{
    "uniprot_canonical_ac": "A2ACG1-1",
    "uniprot_ac": "A2ACG1",
    "uniprot_id": "TLDC2_MOUSE",
    "mass": {
        "chemical_mass": 21987.0,
        "monoisotopic_mass": 21987.0
    },
    "refseq": {
        "ac": "NP_001170910",
        "name": "TLD domain-containing protein 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170910"
    },
    "gene_names": [
        {
            "name": "Tldc2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2ACG1",
            "id": "A2ACG1"
        },
        {
            "name": "Gm1332",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170910",
            "id": "NP_001170910"
        },
        {
            "name": "Gm1332",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2ACG1",
            "id": "A2ACG1"
        },
        {
            "name": "Tldc2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170910",
            "id": "NP_001170910"
        }
    ],
    "protein_names": [
        {
            "name": "TLD domain-containing protein 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2ACG1#names_and_taxonomy",
            "id": "A2ACG1"
        },
        {
            "name": "TBC/LysM-associated domain-containing protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170910",
            "id": "NP_001170910"
        },
        {
            "name": "TBC/LysM-associated domain-containing protein 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2ACG1#names_and_taxonomy",
            "id": "A2ACG1"
        },
        {
            "name": "TLD domain-containing protein 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170910",
            "id": "NP_001170910"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0070339",
            "recommended_name": {
                "id": "DOID:0070339",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070339",
                "name": "cerebellar hyplasia/atrophy, epilepsy, and global developmental delay",
                "description": "A syndrome with a cerebellar malformation as a major feature characterized by cerebellar hypoplasia, bilateral retinal pigmentary changes, intellectual disability that can range from mild to moderate and pronounced language development delay. It presents with early developmental delay, central and peripheral non-progressive visual impairment or asymptomatic retinal changes, hypotonia, non-progressive ataxia and nystagmus."
            },
            "synonyms": [
                {
                    "id": "MONDO:0008939",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008939",
                    "name": "isolated cerebellar hypoplasia/agenesis",
                    "description": "Hypoplasia of the cerebellum that is associated with inherited metabolic disorders and neurodegenerative disorders. Signs and symptoms include mental and developmental delays, walking and balance difficulties, floppy muscle tone, and seizures."
                },
                {
                    "id": "MONDO:0008939",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008939",
                    "name": "isolated cerebellar agenesis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008939",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008939",
                    "name": "near total absence of cerebellum",
                    "description": ""
                },
                {
                    "id": "MONDO:0008939",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008939",
                    "name": "Chiari 4 malformation",
                    "description": ""
                },
                {
                    "id": "MONDO:0008939",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008939",
                    "name": "Chiari IV malformation",
                    "description": ""
                },
                {
                    "id": "MONDO:0008939",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008939",
                    "name": "congenital cerebellar Hypoplasia",
                    "description": ""
                },
                {
                    "id": "MONDO:0008939",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008939",
                    "name": "subtotal absence of cerebellum",
                    "description": ""
                },
                {
                    "id": "MONDO:0008939",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008939",
                    "name": "cerebellar hypoplasia",
                    "description": ""
                },
                {
                    "id": "MIM:213000",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/213000",
                    "name": "Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay",
                    "description": "Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay"
                }
            ],
            "evidence": [
                {
                    "id": "0070339",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070339"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2ACG1",
                    "url": "https://www.uniprot.org/uniprot/A2ACG1"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Tldc2",
            "url": "https://www.uniprot.org/uniprot/A2ACG1",
            "locus": {
                "chromosome": "2",
                "start_pos": 157087055,
                "end_pos": 157096482,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000074628",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000074628"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000074628",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074628",
            "database": "Bgee"
        },
        {
            "id": "383766",
            "url": "https://www.ncbi.nlm.nih.gov/gene/383766",
            "database": "GeneID"
        },
        {
            "id": "IPR006571",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006571",
            "database": "InterPro"
        },
        {
            "id": "mmu:383766",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:383766",
            "database": "KEGG Pathway"
        },
        {
            "id": "2686178",
            "url": "http://www.informatics.jax.org/marker/MGI:2686178",
            "database": "MGI"
        },
        {
            "id": "GHYGLWC",
            "url": "https://omabrowser.org/oma/group/GHYGLWC/",
            "database": "OMA"
        },
        {
            "id": "767847at2759",
            "url": "http://www.orthodb.org/?query=767847at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF07534",
            "url": "http://pfam.xfam.org/family/PF07534",
            "database": "Pfam"
        },
        {
            "id": "PR_A2ACG1",
            "url": "http://purl.obolibrary.org/obo/PR_A2ACG1",
            "database": "PRO"
        },
        {
            "id": "NP_001170910",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170910",
            "database": "RefSeq"
        },
        {
            "id": "A2ACG1",
            "url": "https://www.uniprot.org/uniprot/A2ACG1",
            "database": "UniProtKB"
        },
        {
            "id": "A2ACG1-1",
            "url": "https://www.uniprot.org/uniprot/A2ACG1-1",
            "database": "UniProtKB"
        },
        {
            "id": "E9PZS3",
            "url": "https://www.uniprot.org/uniprot/E9PZS3",
            "database": "UniProtKB"
        },
        {
            "id": "E9PZS3-1",
            "url": "https://www.uniprot.org/uniprot/E9PZS3-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MEDTLSGEEGEEEEEEEPAPAPAPQDPVEPQLTEASQVLGASEIKQLSLHLPPRVTGHPWSLVFCTSRDGFSLRRLYRQMEGHSGPVLLLLRDQDGQMFGAFSSSAIRLSKGFYGTGETFLFSFSPQLKVFKWTGHNSFFVKGDLDSLMMGSGSGQFGLWLDGDLYHGGSYPCATFNNEVLARREQFCIKELEAWVLS",
        "length": 198,
        "header": "sp|A2ACG1-1|TLDC2_MOUSE Isoform 1 of TLD domain-containing protein 2  OS=Mus musculus OX=10090 GN=Tldc2 PE=3 SV=1 CANONICAL=A2ACG1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2ACG1-1",
            "url": "https://www.uniprot.org/uniprot/A2ACG1#A2ACG1-1",
            "sequence": {
                "sequence": "MEDTLSGEEGEEEEEEEPAPAPAPQDPVEPQLTEASQVLGASEIKQLSLHLPPRVTGHPWSLVFCTSRDGFSLRRLYRQMEGHSGPVLLLLRDQDGQMFGAFSSSAIRLSKGFYGTGETFLFSFSPQLKVFKWTGHNSFFVKGDLDSLMMGSGSGQFGLWLDGDLYHGGSYPCATFNNEVLARREQFCIKELEAWVLS",
                "length": 198,
                "header": "sp|A2ACG1-1|TLDC2_MOUSE Isoform 1 of TLD domain-containing protein 2  OS=Mus musculus OX=10090 GN=Tldc2 PE=3 SV=1 CANONICAL=A2ACG1-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 156938398,
                "end_pos": 156930383,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000099140",
                        "url": "https://www.ensembl.org/id/ENSMUST00000099140"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000096743",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000096743"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9PZS3-1",
            "url": "https://www.uniprot.org/uniprot/A2ACG1#E9PZS3-1",
            "sequence": {
                "sequence": "MKGWQWRYTQLPTEMEDTLSGEEGEEEEEEEPAPAPAPQDPVEPQLTEASQVLGASEIKQLSLHLPPRVTGHPWSLVFCTSRDGFSLRRLYRQMEGHSGPVLLLLRDQDGQMFGAFSSSAIRLSKGFYGTGETFLFSFSPQLKVFKWTGHNSFFVKGDLDSLMMGSGSGQFGLWLDGDLYHGGSYPCATFNNEVLARREQFCIKELEAWVLS",
                "length": 212,
                "header": "tr|E9PZS3-1|E9PZS3_MOUSE Computationally mapped isoform of TLD domain-containing protein 2  OS=Mus musculus OX=10090 GN=Tldc2 PE=4 SV=1 CANONICAL=A2ACG1-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 156938398,
                "end_pos": 156928975,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000166140",
                        "url": "https://www.ensembl.org/id/ENSMUST00000166140"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000129278",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000129278"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:383766",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:383766",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0PJX2-1",
            "protein_name": "TLD domain-containing protein 2",
            "gene_name": "TLDC2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MRGLRWRYTRLPSQVEDTLSGEEGNEEEEEEEAAPDPAAAPEDPTVPQLTEASQVLSASEIRQLSFHFPPRVTGHPWSLVFCTSRDGFSLQSLYRRMEGCSGPVLLVLRDQDGQIFGAFSSSAIRLSKGFYGTGETFLFSFSPQLKVFKWTGSNSFFVKGDLDSLMMGSGSGRFGLWLDGDLFRGGSSPCPTFNNEVLARQEQFCIQELEAWLLS",
                "length": 215
            },
            "evidence": [
                {
                    "id": "31961",
                    "url": "http://www.informatics.jax.org/homology/31961",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "D3ZQ38-1",
            "protein_name": "TBC/LysM-associated domain-containing 2",
            "gene_name": "Tldc2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MKGRQWRYTQLPTEMEDTLSGEEGEEEEEEEPAPAPQDPVEPQLTEASQVLGASEIKQLSLHLPPRVTGHPWNLIFCTSRDGFSLQRLYRQMEGHSGPVLLLLRDQDGQMFGAFSSSALRLSKGFYGTGETFLFSFSPQLKVFKWTGHNSFFVKGDLDSLMMGSGSGQFGLWLDGDLYHGGSYPCATFNNEVLARREQFCIRELEAWALS",
                "length": 210
            },
            "evidence": [
                {
                    "id": "31961",
                    "url": "http://www.informatics.jax.org/homology/31961",
                    "database": "MGI"
                },
                {
                    "id": "A2ACG1",
                    "url": "https://omabrowser.org/oma/group/A2ACG1/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ACG1",
                                "url": "https://www.uniprot.org/uniprot/A2ACG1"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "response to oxidative stress",
                        "id": "GO:0006979",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ACG1",
                                "url": "https://www.uniprot.org/uniprot/A2ACG1"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "negative regulation of oxidative stress-induced neuron death",
                        "id": "GO:1903204",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903204",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ACG1",
                                "url": "https://www.uniprot.org/uniprot/A2ACG1"
                            }
                        ],
                        "pmid": "26668325"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}