{
    "uniprot_canonical_ac": "A2AF31-1",
    "uniprot_ac": "A2AF31",
    "uniprot_id": "A2AF31_MOUSE",
    "mass": {
        "chemical_mass": 5247.0,
        "monoisotopic_mass": 5247.0
    },
    "refseq": {
        "ac": "NP_001074436",
        "name": "thymosin beta-like",
        "summary": "This gene is part of tandem duplication; the other copy of this gene is about 1.5 kb away. Readthrough transcripts that include two exons transcribed from each gene exist. [provided by RefSeq, Jul 2008].",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436"
    },
    "gene_names": [
        {
            "name": "Tmsb15b2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AF31",
            "id": "A2AF31"
        },
        {
            "name": "Tmsb15l",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AF31",
            "id": "A2AF31"
        },
        {
            "name": "4930488E11Rik",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF31",
            "id": "A2AF31"
        },
        {
            "name": "Tb15c",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436",
            "id": "NP_001074436"
        },
        {
            "name": "Tmsb15b2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436",
            "id": "NP_001074436"
        },
        {
            "name": "Tmsb15b2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AF31",
            "id": "A2AF31"
        }
    ],
    "protein_names": [
        {
            "name": "Thymosin beta",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AF31#names_and_taxonomy",
            "id": "A2AF31"
        },
        {
            "name": "Tmsb15b1-Tmsb15b2 protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997150",
            "id": "NP_997150"
        },
        {
            "name": "Tmsb15b1-Tmsb15b2 readthrough transcript",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997150",
            "id": "NP_997150"
        },
        {
            "name": "thymosin beta-like",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436",
            "id": "NP_001074436"
        }
    ],
    "function": [
        {
            "annotation": "Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF31",
                    "url": "https://www.uniprot.org/uniprot/A2AF31#function"
                },
                {
                    "database": "PubMed",
                    "id": "PIRNR001828",
                    "url": "https://glygen.org/publication/PubMed/PIRNR001828"
                }
            ]
        },
        {
            "annotation": "This gene is part of tandem duplication; the other copy of this gene is about 1.5 kb away. Readthrough transcripts that include two exons transcribed from each gene exist. [provided by RefSeq, Jul 2008].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001074436",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436"
                }
            ]
        },
        {
            "annotation": "This record represents readthrough transcripts derived from two adjacent genes, represented by GeneIDs 100034363 and 666244. Each gene has three exons. The readthrough transcripts include two exons from each gene, such that the second exon is represented twice, although not identically, in the readthrough transcripts. [provided by RefSeq, Jul 2008].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_997150",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997150"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AF31",
                    "url": "https://www.uniprot.org/uniprot/A2AF31"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Tmsb15b2",
            "url": "https://www.uniprot.org/uniprot/A2AF31",
            "locus": {
                "chromosome": "X",
                "start_pos": 136975497,
                "end_pos": 136955265,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000089996",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000089996"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000072955",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000072955",
            "database": "Bgee"
        },
        {
            "id": "ENSMUSG00000089996",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000089996",
            "database": "Bgee"
        },
        {
            "id": "100034363",
            "url": "https://www.ncbi.nlm.nih.gov/gene/100034363",
            "database": "GeneID"
        },
        {
            "id": "399591",
            "url": "https://www.ncbi.nlm.nih.gov/gene/399591",
            "database": "GeneID"
        },
        {
            "id": "IPR001152",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001152",
            "database": "InterPro"
        },
        {
            "id": "IPR038386",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038386",
            "database": "InterPro"
        },
        {
            "id": "mmu:100034363",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100034363",
            "database": "KEGG Pathway"
        },
        {
            "id": "mmu:399591",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:399591",
            "database": "KEGG Pathway"
        },
        {
            "id": "3026988",
            "url": "http://www.informatics.jax.org/marker/MGI:3026988",
            "database": "MGI"
        },
        {
            "id": "3843061",
            "url": "http://www.informatics.jax.org/marker/MGI:3843061",
            "database": "MGI"
        },
        {
            "id": "PICFARF",
            "url": "https://omabrowser.org/oma/group/PICFARF/",
            "database": "OMA"
        },
        {
            "id": "1640382at2759",
            "url": "http://www.orthodb.org/?query=1640382at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR12021",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12021",
            "database": "PANTHER"
        },
        {
            "id": "PF01290",
            "url": "http://pfam.xfam.org/family/PF01290",
            "database": "Pfam"
        },
        {
            "id": "NP_001074436",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436",
            "database": "RefSeq"
        },
        {
            "id": "NP_997150",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997150",
            "database": "RefSeq"
        },
        {
            "id": "A2AF31",
            "url": "https://www.uniprot.org/uniprot/A2AF31",
            "database": "UniProtKB"
        },
        {
            "id": "A2AF31-1",
            "url": "https://www.uniprot.org/uniprot/A2AF31-1",
            "database": "UniProtKB"
        },
        {
            "id": "Q8C0W0",
            "url": "https://www.uniprot.org/uniprot/Q8C0W0",
            "database": "UniProtKB"
        },
        {
            "id": "Q8C0W0-1",
            "url": "https://www.uniprot.org/uniprot/Q8C0W0-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MSDKPDLSEVETFDKAKLKKTNTEVKNTLPSKETIQQEKEHNERT",
        "length": 45,
        "header": "tr|A2AF31-1|A2AF31_MOUSE Isoform 1 of Thymosin beta  OS=Mus musculus OX=10090 GN=Tmsb15b2 PE=1 SV=1 CANONICAL=A2AF31-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AF31-1",
            "url": "https://www.uniprot.org/uniprot/A2AF31#A2AF31-1",
            "sequence": {
                "sequence": "MSDKPDLSEVETFDKAKLKKTNTEVKNTLPSKETIQQEKEHNERT",
                "length": 45,
                "header": "tr|A2AF31-1|A2AF31_MOUSE Isoform 1 of Thymosin beta  OS=Mus musculus OX=10090 GN=Tmsb15b2 PE=1 SV=1 CANONICAL=A2AF31-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 135857583,
                "end_pos": 135856197,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000069803",
                        "url": "https://www.ensembl.org/id/ENSMUST00000069803"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000063549",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000063549"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8C0W0-1",
            "url": "https://www.uniprot.org/uniprot/A2AF31#Q8C0W0-1",
            "sequence": {
                "sequence": "MSDKPDLSEVETFDKSKLKKTNTEVKNTLPSNENKMSDKPDLSEVETFDKAKLKKTNTEVKNTLPSKETIQQEKEHNERT",
                "length": 80,
                "header": "tr|Q8C0W0-1|Q8C0W0_MOUSE Computationally mapped isoform of Thymosin beta 15b2  OS=Mus musculus OX=10090 GN=Tmsb15l PE=1 SV=1 CANONICAL=A2AF31-1"
            },
            "locus": {
                "chromosome": "X",
                "start_pos": 135876246,
                "end_pos": 135856197,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000180194",
                        "url": "https://www.ensembl.org/id/ENSMUST00000180194"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000137225",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000137225"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:100034363",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100034363",
            "resource": "KEGG Pathway"
        },
        {
            "id": "mmu:399591",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:399591",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2AEH9-1",
            "protein_name": "Thymosin beta 15a",
            "gene_name": "Tmsb15a",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MTHWYCKGSISLALKLTEDRAVGLIGGAVSLIVKMGDRPDLSEVERFDKSKLKKTITEVKNTLPSKETIEQEKEFVKRS",
                "length": 79
            },
            "evidence": [
                {
                    "id": "116060",
                    "url": "http://www.informatics.jax.org/homology/116060",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P20065-1",
            "protein_name": "Thymosin beta-4",
            "gene_name": "Tmsb4x",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MLLPATMSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES",
                "length": 50
            },
            "evidence": [
                {
                    "id": "116060",
                    "url": "http://www.informatics.jax.org/homology/116060",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q6ZWY8-1",
            "protein_name": "Thymosin beta-10",
            "gene_name": "Tmsb10",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MADKPDMGEIASFDKAKLKKTETQEKNTLPTKETIEQEKRSEIS",
                "length": 44
            },
            "evidence": [
                {
                    "id": "116060",
                    "url": "http://www.informatics.jax.org/homology/116060",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "actin monomer binding",
                        "id": "GO:0003785",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": "19233202"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "stress fiber",
                        "id": "GO:0001725",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": "19233202"
                    },
                    {
                        "name": "filamentous actin",
                        "id": "GO:0031941",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031941",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": "19233202"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "actin filament organization",
                        "id": "GO:0007015",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sequestering of actin monomers",
                        "id": "GO:0042989",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042989",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": "19233202"
                    },
                    {
                        "name": "negative regulation of stress fiber assembly",
                        "id": "GO:0051497",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": "19233202"
                    },
                    {
                        "name": "negative regulation of actin filament polymerization",
                        "id": "GO:0030837",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030837",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": "19233202"
                    },
                    {
                        "name": "regulation of cell migration",
                        "id": "GO:0030334",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AF31",
                                "url": "https://www.uniprot.org/uniprot/A2AF31"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}