{ "uniprot_canonical_ac": "A2ABV5-1", "uniprot_ac": "A2ABV5", "uniprot_id": "MED14_MOUSE", "mass": { "chemical_mass": 160966.0, "monoisotopic_mass": 160966.0 }, "refseq": { "ac": "NP_001041673", "name": "mediator of RNA polymerase II transcription subunit 14 isoform a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673" }, "gene_names": [ { "name": "Med14", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5" }, { "name": "9930001L01Rik; AU041628; Crsp2; Gm641; ORF1; Trap170", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673", "id": "NP_001041673" }, { "name": "Crsp2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5" }, { "name": "Gm641", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5" }, { "name": "Med14", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673", "id": "NP_001041673" }, { "name": "Trap170", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5" } ], "protein_names": [ { "name": "Mediator of RNA polymerase II transcription subunit 14", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2ABV5#names_and_taxonomy", "id": "A2ABV5" }, { "name": "CRSP complex subunit 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ABV5#names_and_taxonomy", "id": "A2ABV5" }, { "name": "Cofactor required for Sp1 transcriptional activation subunit 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ABV5#names_and_taxonomy", "id": "A2ABV5" }, { "name": "Mediator complex subunit 14", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ABV5#names_and_taxonomy", "id": "A2ABV5" }, { "name": "Thyroid hormone receptor-associated protein complex 170 kDa component", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ABV5#names_and_taxonomy", "id": "A2ABV5" }, { "name": "Trap170", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2ABV5#names_and_taxonomy", "id": "A2ABV5" }, { "name": "cofactor required for Sp1 transcriptional activation, subunit 2; mediator of RNA polymerase II transcription subunit 14; CRSP complex subunit 2; thyroid hormone receptor-associated protein complex 170 kDa component; cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673", "id": "NP_001041673" }, { "name": "mediator of RNA polymerase II transcription subunit 14 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673", "id": "NP_001041673" } ], "function": [ { "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5#function" }, { "database": "UniProtKB", "id": "A2BDN7", "url": "https://www.uniprot.org/uniprot/A2BDN7#function" }, { "database": "PubMed", "id": "RU365082", "url": "https://glygen.org/publication/PubMed/RU365082" } ] }, { "annotation": "MED14 constitutes a novel anchoring point between Mediator and the N-terminal domain of PPARgamma that is necessary for functional PPARgamma-mediated recruitment of Mediator and transactivation of PPARgamma subtype-specific target genes.", "evidence": [ { "database": "RefSeq", "id": "NP_001041673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673" }, { "database": "PubMed", "id": "20194623", "url": "https://glygen.org/publication/PubMed/20194623" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Med14", "url": "https://www.uniprot.org/uniprot/A2ABV5", "locus": { "chromosome": "X", "start_pos": 12762073, "end_pos": 12675369, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000064127", "url": "https://www.ensembl.org/id/ENSMUSG00000064127" } ] } } ], "crossref": [ { "id": "ENSMUSG00000064127", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000064127", "database": "Bgee" }, { "id": "26896", "url": "https://www.ncbi.nlm.nih.gov/gene/26896", "database": "GeneID" }, { "id": "A2ABV5", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ABV5*", "database": "IntAct" }, { "id": "IPR013947", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013947", "database": "InterPro" }, { "id": "mmu:26896", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:26896", "database": "KEGG Pathway" }, { "id": "1349442", "url": "http://www.informatics.jax.org/marker/MGI:1349442", "database": "MGI" }, { "id": "SHQKEQG", "url": "https://omabrowser.org/oma/group/SHQKEQG/", "database": "OMA" }, { "id": "1215335at2759", "url": "http://www.orthodb.org/?query=1215335at2759", "database": "OrthoDB" }, { "id": "PTHR12809", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12809", "database": "PANTHER" }, { "id": "6W1S", "url": "https://www.rcsb.org/structure/6W1S", "database": "PDB" }, { "id": "PF08638", "url": "http://pfam.xfam.org/family/PF08638", "database": "Pfam" }, { "id": "PR_A2ABV5", "url": "http://purl.obolibrary.org/obo/PR_A2ABV5", "database": "PRO" }, { "id": "R-MMU-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "database": "Reactome" }, { "id": "NP_001041673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673", "database": "RefSeq" }, { "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5", "database": "UniProtKB" }, { "id": "A2ABV5-1", "url": "https://www.uniprot.org/uniprot/A2ABV5-1", "database": "UniProtKB" }, { "id": "A2ABV5-2", "url": "https://www.uniprot.org/uniprot/A2ABV5-2", "database": "UniProtKB" }, { "id": "A2ABV5-3", "url": "https://www.uniprot.org/uniprot/A2ABV5-3", "database": "UniProtKB" }, { "id": "A2ABV5-4", "url": "https://www.uniprot.org/uniprot/A2ABV5-4", "database": "UniProtKB" }, { "id": "A2BDN7", "url": "https://www.uniprot.org/uniprot/A2BDN7", "database": "UniProtKB" }, { "id": "A2BDN7-1", "url": "https://www.uniprot.org/uniprot/A2BDN7-1", "database": "UniProtKB" }, { "id": "A2BDP0", "url": "https://www.uniprot.org/uniprot/A2BDP0", "database": "UniProtKB" }, { "id": "A2BDP0-1", "url": "https://www.uniprot.org/uniprot/A2BDP0-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP", "length": 1459, "header": "sp|A2ABV5-1|MED14_MOUSE Isoform 1 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1" }, "isoforms": [ { "isoform_ac": "A2ABV5-1", "url": "https://www.uniprot.org/uniprot/A2ABV5#A2ABV5-1", "sequence": { "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP", "length": 1459, "header": "sp|A2ABV5-1|MED14_MOUSE Isoform 1 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1" }, "locus": { "chromosome": "X", "start_pos": 12627938, "end_pos": 12543820, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000096495", "url": "https://www.ensembl.org/id/ENSMUST00000096495" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000094239", "url": "https://www.ensembl.org/id/ENSMUSP00000094239" } ] } }, { "isoform_ac": "A2ABV5-2", "url": "https://www.uniprot.org/uniprot/A2ABV5#A2ABV5-2", "sequence": { "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGKIFHTVFLLMSIFLKVLVTISFFL", "length": 770, "header": "sp|A2ABV5-2|MED14_MOUSE Isoform 2 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1" }, "locus": {} }, { "isoform_ac": "A2ABV5-3", "url": "https://www.uniprot.org/uniprot/A2ABV5#A2ABV5-3", "sequence": { "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSKHSRAGEMAQQLRVPTALPKVLSSNPINHMVAHNHL", "length": 471, "header": "sp|A2ABV5-3|MED14_MOUSE Isoform 3 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1" }, "locus": {} }, { "isoform_ac": "A2ABV5-4", "url": "https://www.uniprot.org/uniprot/A2ABV5#A2ABV5-4", "sequence": { "sequence": "MVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANES", "length": 362, "header": "sp|A2ABV5-4|MED14_MOUSE Isoform 4 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1" }, "locus": {} }, { "isoform_ac": "A2BDN7-1", "url": "https://www.uniprot.org/uniprot/A2ABV5#A2BDN7-1", "sequence": { "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKVPIMEGEN", "length": 700, "header": "tr|A2BDN7-1|A2BDN7_MOUSE Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1" }, "locus": { "chromosome": "X", "start_pos": 12627938, "end_pos": 12575455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000076016", "url": "https://www.ensembl.org/id/ENSMUST00000076016" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000075395", "url": "https://www.ensembl.org/id/ENSMUSP00000075395" } ] } }, { "isoform_ac": "A2BDP0-1", "url": "https://www.uniprot.org/uniprot/A2ABV5#A2BDP0-1", "sequence": { "sequence": "MCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGT", "length": 798, "header": "tr|A2BDP0-1|A2BDP0_MOUSE Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1" }, "locus": { "chromosome": "X", "start_pos": 12582266, "end_pos": 12546478, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000115481", "url": "https://www.ensembl.org/id/ENSMUST00000115481" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000111143", "url": "https://www.ensembl.org/id/ENSMUSP00000111143" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1117, "end_pos": 1117, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "iPTMnet", "id": "A2ABV5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1117, "end_pos": 1117, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1124, "end_pos": 1124, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "iPTMnet", "id": "A2ABV5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1124, "end_pos": 1124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1133, "end_pos": 1133, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "iPTMnet", "id": "A2ABV5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1133, "end_pos": 1133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1141, "end_pos": 1141, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "iPTMnet", "id": "A2ABV5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1141, "end_pos": 