{
    "uniprot_canonical_ac": "A2ABG4-1",
    "uniprot_ac": "A2ABG4",
    "uniprot_id": "A2ABG4_MOUSE",
    "mass": {
        "chemical_mass": 86535.0,
        "monoisotopic_mass": 86535.0
    },
    "refseq": {
        "ac": "NP_766031",
        "name": "TBC1 domain family member 16 isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766031"
    },
    "gene_names": [
        {
            "name": "Tbc1d16",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2ABG4",
            "id": "A2ABG4"
        },
        {
            "name": "B930087K01; BC026530; Tcd1d16",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766031",
            "id": "NP_766031"
        },
        {
            "name": "Tbc1d16",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766031",
            "id": "NP_766031"
        }
    ],
    "protein_names": [
        {
            "name": "TBC1 domain family member 16 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766031",
            "id": "NP_766031"
        },
        {
            "name": "TBC1 domain family member 16 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334554",
            "id": "NP_001334554"
        },
        {
            "name": "TBC1 domain family, member 16",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2ABG4#names_and_taxonomy",
            "id": "A2ABG4"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2ABG4",
                    "url": "https://www.uniprot.org/uniprot/A2ABG4"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Tbc1d16",
            "url": "https://www.uniprot.org/uniprot/A2ABG4",
            "locus": {
                "chromosome": "11",
                "start_pos": 119228499,
                "end_pos": 119143045,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000039976",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000039976"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000039976",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039976",
            "database": "Bgee"
        },
        {
            "id": "207592",
            "url": "https://www.ncbi.nlm.nih.gov/gene/207592",
            "database": "GeneID"
        },
        {
            "id": "IPR000195",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195",
            "database": "InterPro"
        },
        {
            "id": "IPR035969",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969",
            "database": "InterPro"
        },
        {
            "id": "mmu:207592",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:207592",
            "database": "KEGG Pathway"
        },
        {
            "id": "2652878",
            "url": "http://www.informatics.jax.org/marker/MGI:2652878",
            "database": "MGI"
        },
        {
            "id": "CHRWVLL",
            "url": "https://omabrowser.org/oma/group/CHRWVLL/",
            "database": "OMA"
        },
        {
            "id": "1495285at2759",
            "url": "http://www.orthodb.org/?query=1495285at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00566",
            "url": "http://pfam.xfam.org/family/PF00566",
            "database": "Pfam"
        },
        {
            "id": "R-MMU-8854214",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854214",
            "database": "Reactome"
        },
        {
            "id": "NP_001334554",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334554",
            "database": "RefSeq"
        },
        {
            "id": "NP_766031",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766031",
            "database": "RefSeq"
        },
        {
            "id": "A2ABG4",
            "url": "https://www.uniprot.org/uniprot/A2ABG4",
            "database": "UniProtKB"
        },
        {
            "id": "A2ABG4-1",
            "url": "https://www.uniprot.org/uniprot/A2ABG4-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2AFK9",
            "url": "https://www.uniprot.org/uniprot/A2AFK9",
            "database": "UniProtKB"
        },
        {
            "id": "A2AFK9-1",
            "url": "https://www.uniprot.org/uniprot/A2AFK9-1",
            "database": "UniProtKB"
        },
        {
            "id": "Q6PFC0",
            "url": "https://www.uniprot.org/uniprot/Q6PFC0",
            "database": "UniProtKB"
        },
        {
            "id": "Q6PFC0-1",
            "url": "https://www.uniprot.org/uniprot/Q6PFC0-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRRRRTTSLGALYQPSPTEPRPPLIPKDEDILVVVQNTQDTAHISPTDEDGEKLAQGPEVDGALSTSQPVHSDSGILSTVSSQDGTEDGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGLLQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQWKFCTETHLRDQQVTDERTCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRLSMTPEEQRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTVELPSPKPSREGKKGPKAPREAFGFRR",
        "length": 766,
        "header": "tr|A2ABG4-1|A2ABG4_MOUSE Isoform 1 of TBC1 domain family, member 16  OS=Mus musculus OX=10090 GN=Tbc1d16 PE=1 SV=1 CANONICAL=A2ABG4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2ABG4-1",
            "url": "https://www.uniprot.org/uniprot/A2ABG4#A2ABG4-1",
            "sequence": {
                "sequence": "MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRRRRTTSLGALYQPSPTEPRPPLIPKDEDILVVVQNTQDTAHISPTDEDGEKLAQGPEVDGALSTSQPVHSDSGILSTVSSQDGTEDGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGLLQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQWKFCTETHLRDQQVTDERTCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRLSMTPEEQRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTVELPSPKPSREGKKGPKAPREAFGFRR",
                "length": 766,
                "header": "tr|A2ABG4-1|A2ABG4_MOUSE Isoform 1 of TBC1 domain family, member 16  OS=Mus musculus OX=10090 GN=Tbc1d16 PE=1 SV=1 CANONICAL=A2ABG4-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 119101508,
                "end_pos": 119038397,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000036113",
                        "url": "https://www.ensembl.org/id/ENSMUST00000036113"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000048516",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000048516"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2AFK9-1",
            "url": "https://www.uniprot.org/uniprot/A2ABG4#A2AFK9-1",
            "sequence": {
                "sequence": "MSLGRLLRRASSKA",
                "length": 14,
                "header": "tr|A2AFK9-1|A2AFK9_MOUSE Computationally mapped isoform of TBC1 domain family, member 16  OS=Mus musculus OX=10090 GN=Tbc1d16 PE=4 SV=1 CANONICAL=A2ABG4-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 119101508,
                "end_pos": 119101467,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000125856",
                        "url": "https://www.ensembl.org/id/ENSMUST00000125856"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000119431",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000119431"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6PFC0-1",
            "url": "https://www.uniprot.org/uniprot/A2ABG4#Q6PFC0-1",
            "sequence": {
                "sequence": "MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRRRRTTSLGALYQPSPTEPRPPLIPKDEDILVVVQNTQDTAHISPTDEDGEKLAQGPEVDGALSTSQPVHSDSGILSTVSSQDGTEDGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGLLQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQWKFCTETHLRDQVTDERTCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRLSMTPEEQRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTVELPSPKPSREGKKGPKAPREAFGFRR",
                "length": 765,
                "header": "tr|Q6PFC0-1|Q6PFC0_MOUSE Computationally mapped isoform of TBC1 domain family, member 16  OS=Mus musculus OX=10090 GN=Tbc1d16 PE=1 SV=1 CANONICAL=A2ABG4-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 119101508,
                "end_pos": 119038397,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000207655",
                        "url": "https://www.ensembl.org/id/ENSMUST00000207655"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000147182",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000147182"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:207592",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:207592",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-8854214",
            "name": "TBC/RABGAPs",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854214",
            "resource": "Reactome",
            "description": "TBC/RABGAPs"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "M0R716-1",
            "protein_name": "TBC1 domain family, member 16",
            "gene_name": "Tbc1d16",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPEGSPVRKAPRPRRRRTTSLGATYQPSPTEPRPPLIPKDEDILVVVQNTQDSVHISPTDEDGVKLAQGPEVDGPLPTSQPVHSDSGILSTVSSQDGTENGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGLLQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQWKFCTETHLRDQVTDERTCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRLSMPPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEGEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTVETPSPKPPREGKKGPKAPREAFGFRR",
                "length": 765
            },
            "evidence": [
                {
                    "id": "10380",
                    "url": "http://www.informatics.jax.org/homology/10380",
                    "database": "MGI"
                },
                {
                    "id": "A2ABG4",
                    "url": "https://omabrowser.org/oma/group/A2ABG4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8TBP0-1",
            "protein_name": "TBC1 domain family member 16",
            "gene_name": "TBC1D16",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSGASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPACSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLSPISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR",
                "length": 767
            },
            "evidence": [
                {
                    "id": "10380",
                    "url": "http://www.informatics.jax.org/homology/10380",
                    "database": "MGI"
                },
                {
                    "id": "A2ABG4",
                    "url": "https://omabrowser.org/oma/group/A2ABG4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "GTPase activator activity",
                        "id": "GO:0005096",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ABG4",
                                "url": "https://www.uniprot.org/uniprot/A2ABG4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "early endosome",
                        "id": "GO:0005769",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ABG4",
                                "url": "https://www.uniprot.org/uniprot/A2ABG4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ABG4",
                                "url": "https://www.uniprot.org/uniprot/A2ABG4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "intracellular protein transport",
                        "id": "GO:0006886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ABG4",
                                "url": "https://www.uniprot.org/uniprot/A2ABG4"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "regulation of receptor recycling",
                        "id": "GO:0001919",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001919",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ABG4",
                                "url": "https://www.uniprot.org/uniprot/A2ABG4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "activation of GTPase activity",
                        "id": "GO:0090630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2ABG4",
                                "url": "https://www.uniprot.org/uniprot/A2ABG4"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 249,
            "end_pos": 251,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}