{
    "uniprot_canonical_ac": "A2AC93-1",
    "uniprot_ac": "A2AC93",
    "uniprot_id": "DNAI2_MOUSE",
    "mass": {
        "chemical_mass": 70968.0,
        "monoisotopic_mass": 70968.0
    },
    "refseq": {
        "ac": "NP_001030050",
        "name": "dynein axonemal intermediate chain 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050"
    },
    "gene_names": [
        {
            "name": "Dnai2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AC93",
            "id": "A2AC93"
        },
        {
            "name": "Dnai2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050",
            "id": "NP_001030050"
        },
        {
            "name": "Dnaic2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AC93",
            "id": "A2AC93"
        },
        {
            "name": "b2b3405Clo; C030015H18Rik; Dnaic2; Gm728",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050",
            "id": "NP_001030050"
        }
    ],
    "protein_names": [
        {
            "name": "Dynein axonemal intermediate chain 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2AC93#names_and_taxonomy",
            "id": "A2AC93"
        },
        {
            "name": "Axonemal dynein intermediate chain 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2AC93#names_and_taxonomy",
            "id": "A2AC93"
        },
        {
            "name": "dynein axonemal intermediate chain 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050",
            "id": "NP_001030050"
        },
        {
            "name": "dynein, axonemal, intermediate polypeptide 2; dynein intermediate chain 2, axonemal",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050",
            "id": "NP_001030050"
        }
    ],
    "function": [
        {
            "annotation": "Dnaic2 plays a role in oogenesis and spermatogenesis by activation of Stat3.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001030050",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050"
                },
                {
                    "database": "PubMed",
                    "id": "30387321",
                    "url": "https://glygen.org/publication/PubMed/30387321"
                }
            ]
        },
        {
            "annotation": "Part of the dynein complex of respiratory cilia.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AC93",
                    "url": "https://www.uniprot.org/uniprot/A2AC93#function"
                }
            ]
        },
        {
            "annotation": "Results obtained with Western blot analysis revealed that the expression of DNAI2 protein was significantly less in oviducts of dNOD mice as compared to that of cNOD mice corroborating the results obtained with immunohistochemistry",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001030050",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050"
                },
                {
                    "database": "PubMed",
                    "id": "27823762",
                    "url": "https://glygen.org/publication/PubMed/27823762"
                }
            ]
        },
        {
            "annotation": "These data suggest that Dnaic2 plays a role in ovarian follicular development.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001030050",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050"
                },
                {
                    "database": "PubMed",
                    "id": "18547164",
                    "url": "https://glygen.org/publication/PubMed/18547164"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050144",
            "recommended_name": {
                "id": "DOID:0050144",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050144",
                "name": "Kartagener syndrome",
                "description": "A primary ciliary dyskinesia that is characterized by sinusitis, bronchiectasis and situs inversus with dextrocardia resulting from dysfunction of the cilia during embryologic development."
            },
            "synonyms": [
                {
                    "id": "DOID:0050144",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050144",
                    "name": "Kartagener's syndrome",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0050144",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050144"
                }
            ]
        },
        {
            "disease_id": "DOID:0110622",
            "recommended_name": {
                "id": "DOID:0110622",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110622",
                "name": "primary ciliary dyskinesia 9",
                "description": "A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer dynein arm defect, neonatal respiratory distress, sinusitis, otitis, bronchiectasis, and variable occurence of laterality defects and has_material_basis_in homozygous mutation in the DNAI2 gene on chromosome 17q25."
            },
            "synonyms": [
                {
                    "id": "DOID:0110622",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110622",
                    "name": "CILD9",
                    "description": ""
                },
                {
                    "id": "DOID:0110622",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110622",
                    "name": "primary ciliary dyskinesia 9 with or without situs inversus",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "primary ciliary dyskinesia 9",
                    "description": "Any primary ciliary dyskinesia in which the cause of the disease is a mutation in the DNAI2 gene."
