{ "uniprot_canonical_ac": "A2AKM2-1", "uniprot_ac": "A2AKM2", "uniprot_id": "HACD4_MOUSE", "mass": { "chemical_mass": 27235.0, "monoisotopic_mass": 27235.0 }, "refseq": { "ac": "NP_080036", "name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080036" }, "gene_names": [ { "name": "Hacd4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AKM2", "id": "A2AKM2" }, { "name": "4933428I03Rik; Hcad4; Ptplad2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080036", "id": "NP_080036" }, { "name": "Hacd4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080036", "id": "NP_080036" }, { "name": "Hcad4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AKM2", "id": "A2AKM2" }, { "name": "Ptplad2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AKM2", "id": "A2AKM2" } ], "protein_names": [ { "name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AKM2#names_and_taxonomy", "id": "A2AKM2" }, { "name": "3-hydroxyacyl-CoA dehydratase 4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AKM2#names_and_taxonomy", "id": "A2AKM2" }, { "name": "4.2.1.134", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AKM2#names_and_taxonomy", "id": "A2AKM2" }, { "name": "HACD4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AKM2#names_and_taxonomy", "id": "A2AKM2" }, { "name": "Protein-tyrosine phosphatase-like A domain-containing protein 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AKM2#names_and_taxonomy", "id": "A2AKM2" }, { "name": "protein tyrosine phosphatase-like protein PTPLAD2; protein-tyrosine phosphatase-like A domain-containing protein 2; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; protein tyrosine phosphatase-like A domain containing 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080036", "id": "NP_080036" }, { "name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080036", "id": "NP_080036" } ], "function": [ { "annotation": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.", "evidence": [ { "database": "UniProtKB", "id": "Z4YMP4", "url": "https://www.uniprot.org/uniprot/Z4YMP4#function" }, { "database": "PubMed", "id": "RU363109", "url": "https://glygen.org/publication/PubMed/RU363109" }, { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2#function" }, { "database": "PubMed", "id": "Q5VWC8", "url": "https://glygen.org/publication/PubMed/Q5VWC8" }, { "database": "UniProtKB", "id": "F7CPS1", "url": "https://www.uniprot.org/uniprot/F7CPS1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Hacd4", "url": "https://www.uniprot.org/uniprot/A2AKM2", "locus": { "chromosome": "4", "start_pos": 88438928, "end_pos": 88396144, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000028497", "url": "https://www.ensembl.org/id/ENSMUSG00000028497" } ] } } ], "crossref": [ { "id": "ENSMUSG00000028497", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028497", "database": "Bgee" }, { "id": "66775", "url": "https://www.ncbi.nlm.nih.gov/gene/66775", "database": "GeneID" }, { "id": "IPR007482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007482", "database": "InterPro" }, { "id": "mmu:66775", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66775", "database": "KEGG Pathway" }, { "id": "1914025", "url": "http://www.informatics.jax.org/marker/MGI:1914025", "database": "MGI" }, { "id": "1458293at2759", "url": "http://www.orthodb.org/?query=1458293at2759", "database": "OrthoDB" }, { "id": "PTHR11035", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11035", "database": "PANTHER" }, { "id": "PF04387", "url": "http://pfam.xfam.org/family/PF04387", "database": "Pfam" }, { "id": "PR_A2AKM2", "url": "http://purl.obolibrary.org/obo/PR_A2AKM2", "database": "PRO" }, { "id": "R-MMU-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75876", "database": "Reactome" }, { "id": "NP_080036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080036", "database": "RefSeq" }, { "id": "39159", "url": "https://www.rhea-db.org/rhea/39159", "database": "Rhea" }, { "id": "45812", "url": "https://www.rhea-db.org/rhea/45812", "database": "Rhea" }, { "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2", "database": "UniProtKB" }, { "id": "A2AKM2-1", "url": "https://www.uniprot.org/uniprot/A2AKM2-1", "database": "UniProtKB" }, { "id": "A2AKM2-2", "url": "https://www.uniprot.org/uniprot/A2AKM2-2", "database": "UniProtKB" }, { "id": "F7CPS1", "url": "https://www.uniprot.org/uniprot/F7CPS1", "database": "UniProtKB" }, { "id": "F7CPS1-1", "url": "https://www.uniprot.org/uniprot/F7CPS1-1", "database": "UniProtKB" }, { "id": "Z4YMP4", "url": "https://www.uniprot.org/uniprot/Z4YMP4", "database": "UniProtKB" }, { "id": "Z4YMP4-1", "url": "https://www.uniprot.org/uniprot/Z4YMP4-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MGPSVLPAWLQPRYRKNVYLFIYYLIQFCGHSWILANMTVRFFSFGKDSMADTFYAIGLVMRVCQSISLLELLHIYIGIESNQLFPRFLQLTERVIILFGVITSQEEVQEKCVVCVLFILWNLLDMVRYTYSMLSVIGTSYAALTWLSQTLWMPIYPLCVLAEAFTIYQSLPYFESFGTNSTVLPFDLSTCFPYVLKLYLMMLFIGMYFTYSHLYTERKDFLRVFSVKQKNV", "length": 232, "header": "sp|A2AKM2-1|HACD4_MOUSE Isoform 1 of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 OS=Mus musculus OX=10090 GN=Hacd4 PE=2 SV=2 CANONICAL=A2AKM2-1" }, "isoforms": [ { "isoform_ac": "A2AKM2-1", "url": "https://www.uniprot.org/uniprot/A2AKM2#A2AKM2-1", "sequence": { "sequence": "MGPSVLPAWLQPRYRKNVYLFIYYLIQFCGHSWILANMTVRFFSFGKDSMADTFYAIGLVMRVCQSISLLELLHIYIGIESNQLFPRFLQLTERVIILFGVITSQEEVQEKCVVCVLFILWNLLDMVRYTYSMLSVIGTSYAALTWLSQTLWMPIYPLCVLAEAFTIYQSLPYFESFGTNSTVLPFDLSTCFPYVLKLYLMMLFIGMYFTYSHLYTERKDFLRVFSVKQKNV", "length": 232, "header": "sp|A2AKM2-1|HACD4_MOUSE Isoform 1 of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 OS=Mus musculus OX=10090 GN=Hacd4 PE=2 SV=2 CANONICAL=A2AKM2-1" }, "locus": { "chromosome": "4", "start_pos": 88357107, "end_pos": 88332504, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000030221", "url": "https://www.ensembl.org/id/ENSMUST00000030221" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000030221", "url": "https://www.ensembl.org/id/ENSMUSP00000030221" } ] } }, { "isoform_ac": "A2AKM2-2", "url": "https://www.uniprot.org/uniprot/A2AKM2#A2AKM2-2", "sequence": { "sequence": "MGPSVLPAWLQPRYRKNVYLFIYYLIQFCGHSWILANMTVRFFSFGKDSMADTFYAIGLVMRVCQSISLLELLHIYIGIESNQLFPRFLQLTERVIILFGVITSQEEVQEKCVVCVLFILWNLLDMVRYTYSMLSVIGTSYAALTWLSQTLWMPIYPLCVLAEAFTIYQSLPYFESFGTNSTVLPFDLSTCFPYVLKLYLMMLFIGNAKMFLIKCKKLCLKVFHSPIHLLHVLNTGHTTRPTTRPDI", "length": 247, "header": "sp|A2AKM2-2|HACD4_MOUSE Isoform 2 of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 OS=Mus musculus OX=10090 GN=Hacd4 PE=2 SV=2 CANONICAL=A2AKM2-1" }, "locus": {} }, { "isoform_ac": "F7CPS1-1", "url": "https://www.uniprot.org/uniprot/A2AKM2#F7CPS1-1", "sequence": { "sequence": "XLSQPTPAASRRCQRSRLWPMGPSVLPAWLQPRYRKNVYLFIYYLIQFCGHSWILANMTVRFFSFGKDSMADTFYAIGLVMRVCQSISLLELLHIYIGIESNQLFPRFLQLTERVIILFGVITSQEEVQEKCVVCVLFILWNLLDMVRYTYSMLSVIGTSYAALTWLSQTLWMPIYPLCVLAEAFTIYQSLPYFESFGTNSTVLPFDLSTCFPYVLKLYLMMLFIGMYFTYSHLYTERKDFLRVFSVKQKNV", "length": 252, "header": "tr|F7CPS1-1|HACD4_MOUSE Computationally mapped isoform of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 OS=Mus musculus OX=10090 GN=Hacd4 PE=2 SV=1 CANONICAL=A2AKM2-1" }, "locus": { "chromosome": "4", "start_pos": 88357165, "end_pos": 88332502, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000151280", "url": "https://www.ensembl.org/id/ENSMUST00000151280" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122565", "url": "https://www.ensembl.org/id/ENSMUSP00000122565" } ] } }, { "isoform_ac": "Z4YMP4-1", "url": "https://www.uniprot.org/uniprot/A2AKM2#Z4YMP4-1", "sequence": { "sequence": "TPAASRRCQRSRLWPMGPSVLPAWLQPRYRKNVYLFIYYLIQFCGHSWILANMTVRFFSFGKDSMADTFYAIGLVMRVCQSISLLELLHIYIGIESNQLFPRFLQLTERVIILFGVITSQEEVQEKCVVCVLFILWNLLDMVRYTYSMLSVIGTSYAALTWLSQTLWMPIYPLCVLAEAFTIYQSLPYFESFGTNSTVLPFDLSTCFPYVLKLYLMMLFIGNAKMFLIKCKKLCLKVFHSPIHLLHVLNTGHTTRPTTRPDI", "length": 262, "header": "tr|Z4YMP4-1|HACD4_MOUSE Computationally mapped isoform of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 OS=Mus musculus OX=10090 GN=Hacd4 PE=2 SV=1 CANONICAL=A2AKM2-1" }, "locus": { "chromosome": "4", "start_pos": 88357152, "end_pos": 88316332, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000132493", "url": "https://www.ensembl.org/id/ENSMUST00000132493" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119411", "url": "https://www.ensembl.org/id/ENSMUSP00000119411" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "mmu:66775", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66775", "resource": "KEGG Pathway" }, { "id": "R-MMU-75876", "name": "Synthesis of very long-chain fatty acyl-CoAs", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-75876", "resource": "Reactome", "description": "Synthesis of very long-chain fatty acyl-CoAs" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z8V6-1", "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "gene_name": "Hacd4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGPSVLPAWLQPRYRKSAYLFIYYLIQFCGHSWILTNMTVRFFSFGKDSMVDTFYAIGLVMRVCQSISLLELLHIYIGIESNQLFPKFLQLTERIIILFGVITSQEEVQEKYVVCVLFIFWNLLDMVRYTYSMLSVIGTSYAVLTWLSQTLWMPIYPLCVLAEAFTIYQSLPYFELFGKNSTMLPFDISTYFPYVLKLYLMMLFIGMYFTYSHLYTERKDILRGSSVKQKKM", "length": 232 }, "evidence": [ { "id": "12033", "url": "http://www.informatics.jax.org/homology/12033", "database": "MGI" }, { "id": "A2AKM2", "url": "https://omabrowser.org/oma/group/A2AKM2/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VWC8-1", "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4", "gene_name": "HACD4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPLALPAWLQPRYRKNAYLFIYYLIQFCGHSWIFTNMTVRFFSFGKDSMVDTFYAIGLVMRLCQSVSLLELLHIYVGIESNHLLPRFLQLTERIIILFVVITSQEEVQEKYVVCVLFVFWNLLDMVRYTYSMLSVIGISYAVLTWLSQTLWMPIYPLCVLAEAFAIYQSLPYFESFGTYSTKLPFDLSIYFPYVLKIYLMMLFIGMYFTYSHLYSERRDILGIFPIKKKKM", "length": 232 }, "evidence": [ { "id": "12033", "url": "http://www.informatics.jax.org/homology/12033", "database": "MGI" }, { "id": "A2AKM2", "url": "https://omabrowser.org/oma/group/A2AKM2/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "integral component of endoplasmic reticulum membrane", "id": "GO:0030176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030176", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "21873635" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "fatty acid elongation", "id": "GO:0030497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030497", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "very long-chain fatty acid biosynthetic process", "id": "GO:0042761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042761", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "sphingolipid biosynthetic process", "id": "GO:0030148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030148", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "21873635" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "very-long-chain 3-hydroxyacyl-CoA dehydratase activity", "id": "GO:0102158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102158", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "3-hydroxy-arachidoyl-CoA dehydratase activity", "id": "GO:0102343", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102343", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "3-hydroxy-behenoyl-CoA dehydratase activity", "id": "GO:0102344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102344", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "3-hydroxy-lignoceroyl-CoA dehydratase activity", "id": "GO:0102345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102345", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" }, { "name": "3-hydroxyacyl-CoA dehydratase activity", "id": "GO:0018812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018812", "evidence": [ { "database": "UniProtKB", "id": "A2AKM2", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "39159", "name": "", "equation": "(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LSK3-1", "P97852-1", "D3Z8V6-1", "D4ABI7-1", "D3ZHG0-1", "P51659-1", "Q5VWC8-1", "B0YJ81-1", "Q6Y1H2-1", "Q9P035-1", "P51660-1", "A2AKM2-1", "Q9QY80-1", "Q9D3B1-1", "Q8K2C9-1" ], "evidence": [ { "id": "39159", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39159" } ] }, { "id": "45812", "name": "", "equation": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LSK3-1", "D3ZHG0-1", "D3Z8V6-1", "D4ABI7-1", "B0YJ81-1", "Q6Y1H2-1", "Q5VWC8-1", "Q9P035-1", "A2AKM2-1", "Q9QY80-1", "Q9D3B1-1", "Q8K2C9-1", "Q9VKD2-1", "Q9VJX8-1" ], "evidence": [ { "id": "45812", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45812" } ] }, { "id": "R-MMU-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-5676631" ], "output_participant_list": [ "R-ALL-5676634" ], "enzyme_list": [ "Q8K2C9-1", "A2AKM2-1", "Q9QY80-1", "Q9D3B1-1" ], "evidence": [ { "id": "R-MMU-5676637", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5676637" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5676631", "participant_name": "VLC3HA-CoA [cytosol]", "crossref": [ { "id": "15456", "database": "ChEBI", "url": "" }, { "id": "C01086", "database": "COMPOUND", "url": "" }, { "id": "15456", "database": "ChEBI", "url": "" }, { "id": "C01086", "database": "COMPOUND", "url": "" }, { "id": "15456", "database": "ChEBI", "url": "" }, { "id": "C01086", "database": "COMPOUND", "url": "" }, { "id": "15456", "database": "ChEBI", "url": "" }, { "id": "C01086", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-5676634", "participant_name": "2,3-TE-CoA [cytosol]", "crossref": [ { "id": "C02609", "database": "COMPOUND", "url": "" }, { "id": "50998", "database": "ChEBI", "url": "" }, { "id": "C02609", "database": "COMPOUND", "url": "" }, { "id": "50998", "database": "ChEBI", "url": "" }, { "id": "C02609", "database": "COMPOUND", "url": "" }, { "id": "50998", "database": "ChEBI", "url": "" }, { "id": "C02609", "database": "COMPOUND", "url": "" }, { "id": "50998", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A2AKM2", "gene_name": "Hacd4", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "A2AKM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "A2AKM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AKM2" } ] } ] }, { "uniprot_ac": "B0YJ81", "gene_name": "HACD1", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "B0YJ81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0YJ81" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "B0YJ81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0YJ81" } ] } ] }, { "uniprot_ac": "D3Z8V6", "gene_name": "Hacd4", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "D3Z8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8V6" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "D3Z8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8V6" } ] } ] }, { "uniprot_ac": "D3ZHG0", "gene_name": "Hacd2", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "D3ZHG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHG0" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "D3ZHG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHG0" } ] } ] }, { "uniprot_ac": "D4ABI7", "gene_name": "Hacd3", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "D4ABI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABI7" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "D4ABI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABI7" } ] } ] }, { "uniprot_ac": "F1LSK3", "gene_name": "Hacd1", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "F1LSK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSK3" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "F1LSK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSK3" } ] } ] }, { "uniprot_ac": "P51659", "gene_name": "HSD17B4", "activity": [ { "ec_number": "1.1.1.n12", "activity": "(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.", "evidence": [ { "id": "P51659", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51659" } ] }, { "ec_number": "4.2.1.107", "activity": "(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O.", "evidence": [ { "id": "P51659", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51659" } ] }, { "ec_number": "4.2.1.119", "activity": "(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.", "evidence": [ { "id": "P51659", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51659" } ] } ] }, { "uniprot_ac": "P51660", "gene_name": "Hsd17b4", "activity": [ { "ec_number": "1.1.1.n12", "activity": "(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.", "evidence": [ { "id": "P51660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51660" } ] }, { "ec_number": "4.2.1.107", "activity": "(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O.", "evidence": [ { "id": "P51660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51660" } ] }, { "ec_number": "4.2.1.119", "activity": "(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.", "evidence": [ { "id": "P51660", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51660" } ] } ] }, { "uniprot_ac": "P97852", "gene_name": "Hsd17b4", "activity": [ { "ec_number": "1.1.1.n12", "activity": "(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.", "evidence": [ { "id": "P97852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97852" } ] }, { "ec_number": "4.2.1.107", "activity": "(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O.", "evidence": [ { "id": "P97852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97852" } ] }, { "ec_number": "4.2.1.119", "activity": "(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.", "evidence": [ { "id": "P97852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97852" } ] } ] }, { "uniprot_ac": "Q5VWC8", "gene_name": "HACD4", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "Q5VWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VWC8" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "Q5VWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VWC8" } ] } ] }, { "uniprot_ac": "Q6Y1H2", "gene_name": "HACD2", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "Q6Y1H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Y1H2" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "Q6Y1H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Y1H2" } ] } ] }, { "uniprot_ac": "Q8K2C9", "gene_name": "Hacd3", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "Q8K2C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2C9" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "Q8K2C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2C9" } ] } ] }, { "uniprot_ac": "Q9D3B1", "gene_name": "Hacd2", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "Q9D3B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D3B1" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "Q9D3B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D3B1" } ] } ] }, { "uniprot_ac": "Q9P035", "gene_name": "HACD3", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "Q9P035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P035" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "Q9P035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P035" } ] } ] }, { "uniprot_ac": "Q9QY80", "gene_name": "Hacd1", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "Q9QY80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QY80" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "Q9QY80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QY80" } ] } ] }, { "uniprot_ac": "Q9VJX8", "gene_name": "Hacd2", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "Q9VJX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJX8" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "Q9VJX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJX8" } ] } ] }, { "uniprot_ac": "Q9VKD2", "gene_name": "Hacd1", "activity": [ { "ec_number": "4.2.1.134", "activity": "A very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H(2)O.", "evidence": [ { "id": "Q9VKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VKD2" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "Q9VKD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VKD2" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }