{
    "uniprot_canonical_ac": "A2A9F4-1",
    "uniprot_ac": "A2A9F4",
    "uniprot_id": "KDF1_MOUSE",
    "mass": {
        "chemical_mass": 43496.0,
        "monoisotopic_mass": 43496.0
    },
    "refseq": {
        "ac": "NP_001077385",
        "name": "keratinocyte differentiation factor 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385"
    },
    "gene_names": [
        {
            "name": "Kdf1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2A9F4",
            "id": "A2A9F4"
        },
        {
            "name": "1810019J16Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385",
            "id": "NP_001077385"
        },
        {
            "name": "1810019J16Rik",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2A9F4",
            "id": "A2A9F4"
        },
        {
            "name": "Kdf1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385",
            "id": "NP_001077385"
        }
    ],
    "protein_names": [
        {
            "name": "Keratinocyte differentiation factor 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2A9F4#names_and_taxonomy",
            "id": "A2A9F4"
        },
        {
            "name": "keratinocyte differentiation factor 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385",
            "id": "NP_001077385"
        }
    ],
    "function": [
        {
            "annotation": "Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A9F4",
                    "url": "https://www.uniprot.org/uniprot/A2A9F4#function"
                },
                {
                    "database": "PubMed",
                    "id": "24075906",
                    "url": "https://glygen.org/publication/PubMed/24075906"
                }
            ]
        },
        {
            "annotation": "Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKalpha.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001077385",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385"
                },
                {
                    "database": "PubMed",
                    "id": "32239614",
                    "url": "https://glygen.org/publication/PubMed/32239614"
                }
            ]
        },
        {
            "annotation": "The Keratinocyte differentiation factor 1 is an essential regulator of the proliferation-differentiation balance in epidermal progenitor cells.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001077385",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385"
                },
                {
                    "database": "PubMed",
                    "id": "24075906",
                    "url": "https://glygen.org/publication/PubMed/24075906"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0111652",
            "recommended_name": {
                "id": "DOID:0111652",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111652",
                "name": "ectodermal dysplasia 12",
                "description": "A hypohidrotic ectodermal dysplasia that has_material_basis_in heterozygous mutation in KDF1 on chromosome 1p36.11."
            },
            "synonyms": [
                {
                    "id": "DOID:0111652",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111652",
                    "name": "ECTD12",
                    "description": ""
                },
                {
                    "id": "DOID:0111652",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111652",
                    "name": "ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type",
                    "description": ""
                },
                {
                    "id": "MONDO:0015024",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0015024",
                    "name": "ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type",
                    "description": "Any ectodermal dysplasia syndrome in which the cause of the disease is a mutation in the KDF1 gene."
                },
                {
                    "id": "MONDO:0015024",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0015024",
                    "name": "ectodermal dysplasia 12, hypohidrotic/hair/Tooth/nail type",
                    "description": ""
                },
                {
                    "id": "MONDO:0015024",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0015024",
                    "name": "ectodermal dysplasia syndrome caused by mutation in KDF1",
                    "description": ""
                },
                {
                    "id": "MONDO:0015024",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0015024",
                    "name": "KDF1 ectodermal dysplasia syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0015024",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0015024",
                    "name": "ECTD12",
                    "description": ""
                },
                {
                    "id": "MONDO:0015024",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0015024",
                    "name": "ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type; ECTD12",
                    "description": ""
                },
                {
                    "id": "MIM:617337",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/617337",
                    "name": "Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type",
                    "description": "Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type"
                }
            ],
            "evidence": [
                {
                    "id": "0111652",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111652"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A9F4",
                    "url": "https://www.uniprot.org/uniprot/A2A9F4"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Kdf1",
            "url": "https://www.uniprot.org/uniprot/A2A9F4",
            "locus": {
                "chromosome": "4",
                "start_pos": 133518963,
                "end_pos": 133530790,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000037600",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000037600"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000037600",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037600",
            "database": "Bgee"
