{ "uniprot_canonical_ac": "A2AEV7-1", "uniprot_ac": "A2AEV7", "uniprot_id": "CC120_MOUSE", "mass": { "chemical_mass": 67407.0, "monoisotopic_mass": 67407.0 }, "refseq": { "ac": "NP_997085", "name": "coiled-coil domain-containing protein 120", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085" }, "gene_names": [ { "name": "Ccdc120", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AEV7", "id": "A2AEV7" }, { "name": "AA030924; DXImx50e; Jm11; Sfc25", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085", "id": "NP_997085" }, { "name": "Ccdc120", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085", "id": "NP_997085" } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 120", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AEV7#names_and_taxonomy", "id": "A2AEV7" }, { "name": "coiled-coil domain-containing protein 120", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085", "id": "NP_997085" } ], "function": [ { "annotation": "Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7#function" }, { "database": "PubMed", "id": "Q96HB5", "url": "https://glygen.org/publication/PubMed/Q96HB5" }, { "database": "PubMed", "id": "28422092", "url": "https://glygen.org/publication/PubMed/28422092" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ccdc120", "url": "https://www.uniprot.org/uniprot/A2AEV7", "locus": { "chromosome": "X", "start_pos": 7750905, "end_pos": 7731714, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000031150", "url": "https://www.ensembl.org/id/ENSMUSG00000031150" } ] } } ], "crossref": [ { "id": "ENSMUSG00000031150", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031150", "database": "Bgee" }, { "id": "54648", "url": "https://www.ncbi.nlm.nih.gov/gene/54648", "database": "GeneID" }, { "id": "IPR021774", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021774", "database": "InterPro" }, { "id": "IPR039108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039108", "database": "InterPro" }, { "id": "IPR043447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043447", "database": "InterPro" }, { "id": "mmu:54648", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:54648", "database": "KEGG Pathway" }, { "id": "1859619", "url": "http://www.informatics.jax.org/marker/MGI:1859619", "database": "MGI" }, { "id": "AQRKQMK", "url": "https://omabrowser.org/oma/group/AQRKQMK/", "database": "OMA" }, { "id": "595503at2759", "url": "http://www.orthodb.org/?query=595503at2759", "database": "OrthoDB" }, { "id": "PTHR16093", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16093", "database": "PANTHER" }, { "id": "PTHR16093:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16093:SF5", "database": "PANTHER" }, { "id": "PF11819", "url": "http://pfam.xfam.org/family/PF11819", "database": "Pfam" }, { "id": "PR_A2AEV7", "url": "http://purl.obolibrary.org/obo/PR_A2AEV7", "database": "PRO" }, { "id": "NP_997085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997085", "database": "RefSeq" }, { "id": "A0A286YDD1", "url": "https://www.uniprot.org/uniprot/A0A286YDD1", "database": "UniProtKB" }, { "id": "A0A286YDD1-1", "url": "https://www.uniprot.org/uniprot/A0A286YDD1-1", "database": "UniProtKB" }, { "id": "A0A5H1ZRM7", "url": "https://www.uniprot.org/uniprot/A0A5H1ZRM7", "database": "UniProtKB" }, { "id": "A0A5H1ZRM7-1", "url": "https://www.uniprot.org/uniprot/A0A5H1ZRM7-1", "database": "UniProtKB" }, { "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7", "database": "UniProtKB" }, { "id": "A2AEV7-1", "url": "https://www.uniprot.org/uniprot/A2AEV7-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDRQRALQEALSVKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSAGALVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG", "length": 629, "header": "sp|A2AEV7-1|CC120_MOUSE Isoform 1 of Coiled-coil domain-containing protein 120 OS=Mus musculus OX=10090 GN=Ccdc120 PE=1 SV=1 CANONICAL=A2AEV7-1" }, "isoforms": [ { "isoform_ac": "A0A286YDD1-1", "url": "https://www.uniprot.org/uniprot/A2AEV7#A0A286YDD1-1", "sequence": { "sequence": "XAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYYTDFLYPPELSARLSDLTLEGEPSSSSDTQTPGTLV", "length": 278, "header": "tr|A0A286YDD1-1|CC120_MOUSE Computationally mapped isoform of Coiled-coil domain-containing protein 120 OS=Mus musculus OX=10090 GN=Ccdc120 PE=1 SV=1 CANONICAL=A2AEV7-1" }, "locus": { "chromosome": "X", "start_pos": 7600143, "end_pos": 7598860, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000224502", "url": "https://www.ensembl.org/id/ENSMUST00000224502" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000153379", "url": "https://www.ensembl.org/id/ENSMUSP00000153379" } ] } }, { "isoform_ac": "A0A5H1ZRM7-1", "url": "https://www.uniprot.org/uniprot/A2AEV7#A0A5H1ZRM7-1", "sequence": { "sequence": "MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDR", "length": 38, "header": "tr|A0A5H1ZRM7-1|CC120_MOUSE Computationally mapped isoform of Coiled-coil domain-containing protein 120 OS=Mus musculus OX=10090 GN=Ccdc120 PE=1 SV=1 CANONICAL=A2AEV7-1" }, "locus": { "chromosome": "X", "start_pos": 7604449, "end_pos": 7604202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000128289", "url": "https://www.ensembl.org/id/ENSMUST00000128289" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119351", "url": "https://www.ensembl.org/id/ENSMUSP00000119351" } ] } }, { "isoform_ac": "A2AEV7-1", "url": "https://www.uniprot.org/uniprot/A2AEV7#A2AEV7-1", "sequence": { "sequence": "MEVKGQLISSPTFTAPAALFGEAAPLVKSDRLRGLLDRQRALQEALSVKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHPNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSAGALVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHSRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGAPRLPTVCGDFLLDYPLDRGLPRGSGGAGWGELLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNTRAIRSKPSGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYGGAFTDG", "length": 629, "header": "sp|A2AEV7-1|CC120_MOUSE Isoform 1 of Coiled-coil domain-containing protein 120 OS=Mus musculus OX=10090 GN=Ccdc120 PE=1 SV=1 CANONICAL=A2AEV7-1" }, "locus": { "chromosome": "X", "start_pos": 7604449, "end_pos": 7599398, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000033490", "url": "https://www.ensembl.org/id/ENSMUST00000033490" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000033490", "url": "https://www.ensembl.org/id/ENSMUSP00000033490" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 355, "end_pos": 355, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ] }, { "start_pos": 357, "end_pos": 357, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" }, { "database": "iPTMnet", "id": "A2AEV7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AEV7" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 357, "end_pos": 357, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" }, { "database": "iPTMnet", "id": "A2AEV7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AEV7" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "evidence": [ { "database": "UniProtKB", "id": "A0A286YDD1", "url": "https://www.uniprot.org/uniprot/A0A286YDD1" }, { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68.", "journal": "Nat. Commun.", "date": "2017", "authors": "Chen J., Wang S., Zhang D., Xia Y., He R., Huang N., Teng J., Bao Y.", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "reference": [ { "type": "PubMed", "id": "28422092", "url": "https://glygen.org/publication/PubMed/28422092" } ] } ], "pathway": [ { "id": "mmu:54648", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:54648", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZAB5-1", "protein_name": "Coiled-coil domain-containing 120", "gene_name": "Ccdc120", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVKGQLINSPTFNAPAALFGEAAPQVKSDRLRGLLDRQQALQETLRLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPAARAYPPPHSNPAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLNGEQRRRRRQVQVDALRRLHELEEQLRDFRARLGLPVLQPLPLSSGAPVNAQGVCLGTRLAQLSQEDVVLHSESSSLSESGASHDNEEPHSCFPLTERPSPPKAWDQFRAVSGGSPERRAPWKPPPSDIYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGSGPRLCKPEGLHPRQWSGSQDSQMGFPRPDPASDRASLFAARTRRSNSSEALLVDRAAAGGAGSPPAPLAPPAAGPPVCKSSEVLYERPQPVPSFSSRTTGPPDPPRAARPSSAAPASRGPPRLPPVCGDFLLDYSLDRGLPRGSGGAGWGDLLPAPEVPGPLSRRDGLLAMLPGPPPIYAADGSSPLLRSKDPNSRAIRSKPCGLPPEAVEGLEVHPNPLLWMPPPTRIPPAGERGGHKNLALEGLRDWYIRNSGLAVGPQRRPMLPHVGPTHTPFLHARCYEVGQSLYGPPSQAPLPHSRSFTAPPVSGRYYTDFLYPPELSARLSDLTLEGEQSSSSDTQTPGTLV", "length": 658 }, "evidence": [ { "id": "14146", "url": "http://www.informatics.jax.org/homology/14146", "database": "MGI" }, { "id": "A2AEV7", "url": "https://omabrowser.org/oma/group/A2AEV7/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96HB5-1", "protein_name": "Coiled-coil domain-containing protein 120", "gene_name": "CCDC120", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVKGQLISSPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVITTQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCFSLAERPSPPKAWDQLRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVLTRGAGPQLCKPEGLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEALLVDRAAGGGAGSPPAPLAPSASGPPVCKSSEVLYERPQPTPAFSSRTAGPPDPPRAARPSSAAPASRGAPRLPPVCGDFLLDYSLDRGLPRSGGGTGWGELPPAAEVPGPLSRRDGLLTMLPGPPPVYAADSNSPLLRTKDPHTRATRTKPCGLPPEAAEGPEVHPNPLLWMPPPTRIPSAGERSGHKNLALEGLRDWYIRNSGLAAGPQRRPVLPSVGPPHPPFLHARCYEVGQALYGAPSQAPLPHSRSFTAPPVSGRYGGCFY", "length": 630 }, "evidence": [ { "id": "14146", "url": "http://www.informatics.jax.org/homology/14146", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "centriolar subdistal appendage", "id": "GO:0120103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120103", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "pmid": "" }, { "name": "microtubule anchoring at centrosome", "id": "GO:0034454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034454", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Ubiquitinated; interaction with CYTH2 may prevent ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "A2AEV7", "url": "https://www.uniprot.org/uniprot/A2AEV7" }, { "database": "PubMed", "id": "Q96HB5", "url": "https://glygen.org/publication/PubMed/Q96HB5" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }