{ "uniprot_canonical_ac": "A2AL36-1", "uniprot_ac": "A2AL36", "uniprot_id": "CNTRL_MOUSE", "mass": { "chemical_mass": 268880.0, "monoisotopic_mass": 268880.0 }, "refseq": { "ac": "NP_036148", "name": "centriolin isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148" }, "gene_names": [ { "name": "Cntrl", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AL36", "id": "A2AL36" }, { "name": "6720467O09Rik; AA968343; b2b1468.1Clo; b2b1468Clo; Cep1; Cep110; IB3/5; Ma2a8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148", "id": "NP_036148" }, { "name": "Cep110", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AL36", "id": "A2AL36" }, { "name": "Cep1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AL36", "id": "A2AL36" }, { "name": "Cntrl", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148", "id": "NP_036148" } ], "protein_names": [ { "name": "Centriolin", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AL36#names_and_taxonomy", "id": "A2AL36" }, { "name": "Centrosomal protein 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AL36#names_and_taxonomy", "id": "A2AL36" }, { "name": "Centrosomal protein of 110 kDa", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AL36#names_and_taxonomy", "id": "A2AL36" }, { "name": "Cep110", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AL36#names_and_taxonomy", "id": "A2AL36" }, { "name": "antigen identified by monoclonal antibody 2A8; 110 kDa centrosomal protein; centrosomal protein of 110 kDa; centrosomal protein 110", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148", "id": "NP_036148" }, { "name": "centriolin isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148", "id": "NP_036148" } ], "function": [ { "annotation": "CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models", "evidence": [ { "database": "RefSeq", "id": "NP_036148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148" }, { "database": "PubMed", "id": "23777766", "url": "https://glygen.org/publication/PubMed/23777766" } ] }, { "annotation": "Centriolin depletion affects spindle size and peripheral spindle migration in oocytes.", "evidence": [ { "database": "RefSeq", "id": "NP_036148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148" }, { "database": "PubMed", "id": "28075662", "url": "https://glygen.org/publication/PubMed/28075662" } ] }, { "annotation": "Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36#function" } ] } ], "disease": [ { "disease_id": "DOID:12712", "recommended_name": { "id": "DOID:12712", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12712", "name": "nephronophthisis", "description": "A kidney disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy)." }, "synonyms": [ { "id": "DOID:12712", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12712", "name": "medullary cystic disease", "description": "" }, { "id": "DOID:12712", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12712", "name": "medullary cystic kidney", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "nephronophthisis 1", "description": "Progressive tubulointerstitial nephritis inherited in an autosomal recessive manner. It is caused by mutations in the NPHP1 gene. Patients present with anemia, polyuria, and polydipsia during childhood. The progressive bilateral kidney damage results in renal failure." }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "NPH1", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "juvenile nephronophthisis", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "familial juvenile nephronophthisis", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "nephronophthisis type 1", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "NPHP1", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "nephronophthisis 1; NPHP1", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "NPHP1 nephronophthisis (disease)", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "nephronophthisis, familial juvenile", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "juvenile nephronophthisis 1", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "nephronophthisis 1", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "Nph1", "description": "" }, { "id": "MONDO:0009728", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009728", "name": "nephronophthisis (disease) caused by mutation in NPHP1", "description": "" }, { "id": "MIM:256100", "resource": "MIM", "url": "https://www.omim.org/entry/256100", "name": "Nephronophthisis 1", "description": "Nephronophthisis 1" } ], "evidence": [ { "id": "12712", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12712" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Cntrl", "url": "https://www.uniprot.org/uniprot/A2AL36", "locus": { "chromosome": "2", "start_pos": 35109492, "end_pos": 35178822, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000057110", "url": "https://www.ensembl.org/id/ENSMUSG00000057110" } ] } } ], "crossref": [ { "id": "ENSMUSG00000057110", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000057110", "database": "Bgee" }, { "id": "26920", "url": "https://www.ncbi.nlm.nih.gov/gene/26920", "database": "GeneID" }, { "id": "A2AL36", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AL36*", "database": "IntAct" }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro" }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro" }, { "id": "IPR028640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028640", "database": "InterPro" }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro" }, { "id": "1889576", "url": "http://www.informatics.jax.org/marker/MGI:1889576", "database": "MGI" }, { "id": "QMQHEYL", "url": "https://omabrowser.org/oma/group/QMQHEYL/", "database": "OMA" }, { "id": "79816at2759", "url": "http://www.orthodb.org/?query=79816at2759", "database": "OrthoDB" }, { "id": "PTHR34491:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34491:SF2", "database": "PANTHER" }, { "id": "PR_A2AL36", "url": "http://purl.obolibrary.org/obo/PR_A2AL36", "database": "PRO" }, { "id": "R-MMU-2565942", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2565942", "database": "Reactome" }, { "id": "R-MMU-380259", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380259", "database": "Reactome" }, { "id": "R-MMU-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380270", "database": "Reactome" }, { "id": "R-MMU-380284", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380284", "database": "Reactome" }, { "id": "R-MMU-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380320", "database": "Reactome" }, { "id": "R-MMU-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5620912", "database": "Reactome" }, { "id": "R-MMU-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518", "database": "Reactome" }, { "id": "NP_036148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148", "database": "RefSeq" }, { "id": "XP_006498131", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006498131", "database": "RefSeq" }, { "id": "A0A0G2JE96", "url": "https://www.uniprot.org/uniprot/A0A0G2JE96", "database": "UniProtKB" }, { "id": "A0A0G2JE96-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JE96-1", "database": "UniProtKB" }, { "id": "A0A0G2JFA2", "url": "https://www.uniprot.org/uniprot/A0A0G2JFA2", "database": "UniProtKB" }, { "id": "A0A0G2JFA2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JFA2-1", "database": "UniProtKB" }, { "id": "A0A0J9YTY9", "url": "https://www.uniprot.org/uniprot/A0A0J9YTY9", "database": "UniProtKB" }, { "id": "A0A0J9YTY9-1", "url": "https://www.uniprot.org/uniprot/A0A0J9YTY9-1", "database": "UniProtKB" }, { "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36", "database": "UniProtKB" }, { "id": "A2AL36-1", "url": "https://www.uniprot.org/uniprot/A2AL36-1", "database": "UniProtKB" }, { "id": "A2AL36-2", "url": "https://www.uniprot.org/uniprot/A2AL36-2", "database": "UniProtKB" }, { "id": "A2AS42", "url": "https://www.uniprot.org/uniprot/A2AS42", "database": "UniProtKB" }, { "id": "A2AS42-1", "url": "https://www.uniprot.org/uniprot/A2AS42-1", "database": "UniProtKB" }, { "id": "E9Q9E7", "url": "https://www.uniprot.org/uniprot/E9Q9E7", "database": "UniProtKB" }, { "id": "E9Q9E7-1", "url": "https://www.uniprot.org/uniprot/E9Q9E7-1", "database": "UniProtKB" }, { "id": "F6QP53", "url": "https://www.uniprot.org/uniprot/F6QP53", "database": "UniProtKB" }, { "id": "F6QP53-1", "url": "https://www.uniprot.org/uniprot/F6QP53-1", "database": "UniProtKB" }, { "id": "R4GML3", "url": "https://www.uniprot.org/uniprot/R4GML3", "database": "UniProtKB" }, { "id": "R4GML3-1", "url": "https://www.uniprot.org/uniprot/R4GML3-1", "database": "UniProtKB" }, { "id": "R4GML4", "url": "https://www.uniprot.org/uniprot/R4GML4", "database": "UniProtKB" }, { "id": "R4GML4-1", "url": "https://www.uniprot.org/uniprot/R4GML4-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH", "length": 2334, "header": "sp|A2AL36-1|CNTRL_MOUSE Isoform 1 of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JE96-1", "url": "https://www.uniprot.org/uniprot/A2AL36#A0A0G2JE96-1", "sequence": { "sequence": "MKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVN", "length": 139, "header": "tr|A0A0G2JE96-1|A0A0G2JE96_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=4 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35027691, "end_pos": 35023976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000150807", "url": "https://www.ensembl.org/id/ENSMUST00000150807" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000142683", "url": "https://www.ensembl.org/id/ENSMUSP00000142683" } ] } }, { "isoform_ac": "A0A0G2JFA2-1", "url": "https://www.uniprot.org/uniprot/A2AL36#A0A0G2JFA2-1", "sequence": { "sequence": "DAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEE", "length": 71, "header": "tr|A0A0G2JFA2-1|A0A0G2JFA2_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=1 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35051941, "end_pos": 35050320, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000124081", "url": "https://www.ensembl.org/id/ENSMUST00000124081" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143087", "url": "https://www.ensembl.org/id/ENSMUSP00000143087" } ] } }, { "isoform_ac": "A0A0J9YTY9-1", "url": "https://www.uniprot.org/uniprot/A2AL36#A0A0J9YTY9-1", "sequence": { "sequence": "QLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEVGTQVSQDVLISTVSE", "length": 122, "header": "tr|A0A0J9YTY9-1|A0A0J9YTY9_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=1 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35037471, "end_pos": 35035108, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000201787", "url": "https://www.ensembl.org/id/ENSMUST00000201787" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143914", "url": "https://www.ensembl.org/id/ENSMUSP00000143914" } ] } }, { "isoform_ac": "A2AL36-1", "url": "https://www.uniprot.org/uniprot/A2AL36#A2AL36-1", "sequence": { "sequence": "MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH", "length": 2334, "header": "sp|A2AL36-1|CNTRL_MOUSE Isoform 1 of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35068104, "end_pos": 35001598, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000028237", "url": "https://www.ensembl.org/id/ENSMUST00000028237" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000028237", "url": "https://www.ensembl.org/id/ENSMUSP00000028237" } ] } }, { "isoform_ac": "A2AL36-2", "url": "https://www.uniprot.org/uniprot/A2AL36#A2AL36-2", "sequence": { "sequence": "MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHVSKMGNLD", "length": 559, "header": "sp|A2AL36-2|CNTRL_MOUSE Isoform 2 of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35019851, "end_pos": 35001598, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000028235", "url": "https://www.ensembl.org/id/ENSMUST00000028235" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000028235", "url": "https://www.ensembl.org/id/ENSMUSP00000028235" } ] } }, { "isoform_ac": "A2AS42-1", "url": "https://www.uniprot.org/uniprot/A2AL36#A2AS42-1", "sequence": { "sequence": "MKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEVGTQVSQDVLISTVSE", "length": 481, "header": "tr|A2AS42-1|A2AS42_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=1 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35037471, "end_pos": 35023976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113033", "url": "https://www.ensembl.org/id/ENSMUST00000113033" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000108656", "url": "https://www.ensembl.org/id/ENSMUSP00000108656" } ] } }, { "isoform_ac": "E9Q9E7-1", "url": "https://www.uniprot.org/uniprot/A2AL36#E9Q9E7-1", "sequence": { "sequence": "MKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH", "length": 1780, "header": "tr|E9Q9E7-1|E9Q9E7_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35068104, "end_pos": 35023976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113037", "url": "https://www.ensembl.org/id/ENSMUST00000113037" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000108660", "url": "https://www.ensembl.org/id/ENSMUSP00000108660" } ] } }, { "isoform_ac": "F6QP53-1", "url": "https://www.uniprot.org/uniprot/A2AL36#F6QP53-1", "sequence": { "sequence": "XETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEVGTQVSQDVLISTVSE", "length": 635, "header": "tr|F6QP53-1|F6QP53_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=1 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35037472, "end_pos": 35017393, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000123884", "url": "https://www.ensembl.org/id/ENSMUST00000123884" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119760", "url": "https://www.ensembl.org/id/ENSMUSP00000119760" } ] } }, { "isoform_ac": "R4GML3-1", "url": "https://www.uniprot.org/uniprot/A2AL36#R4GML3-1", "sequence": { "sequence": "MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH", "length": 2333, "header": "tr|R4GML3-1|R4GML3_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35068104, "end_pos": 35001598, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113032", "url": "https://www.ensembl.org/id/ENSMUST00000113032" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000108655", "url": "https://www.ensembl.org/id/ENSMUSP00000108655" } ] } }, { "isoform_ac": "R4GML4-1", "url": "https://www.uniprot.org/uniprot/A2AL36#R4GML4-1", "sequence": { "sequence": "MKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLN", "length": 987, "header": "tr|R4GML4-1|R4GML4_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1" }, "locus": { "chromosome": "2", "start_pos": 35050647, "end_pos": 35023976, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113034", "url": "https://www.ensembl.org/id/ENSMUST00000113034" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000108657", "url": "https://www.ensembl.org/id/ENSMUSP00000108657" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1478, "end_pos": 1478, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ] }, { "start_pos": 832, "end_pos": 832, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" }, { "database": "iPTMnet", "id": "A2AL36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AL36" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 832, "end_pos": 832, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33).", "journal": "Blood", "date": "2000", "authors": "Rattner J.B., Birnbaum D., Dastugue N., Guasch G., Mack G.J., Pebusque M.-J., Popovici C.", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "reference": [ { "type": "PubMed", "id": "10688839", "url": "https://glygen.org/publication/PubMed/10688839" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" }, { "database": "iPTMnet", "id": "A2AL36", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AL36" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.", "journal": "Blood", "date": "2013", "authors": "Ren M, Qin H, Kitamura E, Cowell JK", "evidence": [ { "database": "RefSeq", "id": "NP_036148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148" } ], "reference": [ { "type": "PubMed", "id": "23777766", "url": "https://glygen.org/publication/PubMed/23777766" } ] }, { "title": "Centriolin, a centriole-appendage protein, regulates peripheral spindle migration and asymmetric division in mouse meiotic oocytes.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2017", "authors": "Sun TY, Wang HY, Kwon JW, Yuan B, Lee IW, Cui XS, Kim NH", "evidence": [ { "database": "RefSeq", "id": "NP_036148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148" } ], "reference": [ { "type": "PubMed", "id": "28075662", "url": "https://glygen.org/publication/PubMed/28075662" } ] } ], "pathway": [ { "id": "R-MMU-2565942", "name": "Regulation of PLK1 Activity at G2/M Transition", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-MMU-380259", "name": "Loss of Nlp from mitotic centrosomes", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-MMU-380270", "name": "Recruitment of mitotic centrosome proteins and complexes", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-MMU-380284", "name": "Loss of proteins required for interphase microtubule organization from the centrosome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-MMU-380320", "name": "Recruitment of NuMA to mitotic centrosomes", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-MMU-5620912", "name": "Anchoring of the basal body to the plasma membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-MMU-8854518", "name": "AURKA Activation by TPX2", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A619-1", "protein_name": "Centriolin", "gene_name": "Cntrl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 2336 }, "evidence": [ { "id": "38260", "url": "http://www.informatics.jax.org/homology/38260", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z7A1-1", "protein_name": "Centriolin", "gene_name": "CNTRL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRRGYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYWVYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGMALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR", "length": 2325 }, "evidence": [ { "id": "38260", "url": "http://www.informatics.jax.org/homology/38260", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "" }, { "name": "meiotic spindle pole", "id": "GO:0090619", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090619", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "28075662" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "8982254" }, { "name": "Flemming body", "id": "GO:0090543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090543", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "" }, { "name": "meiotic spindle", "id": "GO:0072687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072687", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "28075662" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "25220058" }, { "name": "centriolar subdistal appendage", "id": "GO:0120103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120103", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytoskeletal protein binding", "id": "GO:0008092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of cytoskeleton organization", "id": "GO:0051493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051493", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "27002738" }, { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "" }, { "name": "ventricular septum development", "id": "GO:0003281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003281", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "25807483" }, { "name": "aorta development", "id": "GO:0035904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035904", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "25807483" }, { "name": "coronary vasculature development", "id": "GO:0060976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060976", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "25807483" }, { "name": "cardiac septum development", "id": "GO:0003279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003279", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "25807483" }, { "name": "female germ-line stem cell asymmetric division", "id": "GO:0048132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048132", "evidence": [ { "database": "UniProtKB", "id": "A2AL36", "url": "https://www.uniprot.org/uniprot/A2AL36" } ], "pmid": "28075662" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1101, "end_pos": 1103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1274, "end_pos": 1276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }