{
    "uniprot_canonical_ac": "A2AJB7-1",
    "uniprot_ac": "A2AJB7",
    "uniprot_id": "LCN5_MOUSE",
    "mass": {
        "chemical_mass": 21013.0,
        "monoisotopic_mass": 21013.0
    },
    "refseq": {
        "ac": "NP_001036095",
        "name": "epididymal-specific lipocalin-5 isoform b precursor",
        "summary": "This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095"
    },
    "gene_names": [
        {
            "name": "Lcn5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AJB7",
            "id": "A2AJB7"
        },
        {
            "name": "E-RABP; Erabp; MEP10",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095",
            "id": "NP_001036095"
        },
        {
            "name": "Lcn5",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095",
            "id": "NP_001036095"
        },
        {
            "name": "Mep10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJB7",
            "id": "A2AJB7"
        }
    ],
    "protein_names": [
        {
            "name": "Epididymal-specific lipocalin-5",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#names_and_taxonomy",
            "id": "A2AJB7"
        },
        {
            "name": "E-RABP",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#names_and_taxonomy",
            "id": "A2AJB7"
        },
        {
            "name": "Epididymal retinoic acid-binding protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#names_and_taxonomy",
            "id": "A2AJB7"
        },
        {
            "name": "Epididymal secretory protein 10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#names_and_taxonomy",
            "id": "A2AJB7"
        },
        {
            "name": "MEP 10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#names_and_taxonomy",
            "id": "A2AJB7"
        },
        {
            "name": "epididymal-specific lipocalin-5 isoform b precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095",
            "id": "NP_001036095"
        },
        {
            "name": "epididymal-specific lipocalin-5; epididymal retinoic acid binding protein; epididymal secretory protein 10",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095",
            "id": "NP_001036095"
        },
        {
            "name": "mE-RABP",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#names_and_taxonomy",
            "id": "A2AJB7"
        }
    ],
    "function": [
        {
            "annotation": "Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJB7",
                    "url": "https://www.uniprot.org/uniprot/A2AJB7#function"
                },
                {
                    "database": "PubMed",
                    "id": "1591332",
                    "url": "https://glygen.org/publication/PubMed/1591332"
                },
                {
                    "database": "PubMed",
                    "id": "1591333",
                    "url": "https://glygen.org/publication/PubMed/1591333"
                }
            ]
        },
        {
            "annotation": "Forkhead box A2 restricts androgen-regulated gene expression of lipocalin 5 in the mouse epididymis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001036095",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095"
                },
                {
                    "database": "PubMed",
                    "id": "16740652",
                    "url": "https://glygen.org/publication/PubMed/16740652"
                }
            ]
        },
        {
            "annotation": "This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001036095",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJB7",
                    "url": "https://www.uniprot.org/uniprot/A2AJB7"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Lcn5",
            "url": "https://www.uniprot.org/uniprot/A2AJB7",
            "locus": {
                "chromosome": "2",
                "start_pos": 25657952,
                "end_pos": 25661977,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000026937",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000026937"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000026937",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026937",
            "database": "Bgee"
        },
        {
            "id": "13863",
            "url": "https://www.ncbi.nlm.nih.gov/gene/13863",
            "database": "GeneID"
        },
        {
            "id": "IPR000566",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000566",
            "database": "InterPro"
        },
        {
            "id": "IPR002345",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002345",
            "database": "InterPro"
        },
        {
            "id": "IPR012674",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674",
            "database": "InterPro"
        },
        {
            "id": "IPR022272",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR022272",
            "database": "InterPro"
        },
        {
            "id": "mmu:13863",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13863",
            "database": "KEGG Pathway"
        },
        {
            "id": "1277241",
            "url": "http://www.informatics.jax.org/marker/MGI:1277241",
            "database": "MGI"
        },
        {
            "id": "KDLTCVN",
            "url": "https://omabrowser.org/oma/group/KDLTCVN/",
            "database": "OMA"
        },
        {
            "id": "1291941at2759",
            "url": "http://www.orthodb.org/?query=1291941at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR11430",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430",
            "database": "PANTHER"
        },
        {
            "id": "PF00061",
            "url": "http://pfam.xfam.org/family/PF00061",
            "database": "Pfam"
        },
        {
            "id": "PR_A2AJB7",
            "url": "http://purl.obolibrary.org/obo/PR_A2AJB7",
            "database": "PRO"
        },
        {
            "id": "NP_001036095",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095",
            "database": "RefSeq"
        },
        {
            "id": "A2AJB7",
            "url": "https://www.uniprot.org/uniprot/A2AJB7",
            "database": "UniProtKB"
        },
        {
            "id": "A2AJB7-1",
            "url": "https://www.uniprot.org/uniprot/A2AJB7-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2AJB7-2",
            "url": "https://www.uniprot.org/uniprot/A2AJB7-2",
            "database": "UniProtKB"
        },
        {
            "id": "A2AJB7-3",
            "url": "https://www.uniprot.org/uniprot/A2AJB7-3",
            "database": "UniProtKB"
        },
        {
            "id": "A2AJB7-4",
            "url": "https://www.uniprot.org/uniprot/A2AJB7-4",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDLTCVNALQSGQI",
        "length": 192,
        "header": "sp|A2AJB7-1|LCN5_MOUSE Isoform 1 of Epididymal-specific lipocalin-5  OS=Mus musculus OX=10090 GN=Lcn5 PE=1 SV=1 CANONICAL=A2AJB7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AJB7-1",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#A2AJB7-1",
            "sequence": {
                "sequence": "MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDLTCVNALQSGQI",
                "length": 192,
                "header": "sp|A2AJB7-1|LCN5_MOUSE Isoform 1 of Epididymal-specific lipocalin-5  OS=Mus musculus OX=10090 GN=Lcn5 PE=1 SV=1 CANONICAL=A2AJB7-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 25551563,
                "end_pos": 25547993,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000028306",
                        "url": "https://www.ensembl.org/id/ENSMUST00000028306"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000028306",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000028306"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AJB7-2",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#A2AJB7-2",
            "sequence": {
                "sequence": "MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDYIEIKALPKPGS",
                "length": 192,
                "header": "sp|A2AJB7-2|LCN5_MOUSE Isoform 2 of Epididymal-specific lipocalin-5  OS=Mus musculus OX=10090 GN=Lcn5 PE=1 SV=1 CANONICAL=A2AJB7-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 25551458,
                "end_pos": 25547993,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000100312",
                        "url": "https://www.ensembl.org/id/ENSMUST00000100312"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000097887",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000097887"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AJB7-3",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#A2AJB7-3",
            "sequence": {
                "sequence": "MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHD",
                "length": 180,
                "header": "sp|A2AJB7-3|LCN5_MOUSE Isoform 3 of Epididymal-specific lipocalin-5  OS=Mus musculus OX=10090 GN=Lcn5 PE=1 SV=1 CANONICAL=A2AJB7-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 25551008,
                "end_pos": 25547993,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000100313",
                        "url": "https://www.ensembl.org/id/ENSMUST00000100313"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000097888",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000097888"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AJB7-4",
            "url": "https://www.uniprot.org/uniprot/A2AJB7#A2AJB7-4",
            "sequence": {
                "sequence": "MAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDLTCVNALQSGQI",
                "length": 164,
                "header": "sp|A2AJB7-4|LCN5_MOUSE Isoform 4 of Epididymal-specific lipocalin-5  OS=Mus musculus OX=10090 GN=Lcn5 PE=1 SV=1 CANONICAL=A2AJB7-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry.",
            "journal": "Proteomics",
            "date": "2003",
            "authors": "Caprioli R.M., Orgebin-Crist M.-C., Chaurand P., DaGue B.B., Fouchecourt S., Reyzer M.L., Xu B.J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJB7",
                    "url": "https://www.uniprot.org/uniprot/A2AJB7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "14595821",
                    "url": "https://glygen.org/publication/PubMed/14595821"
                }
            ]
        },
        {
            "title": "Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis.",
            "journal": "Biol. Reprod.",
            "date": "1992",
            "authors": "Griswold M.D., Orgebin-Crist M.-C., Holland M.K., Rankin T.L., Tsuruta K.J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJB7",
                    "url": "https://www.uniprot.org/uniprot/A2AJB7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1591332",
                    "url": "https://glygen.org/publication/PubMed/1591332"
                }
            ]
        },
        {
            "title": "The 18-kDa mouse epididymal protein (MEP 10) binds retinoic acid.",
            "journal": "Biol. Reprod.",
            "date": "1992",
            "authors": "Orgebin-Crist M.-C., Ong D.E., Rankin T.L.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJB7",
                    "url": "https://www.uniprot.org/uniprot/A2AJB7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "1591333",
                    "url": "https://glygen.org/publication/PubMed/1591333"
                }
            ]
        },
        {
            "title": "The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis.",
            "journal": "Molecular endocrinology (Baltimore, Md.)",
            "date": "2006",
            "authors": "Yu X, Suzuki K, Wang Y, Gupta A, Jin R, Orgebin-Crist MC, Matusik R",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001036095",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036095"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16740652",
                    "url": "https://glygen.org/publication/PubMed/16740652"
                }
            ]
        },
        {
            "title": "Secretion and transport of mouse epididymal proteins after injection of 35S-methionine.",
            "journal": "Biol. Reprod.",
            "date": "1990",
            "authors": "Cornwall G.A., Orgebin-Crist M.-C., Vreeburg J.T.M., Holland M.K.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJB7",
                    "url": "https://www.uniprot.org/uniprot/A2AJB7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "2393684",
                    "url": "https://glygen.org/publication/PubMed/2393684"
                }
            ]
        },
        {
            "title": "Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid.",
            "journal": "Endocrinology",
            "date": "1998",
            "authors": "Matusik R.J., Newcomer M.E., Lareyre J.-J., Orgebin-Crist M.-C., Kasper S., Ong D.E., Zhao G.-Q., Zheng W.-L.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJB7",
                    "url": "https://www.uniprot.org/uniprot/A2AJB7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9607808",
                    "url": "https://glygen.org/publication/PubMed/9607808"
                }
            ]
        },
        {
            "title": "Genomic organization and chromosomal localization of the murine epididymal retinoic acid-binding protein (mE-RABP) gene.",
            "journal": "Mol. Reprod. Dev.",
            "date": "1998",
            "authors": "Mattei M.-G., Matusik R.J., Lareyre J.-J., Orgebin-Crist M.-C., Kasper S., Ong D.E.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJB7",
                    "url": "https://www.uniprot.org/uniprot/A2AJB7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9669522",
                    "url": "https://glygen.org/publication/PubMed/9669522"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:13863",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13863",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P06911-1",
            "protein_name": "Epididymal-specific lipocalin-5",
            "gene_name": "Lcn5",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MENIMPFALLGLCVGLAAGTEGAVVKDFDISKFLGFWYEIAFASKMGTPGLAHKEEKMGAMVVELKENLLALTTTYYSEDHCVLEKVTATEGDGPAKFQVTRLSGKKEVVVEATDYLTYAIIDITSLVAGAVHRTMKLYSRSLDDNGEALYNFRKITSDHGFSETDLYILKHDLTCVKVLQSAAESRP",
                "length": 188
            },
            "evidence": [
                {
                    "id": "7305",
                    "url": "http://www.informatics.jax.org/homology/7305",
                    "database": "MGI"
                },
                {
                    "id": "A2AJB7",
                    "url": "https://omabrowser.org/oma/group/A2AJB7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "extracellular space",
                        "id": "GO:0005615",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJB7",
                                "url": "https://www.uniprot.org/uniprot/A2AJB7"
                            }
                        ],
                        "pmid": "11058762"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "retinoic acid metabolic process",
                        "id": "GO:0042573",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042573",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJB7",
                                "url": "https://www.uniprot.org/uniprot/A2AJB7"
                            }
                        ],
                        "pmid": "10936050"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "small molecule binding",
                        "id": "GO:0036094",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036094",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJB7",
                                "url": "https://www.uniprot.org/uniprot/A2AJB7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "retinoid binding",
                        "id": "GO:0005501",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005501",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJB7",
                                "url": "https://www.uniprot.org/uniprot/A2AJB7"
                            }
                        ],
                        "pmid": "11058762"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}