{ "uniprot_canonical_ac": "A2AI08-1", "uniprot_ac": "A2AI08", "uniprot_id": "TPRN_MOUSE", "mass": { "chemical_mass": 80089.0, "monoisotopic_mass": 80089.0 }, "refseq": { "ac": "NP_780495", "name": "taperin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495" }, "gene_names": [ { "name": "Tprn", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AI08", "id": "A2AI08" }, { "name": "C430004E15Rik; C87750", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495", "id": "NP_780495" }, { "name": "Tprn", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495", "id": "NP_780495" } ], "protein_names": [ { "name": "Taperin", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AI08#names_and_taxonomy", "id": "A2AI08" }, { "name": "taperin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495", "id": "NP_780495" } ], "function": [ { "annotation": "Stereocilia lacking GRXCR2 are longer than normal and disorganized due to the mislocalization of taperin, which could modulate the actin cytoskeleton in stereocilia.", "evidence": [ { "database": "RefSeq", "id": "NP_780495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495" }, { "database": "PubMed", "id": "30380417", "url": "https://glygen.org/publication/PubMed/30380417" } ] }, { "annotation": "Taperin plays an important role in maintenance of hair cell stereocilia.", "evidence": [ { "database": "RefSeq", "id": "NP_780495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495" }, { "database": "PubMed", "id": "27693694", "url": "https://glygen.org/publication/PubMed/27693694" } ] }, { "annotation": "Tprn is critical to the retention of the integrity of the stereociliary rootlet. Loss of Tprn in Tprn-null mice caused the disruption of the stereociliary rootlet, which resulted in damage to stereociliary bundles and hearing impairments.", "evidence": [ { "database": "RefSeq", "id": "NP_780495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495" }, { "database": "PubMed", "id": "30159668", "url": "https://glygen.org/publication/PubMed/30159668" } ] } ], "disease": [ { "disease_id": "DOID:0110526", "recommended_name": { "id": "DOID:0110526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110526", "name": "autosomal recessive nonsyndromic deafness 79", "description": "An autosomal recessive nonsyndromic deafness that is characterized by prelingual onset with severe to profound, stable hearing loss and has_material_basis_in mutation in the TPRN gene on chromosome 9q34." }, "synonyms": [ { "id": "DOID:0110526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110526", "name": "DFNB79", "description": "" }, { "id": "DOID:0110526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110526", "name": "autosomal recessive deafness 79", "description": "" }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "autosomal recessive nonsyndromic deafness 79", "description": "Any autosomal recessive nonsyndromic deafness in which the cause of the disease is a mutation in the TPRN gene." }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "autosomal recessive nonsyndromic deafness caused by mutation in TPRN", "description": "" }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "deafness, autosomal recessive type 79", "description": "" }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "DFNB79", "description": "" }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "deafness, autosomal recessive 79; DFNB79", "description": "" }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "autosomal recessive deafness 79", "description": "" }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "deafness, autosomal recessive 79", "description": "" }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "TPRN autosomal recessive nonsyndromic deafness", "description": "" }, { "id": "MONDO:0013215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013215", "name": "autosomal recessive nonsyndromic deafness type 79", "description": "" }, { "id": "MIM:613307", "resource": "MIM", "url": "https://www.omim.org/entry/613307", "name": "Deafness, autosomal recessive, 79", "description": "Deafness, autosomal recessive, 79" } ], "evidence": [ { "id": "0110526", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110526" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Tprn", "url": "https://www.uniprot.org/uniprot/A2AI08", "locus": { "chromosome": "2", "start_pos": 25262618, "end_pos": 25269885, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000048707", "url": "https://www.ensembl.org/id/ENSMUSG00000048707" } ] } } ], "crossref": [ { "id": "ENSMUSG00000048707", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048707", "database": "Bgee" }, { "id": "97031", "url": "https://www.ncbi.nlm.nih.gov/gene/97031", "database": "GeneID" }, { "id": "IPR025903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025903", "database": "InterPro" }, { "id": "IPR025907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025907", "database": "InterPro" }, { "id": "IPR026671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026671", "database": "InterPro" }, { "id": "IPR033359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033359", "database": "InterPro" }, { "id": "mmu:97031", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:97031", "database": "KEGG Pathway" }, { "id": "2139535", "url": "http://www.informatics.jax.org/marker/MGI:2139535", "database": "MGI" }, { "id": "QHFANNK", "url": "https://omabrowser.org/oma/group/QHFANNK/", "database": "OMA" }, { "id": "732540at2759", "url": "http://www.orthodb.org/?query=732540at2759", "database": "OrthoDB" }, { "id": "PTHR21685", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21685", "database": "PANTHER" }, { "id": "PTHR21685:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21685:SF1", "database": "PANTHER" }, { "id": "PF13914", "url": "http://pfam.xfam.org/family/PF13914", "database": "Pfam" }, { "id": "PF13916", "url": "http://pfam.xfam.org/family/PF13916", "database": "Pfam" }, { "id": "PR_A2AI08", "url": "http://purl.obolibrary.org/obo/PR_A2AI08", "database": "PRO" }, { "id": "NP_780495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495", "database": "RefSeq" }, { "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08", "database": "UniProtKB" }, { "id": "A2AI08-1", "url": "https://www.uniprot.org/uniprot/A2AI08-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGQGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGTRPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPLAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSPLAAEMQWAVRKGACPRPAISDTDKCVRWQRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLPVTFIDEVDSEEEAFQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQSQQGAEEQDAESLSGPHTTLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEGEEDGEEEEVGPDSEKPFTVFLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQTPTDVELPPKEVMLTPASQNDLSDFRSEPALYF", "length": 749, "header": "sp|A2AI08-1|TPRN_MOUSE Isoform 1 of Taperin OS=Mus musculus OX=10090 GN=Tprn PE=1 SV=1 CANONICAL=A2AI08-1" }, "isoforms": [ { "isoform_ac": "A2AI08-1", "url": "https://www.uniprot.org/uniprot/A2AI08#A2AI08-1", "sequence": { "sequence": "MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGQGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGTRPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPLAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSPLAAEMQWAVRKGACPRPAISDTDKCVRWQRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLPVTFIDEVDSEEEAFQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQSQQGAEEQDAESLSGPHTTLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEGEEDGEEEEVGPDSEKPFTVFLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQTPTDVELPPKEVMLTPASQNDLSDFRSEPALYF", "length": 749, "header": "sp|A2AI08-1|TPRN_MOUSE Isoform 1 of Taperin OS=Mus musculus OX=10090 GN=Tprn PE=1 SV=1 CANONICAL=A2AI08-1" }, "locus": { "chromosome": "2", "start_pos": 25159427, "end_pos": 25152700, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000114336", "url": "https://www.ensembl.org/id/ENSMUST00000114336" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000109975", "url": "https://www.ensembl.org/id/ENSMUSP00000109975" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 274, "end_pos": 274, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ] }, { "start_pos": 401, "end_pos": 401, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ] }, { "start_pos": 457, "end_pos": 457, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" }, { "database": "iPTMnet", "id": "A2AI08", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AI08" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 457, "end_pos": 457, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "start_pos": 501, "end_pos": 501, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" }, { "database": "iPTMnet", "id": "A2AI08", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AI08" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 501, "end_pos": 501, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" }, { "database": "iPTMnet", "id": "A2AI08", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AI08" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss.", "journal": "Am. J. Hum. Genet.", "date": "2010", "authors": "Li Y., Nurnberg P., Baessmann I., Veltman J.A., Nurnberg G., Kremer H., Wollnik B., Pohl E., Kubisch C., Schraders M., Barakat A., Admiraal R.J., Boulouiz R., Charif M., Kandil M., von Ameln S.", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "reference": [ { "type": "PubMed", "id": "20170898", "url": "https://glygen.org/publication/PubMed/20170898" } ] }, { "title": "Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79.", "journal": "Am. J. Hum. Genet.", "date": "2010", "authors": "Ahmed Z.M., Morell R.J., Riazuddin S., Belyantseva I.A., Friedman T.B., Khan S.N., Riazuddin S.', Rehman A.U., Khan S.Y., Shahzad M., Boger E.T.", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "reference": [ { "type": "PubMed", "id": "20170899", "url": "https://glygen.org/publication/PubMed/20170899" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" }, { "database": "iPTMnet", "id": "A2AI08", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AI08" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice.", "journal": "Biochemical and biophysical research communications", "date": "2016", "authors": "Chen M, Wang Q, Zhu GH, Hu P, Zhou Y, Wang T, Lai RS, Xiao ZA, Xie DH", "evidence": [ { "database": "RefSeq", "id": "NP_780495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495" } ], "reference": [ { "type": "PubMed", "id": "27693694", "url": "https://glygen.org/publication/PubMed/27693694" } ] }, { "title": "Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice.", "journal": "Frontiers of medicine", "date": "2019", "authors": "Men Y, Li X, Tu H, Zhang A, Fu X, Wang Z, Jin Y, Hou C, Zhang T, Zhang S, Zhou Y, Li B, Li J, Sun X, Wang H, Gao J", "evidence": [ { "database": "RefSeq", "id": "NP_780495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495" } ], "reference": [ { "type": "PubMed", "id": "30159668", "url": "https://glygen.org/publication/PubMed/30159668" } ] }, { "title": "GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing.", "journal": "Cell reports", "date": "2018", "authors": "Liu C, Luo N, Tung CY, Perrin BJ, Zhao B", "evidence": [ { "database": "RefSeq", "id": "NP_780495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780495" } ], "reference": [ { "type": "PubMed", "id": "30380417", "url": "https://glygen.org/publication/PubMed/30380417" } ] } ], "pathway": [ { "id": "mmu:97031", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:97031", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q4KMQ1-1", "protein_name": "Taperin", "gene_name": "TPRN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENPFMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRAAEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAPGPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAGSPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIRPAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGPASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPPPFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPARPLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF", "length": 711 }, "evidence": [ { "id": "52156", "url": "http://www.informatics.jax.org/homology/52156", "database": "MGI" }, { "id": "A2AI08", "url": "https://omabrowser.org/oma/group/A2AI08/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q5XHX2-1", "protein_name": "Taperin", "gene_name": "Tprn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGPGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGARPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPASSIRAAEVVVYEEPQPGRVSRLLEKFDSPAAPRRRGSPERFRPALPQLPVAPASAATRAPTNRSLAPAPPVLPSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPGSAVNRSLSNGPMTQESPAGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATPVGPPAFLAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPSAAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSSLAAEMQWAVREGGCPRPAISDTDKSVRRQRPASPPPFLPATTEAEPAEGLGVPGLTKNGQEPVRPGLPVTFIDEVDSEEAAFQEAKLPSSAVGVPSQYHLHPSTPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQFQQGAEEQDADSLSGPHTTLENALKKRYPTVNEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEEEEEGEDGEEEEVGPDSEKSFTVLLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQAPTEVELPPKEVMLTPASQNDLSDFRSEPALYF", "length": 753 }, "evidence": [ { "id": "52156", "url": "http://www.informatics.jax.org/homology/52156", "database": "MGI" }, { "id": "A2AI08", "url": "https://omabrowser.org/oma/group/A2AI08/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "pmid": "" }, { "name": "stereocilium", "id": "GO:0032420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032420", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "pmid": "20170899" }, { "name": "stereocilium base", "id": "GO:0120044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120044", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "pmid": "28209736" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "pmid": "27693694" }, { "name": "auditory receptor cell stereocilium organization", "id": "GO:0060088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060088", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "pmid": "30380417" }, { "name": "stereocilium maintenance", "id": "GO:0120045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120045", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "pmid": "27693694" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatase binding", "id": "GO:0019902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "evidence": [ { "database": "UniProtKB", "id": "A2AI08", "url": "https://www.uniprot.org/uniprot/A2AI08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }