{
    "uniprot_canonical_ac": "A2AF47-1",
    "uniprot_ac": "A2AF47",
    "uniprot_id": "DOC11_MOUSE",
    "mass": {
        "chemical_mass": 237771.0,
        "monoisotopic_mass": 237771.0
    },
    "refseq": {
        "ac": "NP_001009947",
        "name": "dedicator of cytokinesis protein 11",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
    },
    "gene_names": [
        {
            "name": "Dock11",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AF47",
            "id": "A2AF47"
        },
        {
            "name": "5033414A21Rik; 8030476J24; sph238; Zizimin2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947",
            "id": "NP_001009947"
        },
        {
            "name": "Dock11",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947",
            "id": "NP_001009947"
        },
        {
            "name": "Ziz2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF47",
            "id": "A2AF47"
        }
    ],
    "protein_names": [
        {
            "name": "Dedicator of cytokinesis protein 11",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AF47#names_and_taxonomy",
            "id": "A2AF47"
        },
        {
            "name": "ACG",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF47#names_and_taxonomy",
            "id": "A2AF47"
        },
        {
            "name": "Activated Cdc42-associated guanine nucleotide exchange factor",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF47#names_and_taxonomy",
            "id": "A2AF47"
        },
        {
            "name": "Zizimin-2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF47#names_and_taxonomy",
            "id": "A2AF47"
        },
        {
            "name": "dedicator of cytokinesis protein 11",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947",
            "id": "NP_001009947"
        },
        {
            "name": "spleen specific 238 kDa protein with PH domain; ACG; zizimin-2; activated Cdc42-associated guanine nucleotide exchange factor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947",
            "id": "NP_001009947"
        }
    ],
    "function": [
        {
            "annotation": "Cloning of zizimin2; expressed predominantly in lymphocytes with an opposite pattern than zizimin1 [zizimin2]",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001009947",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
                },
                {
                    "database": "PubMed",
                    "id": "15710388",
                    "url": "https://glygen.org/publication/PubMed/15710388"
                }
            ]
        },
        {
            "annotation": "Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001009947",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
                },
                {
                    "database": "PubMed",
                    "id": "32878909",
                    "url": "https://glygen.org/publication/PubMed/32878909"
                }
            ]
        },
        {
            "annotation": "Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399). Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47#function"
                },
                {
                    "database": "PubMed",
                    "id": "16968698",
                    "url": "https://glygen.org/publication/PubMed/16968698"
                },
                {
                    "database": "PubMed",
                    "id": "15710388",
                    "url": "https://glygen.org/publication/PubMed/15710388"
                },
                {
                    "database": "PubMed",
                    "id": "25729399",
                    "url": "https://glygen.org/publication/PubMed/25729399"
                },
                {
                    "database": "PubMed",
                    "id": "22494997",
                    "url": "https://glygen.org/publication/PubMed/22494997"
                },
                {
                    "database": "PubMed",
                    "id": "25851601",
                    "url": "https://glygen.org/publication/PubMed/25851601"
                }
            ]
        },
        {
            "annotation": "These data suggested that Zizimin2 is associated with the reduction of immune response in acquired immunity along with aging.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001009947",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
                },
                {
                    "database": "PubMed",
                    "id": "23092103",
                    "url": "https://glygen.org/publication/PubMed/23092103"
                }
            ]
        },
        {
            "annotation": "This study shows that Zizimin2 is involved in age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001009947",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
                },
                {
                    "database": "PubMed",
                    "id": "29099971",
                    "url": "https://glygen.org/publication/PubMed/29099971"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Dock11",
            "url": "https://www.uniprot.org/uniprot/A2AF47",
            "locus": {
                "chromosome": "X",
                "start_pos": 35888832,
                "end_pos": 36076562,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000031093",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000031093"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000031093",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031093",
            "database": "Bgee"
        },
        {
            "id": "cd08697",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08697",
            "database": "CDD"
        },
        {
            "id": "75974",
            "url": "https://www.ncbi.nlm.nih.gov/gene/75974",
            "database": "GeneID"
        },
        {
            "id": "A2AF47",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AF47*",
            "database": "IntAct"
        },
        {
            "id": "IPR001849",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849",
            "database": "InterPro"
        },
        {
            "id": "IPR010703",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR010703",
            "database": "InterPro"
        },
        {
            "id": "IPR011993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
            "database": "InterPro"
        },
        {
            "id": "IPR016024",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024",
            "database": "InterPro"
        },
        {
            "id": "IPR021816",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR021816",
            "database": "InterPro"
        },
        {
            "id": "IPR026791",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026791",
            "database": "InterPro"
        },
        {
            "id": "IPR027007",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027007",
            "database": "InterPro"
        },
        {
            "id": "IPR027357",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027357",
            "database": "InterPro"
        },
        {
            "id": "IPR035892",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892",
            "database": "InterPro"
        },
        {
            "id": "IPR037809",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037809",
            "database": "InterPro"
        },
        {
            "id": "IPR043161",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043161",
            "database": "InterPro"
        },
        {
            "id": "IPR043162",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043162",
            "database": "InterPro"
        },
        {
            "id": "mmu:75974",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75974",
            "database": "KEGG Pathway"
        },
        {
            "id": "1923224",
            "url": "http://www.informatics.jax.org/marker/MGI:1923224",
            "database": "MGI"
        },
        {
            "id": "IIHEQVI",
            "url": "https://omabrowser.org/oma/group/IIHEQVI/",
            "database": "OMA"
        },
        {
            "id": "20156at2759",
            "url": "http://www.orthodb.org/?query=20156at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR23317",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23317",
            "database": "PANTHER"
        },
        {
            "id": "PF00169",
            "url": "http://pfam.xfam.org/family/PF00169",
            "database": "Pfam"
        },
        {
            "id": "PF06920",
            "url": "http://pfam.xfam.org/family/PF06920",
            "database": "Pfam"
        },
        {
            "id": "PF11878",
            "url": "http://pfam.xfam.org/family/PF11878",
            "database": "Pfam"
        },
        {
            "id": "PF14429",
            "url": "http://pfam.xfam.org/family/PF14429",
            "database": "Pfam"
        },
        {
            "id": "PR_A2AF47",
            "url": "http://purl.obolibrary.org/obo/PR_A2AF47",
            "database": "PRO"
        },
        {
            "id": "R-MMU-9013148",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148",
            "database": "Reactome"
        },
        {
            "id": "R-MMU-9013149",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149",
            "database": "Reactome"
        },
        {
            "id": "R-MMU-983231",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983231",
            "database": "Reactome"
        },
        {
            "id": "NP_001009947",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947",
            "database": "RefSeq"
        },
        {
            "id": "A2AF47",
            "url": "https://www.uniprot.org/uniprot/A2AF47",
            "database": "UniProtKB"
        },
        {
            "id": "A2AF47-1",
            "url": "https://www.uniprot.org/uniprot/A2AF47-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2AF65",
            "url": "https://www.uniprot.org/uniprot/A2AF65",
            "database": "UniProtKB"
        },
        {
            "id": "A2AF65-1",
            "url": "https://www.uniprot.org/uniprot/A2AF65-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2AF67",
            "url": "https://www.uniprot.org/uniprot/A2AF67",
            "database": "UniProtKB"
        },
        {
            "id": "A2AF67-1",
            "url": "https://www.uniprot.org/uniprot/A2AF67-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFMVNCHDLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSNDGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYAEV",
        "length": 2073,
        "header": "sp|A2AF47-1|DOC11_MOUSE Isoform 1 of Dedicator of cytokinesis protein 11  OS=Mus musculus OX=10090 GN=Dock11 PE=1 SV=1 CANONICAL=A2AF47-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AF47-1",
            "url": "https://www.uniprot.org/uniprot/A2AF47#A2AF47-1",
            "sequence": {
                "sequence": "MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFMVNCHDLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSNDGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYAEV",
                "length": 2073,
                "header": "sp|A2AF47-1|DOC11_MOUSE Isoform 1 of Dedicator of cytokinesis protein 11  OS=Mus musculus OX=10090 GN=Dock11 PE=1 SV=1 CANONICAL=A2AF47-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 35339868,
                "end_pos": 35152584,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000033419",
                        "url": "https://www.ensembl.org/id/ENSMUST00000033419"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000033419",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000033419"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AF65-1",
            "url": "https://www.uniprot.org/uniprot/A2AF47#A2AF65-1",
            "sequence": {
                "sequence": "MRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQL",
                "length": 527,
                "header": "tr|A2AF65-1|A2AF65_MOUSE Computationally mapped isoform of Dedicator of cytokinesis protein 11  OS=Mus musculus OX=10090 GN=Dock11 PE=1 SV=1 CANONICAL=A2AF47-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 35339572,
                "end_pos": 35304891,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000115264",
                        "url": "https://www.ensembl.org/id/ENSMUST00000115264"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000110919",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000110919"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AF67-1",
            "url": "https://www.uniprot.org/uniprot/A2AF47#A2AF67-1",
            "sequence": {
                "sequence": "MKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFMVNCHDLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSNDGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDFFSFAVDRLTSVDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYAEV",
                "length": 1902,
                "header": "tr|A2AF67-1|A2AF67_MOUSE Computationally mapped isoform of Dedicator of cytokinesis protein 11  OS=Mus musculus OX=10090 GN=Dock11 PE=1 SV=1 CANONICAL=A2AF47-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 35339868,
                "end_pos": 35211050,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000115266",
                        "url": "https://www.ensembl.org/id/ENSMUST00000115266"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000110921",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000110921"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 1237,
            "end_pos": 1237,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ]
        },
        {
            "start_pos": 1240,
            "end_pos": 1240,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ]
        },
        {
            "start_pos": 12,
            "end_pos": 12,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ]
        },
        {
            "start_pos": 161,
            "end_pos": 161,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ]
        },
        {
            "start_pos": 16,
            "end_pos": 16,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ]
        },
        {
            "start_pos": 23,
            "end_pos": 23,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ]
        },
        {
            "start_pos": 248,
            "end_pos": 248,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ]
        },
        {
            "start_pos": 306,
            "end_pos": 306,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ]
        },
        {
            "start_pos": 445,
            "end_pos": 445,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AF47",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AF47"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 445,
            "end_pos": 445,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.",
            "journal": "FEBS Lett.",
            "date": "2005",
            "authors": "Maruyama M., Meller N., Nishikimi A., Schwartz M.A., Isobe K., Uekawa N.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001009947",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15710388",
                    "url": "https://glygen.org/publication/PubMed/15710388"
                }
            ]
        },
        {
            "title": "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42.",
            "journal": "J. Biol. Chem.",
            "date": "2006",
            "authors": "Yang W., Lin Q., Feng Q., Cerione R.A., Baird D.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16968698",
                    "url": "https://glygen.org/publication/PubMed/16968698"
                }
            ]
        },
        {
            "title": "Large-scale phosphorylation analysis of mouse liver.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2007",
            "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                },
                {
                    "database": "UniProtKB",
                    "id": "A2AF67",
                    "url": "https://www.uniprot.org/uniprot/A2AF67"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2AF47",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AF47"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "title": "Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells.",
            "journal": "Immun. Ageing",
            "date": "2012",
            "authors": "Maruyama M., Sakabe I., Asai A., Iijima J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22494997",
                    "url": "https://glygen.org/publication/PubMed/22494997"
                }
            ]
        },
        {
            "title": "Restricted expression of new guanine nucleotide exchange factor Zizimin2 in aged acquired immune system.",
            "journal": "Nagoya journal of medical science",
            "date": "2012",
            "authors": "Jia Y, Sakabe I, Matsuda T, Hayakawa T, Maruyama M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001009947",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "23092103",
                    "url": "https://glygen.org/publication/PubMed/23092103"
                }
            ]
        },
        {
            "title": "The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation.",
            "journal": "Immun. Ageing",
            "date": "2015",
            "authors": "Maruyama M., Matsuda T., Takaoka A., Yanase S.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25729399",
                    "url": "https://glygen.org/publication/PubMed/25729399"
                }
            ]
        },
        {
            "title": "The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.",
            "journal": "Mol. Biol. Cell",
            "date": "2015",
            "authors": "Schmidt S., Debant A., Gasman S., Raynaud F., Dusart I., Wehrle R., Vodjdani G., Bellanger J.M., Doulazmi M., Fagni L., Jaudon F.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF47",
                    "url": "https://www.uniprot.org/uniprot/A2AF47"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25851601",
                    "url": "https://glygen.org/publication/PubMed/25851601"
                }
            ]
        },
        {
            "title": "Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM.",
            "journal": "International immunology",
            "date": "2017",
            "authors": "Sakamoto A, Matsuda T, Kawaguchi K, Takaoka A, Maruyama M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001009947",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29099971",
                    "url": "https://glygen.org/publication/PubMed/29099971"
                }
            ]
        },
        {
            "title": "Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells.",
            "journal": "ImmunoHorizons",
            "date": "2020",
            "authors": "Sakamoto A, Maruyama M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001009947",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32878909",
                    "url": "https://glygen.org/publication/PubMed/32878909"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:75974",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75974",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-9013148",
            "name": "CDC42 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148",
            "resource": "Reactome",
            "description": "CDC42 GTPase cycle"
        },
        {
            "id": "R-MMU-9013149",
            "name": "RAC1 GTPase cycle",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149",
            "resource": "Reactome",
            "description": "RAC1 GTPase cycle"
        },
        {
            "id": "R-MMU-983231",
            "name": "Factors involved in megakaryocyte development and platelet production",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983231",
            "resource": "Reactome",
            "description": "Factors involved in megakaryocyte development and platelet production"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A0G2JV16-1",
            "protein_name": "Dedicator of cytokinesis 11",
            "gene_name": "Dock11",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPMEDISLSVIGRQLRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINTDSLVQEKKETVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFLVNCHDLTFNILGHIGDNAKGPPTNVEPFFITLALFDVKNNCKISADFHVDLNPPSVREMLWGMSTQLANDGNTKGSSPESLIHGIAESRLCYIRQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDLQGSLDLDGKFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLNITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDTSALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVTTLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHILHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDFFSFAVDRLTSVDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFVSPTSRGSLATDKEPAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTGENTRQSSSRTSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKSQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISFRLVKLYGEKFGTENIKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPITCEQQVNLKPIDVATDEIKDKTAELHKLCSSADVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYSEV",
                "length": 2086
            },
            "evidence": [
                {
                    "id": "70950",
                    "url": "http://www.informatics.jax.org/homology/70950",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q5JSL3-1",
            "protein_name": "Dedicator of cytokinesis protein 11",
            "gene_name": "DOCK11",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKVVEPLDYENVIAQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINTDSLVQEKKETVETAQDDETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDIKPFEEKCNKRFLVNCHDLTFNILGQIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGSSTQLASDGSPKGSSPESYIHGIAESQLRYIQQGIFSVTNPHPEIFLVARIEKVLQGNITHCAEPYIKNSDPVKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDTQGSLDLDGRFSPLYKQDSSKLSSEDILKLLSEYKKPEKTKLQIIPGQLNITVECVPVDLSNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRIITFEQQLPVSANLPPGYLNLNDAESRRQCNVDIKWVDGAKPLLKIKSHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLDSYLRSFIKYSFRPEKPSAPQAQLIHETLATTMIAILKQSADFLSINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFIFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFTSPANRGSLSTDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDQGNTGENTRQSSTRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTLLTYWNKVSPQELINILILLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSTTTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKTQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRAFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVAEFLHRKKLFPNGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIVPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKYAHIQVTYVKPYFDDKELTERKTEFERNHNISRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQINLKPIDVATDEIKDKTAELQKLCSSTDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNDSQASKYPPKKVSELKDMFRKFIQACSIALELNERLIKEDQVEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMSNTLHVFCAISGTSSDRGYGSPRYAEV",
                "length": 2073
            },
            "evidence": [
                {
                    "id": "70950",
                    "url": "http://www.informatics.jax.org/homology/70950",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "positive regulation of GTPase activity",
                        "id": "GO:0043547",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF47",
                                "url": "https://www.uniprot.org/uniprot/A2AF47"
                            }
                        ],
                        "pmid": "22494997"
                    },
                    {
                        "name": "small GTPase mediated signal transduction",
                        "id": "GO:0007264",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF47",
                                "url": "https://www.uniprot.org/uniprot/A2AF47"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of filopodium assembly",
                        "id": "GO:0051491",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF47",
                                "url": "https://www.uniprot.org/uniprot/A2AF47"
                            }
                        ],
                        "pmid": "22494997"
                    },
                    {
                        "name": "B cell homeostasis",
                        "id": "GO:0001782",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001782",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF47",
                                "url": "https://www.uniprot.org/uniprot/A2AF47"
                            }
                        ],
                        "pmid": "25729399"
                    },
                    {
                        "name": "marginal zone B cell differentiation",
                        "id": "GO:0002315",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002315",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF47",
                                "url": "https://www.uniprot.org/uniprot/A2AF47"
                            }
                        ],
                        "pmid": "25729399"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "guanyl-nucleotide exchange factor activity",
                        "id": "GO:0005085",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF47",
                                "url": "https://www.uniprot.org/uniprot/A2AF47"
                            }
                        ],
                        "pmid": "22494997"
                    },
                    {
                        "name": "small GTPase binding",
                        "id": "GO:0031267",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF47",
                                "url": "https://www.uniprot.org/uniprot/A2AF47"
                            }
                        ],
                        "pmid": "15710388"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 1024,
            "end_pos": 1026,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1358,
            "end_pos": 1360,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1380,
            "end_pos": 1382,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 178,
            "end_pos": 180,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1968,
            "end_pos": 1970,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 2047,
            "end_pos": 2049,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 488,
            "end_pos": 490,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 617,
            "end_pos": 619,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 881,
            "end_pos": 883,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 891,
            "end_pos": 893,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}