{ "uniprot_canonical_ac": "A2AAX3-1", "uniprot_ac": "A2AAX3", "uniprot_id": "KLH15_MOUSE", "mass": { "chemical_mass": 69745.0, "monoisotopic_mass": 69745.0 }, "refseq": { "ac": "NP_001034148", "name": "kelch-like protein 15 isoform c", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034148" }, "gene_names": [ { "name": "Klhl15", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AAX3", "id": "A2AAX3" }, { "name": "6330500C13Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034148", "id": "NP_001034148" }, { "name": "Klhl15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034148", "id": "NP_001034148" } ], "protein_names": [ { "name": "Kelch-like protein 15", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2AAX3#names_and_taxonomy", "id": "A2AAX3" }, { "name": "kelch-like protein 15 isoform c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034148", "id": "NP_001034148" }, { "name": "kelch-like protein 15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034148", "id": "NP_001034148" } ], "function": [ { "annotation": "Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).", "evidence": [ { "database": "UniProtKB", "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3#function" }, { "database": "PubMed", "id": "Q96M94", "url": "https://glygen.org/publication/PubMed/Q96M94" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Klhl15", "url": "https://www.uniprot.org/uniprot/A2AAX3", "locus": { "chromosome": "X", "start_pos": 94234599, "end_pos": 94277724, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000043929", "url": "https://www.ensembl.org/id/ENSMUSG00000043929" } ] } } ], "crossref": [ { "id": "ENSMUSG00000043929", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000043929", "database": "Bgee" }, { "id": "236904", "url": "https://www.ncbi.nlm.nih.gov/gene/236904", "database": "GeneID" }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro" }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro" }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro" }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro" }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro" }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro" }, { "id": "IPR030597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030597", "database": "InterPro" }, { "id": "mmu:236904", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:236904", "database": "KEGG Pathway" }, { "id": "1923400", "url": "http://www.informatics.jax.org/marker/MGI:1923400", "database": "MGI" }, { "id": "SSVFEKX", "url": "https://omabrowser.org/oma/group/SSVFEKX/", "database": "OMA" }, { "id": "250404at2759", "url": "http://www.orthodb.org/?query=250404at2759", "database": "OrthoDB" }, { "id": "PTHR45632:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF12", "database": "PANTHER" }, { "id": "PF00651", "url": "http://pfam.xfam.org/family/PF00651", "database": "Pfam" }, { "id": "PF01344", "url": "http://pfam.xfam.org/family/PF01344", "database": "Pfam" }, { "id": "PF07707", "url": "http://pfam.xfam.org/family/PF07707", "database": "Pfam" }, { "id": "PR_A2AAX3", "url": "http://purl.obolibrary.org/obo/PR_A2AAX3", "database": "PRO" }, { "id": "NP_001034148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034148", "database": "RefSeq" }, { "id": "A2AAX0", "url": "https://www.uniprot.org/uniprot/A2AAX0", "database": "UniProtKB" }, { "id": "A2AAX0-1", "url": "https://www.uniprot.org/uniprot/A2AAX0-1", "database": "UniProtKB" }, { "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3", "database": "UniProtKB" }, { "id": "A2AAX3-1", "url": "https://www.uniprot.org/uniprot/A2AAX3-1", "database": "UniProtKB" }, { "id": "A2AAX3-2", "url": "https://www.uniprot.org/uniprot/A2AAX3-2", "database": "UniProtKB" }, { "id": "A2AAX3-3", "url": "https://www.uniprot.org/uniprot/A2AAX3-3", "database": "UniProtKB" } ], "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN", "length": 604, "header": "sp|A2AAX3-1|KLH15_MOUSE Isoform 1 of Kelch-like protein 15 OS=Mus musculus OX=10090 GN=Klhl15 PE=2 SV=1 CANONICAL=A2AAX3-1" }, "isoforms": [ { "isoform_ac": "A2AAX0-1", "url": "https://www.uniprot.org/uniprot/A2AAX3#A2AAX0-1", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQ", "length": 106, "header": "tr|A2AAX0-1|A2AAX0_MOUSE Computationally mapped isoform of Kelch-like protein 15 OS=Mus musculus OX=10090 GN=Klhl15 PE=1 SV=1 CANONICAL=A2AAX3-1" }, "locus": { "chromosome": "X", "start_pos": 93296345, "end_pos": 93296028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000153900", "url": "https://www.ensembl.org/id/ENSMUST00000153900" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000120863", "url": "https://www.ensembl.org/id/ENSMUSP00000120863" } ] } }, { "isoform_ac": "A2AAX3-1", "url": "https://www.uniprot.org/uniprot/A2AAX3#A2AAX3-1", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN", "length": 604, "header": "sp|A2AAX3-1|KLH15_MOUSE Isoform 1 of Kelch-like protein 15 OS=Mus musculus OX=10090 GN=Klhl15 PE=2 SV=1 CANONICAL=A2AAX3-1" }, "locus": { "chromosome": "X", "start_pos": 93317068, "end_pos": 93296028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113915", "url": "https://www.ensembl.org/id/ENSMUST00000113915" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000109548", "url": "https://www.ensembl.org/id/ENSMUSP00000109548" } ] } }, { "isoform_ac": "A2AAX3-2", "url": "https://www.uniprot.org/uniprot/A2AAX3#A2AAX3-2", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVGTFESDRQDSSI", "length": 248, "header": "sp|A2AAX3-2|KLH15_MOUSE Isoform 2 of Kelch-like protein 15 OS=Mus musculus OX=10090 GN=Klhl15 PE=2 SV=1 CANONICAL=A2AAX3-1" }, "locus": { "chromosome": "X", "start_pos": 93296771, "end_pos": 93296028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000096369", "url": "https://www.ensembl.org/id/ENSMUST00000096369" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000094097", "url": "https://www.ensembl.org/id/ENSMUSP00000094097" } ] } }, { "isoform_ac": "A2AAX3-3", "url": "https://www.uniprot.org/uniprot/A2AAX3#A2AAX3-3", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKTS", "length": 237, "header": "sp|A2AAX3-3|KLH15_MOUSE Isoform 3 of Kelch-like protein 15 OS=Mus musculus OX=10090 GN=Klhl15 PE=2 SV=1 CANONICAL=A2AAX3-1" }, "locus": { "chromosome": "X", "start_pos": 93297551, "end_pos": 93296028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113911", "url": "https://www.ensembl.org/id/ENSMUST00000113911" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000109544", "url": "https://www.ensembl.org/id/ENSMUSP00000109544" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:236904", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:236904", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZA50-1", "protein_name": "Kelch-like protein 15", "gene_name": "Klhl15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN", "length": 604 }, "evidence": [ { "id": "17703", "url": "http://www.informatics.jax.org/homology/17703", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96M94-1", "protein_name": "Kelch-like protein 15", "gene_name": "KLHL15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN", "length": 604 }, "evidence": [ { "id": "17703", "url": "http://www.informatics.jax.org/homology/17703", "database": "MGI" }, { "id": "A2AAX3", "url": "https://omabrowser.org/oma/group/A2AAX3/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3" } ], "pmid": "" }, { "name": "negative regulation of double-strand break repair via homologous recombination", "id": "GO:2000042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", "evidence": [ { "database": "UniProtKB", "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3" } ], "pmid": "" }, { "name": "nuclear protein quality control by the ubiquitin-proteasome system", "id": "GO:0071630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071630", "evidence": [ { "database": "UniProtKB", "id": "A2AAX3", "url": "https://www.uniprot.org/uniprot/A2AAX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }