{
    "uniprot_canonical_ac": "A2A995-1",
    "uniprot_ac": "A2A995",
    "uniprot_id": "FYB2_MOUSE",
    "mass": {
        "chemical_mass": 82296.0,
        "monoisotopic_mass": 82296.0
    },
    "refseq": {
        "ac": "NP_001156452",
        "name": "FYN-binding protein 2 isoform b",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156452"
    },
    "gene_names": [
        {
            "name": "Fyb2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2A995",
            "id": "A2A995"
        },
        {
            "name": "1700024P16Rik; ARAP; C1orf168; Gm620",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156452",
            "id": "NP_001156452"
        },
        {
            "name": "1700024P16Rik",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2A995",
            "id": "A2A995"
        },
        {
            "name": "ARAP",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2A995",
            "id": "A2A995"
        },
        {
            "name": "Fyb2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156452",
            "id": "NP_001156452"
        }
    ],
    "protein_names": [
        {
            "name": "FYN-binding protein 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2A995#names_and_taxonomy",
            "id": "A2A995"
        },
        {
            "name": "Activation-dependent, raft-recruited ADAP-like phosphoprotein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2A995#names_and_taxonomy",
            "id": "A2A995"
        },
        {
            "name": "FYN-binding protein 2 isoform b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156452",
            "id": "NP_001156452"
        },
        {
            "name": "uncharacterized protein C1orf168 homolog; activation-dependent, raft-recruited ADAP-like phosphoprotein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156452",
            "id": "NP_001156452"
        }
    ],
    "function": [
        {
            "annotation": "Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A995",
                    "url": "https://www.uniprot.org/uniprot/A2A995#function"
                },
                {
                    "database": "PubMed",
                    "id": "Q5VWT5",
                    "url": "https://glygen.org/publication/PubMed/Q5VWT5"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A995",
                    "url": "https://www.uniprot.org/uniprot/A2A995"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Fyb2",
            "url": "https://www.uniprot.org/uniprot/A2A995",
            "locus": {
                "chromosome": "4",
                "start_pos": 104913456,
                "end_pos": 105016863,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000078612",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000078612"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000078612",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000078612",
            "database": "Bgee"
        },
        {
            "id": "242594",
            "url": "https://www.ncbi.nlm.nih.gov/gene/242594",
            "database": "GeneID"
        },
        {
            "id": "IPR001452",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452",
            "database": "InterPro"
        },
        {
            "id": "IPR029294",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029294",
            "database": "InterPro"
        },
        {
            "id": "IPR036028",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028",
            "database": "InterPro"
        },
        {
            "id": "IPR043443",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043443",
            "database": "InterPro"
        },
        {
            "id": "mmu:242594",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:242594",
            "database": "KEGG Pathway"
        },
        {
            "id": "2685466",
            "url": "http://www.informatics.jax.org/marker/MGI:2685466",
            "database": "MGI"
        },
        {
            "id": "KPWKSFL",
            "url": "https://omabrowser.org/oma/group/KPWKSFL/",
            "database": "OMA"
        },
        {
            "id": "1812441at2759",
            "url": "http://www.orthodb.org/?query=1812441at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PTHR16830",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16830",
            "database": "PANTHER"
        },
        {
            "id": "PF14603",
            "url": "http://pfam.xfam.org/family/PF14603",
            "database": "Pfam"
        },
        {
            "id": "PR_A2A995",
            "url": "http://purl.obolibrary.org/obo/PR_A2A995",
            "database": "PRO"
        },
        {
            "id": "NP_001156452",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156452",
            "database": "RefSeq"
        },
        {
            "id": "A2A995",
            "url": "https://www.uniprot.org/uniprot/A2A995",
            "database": "UniProtKB"
        },
        {
            "id": "A2A995-1",
            "url": "https://www.uniprot.org/uniprot/A2A995-1",
            "database": "UniProtKB"
        },
        {
            "id": "E9PZ08",
            "url": "https://www.uniprot.org/uniprot/E9PZ08",
            "database": "UniProtKB"
        },
        {
            "id": "E9PZ08-1",
            "url": "https://www.uniprot.org/uniprot/E9PZ08-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MEEEGIRNFKELRAKFQKFNAAPLPGPMRFPAGVSRKHDRGSTQPAQDLANRKCLSSHHHQTPSHSSTGVSQPLKNQTLKSAQGDELQKTSSSSGTPEKSTVCPERDFQKAAVPLDVTKSRAKTSNEEKGMTLSSFRYKLWNWEKVSSQNGEMSPAPLLTNGGIKTFHFEGQKTMGLAQDKPEKSLKATGAQTLPPQSHSMAQRKSPVTSKASSVSLPPHSRKSTKSPATEGSHRSSQCQPVYECELDSLVPEKPQSRHCRLPKTKPLPSIETLGPPPPKPSKPPFVNLYAFHRLPATVTKTPKEETMKEGPLSPDSAELEEAHNYDTTISYLRHSGNSINLCAEGESTEATYEIEIEELQKPWRSFFLPELSPRPKEEENTMEEKESWESEPLEPRKELHPSRPPKVVVYKETPGKTQMAGVHEDRRSVPAGNQEAMTDIMQNRLFPEDVTLTRHSQDKSGYVEALEVTKETPSPSTIRSSSSSEKTYDAVECSREDVRKWDFSSSFTSDSEENCEEMYEDIYKAKNDDPKTEVAGRTALRKLQQIFRKENVVFRMKKTKSKEIVSNGFSVSLPDLGPRSQDDSQDGIIYDDVDTREKESNDEDKVKTWKTKFLIPKGKKWGKGSQGSKSFSPRHFFRTKKQKLEKNRMEKEEKLFRERFQYGKEILVINRAVACASNSRNGMFDLPIIPGEQLEVIDTTEQNLVICRNSKGKYGYVLVEHLDFKHQG",
        "length": 729,
        "header": "sp|A2A995-1|FYB2_MOUSE Isoform 1 of FYN-binding protein 2  OS=Mus musculus OX=10090 GN=Fyb2 PE=1 SV=1 CANONICAL=A2A995-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2A995-1",
            "url": "https://www.uniprot.org/uniprot/A2A995#A2A995-1",
            "sequence": {
                "sequence": "MEEEGIRNFKELRAKFQKFNAAPLPGPMRFPAGVSRKHDRGSTQPAQDLANRKCLSSHHHQTPSHSSTGVSQPLKNQTLKSAQGDELQKTSSSSGTPEKSTVCPERDFQKAAVPLDVTKSRAKTSNEEKGMTLSSFRYKLWNWEKVSSQNGEMSPAPLLTNGGIKTFHFEGQKTMGLAQDKPEKSLKATGAQTLPPQSHSMAQRKSPVTSKASSVSLPPHSRKSTKSPATEGSHRSSQCQPVYECELDSLVPEKPQSRHCRLPKTKPLPSIETLGPPPPKPSKPPFVNLYAFHRLPATVTKTPKEETMKEGPLSPDSAELEEAHNYDTTISYLRHSGNSINLCAEGESTEATYEIEIEELQKPWRSFFLPELSPRPKEEENTMEEKESWESEPLEPRKELHPSRPPKVVVYKETPGKTQMAGVHEDRRSVPAGNQEAMTDIMQNRLFPEDVTLTRHSQDKSGYVEALEVTKETPSPSTIRSSSSSEKTYDAVECSREDVRKWDFSSSFTSDSEENCEEMYEDIYKAKNDDPKTEVAGRTALRKLQQIFRKENVVFRMKKTKSKEIVSNGFSVSLPDLGPRSQDDSQDGIIYDDVDTREKESNDEDKVKTWKTKFLIPKGKKWGKGSQGSKSFSPRHFFRTKKQKLEKNRMEKEEKLFRERFQYGKEILVINRAVACASNSRNGMFDLPIIPGEQLEVIDTTEQNLVICRNSKGKYGYVLVEHLDFKHQG",
                "length": 729,
                "header": "sp|A2A995-1|FYB2_MOUSE Isoform 1 of FYN-binding protein 2  OS=Mus musculus OX=10090 GN=Fyb2 PE=1 SV=1 CANONICAL=A2A995-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 104873337,
                "end_pos": 104770879,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000106804",
                        "url": "https://www.ensembl.org/id/ENSMUST00000106804"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000102416",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000102416"
                    }
                ]
            }
        },
        {
            "isoform_ac": "E9PZ08-1",
            "url": "https://www.uniprot.org/uniprot/A2A995#E9PZ08-1",
            "sequence": {
                "sequence": "MEARPPERGRSHSPGGAGEEPRLQLLRDRRSDCKLAGGGESIVGPRIQLWEAGIVSQSLPRRTTMEEEGIRNFKELRAKFQKFNAAPLPGPMRFPAGVSRKHDRGSTQPAQDLANRKCLSSHHHQTPSHSSTGVSQPLKNQTLKSAQGDELQKTSSSSGTPEKSTVCPERDFQKAAVPLDVTKSRAKTSNEEKGMTLSSFRYKLWNWEKVSSQNGEMSPAPLLTNGGIKTFHFEGQKTMGLAQDKPEKSLKATGAQTLPPQSHSMAQRKSPVTSKASSVSLPPHSRKSTKSPATEGSHRSSQCQPVYECELDSLVPEKPQSRHCRLPKTKPLPSIETLGPPPPKPSKPPFVNLYAFHRLPATVTKTPKEETMKEGPLSPDSAELEEAHNYDTTISYLRHSGNSINLCAEGESTEATYEIEIEELQKPWRSFFLPELSPRPKEEENTMEEKESWESEPLEPRKELHPSRPPKVVVYKETPGKTQMAGVHEDRRSVPAGNQEAMTDIMQNRLFPEDVTLTRHSQDKSGYVEALEVTKETPSPSTIRSSSSSEKTYDAVECSREDVRKWDFSSSFTSDSEENCEEMYEDIYKAKNDDPKTEVAGRTALRKLQQIFRKENVVFRMKKTKSKEIVSNGFSVSLPDLGPRSQDDSQDGIIYDDVDTREKESNDEDKVKTWKTKFLIPKGKKWGKGSQGSKSFSPRHFFRTKKQKLEKNRMEKEEKLFRERFQYGKEILVINRAVACASNSRNGMFDLPIIPGEQLEVIDTTEQNLVICRNSKGKYGYVLVEHLDFKHQG",
                "length": 793,
                "header": "tr|E9PZ08-1|E9PZ08_MOUSE Computationally mapped isoform of FYN-binding protein 2  OS=Mus musculus OX=10090 GN=Fyb2 PE=1 SV=1 CANONICAL=A2A995-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 104873337,
                "end_pos": 104770687,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000106803",
                        "url": "https://www.ensembl.org/id/ENSMUST00000106803"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000102415",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000102415"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 489,
            "end_pos": 489,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A995",
                    "url": "https://www.uniprot.org/uniprot/A2A995"
                }
            ]
        },
        {
            "start_pos": 591,
            "end_pos": 591,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A995",
                    "url": "https://www.uniprot.org/uniprot/A2A995"
                }
            ]
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Large-scale phosphorylation analysis of mouse liver.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2007",
            "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A995",
                    "url": "https://www.uniprot.org/uniprot/A2A995"
                },
                {
                    "database": "UniProtKB",
                    "id": "E9PZ08",
                    "url": "https://www.uniprot.org/uniprot/E9PZ08"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:242594",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:242594",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "F1LYH4-1",
            "protein_name": "Uncharacterized protein",
            "gene_name": "",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "PEGGRSHCPGGAGGESRFQPVPDRGSDCTLAGGGGSVVGPKIQLWEAGIVSQSEPRRTTMEEEGIRNFKELRAKFQKLNAVPLSGPIKLPAGVSRKDGRGYTQPSQDPANRKHLSSHHYRTPSNSSAGLSHPLKTQKIKSAQRDDVQKSSLGTPENSTVYPERNFQKAAMPLDVNKSRSETSNEERGMTLSSFRCKLWNWEKVSSQKSEMSPTALLTNGRLKTFHLEGHKTMGLAQEKPEKNLKTTEAQPLPPQNHLMAQGKSPIASKASKGSLPRYSRKQTESPGTEGSHESSPCQPVYECELVSLVPEKPESQHCQLPKTKPLPSIETLGPPPPKPSKPPFVNIYAFPRQPAVVSKSLKEGKKMHRAHPHCAELEEAHNYDTTISYLRHSGNSINLCAAGESAEATYEIEIEELQKPYFSLVSSYYSPRPKDGENTTREKEPCASEPPKPGKVSYPKHPSKIAVCEGTPGKTQMSGVQENRRSMPAGNQQAIIDIIQSRHFQEDAMLTRHSQGKSGYVEALGVTKETPSPSTVRSSSSSEKTYDDVECSREDIQKWDFSSSFTSDSEENSEETYEDIYRAKTSDPKTDAAGRAALRRLQQLFSRENGVFRMKKTKSKEIVSNGFSMSLPDLGPRSHDGIIYDDVDAREKES",
                "length": 653
            },
            "evidence": [
                {
                    "id": "A2A995",
                    "url": "https://omabrowser.org/oma/group/A2A995/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q5VWT5-1",
            "protein_name": "FYN-binding protein 2",
            "gene_name": "FYB2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEGEGVRNFKELRAKFQNLDAPPLPGPIKFPAGVSPKGDIGGTQSTQILANGKPLSSNHKQRTPYCSSSESQPLQPQKIKLAQKSEIPKCSNSPGPLGKSTVCSATSSQKASLLLEVTQSNVEIITKEKVMVANSFRNKLWNWEKVSSQKSEMSSALLLANYGSKAIHLEGQKGMGLTPEEPRKKLETKGAQTLPSQKHVVAPKILHNVSEDPSFVISQHIRKSWENPPPERSPASSPCQPIYECELASQAPEKQPDVRHHHLPKTKPLPSIDSLGPPPPKPSRPPIVNLQAFQRQPAAVPKTQGEVTVEEGSLSPERLFNAEFEEPHNYEATISYLRHSGNSINLCTAKEIADPTYEVGIEELQKPGKNFPYPEPSAKHEDKKMKEKQPCELKPKNTEKEPYSNHVFKVDACEGTPEKIQMTNVHTGRRNMLAGKQEAMIDIIQTNPCPEGPKLARHSQGHCGHLEVLESTKETPDLGVSKTSSISEEIYDDVEYSRKEVPKLNYSSSLASSSEENRELYEDVYKTKNNYPKIDLDGKEALKRLQQFFKKEKDRFKIKKTKSKENLSAFSILLPDLELKSQEVIIYDDVDLSEKESKDEDKLKMWKPKFLTPKEKKEKNGAEESESFSPRNFFKTKKQNLEKNRMKREEKLFRERFKYDKEIIVINTAVACSNNSRNGIFDLPISPGEELEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQSWSP",
                "length": 728
            },
            "evidence": [
                {
                    "id": "52981",
                    "url": "http://www.informatics.jax.org/homology/52981",
                    "database": "MGI"
                },
                {
                    "id": "A2A995",
                    "url": "https://omabrowser.org/oma/group/A2A995/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A995",
                                "url": "https://www.uniprot.org/uniprot/A2A995"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "membrane raft",
                        "id": "GO:0045121",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A995",
                                "url": "https://www.uniprot.org/uniprot/A2A995"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "immunological synapse",
                        "id": "GO:0001772",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001772",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A995",
                                "url": "https://www.uniprot.org/uniprot/A2A995"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "integrin-mediated signaling pathway",
                        "id": "GO:0007229",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A995",
                                "url": "https://www.uniprot.org/uniprot/A2A995"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "protein localization to plasma membrane",
                        "id": "GO:0072659",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A995",
                                "url": "https://www.uniprot.org/uniprot/A2A995"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "T cell receptor signaling pathway",
                        "id": "GO:0050852",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A995",
                                "url": "https://www.uniprot.org/uniprot/A2A995"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell adhesion mediated by integrin",
                        "id": "GO:0033627",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033627",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A995",
                                "url": "https://www.uniprot.org/uniprot/A2A995"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 76,
            "end_pos": 78,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Phosphorylation is required for its function in T-cell activation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A995",
                    "url": "https://www.uniprot.org/uniprot/A2A995"
                },
                {
                    "database": "PubMed",
                    "id": "Q5VWT5",
                    "url": "https://glygen.org/publication/PubMed/Q5VWT5"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}