1141, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1149, "end_pos": 1149, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "iPTMnet", "id": "A2ABV5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1149, "end_pos": 1149, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 623, "end_pos": 623, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ] }, { "start_pos": 992, "end_pos": 992, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "Detection and cloning of an X-linked locus associated with a NotI site that is not methylated on mouse inactivated X chromosome by the RLGS-M method.", "journal": "Genomics", "date": "1999", "authors": "Muramatsu M., Hayashizaki Y., Shibata H., Takada S., Kamiya M., Wake N., Arima T., Takagi N., Chapman V.M., Kagebayashi H.", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "reference": [ { "type": "PubMed", "id": "10512684", "url": "https://glygen.org/publication/PubMed/10512684" } ] }, { "title": "The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Zhang X., Roeder R.G., Rodriguez P., Stumpf M., Guyot B., Borggrefe T., Waskow C., Kroetschel M., van Essen D.", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "reference": [ { "type": "PubMed", "id": "17132730", "url": "https://glygen.org/publication/PubMed/17132730" } ] }, { "title": "MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Grontved L, Madsen MS, Boergesen M, Roeder RG, Mandrup S", "evidence": [ { "database": "RefSeq", "id": "NP_001041673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673" } ], "reference": [ { "type": "PubMed", "id": "20194623", "url": "https://glygen.org/publication/PubMed/20194623" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" }, { "database": "iPTMnet", "id": "A2ABV5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ABV5" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "pathway": [ { "id": "mmu:26896", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:26896", "resource": "KEGG Pathway" }, { "id": "R-MMU-212436", "name": "Generic Transcription Pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A020-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 14", "gene_name": "Med14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPVQLENHQLIPPGGGGGSGGGGGSSSGSASVPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRSFNANENSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYATHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVSTADRDDSPAMALLLQQFKDNIQDLMSCTNTGKQTRTGTKHKLSDDSCPVECKKAKRSGETCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPASYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGALDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP", "length": 1459 }, "evidence": [ { "id": "22082", "url": "http://www.informatics.jax.org/homology/22082", "database": "MGI" }, { "id": "A2ABV5", "url": "https://omabrowser.org/oma/group/A2ABV5/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O60244-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 14", "gene_name": "MED14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP", "length": 1454 }, "evidence": [ { "id": "22082", "url": "http://www.informatics.jax.org/homology/22082", "database": "MGI" }, { "id": "A2ABV5", "url": "https://omabrowser.org/oma/group/A2ABV5/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" }, { "name": "positive regulation of transcription initiation from RNA polymerase II promoter", "id": "GO:0060261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060261", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" }, { "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" }, { "name": "stem cell population maintenance", "id": "GO:0019827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "20720539" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "" }, { "name": "core mediator complex", "id": "GO:0070847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070847", "evidence": [ { "database": "UniProtKB", "id": "A2ABV5", "url": "https://www.uniprot.org/uniprot/A2ABV5" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1038, "end_pos": 1040, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1263, "end_pos": 1265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1411, "end_pos": 1413, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1450, "end_pos": 1452, "annotation": "n_glycosylation_sequon" }, { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 723, "end_pos": 725, "annotation": "n_glycosylation_sequon" }, { "start_pos": 738, "end_pos": 740, "annotation": "n_glycosylation_sequon" }, { "start_pos": 866, "end_pos": 868, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }