{ "uniprot_canonical_ac": "A2AAY5-1", "uniprot_ac": "A2AAY5", "uniprot_id": "SPD2B_MOUSE", "mass": { "chemical_mass": 101517.0, "monoisotopic_mass": 101517.0 }, "refseq": { "ac": "XP_006514775", "name": "SH3 and PX domain-containing protein 2B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006514775" }, "gene_names": [ { "name": "Sh3pxd2b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5" }, { "name": "Fad49", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5" }, { "name": "Fad4; fad49; G431001E03Rik; Tks; Tks4; TSK4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006514775", "id": "XP_006514775" }, { "name": "Sh3pxd2b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006514775", "id": "XP_006514775" }, { "name": "Tks4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5" } ], "protein_names": [ { "name": "SH3 and PX domain-containing protein 2B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AAY5#names_and_taxonomy", "id": "A2AAY5" }, { "name": "Factor for adipocyte differentiation 49", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AAY5#names_and_taxonomy", "id": "A2AAY5" }, { "name": "SH3 and PX domain-containing protein 2B isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006514775", "id": "XP_006514775" }, { "name": "SH3 and PX domain-containing protein 2B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338", "id": "NP_796338" }, { "name": "Tyrosine kinase substrate with four SH3 domains", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2AAY5#names_and_taxonomy", "id": "A2AAY5" }, { "name": "tyrosine kinase substrate with four SH3 domains; factor for adipocyte differentiation 49", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338", "id": "NP_796338" } ], "function": [ { "annotation": "Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5#function" }, { "database": "PubMed", "id": "19144821", "url": "https://glygen.org/publication/PubMed/19144821" }, { "database": "PubMed", "id": "19755710", "url": "https://glygen.org/publication/PubMed/19755710" }, { "database": "PubMed", "id": "18959745", "url": "https://glygen.org/publication/PubMed/18959745" } ] }, { "annotation": "Beigeing process was more robust in the WAT of Tks4-KO mice compared to the wild-type animals. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "31387265", "url": "https://glygen.org/publication/PubMed/31387265" } ] }, { "annotation": "Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4. Erratum:[Sci Rep. 2020 Jul 20;10(1):12293. PMID: 32686692] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "31591456", "url": "https://glygen.org/publication/PubMed/31591456" } ] }, { "annotation": "Induction of the fad49 gene was observed in adipocyte differentiable 3T3-L1 cells, but not in non-adipogenic NIH-3T3 cells.", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "18959745", "url": "https://glygen.org/publication/PubMed/18959745" } ] }, { "annotation": "SH3PXD2B is a podosomal-adaptor protein required for postnatal growth and development.", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "19669234", "url": "https://glygen.org/publication/PubMed/19669234" } ] }, { "annotation": "Silencing of C/EBPdelta impaired the expression of factor for adipocyte differentiation (fad) 49, which is up-regulated and plays a crucial role early in adipogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "19233245", "url": "https://glygen.org/publication/PubMed/19233245" } ] }, { "annotation": "Suggest the importance of Tks adaptor proteins in melanoma growth and metastasis in vivo is likely via functional invadopodia formation.", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "27802184", "url": "https://glygen.org/publication/PubMed/27802184" } ] }, { "annotation": "These findings establish a role for TKS4 in Frank-Ter Haar syndrome and embryonic development.", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "20137777", "url": "https://glygen.org/publication/PubMed/20137777" } ] }, { "annotation": "Tks4 has a role in the formation and function of podosomes.", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "19144821", "url": "https://glygen.org/publication/PubMed/19144821" } ] }, { "annotation": "Together, these results establish a novel function for Tks4 in the regulation of mesenchymal stromal cells differentiation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "PubMed", "id": "27711054", "url": "https://glygen.org/publication/PubMed/27711054" } ] } ], "disease": [ { "disease_id": "DOID:0111789", "recommended_name": { "id": "DOID:0111789", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111789", "name": "Frank-Ter Haar syndrome", "description": "An otopalatodigital syndrome spectrum disorder characterized by megalocornea, multiple skeletal anomalies, characteristic facial dysmorphism (wide fontanels, prominent forehead, hypertelorism, prominent eyes, full cheeks, and micrognathia) and developmental delay that has_material_basis_in homozygous or compound heterozygous mutation in SH3PXD2B on chromosome 5q35.1." }, "synonyms": [ { "id": "DOID:0111789", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111789", "name": "Borrone dermatocardioskeletal syndrome", "description": "" }, { "id": "DOID:0111789", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111789", "name": "FTHS", "description": "" }, { "id": "DOID:0111789", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111789", "name": "Ter Haar syndrome", "description": "" }, { "id": "DOID:0111789", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111789", "name": "megalocornea, multiple skeletal anomalies, and developmental delay", "description": "" }, { "id": "DOID:0111789", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111789", "name": "autosomal recessive Melnick-Needles syndrome", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "Frank-Ter Haar syndrome", "description": "Frank-ter Haar syndrome (formerly considered as an autosomal recessive form of Melnick-Needles syndrome; see this term) is defined by megalocornea, multiple skeletal anomalies, characteristic facial dysmorphism (wide fontanels, prominent forehead, hypertelorism, prominent eyes, full cheeks and micrognathia) and developmental delay." }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "autosomal recessive Melnick-Needles syndrome (formerly)", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "Ter Haar syndrome", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "megalocornea, multiple skeletal anomalies, and developmental delay", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "Borrone Dermatocardioskeletal syndrome", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "Frank-Ter Haar syndrome", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "FRANK-TER Haar syndrome; FTHS", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "Melnick-Needles syndrome, autosomal recessive, formerly", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "Frank Ter Haar syndrome", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "Melnick-Needles syndrome, autosomal recessive", "description": "" }, { "id": "MONDO:0009579", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009579", "name": "FTHS", "description": "" }, { "id": "MIM:249420", "resource": "MIM", "url": "https://www.omim.org/entry/249420", "name": "Frank-Ter Haar syndrome", "description": "Frank-Ter Haar syndrome" } ], "evidence": [ { "id": "0111789", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111789" } ] }, { "disease_id": "DOID:10754", "recommended_name": { "id": "DOID:10754", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10754", "name": "otitis media", "description": "A otitis which involves inflammation of the middle ear." }, "synonyms": [], "evidence": [ { "id": "10754", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10754" } ] }, { "disease_id": "DOID:1686", "recommended_name": { "id": "DOID:1686", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1686", "name": "glaucoma", "description": "An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function." }, "synonyms": [], "evidence": [ { "id": "1686", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1686" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 25, "end_pos": 25, "sequence_org": "Y", "sequence_mut": "F", "comment": "Reduced phosphorylation. Almost complete loss of phosphorylation; when associated with F-373 and F-508.", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "PubMed", "id": "19144821", "url": "https://glygen.org/publication/PubMed/19144821" } ] }, { "start_pos": 373, "end_pos": 373, "sequence_org": "Y", "sequence_mut": "F", "comment": "Reduced phosphorylation. Almost complete loss of phosphorylation; when associated with F-25 and F-508.", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "PubMed", "id": "19144821", "url": "https://glygen.org/publication/PubMed/19144821" } ] }, { "start_pos": 508, "end_pos": 508, "sequence_org": "Y", "sequence_mut": "F", "comment": "Reduced phosphorylation. Almost complete loss of phosphorylation; when associated with F-25 and F-373.", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "PubMed", "id": "19144821", "url": "https://glygen.org/publication/PubMed/19144821" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Sh3pxd2b", "url": "https://www.uniprot.org/uniprot/A2AAY5", "locus": { "chromosome": "11", "start_pos": 32347820, "end_pos": 32428173, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000040711", "url": "https://www.ensembl.org/id/ENSMUSG00000040711" } ] } } ], "crossref": [ { "id": "ENSMUSG00000040711", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040711", "database": "Bgee" }, { "id": "cd06888", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06888", "database": "CDD" }, { "id": "cd12018", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12018", "database": "CDD" }, { "id": "cd12075", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12075", "database": "CDD" }, { "id": "cd12076", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12076", "database": "CDD" }, { "id": "cd12078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12078", "database": "CDD" }, { "id": "268396", "url": "https://www.ncbi.nlm.nih.gov/gene/268396", "database": "GeneID" }, { "id": "A2AAY5", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AAY5*", "database": "IntAct" }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro" }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro" }, { "id": "IPR030512", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030512", "database": "InterPro" }, { "id": "IPR035477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035477", "database": "InterPro" }, { "id": "IPR035478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035478", "database": "InterPro" }, { "id": "IPR035479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035479", "database": "InterPro" }, { "id": "IPR035480", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035480", "database": "InterPro" }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro" }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro" }, { "id": "IPR037961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037961", "database": "InterPro" }, { "id": "mmu:268396", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268396", "database": "KEGG Pathway" }, { "id": "2442062", "url": "http://www.informatics.jax.org/marker/MGI:2442062", "database": "MGI" }, { "id": "PMIPTKH", "url": "https://omabrowser.org/oma/group/PMIPTKH/", "database": "OMA" }, { "id": "1183210at2759", "url": "http://www.orthodb.org/?query=1183210at2759", "database": "OrthoDB" }, { "id": "PTHR15706:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15706:SF19", "database": "PANTHER" }, { "id": "PF00018", "url": "http://pfam.xfam.org/family/PF00018", "database": "Pfam" }, { "id": "PF00787", "url": "http://pfam.xfam.org/family/PF00787", "database": "Pfam" }, { "id": "PF07653", "url": "http://pfam.xfam.org/family/PF07653", "database": "Pfam" }, { "id": "PR_A2AAY5", "url": "http://purl.obolibrary.org/obo/PR_A2AAY5", "database": "PRO" }, { "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338", "database": "RefSeq" }, { "id": "XP_006514775", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006514775", "database": "RefSeq" }, { "id": "A0A5F8MPP7", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP7", "database": "UniProtKB" }, { "id": "A0A5F8MPP7-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP7-1", "database": "UniProtKB" }, { "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5", "database": "UniProtKB" }, { "id": "A2AAY5-1", "url": "https://www.uniprot.org/uniprot/A2AAY5-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP", "length": 908, "header": "sp|A2AAY5-1|SPD2B_MOUSE Isoform 1 of SH3 and PX domain-containing protein 2B OS=Mus musculus OX=10090 GN=Sh3pxd2b PE=1 SV=1 CANONICAL=A2AAY5-1" }, "isoforms": [ { "isoform_ac": "A0A5F8MPP7-1", "url": "https://www.uniprot.org/uniprot/A2AAY5#A0A5F8MPP7-1", "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVSWRYCSLPRSVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP", "length": 936, "header": "tr|A0A5F8MPP7-1|A0A5F8MPP7_MOUSE Computationally mapped isoform of SH3 and PX domain-containing protein 2B OS=Mus musculus OX=10090 GN=Sh3pxd2b PE=1 SV=1 CANONICAL=A2AAY5-1" }, "locus": { "chromosome": "11", "start_pos": 32373558, "end_pos": 32297894, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000239041", "url": "https://www.ensembl.org/id/ENSMUST00000239041" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158896", "url": "https://www.ensembl.org/id/ENSMUSP00000158896" } ] } }, { "isoform_ac": "A2AAY5-1", "url": "https://www.uniprot.org/uniprot/A2AAY5#A2AAY5-1", "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP", "length": 908, "header": "sp|A2AAY5-1|SPD2B_MOUSE Isoform 1 of SH3 and PX domain-containing protein 2B OS=Mus musculus OX=10090 GN=Sh3pxd2b PE=1 SV=1 CANONICAL=A2AAY5-1" }, "locus": { "chromosome": "11", "start_pos": 32373558, "end_pos": 32297894, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000038753", "url": "https://www.ensembl.org/id/ENSMUST00000038753" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000044276", "url": "https://www.ensembl.org/id/ENSMUSP00000044276" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Tyr", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" }, { "database": "PubMed", "id": "19144821", "url": "https://glygen.org/publication/PubMed/19144821" } ] }, { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "PubMed", "id": "19144821", "url": "https://glygen.org/publication/PubMed/19144821" } ] }, { "start_pos": 279, "end_pos": 279, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" } ] }, { "start_pos": 291, "end_pos": 291, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" } ] }, { "start_pos": 499, "end_pos": 499, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 499, "end_pos": 499, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 528, "end_pos": 528, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 528, "end_pos": 528, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 661, "end_pos": 661, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Tyr", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" }, { "database": "PubMed", "id": "15592455", "url": "https://glygen.org/publication/PubMed/15592455" } ] }, { "start_pos": 661, "end_pos": 661, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "PubMed", "id": "15592455", "url": "https://glygen.org/publication/PubMed/15592455" } ] }, { "start_pos": 840, "end_pos": 840, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "start_pos": 840, "end_pos": 840, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.", "journal": "Nature biotechnology", "date": "2005", "authors": "Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" } ], "reference": [ { "type": "PubMed", "id": "15592455", "url": "https://glygen.org/publication/PubMed/15592455" } ] }, { "title": "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion.", "journal": "FEBS J.", "date": "2008", "authors": "Eguchi T., Osada S., Imagawa M., Nishizuka M., Hishida T.", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" } ], "reference": [ { "type": "PubMed", "id": "18959745", "url": "https://glygen.org/publication/PubMed/18959745" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation.", "journal": "Molecular biology of the cell", "date": "2009", "authors": "Buschman MD, Bromann PA, Cejudo-Martin P, Wen F, Pass I, Courtneidge SA", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" } ], "reference": [ { "type": "PubMed", "id": "19144821", "url": "https://glygen.org/publication/PubMed/19144821" } ] }, { "title": "The role of C/EBPdelta in the early stages of adipogenesis.", "journal": "Biochimie", "date": "2009", "authors": "Hishida T, Nishizuka M, Osada S, Imagawa M", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" } ], "reference": [ { "type": "PubMed", "id": "19233245", "url": "https://glygen.org/publication/PubMed/19233245" } ] }, { "title": "The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.", "journal": "Mamm. Genome", "date": "2009", "authors": "Mao M., Chang B., Johnson K.R., Zheng Q.Y., Donahue L.R., Thedens D.R., Harris B.S., Anderson M.G.", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" } ], "reference": [ { "type": "PubMed", "id": "19669234", "url": "https://glygen.org/publication/PubMed/19669234" } ] }, { "title": "Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.", "journal": "Sci. Signal.", "date": "2009", "authors": "Bokoch G.M., Fowler B., Courtneidge S.A., Gianni D., Diaz B., Taulet N.", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" } ], "reference": [ { "type": "PubMed", "id": "19755710", "url": "https://glygen.org/publication/PubMed/19755710" } ] }, { "title": "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome.", "journal": "Am. J. Hum. Genet.", "date": "2010", "authors": "Megarbane A., Veltman J.A., van Bokhoven H., de Brouwer A., Alanay Y., Albrecht B., Ben-Neriah Z., Courtneidge S.A., Iqbal Z., van Beusekom E., Hennekam R., van der Zwaag B., Ruiz-Lozano P., Millan J.L., Artuso R., Hamel B., Amenduni M., Cejudo-Martin P., Lindsey J.D., Oudakker A., Scimia M.C., Weinreb R.", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" } ], "reference": [ { "type": "PubMed", "id": "20137777", "url": "https://glygen.org/publication/PubMed/20137777" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" }, { "database": "iPTMnet", "id": "A2AAY5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages.", "journal": "Scientific reports", "date": "2016", "authors": "Dulk M, Kudlik G, Fekete A, Ernszt D, Kvell K, Pongracz JE, Mero BL, Szeder B, Radnai L, Geiszt M, Csecsy DE, Kovacs T, Uher F, Lanyi A, Vas V, Buday L", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" } ], "reference": [ { "type": "PubMed", "id": "27711054", "url": "https://glygen.org/publication/PubMed/27711054" } ] }, { "title": "The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.", "journal": "Oncotarget", "date": "2016", "authors": "Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" } ], "reference": [ { "type": "PubMed", "id": "27802184", "url": "https://glygen.org/publication/PubMed/27802184" } ] }, { "title": "Analysis of Tks4 Knockout Mice Suggests a Role for Tks4 in Adipose Tissue Homeostasis in the Context of Beigeing.", "journal": "Cells", "date": "2019", "authors": "Vas V, Hahner T, Kudlik G, Ernszt D, Kvell K, Kuti D, Kovacs KJ, Tovari J, Trexler M, Mero BL, Szeder B, Koprivanacz K, Buday L", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" } ], "reference": [ { "type": "PubMed", "id": "31387265", "url": "https://glygen.org/publication/PubMed/31387265" } ] }, { "title": "Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4.", "journal": "Scientific reports", "date": "2019", "authors": "Mehes E, Barath M, Gulyas M, Bugyik E, Geiszt M, Szoor A, Lanyi A, Czirok A", "evidence": [ { "database": "RefSeq", "id": "NP_796338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338" } ], "reference": [ { "type": "PubMed", "id": "31591456", "url": "https://glygen.org/publication/PubMed/31591456" } ] } ], "pathway": [ { "id": "mmu:268396", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268396", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1X283-1", "protein_name": "SH3 and PX domain-containing protein 2B", "gene_name": "SH3PXD2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP", "length": 911 }, "evidence": [ { "id": "27952", "url": "http://www.informatics.jax.org/homology/27952", "database": "MGI" }, { "id": "A2AAY5", "url": "https://omabrowser.org/oma/group/A2AAY5/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZAF9-1", "protein_name": "SH3 and PX domains 2B", "gene_name": "Sh3pxd2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "ALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGSDPTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGVVVEVIQKNLEGWWKIRFQGKEGWAPASYLKKSSGEPLPPKLGPSSSAHSGALDLDGVSRQQNAVGREKELLNNQRDGRFEGRLAPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGEAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPHRGSSPKPPGVILPMIPAKHAPLARDSKKPEPKPDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELPEEKVEPNPQNLFLKSRPQVRPKPTPSPKTEPAQGEDQVDIYNLRSKLRPAKSQEKALLDGESHHAAGGHDTALGRSFLPGEGPGRGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGSQREESRAIPASGRALLVPPKAKPFLSNSSVGQDDIRGKGGLGPRIAGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCRVLSGAPSWEGWIPSNYLRKKP", "length": 804 }, "evidence": [ { "id": "A2AAY5", "url": "https://omabrowser.org/oma/group/A2AAY5/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { 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"total": 18, "go_terms": [ { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" } ], "pmid": "" }, { "name": "podosome assembly", "id": "GO:0071800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071800", "evidence": [ { "database": "UniProtKB", "id": "A2AAY5", "url": "https://www.uniprot.org/uniprot/A2AAY5" } ], "pmid": "" }, { "name": "cranial skeletal system development", 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