{
    "uniprot_canonical_ac": "A2AF53-1",
    "uniprot_ac": "A2AF53",
    "uniprot_id": "T185A_MOUSE",
    "mass": {
        "chemical_mass": 40620.0,
        "monoisotopic_mass": 40620.0
    },
    "refseq": {
        "ac": "NP_001028500",
        "name": "transmembrane protein 185A isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500"
    },
    "gene_names": [
        {
            "name": "Tmem185a",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AF53",
            "id": "A2AF53"
        },
        {
            "name": "BC023829",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF53",
            "id": "A2AF53"
        },
        {
            "name": "Ee3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF53",
            "id": "A2AF53"
        },
        {
            "name": "Fam11a",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF53",
            "id": "A2AF53"
        },
        {
            "name": "Tmem185a",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500",
            "id": "NP_001028500"
        },
        {
            "name": "ee3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500",
            "id": "NP_001028500"
        }
    ],
    "protein_names": [
        {
            "name": "Transmembrane protein 185A",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AF53#names_and_taxonomy",
            "id": "A2AF53"
        },
        {
            "name": "Erythropoietin-induced EST 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF53#names_and_taxonomy",
            "id": "A2AF53"
        },
        {
            "name": "Protein FAM11A",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF53#names_and_taxonomy",
            "id": "A2AF53"
        },
        {
            "name": "erythropoietin-induced EST 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500",
            "id": "NP_001028500"
        },
        {
            "name": "transmembrane protein 185A isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500",
            "id": "NP_001028500"
        }
    ],
    "function": [
        {
            "annotation": "The mouse ee3 is an orphan G-protein-coupled receptor with potential connections to erythropoietin and 5HT2a receptor signalling. ee3_2, a similar gene, is also described, along with human orthologs.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001028500",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500"
                },
                {
                    "database": "PubMed",
                    "id": "15525354",
                    "url": "https://glygen.org/publication/PubMed/15525354"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF53",
                    "url": "https://www.uniprot.org/uniprot/A2AF53"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Tmem185a",
            "url": "https://www.uniprot.org/uniprot/A2AF53",
            "locus": {
                "chromosome": "X",
                "start_pos": 70477180,
                "end_pos": 70459753,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000073139",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000073139"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000073139",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000073139",
            "database": "Bgee"
        },
        {
            "id": "236848",
            "url": "https://www.ncbi.nlm.nih.gov/gene/236848",
            "database": "GeneID"
        },
        {
            "id": "IPR019396",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019396",
            "database": "InterPro"
        },
        {
            "id": "mmu:236848",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:236848",
            "database": "KEGG Pathway"
        },
        {
            "id": "2448555",
            "url": "http://www.informatics.jax.org/marker/MGI:2448555",
            "database": "MGI"
        },
        {
            "id": "FGKHDKK",
            "url": "https://omabrowser.org/oma/group/FGKHDKK/",
            "database": "OMA"
        },
        {
            "id": "554512at2759",
            "url": "http://www.orthodb.org/?query=554512at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR13568",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13568",
            "database": "PANTHER"
        },
        {
            "id": "PF10269",
            "url": "http://pfam.xfam.org/family/PF10269",
            "database": "Pfam"
        },
        {
            "id": "PR_A2AF53",
            "url": "http://purl.obolibrary.org/obo/PR_A2AF53",
            "database": "PRO"
        },
        {
            "id": "NP_001028500",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500",
            "database": "RefSeq"
        },
        {
            "id": "XP_006528044",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006528044",
            "database": "RefSeq"
        },
        {
            "id": "A2AF53",
            "url": "https://www.uniprot.org/uniprot/A2AF53",
            "database": "UniProtKB"
        },
        {
            "id": "A2AF53-1",
            "url": "https://www.uniprot.org/uniprot/A2AF53-1",
            "database": "UniProtKB"
        },
        {
            "id": "Q3TYW3",
            "url": "https://www.uniprot.org/uniprot/Q3TYW3",
            "database": "UniProtKB"
        },
        {
            "id": "Q3TYW3-1",
            "url": "https://www.uniprot.org/uniprot/Q3TYW3-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD",
        "length": 350,
        "header": "sp|A2AF53-1|T185A_MOUSE Isoform 1 of Transmembrane protein 185A  OS=Mus musculus OX=10090 GN=Tmem185a PE=1 SV=1 CANONICAL=A2AF53-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AF53-1",
            "url": "https://www.uniprot.org/uniprot/A2AF53#A2AF53-1",
            "sequence": {
                "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD",
                "length": 350,
                "header": "sp|A2AF53-1|T185A_MOUSE Isoform 1 of Transmembrane protein 185A  OS=Mus musculus OX=10090 GN=Tmem185a PE=1 SV=1 CANONICAL=A2AF53-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 69520621,
                "end_pos": 69504657,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000114630",
                        "url": "https://www.ensembl.org/id/ENSMUST00000114630"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000110277",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000110277"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q3TYW3-1",
            "url": "https://www.uniprot.org/uniprot/A2AF53#Q3TYW3-1",
            "sequence": {
                "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLEVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD",
                "length": 322,
                "header": "tr|Q3TYW3-1|T185A_MOUSE Computationally mapped isoform of Transmembrane protein 185A  OS=Mus musculus OX=10090 GN=Tmem185a PE=1 SV=1 CANONICAL=A2AF53-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 69520621,
                "end_pos": 69504657,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000101506",
                        "url": "https://www.ensembl.org/id/ENSMUST00000101506"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000099043",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000099043"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.",
            "journal": "J. Neurochem.",
            "date": "2004",
            "authors": "Schneider A., Gassler N., Gruenewald S., Kuner T., Rossner M., Weber D., Kuschinsky W., Maurer M.H., Propst F., Wuerz R.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF53",
                    "url": "https://www.uniprot.org/uniprot/A2AF53"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001028500",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028500"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15525354",
                    "url": "https://glygen.org/publication/PubMed/15525354"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:236848",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:236848",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZWX2-1",
            "protein_name": "Transmembrane protein 185A",
            "gene_name": "Tmem185a",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDSEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD",
                "length": 350
            },
            "evidence": [
                {
                    "id": "66313",
                    "url": "http://www.informatics.jax.org/homology/66313",
                    "database": "MGI"
                },
                {
                    "id": "A2AF53",
                    "url": "https://omabrowser.org/oma/group/A2AF53/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8NFB2-1",
            "protein_name": "Transmembrane protein 185A",
            "gene_name": "TMEM185A",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSSIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDNEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD",
                "length": 350
            },
            "evidence": [
                {
                    "id": "66313",
                    "url": "http://www.informatics.jax.org/homology/66313",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "integral component of membrane",
                        "id": "GO:0016021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF53",
                                "url": "https://www.uniprot.org/uniprot/A2AF53"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite",
                        "id": "GO:0030425",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF53",
                                "url": "https://www.uniprot.org/uniprot/A2AF53"
                            }
                        ],
                        "pmid": "15525354"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 294,
            "end_pos": 296,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}