{
    "uniprot_canonical_ac": "A2AJ77-1",
    "uniprot_ac": "A2AJ77",
    "uniprot_id": "PRD12_MOUSE",
    "mass": {
        "chemical_mass": 40303.0,
        "monoisotopic_mass": 40303.0
    },
    "refseq": {
        "ac": "NP_001116834",
        "name": "PR domain zinc finger protein 12",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
    },
    "gene_names": [
        {
            "name": "Prdm12",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AJ77",
            "id": "A2AJ77"
        },
        {
            "name": "Gm998",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834",
            "id": "NP_001116834"
        },
        {
            "name": "Gm998",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJ77",
            "id": "A2AJ77"
        },
        {
            "name": "Prdm12",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834",
            "id": "NP_001116834"
        }
    ],
    "protein_names": [
        {
            "name": "PR domain zinc finger protein 12",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AJ77#names_and_taxonomy",
            "id": "A2AJ77"
        },
        {
            "name": "2.1.1.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJ77#names_and_taxonomy",
            "id": "A2AJ77"
        },
        {
            "name": "PR domain zinc finger protein 12",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834",
            "id": "NP_001116834"
        },
        {
            "name": "PR domain-containing protein 12",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834",
            "id": "NP_001116834"
        },
        {
            "name": "PR domain-containing protein 12",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AJ77#names_and_taxonomy",
            "id": "A2AJ77"
        }
    ],
    "function": [
        {
            "annotation": "Involved in the positive regulation of histone H3-K9 dimethylation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJ77",
                    "url": "https://www.uniprot.org/uniprot/A2AJ77#function"
                },
                {
                    "database": "PubMed",
                    "id": "26005867",
                    "url": "https://glygen.org/publication/PubMed/26005867"
                }
            ]
        },
        {
            "annotation": "Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001116834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
                },
                {
                    "database": "PubMed",
                    "id": "33789102",
                    "url": "https://glygen.org/publication/PubMed/33789102"
                }
            ]
        },
        {
            "annotation": "PRDM12 in Health and Diseases. Review article Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001116834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
                },
                {
                    "database": "PubMed",
                    "id": "34769459",
                    "url": "https://glygen.org/publication/PubMed/34769459"
                }
            ]
        },
        {
            "annotation": "Prdm12 is induced by the retinoic acid signaling in vivo, and may regulate neural differentiation during animal development.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001116834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
                },
                {
                    "database": "PubMed",
                    "id": "23856557",
                    "url": "https://glygen.org/publication/PubMed/23856557"
                }
            ]
        },
        {
            "annotation": "The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001116834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
                },
                {
                    "database": "PubMed",
                    "id": "32180559",
                    "url": "https://glygen.org/publication/PubMed/32180559"
                }
            ]
        }
    ],
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        {
            "disease_id": "DOID:0070153",
            "recommended_name": {
                "id": "DOID:0070153",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070153",
                "name": "hereditary sensory and autonomic neuropathy type 8",
                "description": "A hereditary sensory neuropathy characterized by congenital insensitivity to pain and decreased sweating and tear production that has_material_basis_in homozygous mutation in the PRDM12 gene on chromosome 9q34."
            },
            "synonyms": [
                {
                    "id": "DOID:0070153",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070153",
                    "name": "hereditary sensory and autonomic neuropathy type VIII",
                    "description": ""
                },
                {
                    "id": "DOID:0070153",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070153",
                    "name": "HSAN8",
                    "description": ""
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "congenital insensitivity to pain-hypohidrosis syndrome",
                    "description": "A hereditary sensory neuropathy characterized by congenital insensitivity to pain and decreased sweating and tear production that has_material_basis_in homozygous mutation in the PRDM12 gene on chromosome 9q34."
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "CIP-hypohidrosis syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "HSAN8",
                    "description": ""
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "hereditary sensory and autonomic neuropathy type 8",
                    "description": ""
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "HSAN 8",
                    "description": ""
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "neuropathy, hereditary sensory and autonomic, type VIII",
                    "description": ""
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "hereditary sensory and autonomic neuropathy type VIII",
                    "description": ""
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "neuropathy, hereditary sensory and autonomic, type VIII; HSAN8",
                    "description": ""
                },
                {
                    "id": "MONDO:0014662",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014662",
                    "name": "neuropathy, hereditary sensory and autonomic, type 8",
                    "description": ""
                },
                {
                    "id": "MIM:616488",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/616488",
                    "name": "Neuropathy, hereditary sensory and autonomic, 8",
                    "description": "Neuropathy, hereditary sensory and autonomic, 8"
                }
            ],
            "evidence": [
                {
                    "id": "0070153",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070153"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJ77",
                    "url": "https://www.uniprot.org/uniprot/A2AJ77"
                }
            ],
            "common_name": "Mouse"
        }
    ],
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        {
            "name": "Prdm12",
            "url": "https://www.uniprot.org/uniprot/A2AJ77",
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                "chromosome": "2",
                "start_pos": 31640037,
                "end_pos": 31655795,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000079466",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000079466"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000079466",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000079466",
            "database": "Bgee"
        },
        {
            "id": "cd19196",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19196",
            "database": "CDD"
        },
        {
            "id": "381359",
            "url": "https://www.ncbi.nlm.nih.gov/gene/381359",
            "database": "GeneID"
        },
        {
            "id": "IPR001214",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214",
            "database": "InterPro"
        },
        {
            "id": "IPR013087",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087",
            "database": "InterPro"
        },
        {
            "id": "IPR017126",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017126",
            "database": "InterPro"
        },
        {
            "id": "IPR036236",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236",
            "database": "InterPro"
        },
        {
            "id": "IPR044406",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR044406",
            "database": "InterPro"
        },
        {
            "id": "mmu:381359",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381359",
            "database": "KEGG Pathway"
        },
        {
            "id": "2685844",
            "url": "http://www.informatics.jax.org/marker/MGI:2685844",
            "database": "MGI"
        },
        {
            "id": "EHQKKND",
            "url": "https://omabrowser.org/oma/group/EHQKKND/",
            "database": "OMA"
        },
        {
            "id": "1318335at2759",
            "url": "http://www.orthodb.org/?query=1318335at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00096",
            "url": "http://pfam.xfam.org/family/PF00096",
            "database": "Pfam"
        },
        {
            "id": "PR_A2AJ77",
            "url": "http://purl.obolibrary.org/obo/PR_A2AJ77",
            "database": "PRO"
        },
        {
            "id": "NP_001116834",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834",
            "database": "RefSeq"
        },
        {
            "id": "A2AJ77",
            "url": "https://www.uniprot.org/uniprot/A2AJ77",
            "database": "UniProtKB"
        },
        {
            "id": "A2AJ77-1",
            "url": "https://www.uniprot.org/uniprot/A2AJ77-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLLEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPVEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEEQKKNKHEDFHPADSATGTAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSTALQAHSPALPAPHAHAPALAAAAAAAAAAHHLPAMVL",
        "length": 365,
        "header": "sp|A2AJ77-1|PRD12_MOUSE Isoform 1 of PR domain zinc finger protein 12  OS=Mus musculus OX=10090 GN=Prdm12 PE=2 SV=1 CANONICAL=A2AJ77-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AJ77-1",
            "url": "https://www.uniprot.org/uniprot/A2AJ77#A2AJ77-1",
            "sequence": {
                "sequence": "MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLLEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPVEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEEQKKNKHEDFHPADSATGTAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSTALQAHSPALPAPHAHAPALAAAAAAAAAAHHLPAMVL",
                "length": 365,
                "header": "sp|A2AJ77-1|PRD12_MOUSE Isoform 1 of PR domain zinc finger protein 12  OS=Mus musculus OX=10090 GN=Prdm12 PE=2 SV=1 CANONICAL=A2AJ77-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 31544493,
                "end_pos": 31530111,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000113470",
                        "url": "https://www.ensembl.org/id/ENSMUST00000113470"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000109098",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000109098"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Prdm12 is induced by retinoic acid and exhibits anti-proliferative properties through the cell cycle modulation of P19 embryonic carcinoma cells.",
            "journal": "Cell structure and function",
            "date": "2013",
            "authors": "Yang CM, Shinkai Y",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001116834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23856557",
                    "url": "https://glygen.org/publication/PubMed/23856557"
                }
            ]
        },
        {
            "title": "Transcriptional regulator PRDM12 is essential for human pain perception.",
            "journal": "Nat. Genet.",
            "date": "2015",
            "authors": "Irvine A.D., Strom T.M., Stucka R., Watson R.M., Wieland T., Pereira D., Bergmann C., De Jonghe P., Valente E.M., Reimann F., Chrast R., Baumgartner M., Dusl M., Willems P.J., Woods C.G., Weiss C., Auer-Grumbach M., Baets J., Parman Y., Reilly M.M., Schabhuettl M., Senderek J., Windhager R., Weis J., Kurth I., Hertz J.M., Carvalho O.P., Karbani G., Nicholas A.K., Rautenstrauss B., Chen Y.C., Michiue T., Zitzelsberger M., Heinritz W., Graul-Neumann L., Passarge E., Nahorski M.S., Moog U., Murphy S.M., Stendel C., Restrepo C.M., Cilio M.R., McAleer M.A., Katona I., Bennett D.L., Themistocleous A.C., Shaikh S.S., Young G.T., Jensen U.B., Cho L.T., Finke C., Kropatsch R., Matsukawa S., McHugh J.C., Moore A.W., Samara C., Schmid A.B., Stafford F., von Au K.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AJ77",
                    "url": "https://www.uniprot.org/uniprot/A2AJ77"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26005867",
                    "url": "https://glygen.org/publication/PubMed/26005867"
                }
            ]
        },
        {
            "title": "The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight.",
            "journal": "Molecular metabolism",
            "date": "2020",
            "authors": "Hael CE, Rojo D, Orquera DP, Low MJ, Rubinstein M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001116834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32180559",
                    "url": "https://glygen.org/publication/PubMed/32180559"
                }
            ]
        },
        {
            "title": "Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.",
            "journal": "Cell reports",
            "date": "2021",
            "authors": "Landy MA, Goyal M, Casey KM, Liu C, Lai HC",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001116834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "33789102",
                    "url": "https://glygen.org/publication/PubMed/33789102"
                }
            ]
        },
        {
            "title": "PRDM12 in Health and Diseases.",
            "journal": "International journal of molecular sciences",
            "date": "2021",
            "authors": "Rienzo M, Di Zazzo E, Casamassimi A, Gazzerro P, Perini G, Bifulco M, Abbondanza C",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001116834",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116834"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34769459",
                    "url": "https://glygen.org/publication/PubMed/34769459"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:381359",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381359",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZEJ0-1",
            "protein_name": "PR domain zinc finger protein 12",
            "gene_name": "Prdm12",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLLEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPVEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEEQKKNKHEDFHPADSATGTAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSTALQAHSPALPAPHAHAPALAAAAAAAAAAHHLPAMVL",
                "length": 365
            },
            "evidence": [
                {
                    "id": "10999",
                    "url": "http://www.informatics.jax.org/homology/10999",
                    "database": "MGI"
                },
                {
                    "id": "A2AJ77",
                    "url": "https://omabrowser.org/oma/group/A2AJ77/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9H4Q4-1",
            "protein_name": "PR domain zinc finger protein 12",
            "gene_name": "PRDM12",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLFEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEDQKKNKHEDFHPADSAAGPAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSTALQAHSPALPAPHAHAPALAAAAAAAAAAAAHHLPAMVL",
                "length": 367
            },
            "evidence": [
                {
                    "id": "10999",
                    "url": "http://www.informatics.jax.org/homology/10999",
                    "database": "MGI"
                },
                {
                    "id": "A2AJ77",
                    "url": "https://omabrowser.org/oma/group/A2AJ77/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 9,
                "go_terms": [
                    {
                        "name": "positive regulation of histone H3-K9 dimethylation",
                        "id": "GO:1900111",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900111",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of transcription by RNA polymerase II",
                        "id": "GO:0000122",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "26443638"
                    },
                    {
                        "name": "neuron projection development",
                        "id": "GO:0031175",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "26005867"
                    },
                    {
                        "name": "sensory perception of pain",
                        "id": "GO:0019233",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019233",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "26005867"
                    },
                    {
                        "name": "detection of temperature stimulus involved in sensory perception of pain",
                        "id": "GO:0050965",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050965",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "26005867"
                    },
                    {
                        "name": "regulation of gene expression",
                        "id": "GO:0010468",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "methylation",
                        "id": "GO:0032259",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neurogenesis",
                        "id": "GO:0022008",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "19050759"
                    },
                    {
                        "name": "positive regulation of histone H3-K9 methylation",
                        "id": "GO:0051574",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051574",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "26005867"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "methyltransferase activity",
                        "id": "GO:0008168",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "histone methyltransferase binding",
                        "id": "GO:1990226",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990226",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "26005867"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": "26005867"
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AJ77",
                                "url": "https://www.uniprot.org/uniprot/A2AJ77"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}