        },
        {
            "id": "69073",
            "url": "https://www.ncbi.nlm.nih.gov/gene/69073",
            "database": "GeneID"
        },
        {
            "id": "IPR028003",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028003",
            "database": "InterPro"
        },
        {
            "id": "mmu:69073",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69073",
            "database": "KEGG Pathway"
        },
        {
            "id": "1916323",
            "url": "http://www.informatics.jax.org/marker/MGI:1916323",
            "database": "MGI"
        },
        {
            "id": "ARNMRRH",
            "url": "https://omabrowser.org/oma/group/ARNMRRH/",
            "database": "OMA"
        },
        {
            "id": "896286at2759",
            "url": "http://www.orthodb.org/?query=896286at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR35085",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35085",
            "database": "PANTHER"
        },
        {
            "id": "PF15551",
            "url": "http://pfam.xfam.org/family/PF15551",
            "database": "Pfam"
        },
        {
            "id": "PR_A2A9F4",
            "url": "http://purl.obolibrary.org/obo/PR_A2A9F4",
            "database": "PRO"
        },
        {
            "id": "NP_001077385",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385",
            "database": "RefSeq"
        },
        {
            "id": "A2A9F2",
            "url": "https://www.uniprot.org/uniprot/A2A9F2",
            "database": "UniProtKB"
        },
        {
            "id": "A2A9F2-1",
            "url": "https://www.uniprot.org/uniprot/A2A9F2-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2A9F3",
            "url": "https://www.uniprot.org/uniprot/A2A9F3",
            "database": "UniProtKB"
        },
        {
            "id": "A2A9F3-1",
            "url": "https://www.uniprot.org/uniprot/A2A9F3-1",
            "database": "UniProtKB"
        },
        {
            "id": "A2A9F4",
            "url": "https://www.uniprot.org/uniprot/A2A9F4",
            "database": "UniProtKB"
        },
        {
            "id": "A2A9F4-1",
            "url": "https://www.uniprot.org/uniprot/A2A9F4-1",
            "database": "UniProtKB"
        },
        {
            "id": "A8Y5H9",
            "url": "https://www.uniprot.org/uniprot/A8Y5H9",
            "database": "UniProtKB"
        },
        {
            "id": "A8Y5H9-1",
            "url": "https://www.uniprot.org/uniprot/A8Y5H9-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMLGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASQDSSFQGTDTDSSGAPLLQVYC",
        "length": 397,
        "header": "sp|A2A9F4-1|KDF1_MOUSE Isoform 1 of Keratinocyte differentiation factor 1  OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=1 CANONICAL=A2A9F4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2A9F2-1",
            "url": "https://www.uniprot.org/uniprot/A2A9F4#A2A9F2-1",
            "sequence": {
                "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVY",
                "length": 172,
                "header": "tr|A2A9F2-1|A2A9F2_MOUSE Computationally mapped isoform of Keratinocyte differentiation factor 1  OS=Mus musculus OX=10090 GN=Kdf1 PE=4 SV=8 CANONICAL=A2A9F4-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 133255800,
                "end_pos": 133255285,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000153811",
                        "url": "https://www.ensembl.org/id/ENSMUST00000153811"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000122170",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000122170"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2A9F3-1",
            "url": "https://www.uniprot.org/uniprot/A2A9F4#A2A9F3-1",
            "sequence": {
                "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSD",
                "length": 265,
                "header": "tr|A2A9F3-1|A2A9F3_MOUSE Computationally mapped isoform of Keratinocyte differentiation factor 1  OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=1 CANONICAL=A2A9F4-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 133256079,
                "end_pos": 133255285,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000149807",
                        "url": "https://www.ensembl.org/id/ENSMUST00000149807"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000119014",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000119014"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A2A9F4-1",
            "url": "https://www.uniprot.org/uniprot/A2A9F4#A2A9F4-1",
            "sequence": {
                "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMLGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASQDSSFQGTDTDSSGAPLLQVYC",
                "length": 397,
                "header": "sp|A2A9F4-1|KDF1_MOUSE Isoform 1 of Keratinocyte differentiation factor 1  OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=1 CANONICAL=A2A9F4-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 133257677,
                "end_pos": 133255285,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000105901",
                        "url": "https://www.ensembl.org/id/ENSMUST00000105901"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000101521",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000101521"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A8Y5H9-1",
            "url": "https://www.uniprot.org/uniprot/A2A9F4#A8Y5H9-1",
            "sequence": {
                "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMLGSGLSQDELTVQISQETTADAIARKLRPYGAPGVVLT",
                "length": 375,
                "header": "tr|A8Y5H9-1|A8Y5H9_MOUSE Computationally mapped isoform of Keratinocyte differentiation factor 1  OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=1 CANONICAL=A2A9F4-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 133257230,
                "end_pos": 133255285,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000121797",
                        "url": "https://www.ensembl.org/id/ENSMUST00000121797"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000113590",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000113590"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 218,
            "end_pos": 218,
            "kinase_uniprot_canonical_ac": "Q3UD01-1",
            "kinase_gene_name": "Atxn7l3b",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A9F4",
                    "url": "https://www.uniprot.org/uniprot/A2A9F4"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2A9F4",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A9F4"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "start_pos": 218,
            "end_pos": 218,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A9F4",
                    "url": "https://www.uniprot.org/uniprot/A2A9F4"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A9F4",
                    "url": "https://www.uniprot.org/uniprot/A2A9F4"
                },
                {
                    "database": "iPTMnet",
                    "id": "A2A9F4",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A9F4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "title": "Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells.",
            "journal": "Dev. Biol.",
            "date": "2013",
            "authors": "Lee S., Kong Y., Weatherbee S.D.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A9F4",
                    "url": "https://www.uniprot.org/uniprot/A2A9F4"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001077385",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24075906",
                    "url": "https://glygen.org/publication/PubMed/24075906"
                }
            ]
        },
        {
            "title": "Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKalpha.",
            "journal": "EMBO reports",
            "date": "2020",
            "authors": "Li Y, Tang L, Yue J, Gou X, Lin A, Weatherbee SD, Wu X",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001077385",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32239614",
                    "url": "https://glygen.org/publication/PubMed/32239614"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:69073",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69073",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6AY88-1",
            "protein_name": "Keratinocyte differentiation factor 1",
            "gene_name": "Kdf1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MPRPGQPRPSSGPPRLGPWERPTELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRSCSPCLSAGDPIEGSSEAAWAKEHNGVPPSPDRAPPSRRDGQKLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDADSCCKEPLADPPPTRHSLPSTFTSSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMVGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASQDSSFQGTDTDSSGAPLLQVYC",
                "length": 397
            },
            "evidence": [
                {
                    "id": "17563",
                    "url": "http://www.informatics.jax.org/homology/17563",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8NAX2-1",
            "protein_name": "Keratinocyte differentiation factor 1",
            "gene_name": "KDF1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MPRPGHPRPASGPPRLGPWERPTELCLETYDKPPQPPPSRRTRRPDPKDPGHHGPESITFISGSAEPALESPTCCLLWRPWVWEWCRAAFCFRRCRDCLQRCGACVRGCSPCLSTEDSTEGTAEANWAKEHNGVPPSPDRAPPSRRDGQRLKSTMGSSFSYPDVKLKGIPVYPYPRATSPAPDADSCCKEPLADPPPMRHSLPSTFASSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRARPQTSEGRSTRAAAPTAAAPDSGHETMVGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASHDSSFQGTDTDSSGAPLLQVYC",
                "length": 398
            },
            "evidence": [
                {
                    "id": "17563",
                    "url": "http://www.informatics.jax.org/homology/17563",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 9,
                "go_terms": [
                    {
                        "name": "limb epidermis development",
                        "id": "GO:0060887",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060887",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "negative regulation of stem cell proliferation",
                        "id": "GO:2000647",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000647",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "establishment of skin barrier",
                        "id": "GO:0061436",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061436",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "morphogenesis of embryonic epithelium",
                        "id": "GO:0016331",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016331",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "keratinocyte development",
                        "id": "GO:0003334",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003334",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "negative regulation of keratinocyte proliferation",
                        "id": "GO:0010839",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010839",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "regulation of epidermal cell division",
                        "id": "GO:0010482",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010482",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "positive regulation of epidermal cell differentiation",
                        "id": "GO:0045606",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045606",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "developmental growth",
                        "id": "GO:0048589",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048589",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 6,
                "go_terms": [
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "cell cortex",
                        "id": "GO:0005938",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "cell junction",
                        "id": "GO:0030054",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "cell leading edge",
                        "id": "GO:0031252",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": "24075906"
                    },
                    {
                        "name": "mitotic spindle",
                        "id": "GO:0072686",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A9F4",
                                "url": "https://www.uniprot.org/uniprot/A2A9F4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}