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "ciliary dyskinesia, primary, type 9",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "CILD9",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "ciliary dyskinesia, primary, 9",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "DNAI2 primary ciliary dyskinesia",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "primary ciliary dyskinesia caused by mutation in DNAI2",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "primary ciliary dyskinesia 9 with or without situs inversus",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "ciliary dyskinesia, primary, 9, with or without situs inversus",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "primary ciliary dyskinesia type 9",
                    "description": ""
                },
                {
                    "id": "MONDO:0012906",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012906",
                    "name": "ciliary dyskinesia, primary, 9; CILD9",
                    "description": ""
                },
                {
                    "id": "MIM:612444",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/612444",
                    "name": "Ciliary dyskinesia, primary, 9",
                    "description": "Ciliary dyskinesia, primary, 9"
                }
            ],
            "evidence": [
                {
                    "id": "0110622",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110622"
                }
            ]
        },
        {
            "disease_id": "DOID:10003",
            "recommended_name": {
                "id": "DOID:10003",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:10003",
                "name": "sensorineural hearing loss",
                "description": ""
            },
            "synonyms": [
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "central hearing loss",
                    "description": ""
                },
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "Perceptive hearing loss",
                    "description": ""
                },
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "High frequency deafness",
                    "description": ""
                },
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "Sensorineural Deafness",
                    "description": ""
                },
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "High Frequency Hearing Loss",
                    "description": ""
                },
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "Sensory hearing loss",
                    "description": ""
                },
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "Perceptive deafness",
                    "description": ""
                },
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "high-frequency hearing loss",
                    "description": ""
                },
                {
                    "id": "DOID:10003",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:10003",
                    "name": "Perceptive hearing loss or deafness",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "10003",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:10003"
                }
            ]
        },
        {
            "disease_id": "DOID:9562",
            "recommended_name": {
                "id": "DOID:9562",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9562",
                "name": "primary ciliary dyskinesia",
                "description": "A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube."
            },
            "synonyms": [
                {
                    "id": "DOID:9562",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9562",
                    "name": "ciliary motility disorder",
                    "description": ""
                },
                {
                    "id": "DOID:9562",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9562",
                    "name": "immotile ciliary syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "primary ciliary dyskinesia 1",
                    "description": "Any primary ciliary dyskinesia in which the cause of the disease is a mutation in the DNAI1 gene."
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "PCD",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "immotile cilia syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "ciliary dyskinesia, primary, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "Kartagener syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "ciliary dyskinesia, primary, 1; CILD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "DNAI1 primary ciliary dyskinesia",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "dextrocardia, bronchiectasis, and sinusitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "ciliary dyskinesia, primary, 1, with or without situs inversus",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "Polynesian bronchiectasis",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "primary ciliary dyskinesia caused by mutation in DNAI1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "primary ciliary dyskinesia type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "CILD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "primary ciliary dyskinesia 1 with or without situs inversus",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "Siewert syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009484",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009484",
                    "name": "ciliary dyskinesia, primary, type 1",
                    "description": ""
                },
                {
                    "id": "MIM:244400",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/244400",
                    "name": "Kartagener syndrome",
                    "description": "Kartagener syndrome"
                }
            ],
            "evidence": [
                {
                    "id": "9562",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:9562"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AC93",
                    "url": "https://www.uniprot.org/uniprot/A2AC93"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Dnai2",
            "url": "https://www.uniprot.org/uniprot/A2AC93",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000034706",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034706",
            "database": "Bgee"
        },
        {
            "id": "432611",
            "url": "https://www.ncbi.nlm.nih.gov/gene/432611",
