": "Thyroid cancer, non-medullary, 1" } ], "evidence": [ { "id": "3969", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3969" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Rap1gap", "url": "https://www.uniprot.org/uniprot/A2ALS5", "locus": { "chromosome": "4", "start_pos": 137664726, "end_pos": 137729861, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000041351", "url": "https://www.ensembl.org/id/ENSMUSG00000041351" } ] } } ], "crossref": [ { "id": "ENSMUSG00000041351", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041351", "database": "Bgee" }, { "id": "110351", "url": "https://www.ncbi.nlm.nih.gov/gene/110351", "database": "GeneID" }, { "id": "A2ALS5", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ALS5*", "database": "IntAct" }, { "id": "IPR000331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000331", "database": "InterPro" }, { "id": "IPR003109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003109", "database": "InterPro" }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro" }, { "id": "IPR035974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035974", "database": "InterPro" }, { "id": "mmu:110351", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110351", "database": "KEGG Pathway" }, { "id": "109338", "url": "http://www.informatics.jax.org/marker/MGI:109338", "database": "MGI" }, { "id": "FPATKNR", "url": "https://omabrowser.org/oma/group/FPATKNR/", "database": "OMA" }, { "id": "845465at2759", "url": "http://www.orthodb.org/?query=845465at2759", "database": "OrthoDB" }, { "id": "PF02145", "url": "http://pfam.xfam.org/family/PF02145", "database": "Pfam" }, { "id": "PF02188", "url": "http://pfam.xfam.org/family/PF02188", "database": "Pfam" }, { "id": "PR_A2ALS5", "url": "http://purl.obolibrary.org/obo/PR_A2ALS5", "database": "PRO" }, { "id": "R-MMU-392517", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-392517", "database": "Reactome" }, { "id": "R-MMU-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8853659", "database": "Reactome" }, { "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624", "database": "RefSeq" }, { "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147", "database": "RefSeq" }, { "id": "A2ALS2", "url": "https://www.uniprot.org/uniprot/A2ALS2", "database": "UniProtKB" }, { "id": "A2ALS2-1", "url": "https://www.uniprot.org/uniprot/A2ALS2-1", "database": "UniProtKB" }, { "id": "A2ALS3", "url": "https://www.uniprot.org/uniprot/A2ALS3", "database": "UniProtKB" }, { "id": "A2ALS3-1", "url": "https://www.uniprot.org/uniprot/A2ALS3-1", "database": "UniProtKB" }, { "id": "A2ALS4", "url": "https://www.uniprot.org/uniprot/A2ALS4", "database": "UniProtKB" }, { "id": "A2ALS4-1", "url": "https://www.uniprot.org/uniprot/A2ALS4-1", "database": "UniProtKB" }, { "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5", "database": "UniProtKB" }, { "id": "A2ALS5-1", "url": "https://www.uniprot.org/uniprot/A2ALS5-1", "database": "UniProtKB" }, { "id": "A2ALS5-2", "url": "https://www.uniprot.org/uniprot/A2ALS5-2", "database": "UniProtKB" }, { "id": "A2ALS5-3", "url": "https://www.uniprot.org/uniprot/A2ALS5-3", "database": "UniProtKB" }, { "id": "A2ALS5-4", "url": "https://www.uniprot.org/uniprot/A2ALS5-4", "database": "UniProtKB" }, { "id": "A2ALS7", "url": "https://www.uniprot.org/uniprot/A2ALS7", "database": "UniProtKB" }, { "id": "A2ALS7-1", "url": "https://www.uniprot.org/uniprot/A2ALS7-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC", "length": 663, "header": "sp|A2ALS5-1|RPGP1_MOUSE Isoform 1 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1" }, "isoforms": [ { "isoform_ac": "A2ALS2-1", "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS2-1", "sequence": { "sequence": "MSGRKRSFTFGAYGGRSDGQKQSFPQALNLLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLV", "length": 165, "header": "tr|A2ALS2-1|A2ALS2_MOUSE Computationally mapped isoform of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=1 CANONICAL=A2ALS5-1" }, "locus": { "chromosome": "4", "start_pos": 137443100, "end_pos": 137409023, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000152567", "url": "https://www.ensembl.org/id/ENSMUST00000152567" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115391", "url": "https://www.ensembl.org/id/ENSMUSP00000115391" } ] } }, { "isoform_ac": "A2ALS3-1", "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS3-1", "sequence": { "sequence": "MSGRKRSFTFGAYGGVDKSFSLRQSVWRSDGQKQSFPQALNLLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTG", "length": 240, "header": "tr|A2ALS3-1|A2ALS3_MOUSE Computationally mapped isoform of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=8 CANONICAL=A2ALS5-1" }, "locus": { "chromosome": "4", "start_pos": 137445265, "end_pos": 137409023, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000150928", "url": "https://www.ensembl.org/id/ENSMUST00000150928" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123561", "url": "https://www.ensembl.org/id/ENSMUSP00000123561" } ] } }, { "isoform_ac": "A2ALS4-1", "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS4-1", "sequence": { "sequence": "MSGRKRSFTFGAYGGVDKSFSLRQSVWRSDGQKQSFPQALNLLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLHMAGRQREHHERGQLPSEVAPSCPPSQASHGHPTQTSASRGTLRVPRSRSNWKHLSSTHPRWAASCHLISRRD", "length": 729, "header": "tr|A2ALS4-1|A2ALS4_MOUSE Computationally mapped isoform of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=1 CANONICAL=A2ALS5-1" }, "locus": { "chromosome": "4", "start_pos": 137455872, "end_pos": 137409023, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000105835", "url": "https://www.ensembl.org/id/ENSMUST00000105835" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101461", "url": "https://www.ensembl.org/id/ENSMUSP00000101461" } ] } }, { "isoform_ac": "A2ALS5-1", "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS5-1", "sequence": { "sequence": "MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC", "length": 663, "header": "sp|A2ALS5-1|RPGP1_MOUSE Isoform 1 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1" }, "locus": {} }, { "isoform_ac": "A2ALS5-2", "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS5-2", "sequence": { "sequence": "MSGRKRSFTFGAYGGVDKSFSLRQSVWRSDGQKQSFPQALNLLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC", "length": 727, "header": "sp|A2ALS5-2|RPGP1_MOUSE Isoform 2 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1" }, "locus": { "chromosome": "4", "start_pos": 137455844, "end_pos": 137409023, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000047243", "url": "https://www.ensembl.org/id/ENSMUST00000047243" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000042473", "url": "https://www.ensembl.org/id/ENSMUSP00000042473" } ] } }, { "isoform_ac": "A2ALS5-3", "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS5-3", "sequence": { "sequence": "MAQPRPPAPHGRPRRGSLPAGAGWQNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC", "length": 694, "header": "sp|A2ALS5-3|RPGP1_MOUSE Isoform 3 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1" }, "locus": { "chromosome": "4", "start_pos": 137455844, "end_pos": 137434897, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000097837", "url": "https://www.ensembl.org/id/ENSMUST00000097837" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000095448", "url": "https://www.ensembl.org/id/ENSMUSP00000095448" } ] } }, { "isoform_ac": "A2ALS5-4", "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS5-4", "sequence": { "sequence": "MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLHMAGRQREHHERGQLPSEVAPSCPPSQASHGHPTQTSASRGTLRVPRSRSNWKHLSSTHPRWAASCHLISRRD", "length": 665, "header": "sp|A2ALS5-4|RPGP1_MOUSE Isoform 4 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1" }, "locus": {} }, { "isoform_ac": "A2ALS7-1", "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS7-1", "sequence": { "sequence": "QLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGKSASRFGRRGSALGIGAVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTP", "length": 405, "header": "tr|A2ALS7-1|A2ALS7_MOUSE Computationally mapped isoform of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=1 CANONICAL=A2ALS5-1" }, "locus": { "chromosome": "4", "start_pos": 137455668, "end_pos": 137446183, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000141306", "url": "https://www.ensembl.org/id/ENSMUST00000141306" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122315", "url": "https://www.ensembl.org/id/ENSMUSP00000122315" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 441, "end_pos": 441, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "iPTMnet", "id": "A2ALS5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 441, "end_pos": 441, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 484, "end_pos": 484, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "iPTMnet", "id": "A2ALS5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 484, "end_pos": 484, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 499, "end_pos": 499, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "iPTMnet", "id": "A2ALS5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5" }, { "database": "PubMed", "id": "19218462", "url": "https://glygen.org/publication/PubMed/19218462" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 499, "end_pos": 499, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "PubMed", "id": "19218462", "url": "https://glygen.org/publication/PubMed/19218462" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 515, "end_pos": 515, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ] }, { "start_pos": 541, "end_pos": 541, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "iPTMnet", "id": "A2ALS5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 541, "end_pos": 541, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 542, "end_pos": 542, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "iPTMnet", "id": "A2ALS5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 542, "end_pos": 542, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Klinger M, Kudlacek O, Seidel MG, Freissmuth M, Sexl V", "evidence": [ { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" }, { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" } ], "reference": [ { "type": "PubMed", "id": "12082090", "url": "https://glygen.org/publication/PubMed/12082090" } ] }, { "title": "Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1).", "journal": "Acta neuropathologica", "date": "2002", "authors": "Kehrer-Sawatzki H, Wilda M, Braun VM, Richter HP, Hameister H", "evidence": [ { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" }, { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" } ], "reference": [ { "type": "PubMed", "id": "12172908", "url": "https://glygen.org/publication/PubMed/12172908" } ] }, { "title": "Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.", "journal": "Neuron", "date": "2003", "authors": "Morozov A, Muzzio IA, Bourtchouladze R, Van-Strien N, Lapidus K, Yin D, Winder DG, Adams JP, Sweatt JD, Kandel ER", "evidence": [ { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" }, { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" } ], "reference": [ { "type": "PubMed", "id": "12873387", "url": "https://glygen.org/publication/PubMed/12873387" } ] }, { "title": "Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons.", "journal": "Brain research. Developmental brain research", "date": "2003", "authors": "Bithell A, Alberta J, Hornby F, Stiles CD, Williams BP", "evidence": [ { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" }, { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" } ], "reference": [ { "type": "PubMed", "id": "14643017", "url": "https://glygen.org/publication/PubMed/14643017" } ] }, { "title": "Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "McAvoy T, Zhou MM, Greengard P, Nairn AC", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "iPTMnet", "id": "A2ALS5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5" } ], "reference": [ { "type": "PubMed", "id": "19218462", "url": "https://glygen.org/publication/PubMed/19218462" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" }, { "database": "iPTMnet", "id": "A2ALS5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.", "journal": "The Journal of clinical investigation", "date": "2014", "authors": "Potla U, Ni J, Vadaparampil J, Yang G, Leventhal JS, Campbell KN, Chuang PY, Morozov A, He JC, D'Agati VD, Klotman PE, Kaufman L", "evidence": [ { "database": "RefSeq", "id": "NP_001074624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624" }, { "database": "RefSeq", "id": "NP_001243147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147" } ], "reference": [ { "type": "PubMed", "id": "24642466", "url": "https://glygen.org/publication/PubMed/24642466" } ] } ], "pathway": [ { "id": "mmu:110351", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110351", "resource": "KEGG Pathway" }, { "id": "R-MMU-392517", "name": "Rap1 signalling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-392517", "resource": "Reactome", "description": "Rap1 signalling" }, { "id": "R-MMU-8853659", "name": "RET signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8853659", "resource": "Reactome", "description": "RET signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LV89-1", "protein_name": "Rap1 GTPase-activating protein", "gene_name": "Rap1gap", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGRKRSFTFGAYGGVDKSFSPRQSVWRSDGQKHSFPQTLNVLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGKSASRFGRRGSALGIGAVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGMESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDAVKSGDPACPEIKIQLETSEQHTPQMGC", "length": 753 }, "evidence": [ { "id": "2163", "url": "http://www.informatics.jax.org/homology/2163", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P47736-1", "protein_name": "Rap1 GTPase-activating protein 1", "gene_name": "RAP1GAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASSFASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHPDAGKLGDPACPEIKIQLEASEQHMPQLGC", "length": 663 }, "evidence": [ { "id": "2163", "url": "http://www.informatics.jax.org/homology/2163", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "GTPase regulator activity", "id": "GO:0030695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030695", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "regulation of small GTPase mediated signal transduction", "id": "GO:0051056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "positive regulation of cell-cell adhesion", "id": "GO:0022409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022409", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "24803656" }, { "name": "negative regulation of microvillus assembly", "id": "GO:1903697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903697", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "regulation of GTPase activity", "id": "GO:0043087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043087", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "positive regulation of GTPase activity", "id": "GO:0043547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "negative regulation of neuron differentiation", "id": "GO:0045665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045665", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis", "id": "GO:0050766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050766", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "24803656" }, { "name": "activation of GTPase activity", "id": "GO:0090630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "21873635" }, { "name": "negative regulation of GTP binding", "id": "GO:1904425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904425", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "negative regulation of thyroid gland epithelial cell proliferation", "id": "GO:1904442", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904442", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "cellular response to glial cell derived neurotrophic factor", "id": "GO:1990792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990792", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "21873635" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A2ALS5", "url": "https://www.uniprot.org/uniprot/A2ALS5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 536, "end_pos": 538, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }