{
    "uniprot_canonical_ac": "A2AHA7-1",
    "uniprot_ac": "A2AHA7",
    "uniprot_id": "A2AHA7_MOUSE",
    "mass": {
        "chemical_mass": 52811.0,
        "monoisotopic_mass": 52811.0
    },
    "refseq": {
        "ac": "XP_006528697",
        "name": "preferentially expressed antigen in melanoma-like 3 isoform X1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528697"
    },
    "gene_names": [
        {
            "name": "Pramel3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AHA7",
            "id": "A2AHA7"
        },
        {
            "name": "Pramel3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528697",
            "id": "XP_006528697"
        }
    ],
    "protein_names": [
        {
            "name": "PRAME-like 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AHA7#names_and_taxonomy",
            "id": "A2AHA7"
        },
        {
            "name": "preferentially expressed antigen in melanoma-like 3 isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528697",
            "id": "XP_006528697"
        },
        {
            "name": "preferentially expressed antigen in melanoma-like 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567",
            "id": "NP_113567"
        }
    ],
    "function": [
        {
            "annotation": "Germ-cell-specific sex-linked genes, like Pramel3, are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_113567",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567"
                },
                {
                    "database": "PubMed",
                    "id": "16118233",
                    "url": "https://glygen.org/publication/PubMed/16118233"
                }
            ]
        },
        {
            "annotation": "Pramel3 is a gene that is expressed in testis that was identified in a genome-wide cDNA subtraction screen.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_113567",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567"
                },
                {
                    "database": "PubMed",
                    "id": "11279525",
                    "url": "https://glygen.org/publication/PubMed/11279525"
                }
            ]
        },
        {
            "annotation": "Pramel3 is found within a region of the X chromosome, that when deleted as part of a 1.1 Mb segmental deletion, causes meiotic failure in male mice. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_113567",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567"
                },
                {
                    "database": "PubMed",
                    "id": "23677977",
                    "url": "https://glygen.org/publication/PubMed/23677977"
                }
            ]
        },
        {
            "annotation": "Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_113567",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567"
                },
                {
                    "database": "PubMed",
                    "id": "17660561",
                    "url": "https://glygen.org/publication/PubMed/17660561"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AHA7",
                    "url": "https://www.uniprot.org/uniprot/A2AHA7"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Pramel3",
            "url": "https://www.uniprot.org/uniprot/A2AHA7",
            "locus": {
                "chromosome": "X",
                "start_pos": 135302307,
                "end_pos": 135312652,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000067360",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000067360"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000067360",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000067360",
            "database": "Bgee"
        },
        {
            "id": "83565",
            "url": "https://www.ncbi.nlm.nih.gov/gene/83565",
            "database": "GeneID"
        },
        {
            "id": "IPR032675",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675",
            "database": "InterPro"
        },
        {
            "id": "mmu:83565",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:83565",
            "database": "KEGG Pathway"
        },
        {
            "id": "1890657",
            "url": "http://www.informatics.jax.org/marker/MGI:1890657",
            "database": "MGI"
        },
        {
            "id": "563553at2759",
            "url": "http://www.orthodb.org/?query=563553at2759",
            "database": "OrthoDB"
        },
        {
            "id": "NP_113567",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567",
            "database": "RefSeq"
        },
        {
            "id": "XP_006528697",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528697",
            "database": "RefSeq"
        },
        {
            "id": "A2AHA7",
            "url": "https://www.uniprot.org/uniprot/A2AHA7",
            "database": "UniProtKB"
        },
        {
            "id": "A2AHA7-1",
            "url": "https://www.uniprot.org/uniprot/A2AHA7-1",
            "database": "UniProtKB"
        },
        {
            "id": "Q99M97",
            "url": "https://www.uniprot.org/uniprot/Q99M97",
            "database": "UniProtKB"
        },
        {
            "id": "Q99M97-1",
            "url": "https://www.uniprot.org/uniprot/Q99M97-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MMDTKDPPTLLDLATQSLLSNEHAAIQALEEIPRELFVPLFTAAFTGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLPALNSATRSPKLRILDLRQDAGCKTVCPEISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSHMNHLKELSLSSFCLTDHLETVLRVLSTDLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNPIYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEAERSDMNWITYSD",
        "length": 463,
        "header": "tr|A2AHA7-1|A2AHA7_MOUSE Isoform 1 of PRAME-like 3  OS=Mus musculus OX=10090 GN=Pramel3 PE=4 SV=1 CANONICAL=A2AHA7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AHA7-1",
            "url": "https://www.uniprot.org/uniprot/A2AHA7#A2AHA7-1",
            "sequence": {
                "sequence": "MMDTKDPPTLLDLATQSLLSNEHAAIQALEEIPRELFVPLFTAAFTGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLPALNSATRSPKLRILDLRQDAGCKTVCPEISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSHMNHLKELSLSSFCLTDHLETVLRVLSTDLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNPIYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEAERSDMNWITYSD",
                "length": 463,
                "header": "tr|A2AHA7-1|A2AHA7_MOUSE Isoform 1 of PRAME-like 3  OS=Mus musculus OX=10090 GN=Pramel3 PE=4 SV=1 CANONICAL=A2AHA7-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 134211358,
                "end_pos": 134208089,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000118821",
                        "url": "https://www.ensembl.org/id/ENSMUST00000118821"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000112761",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000112761"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q99M97-1",
            "url": "https://www.uniprot.org/uniprot/A2AHA7#Q99M97-1",
            "sequence": {
                "sequence": "MDTKDPPTLLDLATQSLLSNEHAAIQALEEIPRELFVPLFTAAFTGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLPALNSATRSPKLRILDLRQDAGCKTVCPEISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSHMNHLKELSLSSFCLTDHLETVLRVLSTDLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNPIYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEAERSDMNWITYSD",
                "length": 462,
                "header": "tr|Q99M97-1|Q99M97_MOUSE Computationally mapped isoform of PRAME-like 3  OS=Mus musculus OX=10090 GN=Pramel3 PE=2 SV=1 CANONICAL=A2AHA7-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 134211358,
                "end_pos": 134208092,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000113176",
                        "url": "https://www.ensembl.org/id/ENSMUST00000113176"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000108801",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000108801"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "An abundance of X-linked genes expressed in spermatogonia.",
            "journal": "Nat. Genet.",
            "date": "2001",
            "authors": "Yang F., Page D.C., McCarrey J.R., Wang P.J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99M97",
                    "url": "https://www.uniprot.org/uniprot/Q99M97"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_113567",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11279525",
                    "url": "https://glygen.org/publication/PubMed/11279525"
                }
            ]
        },
        {
            "title": "Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.",
            "journal": "Human molecular genetics",
            "date": "2005",
            "authors": "Wang PJ, Page DC, McCarrey JR",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_113567",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16118233",
                    "url": "https://glygen.org/publication/PubMed/16118233"
                }
            ]
        },
        {
            "title": "Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.",
            "journal": "Genetics",
            "date": "2007",
            "authors": "Gallardo TD, John GB, Shirley L, Contreras CM, Akbay EA, Haynie JM, Ward SE, Shidler MJ, Castrillon DH",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_113567",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17660561",
                    "url": "https://glygen.org/publication/PubMed/17660561"
                }
            ]
        },
        {
            "title": "A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.",
            "journal": "Biology of reproduction",
            "date": "2013",
            "authors": "Zhou J, McCarrey JR, Wang PJ",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_113567",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113567"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23677977",
                    "url": "https://glygen.org/publication/PubMed/23677977"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:83565",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:83565",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2AWL1-1",
            "protein_name": "Predicted gene 5128",
            "gene_name": "Gm7903",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MMDTKDPPTLLDLATQSLLSNEHAAIQALEEIPRELFVPLFTAAFTGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLPALNSATRSPKLRILDLRQDAGCKTVCPDISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSRMNHLKELSLSSFCLTDHLETVLRVLSADLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNPIYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEAERSDMNWITYSD",
                "length": 463
            },
            "evidence": [
                {
                    "id": "41829",
                    "url": "http://www.informatics.jax.org/homology/41829",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "A2AWL3-1",
            "protein_name": "Expressed sequence AV320801",
            "gene_name": "AV320801",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MWFIMMDTKDPPTLLDLATQNLLSNEHAAIQALEEIPRELFVPLFTAAFTGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLLALNSATRSPKLRILDLRQDAGCKTVCPEISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSRMNHLKELSLSSFCLTDHLENVLRVLSADLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNPIYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEAERSDMNWITYSD",
                "length": 467
            },
            "evidence": [
                {
                    "id": "41829",
                    "url": "http://www.informatics.jax.org/homology/41829",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "L7MUB4-1",
            "protein_name": "Predicted gene 15023",
            "gene_name": "Gm15023",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MWFIMMDTKDPPTLLDLATQSLLSNEHAAIQALEEIPRELFVPLFTAAFTGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLPALNSATRSPKLRILDLRQDAGCKTVCPEISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSRMNHLKELSLSSFCLTDHLENVLRVLSADLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNPIYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEAERSDMNWITYSD",
                "length": 467
            },
            "evidence": [
                {
                    "id": "41829",
                    "url": "http://www.informatics.jax.org/homology/41829",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AHA7",
                                "url": "https://www.uniprot.org/uniprot/A2AHA7"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 123,
            "end_pos": 125,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 350,
            "end_pos": 352,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}