            "database": "GeneID"
        },
        {
            "id": "A2AC93",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AC93*",
            "database": "IntAct"
        },
        {
            "id": "IPR001680",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680",
            "database": "InterPro"
        },
        {
            "id": "IPR015943",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943",
            "database": "InterPro"
        },
        {
            "id": "IPR036322",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322",
            "database": "InterPro"
        },
        {
            "id": "mmu:432611",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:432611",
            "database": "KEGG Pathway"
        },
        {
            "id": "2685574",
            "url": "http://www.informatics.jax.org/marker/MGI:2685574",
            "database": "MGI"
        },
        {
            "id": "HSHHDPV",
            "url": "https://omabrowser.org/oma/group/HSHHDPV/",
            "database": "OMA"
        },
        {
            "id": "PR_A2AC93",
            "url": "http://purl.obolibrary.org/obo/PR_A2AC93",
            "database": "PRO"
        },
        {
            "id": "NP_001030050",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050",
            "database": "RefSeq"
        },
        {
            "id": "A2AC93",
            "url": "https://www.uniprot.org/uniprot/A2AC93",
            "database": "UniProtKB"
        },
        {
            "id": "A2AC93-1",
            "url": "https://www.uniprot.org/uniprot/A2AC93-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2AC93-2",
            "url": "https://www.uniprot.org/uniprot/A2AC93-2",
            "database": "UniProtKB"
        },
        {
            "id": "R4GML5",
            "url": "https://www.uniprot.org/uniprot/R4GML5",
            "database": "UniProtKB"
        },
        {
            "id": "R4GML5-1",
            "url": "https://www.uniprot.org/uniprot/R4GML5-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKVCDDPLFCLRVQDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKPRKKSSVKVEAEEEVEENVGEEEEAGGIIGIDAVEDMSEEAGEEQEDVPT",
        "length": 623,
        "header": "sp|A2AC93-1|DNAI2_MOUSE Isoform 1 of Dynein axonemal intermediate chain 2  OS=Mus musculus OX=10090 GN=Dnai2 PE=1 SV=2 CANONICAL=A2AC93-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2AC93-1",
            "url": "https://www.uniprot.org/uniprot/A2AC93#A2AC93-1",
            "sequence": {
                "sequence": "MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKVCDDPLFCLRVQDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKPRKKSSVKVEAEEEVEENVGEEEEAGGIIGIDAVEDMSEEAGEEQEDVPT",
                "length": 623,
                "header": "sp|A2AC93-1|DNAI2_MOUSE Isoform 1 of Dynein axonemal intermediate chain 2  OS=Mus musculus OX=10090 GN=Dnai2 PE=1 SV=2 CANONICAL=A2AC93-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 114648094,
                "end_pos": 114623739,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000069325",
                        "url": "https://www.ensembl.org/id/ENSMUST00000069325"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000065787",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000065787"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AC93-2",
            "url": "https://www.uniprot.org/uniprot/A2AC93#A2AC93-2",
            "sequence": {
                "sequence": "MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKPRKKSSVKVEAEEEVEENVGEEEEAGGIIGIDAVEDMSEEAGEEQEDVPT",
                "length": 611,
                "header": "sp|A2AC93-2|DNAI2_MOUSE Isoform 2 of Dynein axonemal intermediate chain 2  OS=Mus musculus OX=10090 GN=Dnai2 PE=1 SV=2 CANONICAL=A2AC93-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "R4GML5-1",
            "url": "https://www.uniprot.org/uniprot/A2AC93#R4GML5-1",
            "sequence": {
                "sequence": "MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKP",
                "length": 562,
                "header": "tr|R4GML5-1|DNAI2_MOUSE Computationally mapped isoform of Dynein axonemal intermediate chain 2  OS=Mus musculus OX=10090 GN=Dnai2 PE=1 SV=1 CANONICAL=A2AC93-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 114645288,
                "end_pos": 114623739,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000141762",
                        "url": "https://www.ensembl.org/id/ENSMUST00000141762"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000114700",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000114700"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Mouse dynein axonemal intermediate chain 2: cloning and expression.",
            "journal": "DNA Cell Biol.",
            "date": "2008",
            "authors": "Wu J., Yang Z.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AC93",
                    "url": "https://www.uniprot.org/uniprot/A2AC93"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001030050",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18547164",
                    "url": "https://glygen.org/publication/PubMed/18547164"
                }
            ]
        },
        {
            "title": "Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins.",
            "journal": "Nature",
            "date": "2008",
            "authors": "Reinhardt R., Zentgraf H., Zhang Q., Mizuno H., Takeda H., Watanabe Y., Hagiwara H., Fliegauf M., Loges N.T., Olbrich H., Omran H., Miyawaki A., Yagi T., Tsukahara T., O'Toole E., Mitchell D.R., Seithe H., Koshida S., Hara C., Kamiya R., Kawano H., Kobayashi D., Leblond G.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AC93",
                    "url": "https://www.uniprot.org/uniprot/A2AC93"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19052621",
                    "url": "https://glygen.org/publication/PubMed/19052621"
                }
            ]
        },
        {
            "title": "Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.",
            "journal": "J. Cell Biol.",
            "date": "2014",
            "authors": "Nakamura T., Asai Y., Fukumoto A., Takeda H., Hamada H., Matsuo M., Hasegawa T., Shinohara K., Shiratori H., Dong F., Botilde Y., Nabeshima R.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2AC93",
                    "url": "https://www.uniprot.org/uniprot/A2AC93"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24421334",
                    "url": "https://glygen.org/publication/PubMed/24421334"
                }
            ]
        },
        {
            "title": "Alterations in oviductal cilia morphology and reduced expression of axonemal dynein in diabetic NOD mice.",
            "journal": "Tissue & cell",
            "date": "2016",
            "authors": "Shorter SL, Albaghdadi AJ, Kan FW",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001030050",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27823762",
                    "url": "https://glygen.org/publication/PubMed/27823762"
                }
            ]
        },
        {
            "title": "Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3.",
            "journal": "Journal of cellular and molecular medicine",
            "date": "2019",
            "authors": "Yang Z, Xu B, Hu X, Yao X, Tang Y, Qian C, Wang S, Chen H, Bai X, Wu J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001030050",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30387321",
                    "url": "https://glygen.org/publication/PubMed/30387321"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:432611",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:432611",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q66HC9-1",
            "protein_name": "Dynein axonemal intermediate chain 2",
            "gene_name": "Dnai2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MEIVYVYVKKRSEFGKQCNFSDRQAELNIDISPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMENCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNKKLAVAYSCLQFQRSPMGMSHDSYIWDLENPNRPEIALKPSSPLITLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPTEVVIMDITRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTPAEKIVCTFSGHHGPIYALQRNPFYPKNFLTVGDWAARIWSEESRESSIMWTRYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKVCDDPLFCLRVQDTGCLIACGSELGTTTLLEVSSSLSTLQRNERNIASSIFERETRREKILEARHREMRLKEKGKAEGRDDDQKEEETALDLDELVNKAEEEFFEVIFAELKRKEAEALKKKPKPKKASIEVEGEDELEDIAGEEEESGIIMGEDTGEDDMDEKNEGGAP",
                "length": 619
            },
            "evidence": [
                {
                    "id": "11311",
                    "url": "http://www.informatics.jax.org/homology/11311",
                    "database": "MGI"
                },
                {
                    "id": "A2AC93",
                    "url": "https://omabrowser.org/oma/group/A2AC93/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9GZS0-1",
            "protein_name": "Dynein axonemal intermediate chain 2",
            "gene_name": "DNAI2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIMPNPELAEQFVERNPVDTGIQCSISMSEHEANSERFEMETRGVNHVEGGWPKDVNPLELEQTIRFRKKVEKDENYVNAIMQLGSIMEHCIKQNNAIDIYEEYFNDEEAMEVMEEDPSAKTINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYIWDLENPNKPELALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIESSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKMSEPTEVVILDITKKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKVCDEALFCLRVQDNGCLIACGSQLGTTTLLEVSPGLSTLQRNEKNVASSMFERETRREKILEARHREMRLKEKGKAEGRDEEQTDEELAVDLEALVSKAEEEFFDIIFAELKKKEADAIKLTPVPQQPSPEEDQVVEEGEEAAGEEGDEEVEEDLA",
                "length": 605
            },
            "evidence": [
                {
                    "id": "11311",
                    "url": "http://www.informatics.jax.org/homology/11311",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 10,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": "29916806"
                    },
                    {
                        "name": "microtubule",
                        "id": "GO:0005874",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium",
                        "id": "GO:0005929",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": "29916806"
                    },
                    {
                        "name": "external side of plasma membrane",
                        "id": "GO:0009897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": "18547164"
                    },
                    {
                        "name": "sperm flagellum",
                        "id": "GO:0036126",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "axoneme",
                        "id": "GO:0005930",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": "29916806"
                    },
                    {
                        "name": "axonemal dynein complex",
                        "id": "GO:0005858",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005858",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "outer dynein arm",
                        "id": "GO:0036157",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036157",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "9+2 motile cilium",
                        "id": "GO:0097729",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097729",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": "23525783"
                    },
                    {
                        "name": "dynein axonemal particle",
                        "id": "GO:0120293",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120293",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cilium assembly",
                        "id": "GO:0060271",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule-based movement",
                        "id": "GO:0007018",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "determination of left/right symmetry",
                        "id": "GO:0007368",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cilium movement",
                        "id": "GO:0003341",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "outer dynein arm assembly",
                        "id": "GO:0036158",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036158",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "microtubule motor activity",
                        "id": "GO:0003777",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dynein light chain binding",
                        "id": "GO:0045503",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045503",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "dynein heavy chain binding",
                        "id": "GO:0045504",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045504",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2AC93",
                                "url": "https://www.uniprot.org/uniprot/A2AC93"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 19,
            "end_pos": 21,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}