{ "uniprot_canonical_ac": "A2A863-1", "uniprot_ac": "A2A863", "uniprot_id": "ITB4_MOUSE", "mass": { "chemical_mass": 201650.0, "monoisotopic_mass": 201650.0 }, "refseq": { "ac": "XP_006532635", "name": "integrin beta-4 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006532635" }, "gene_names": [ { "name": "Itgb4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A863", "id": "A2A863" }, { "name": "AA407042; C230078O20; CD104", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006532635", "id": "XP_006532635" }, { "name": "Itgb4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006532635", "id": "XP_006532635" } ], "protein_names": [ { "name": "Integrin beta-4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A863#names_and_taxonomy", "id": "A2A863" }, { "name": "Integrin beta-4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608", "id": "NP_001005608" }, { "name": "integrin beta-4 isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608", "id": "NP_001005608" }, { "name": "integrin beta-4 isoform X4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006532635", "id": "XP_006532635" } ], "function": [ { "annotation": "Airway epithelial integrin beta4 suppresses allergic inflammation by decreasing CCL17 production.", "evidence": [ { "database": "RefSeq", "id": "NP_001005608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608" }, { "database": "PubMed", "id": "32608482", "url": "https://glygen.org/publication/PubMed/32608482" } ] }, { "annotation": "Airway epithelial integrin beta4-deficiency exacerbates lipopolysaccharide-induced acute lung injury.", "evidence": [ { "database": "RefSeq", "id": "NP_001005608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608" }, { "database": "PubMed", "id": "34018612", "url": "https://glygen.org/publication/PubMed/34018612" } ] }, { "annotation": "DNA methylation down-regulates integrin beta4 expression in asthmatic airway epithelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001005608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608" }, { "database": "PubMed", "id": "32618381", "url": "https://glygen.org/publication/PubMed/32618381" } ] }, { "annotation": "Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863#function" }, { "database": "PubMed", "id": "P16144", "url": "https://glygen.org/publication/PubMed/P16144" } ] }, { "annotation": "Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001005608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608" } ] } ], "disease": [ { "disease_id": "DOID:0060733", "recommended_name": { "id": "DOID:0060733", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060733", "name": "junctional epidermolysis bullosa with pyloric atresia", "description": "A junctional epidermolysis bullosa characterized by generalized blistering at birth with congenital atresia of the pylorus and rarely of other portions of the gastrointestinal tract and that has_material_basis_in mutations in the ITGB4 or ITGA6 genes." }, "synonyms": [ { "id": "DOID:0060733", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060733", "name": "Carmi syndrome", "description": "" }, { "id": "DOID:0060733", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060733", "name": "JEB-PA", "description": "" }, { "id": "DOID:0060733", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060733", "name": "junctional epidermolysis bullosa-pyloric atresia syndrome", "description": "" }, { "id": "DOID:0060733", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060733", "name": "epidermolysis bullosa junctionalis with pyloric atresia", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "junctional epidermolysis bullosa with pyloric atresia", "description": "Junctional epidermolysis bullosa with pyloric atresia is a severe subtype of junctional epidermolysis bullosa (JEB, see this term) characterized by generalized blistering at birth and congenital atresia of the pylorus and rarely of other portions of the gastrointestinal tract." }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "Carmi syndrome", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "junctional epidermolysis bullosa with pyloric atresia", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "epidermolysis bullosa, junctional, with pyloric atresia and aplasia cutis congenita", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "epidermolysis bullosa junctionalis with pyloric atresia", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "aplasia cutis congenita with gastrointestinal atresia", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "epidermolysis bullosa JUNCTIONALIS with pyloric atresia", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "epidermolysis bullosa, junctional, with pyloric atresia", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "junctional epidermolysis bullosa-pyloric atresia syndrome", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "JEB-Pa", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "EB-Pa-ACC", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "JEB-PA", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "junctional epidermolysis bullosa - pyloric atresia", "description": "" }, { "id": "MONDO:0009183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009183", "name": "epidermolysis bullosa with pyloric atresia", "description": "" }, { "id": "MIM:226730", "resource": "MIM", "url": "https://www.omim.org/entry/226730", "name": "Epidermolysis bullosa letalis, with pyloric atresia", "description": "Epidermolysis bullosa letalis, with pyloric atresia" } ], "evidence": [ { "id": "0060733", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060733" } ] }, { "disease_id": "DOID:0060738", "recommended_name": { "id": "DOID:0060738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060738", "name": "junctional epidermolysis bullosa non-Herlitz type", "description": "A junctional epidermolysis bullosa characterized by skin and mucosal blistering, nail dystrophy or nail absence and enamel hypoplasia and that has_material_basis_in homozygous or compound heterozygous mutation in several genes including COL17A1, ITGB4 and the 3 genes that encode the subunits of laminin-5: LAMA3, LAMB3, and LAMC2. The non-Herlitz type is less severe than the related Herlitz type of junctional epidermolysis bullosa." }, "synonyms": [ { "id": "DOID:0060738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060738", "name": "junctional epidermolysis bullosa generalisata mitis", "description": "" }, { "id": "DOID:0060738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060738", "name": "GABEB", "description": "" }, { "id": "DOID:0060738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060738", "name": "JEB-nH gen", "description": "" }, { "id": "DOID:0060738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060738", "name": "JEN-nH", "description": "" }, { "id": "DOID:0060738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060738", "name": "generalized atrophic benign epidermolysis bullosa", "description": "" }, { "id": "DOID:0060738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060738", "name": "junctional epidermolysis bullosa, Disentis type", "description": "" }, { "id": "DOID:0060738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060738", "name": "generalized junctional epidermolysis bullosa, non-Herlitz type", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "junctional epidermolysis bullosa, non-Herlitz type", "description": "Junctional epidermolysis bullosa, non-Herlitz (JEB-nH) is a subtype of junctional epidermolysis bullosa (JEB, see this term) characterized by the presence of skin and mucosal blistering, nail dystrophy or nail absence and enamel hypoplasia." }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "JEB-nH", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "epidermolysis bullosa Junctionalis, progressive", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "JEB-I", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "epidermolysis bullosa, generalized atrophic benign", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "epidermolysis bullosa Junctionalis, severe Nonlethal", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "junctional epidermolysis bullosa inversa", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "epidermolysis bullosa, junctional, non-Herlitz type", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "JEN-nH", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "epidermolysis bullosa Junctionalis, Disentis type", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "epidermolysis bullosa, junctional, Localisata variant", "description": "" }, { "id": "MONDO:0009180", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009180", "name": "epidermolysis bullosa Junctionalis, non-Herlitz type", "description": "" }, { "id": "MIM:226650", "resource": "MIM", "url": "https://www.omim.org/entry/226650", "name": "Generalized atrophic benign epidermolysis bullosa", "description": "Generalized atrophic benign epidermolysis bullosa" } ], "evidence": [ { "id": "0060738", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060738" } ] }, { "disease_id": "DOID:0080510", "recommended_name": { "id": "DOID:0080510", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080510", "name": "epidermolysis bullosa simplex localized type", "description": "An epidermolysis bullosa simplex that is characterized by skin blistering that begins anytime between childhood and adulthood and is usually limited to the hands and feet." }, "synonyms": [ { "id": "DOID:0080510", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080510", "name": "epidermolysis bullosa simplex Weber-Cockayne type", "description": "" }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "localized epidermolysis bullosa simplex", "description": "Localized epidermolysis bullosa simplex, formerly known as EBS, Weber-Cockayne, is a basal subtype of epidermolysis bullosa simplex (EBS, see this term). The disease is characterized by blisters occurring mainly on the palms and soles, exacerbated by warm weather." }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "Weber-Cockayne type epidermolysis bullosa simplex", "description": "" }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "EBS, acral form", "description": "" }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "epidermolysis bullosa of hands and feet", "description": "" }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "Weber-Cockayne syndrome", "description": "" }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "EBS-loc", "description": "" }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "epidermolysis bullosa simplex, Weber-Cockayne type", "description": "" }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "epidermolysis bullosa simplex, localized", "description": "" }, { "id": "MONDO:0007551", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007551", "name": "epidermolysis bullosa simplex of palms and soles", "description": "" }, { "id": "MIM:131800", "resource": "MIM", "url": "https://www.omim.org/entry/131800", "name": "Epidermolysis bullosa simplex, Weber-Cockayne type", "description": "Epidermolysis bullosa simplex, Weber-Cockayne type" } ], "evidence": [ { "id": "0080510", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080510" } ] } ], "snv": [ { "evidence": [ { "id": "rs217495444", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs217495444" }, { "id": "rs217495444", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs217495444" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1802, "end_pos": 1802, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TAS->NAS).", "chr_id": "11", "chr_pos": "115898922C>", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Itgb4", "url": "https://www.uniprot.org/uniprot/A2A863", "locus": { "chromosome": "11", "start_pos": 115974709, "end_pos": 116008412, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000020758", "url": "https://www.ensembl.org/id/ENSMUSG00000020758" } ] } } ], "crossref": [ { "id": "ENSMUSG00000020758", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000020758", "database": "Bgee" }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD" }, { "id": "192897", "url": "https://www.ncbi.nlm.nih.gov/gene/192897", "database": "GeneID" }, { "id": "GPDB0001619", "url": "https://acgg.asia/gpdb2/GPDB0001619", "database": "GlycoProtDB" }, { "id": "GPDB0001620", "url": "https://acgg.asia/gpdb2/GPDB0001620", "database": "GlycoProtDB" }, { "id": "GPDB0001621", "url": "https://acgg.asia/gpdb2/GPDB0001621", "database": "GlycoProtDB" }, { "id": "GPDB0001622", "url": "https://acgg.asia/gpdb2/GPDB0001622", "database": "GlycoProtDB" }, { "id": "A2A863", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A863*", "database": "IntAct" }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro" }, { "id": "IPR002369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002369", "database": "InterPro" }, { "id": "IPR003644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003644", "database": "InterPro" }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro" }, { "id": "IPR012013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012013", "database": "InterPro" }, { "id": "IPR012896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012896", "database": "InterPro" }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro" }, { "id": "IPR015812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015812", "database": "InterPro" }, { "id": "IPR033760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033760", "database": "InterPro" }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro" }, { "id": "IPR036349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036349", "database": "InterPro" }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro" }, { "id": "IPR038081", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038081", "database": "InterPro" }, { "id": "IPR040622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040622", "database": "InterPro" }, { "id": "mmu:192897", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:192897", "database": "KEGG Pathway" }, { "id": "96613", "url": "http://www.informatics.jax.org/marker/MGI:96613", "database": "MGI" }, { "id": "YGPVNED", "url": "https://omabrowser.org/oma/group/YGPVNED/", "database": "OMA" }, { "id": "473040at2759", "url": "http://www.orthodb.org/?query=473040at2759", "database": "OrthoDB" }, { "id": "PTHR10082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10082", "database": "PANTHER" }, { "id": "PTHR10082:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10082:SF42", "database": "PANTHER" }, { "id": "PF00041", "url": "http://pfam.xfam.org/family/PF00041", "database": "Pfam" }, { "id": "PF00362", "url": "http://pfam.xfam.org/family/PF00362", "database": "Pfam" }, { "id": "PF03160", "url": "http://pfam.xfam.org/family/PF03160", "database": "Pfam" }, { "id": "PF07965", "url": "http://pfam.xfam.org/family/PF07965", "database": "Pfam" }, { "id": "PF17205", "url": "http://pfam.xfam.org/family/PF17205", "database": "Pfam" }, { "id": "PF18372", "url": "http://pfam.xfam.org/family/PF18372", "database": "Pfam" }, { "id": "PR_A2A863", "url": "http://purl.obolibrary.org/obo/PR_A2A863", "database": "PRO" }, { "id": "R-MMU-2022090", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022090", "database": "Reactome" }, { "id": "R-MMU-3000157", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000157", "database": "Reactome" }, { "id": "R-MMU-3000170", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000170", "database": "Reactome" }, { "id": "R-MMU-446107", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-446107", "database": "Reactome" }, { "id": "NP_001005608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608", "database": "RefSeq" }, { "id": "XP_006532635", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006532635", "database": "RefSeq" }, { "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863", "database": "UniProtKB" }, { "id": "A2A863-1", "url": "https://www.uniprot.org/uniprot/A2A863-1", "database": "UniProtKB" }, { "id": "A2A863-2", "url": "https://www.uniprot.org/uniprot/A2A863-2", "database": "UniProtKB" }, { "id": "A2A863-3", "url": "https://www.uniprot.org/uniprot/A2A863-3", "database": "UniProtKB" }, { "id": "A2A864", "url": "https://www.uniprot.org/uniprot/A2A864", "database": "UniProtKB" }, { "id": "A2A864-1", "url": "https://www.uniprot.org/uniprot/A2A864-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDASVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACCKACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHELKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSDEDGSVAGGVEGEGSGWIRGATPRPPGEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTLPRDYSTLTSLSSQDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFVTRTLTASGSLSTHMDQQFFQT", "length": 1818, "header": "sp|A2A863-1|ITB4_MOUSE Isoform 1 of Integrin beta-4 OS=Mus musculus OX=10090 GN=Itgb4 PE=1 SV=1 CANONICAL=A2A863-1" }, "isoforms": [ { "isoform_ac": "A2A863-1", "url": "https://www.uniprot.org/uniprot/A2A863#A2A863-1", "sequence": { "sequence": "MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDASVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACCKACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHELKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSDEDGSVAGGVEGEGSGWIRGATPRPPGEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTLPRDYSTLTSLSSQDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFVTRTLTASGSLSTHMDQQFFQT", "length": 1818, "header": "sp|A2A863-1|ITB4_MOUSE Isoform 1 of Integrin beta-4 OS=Mus musculus OX=10090 GN=Itgb4 PE=1 SV=1 CANONICAL=A2A863-1" }, "locus": { "chromosome": "11", "start_pos": 115898923, "end_pos": 115868622, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106458", "url": "https://www.ensembl.org/id/ENSMUST00000106458" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102066", "url": "https://www.ensembl.org/id/ENSMUSP00000102066" } ] } }, { "isoform_ac": "A2A863-2", "url": "https://www.uniprot.org/uniprot/A2A863#A2A863-2", "sequence": { "sequence": "MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDASVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACCKACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHELKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTLPRDYSTLTSLSSQDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFVTRTLTASGSLSTHMDQQFFQT", "length": 1753, "header": "sp|A2A863-2|ITB4_MOUSE Isoform 2 of Integrin beta-4 OS=Mus musculus OX=10090 GN=Itgb4 PE=1 SV=1 CANONICAL=A2A863-1" }, "locus": { "chromosome": "11", "start_pos": 115898923, "end_pos": 115868622, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000068981", "url": "https://www.ensembl.org/id/ENSMUST00000068981" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000070811", "url": "https://www.ensembl.org/id/ENSMUSP00000070811" } ] } }, { "isoform_ac": "A2A863-3", "url": "https://www.uniprot.org/uniprot/A2A863#A2A863-3", "sequence": { "sequence": "MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDASVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACCKACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHELKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTLPRDYSTLTSLSSQGLPPIWEDGRSRLPLSWTLGSLSRAHMKGVPASRGSPDSIILAGQSAAPSWGTDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFVTRTLTASGSLSTHMDQQFFQT", "length": 1806, "header": "sp|A2A863-3|ITB4_MOUSE Isoform 3 of Integrin beta-4 OS=Mus musculus OX=10090 GN=Itgb4 PE=1 SV=1 CANONICAL=A2A863-1" }, "locus": { "chromosome": "11", "start_pos": 115898923, "end_pos": 115868622, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106460", "url": "https://www.ensembl.org/id/ENSMUST00000106460" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102068", "url": "https://www.ensembl.org/id/ENSMUSP00000102068" } ] } }, { "isoform_ac": "A2A864-1", "url": "https://www.uniprot.org/uniprot/A2A863#A2A864-1", "sequence": { "sequence": "MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDASVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACCKACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHELKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPSTTTVILDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTLPRDYSTLTSLSSQGLPPIWEDGRSRLPLSWTLGSLSRAHMKGVPASRGSPDSIILAGQSAAPSWGTDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGAPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFPQLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFVTRTLTASGSLSTHMDQQFFQT", "length": 1802, "header": "tr|A2A864-1|A2A864_MOUSE Computationally mapped isoform of Integrin beta OS=Mus musculus OX=10090 GN=Itgb4 PE=1 SV=1 CANONICAL=A2A863-1" }, "locus": { "chromosome": "11", "start_pos": 115898923, "end_pos": 115868622, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000021107", "url": "https://www.ensembl.org/id/ENSMUST00000021107" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000021107", "url": "https://www.ensembl.org/id/ENSMUSP00000021107" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 328, "start_aa": "Asn", "end_pos": 328, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A863#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 493, "start_aa": "Asn", "end_pos": 493, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A863#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 581, "start_aa": "Asn", "end_pos": 581, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A863#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 619, "start_aa": "Asn", "end_pos": 619, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A863#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 697, "start_aa": "Asn", "end_pos": 697, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A863#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 1071, "end_pos": 1071, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" }, { "database": "iPTMnet", "id": "A2A863", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A863" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1071, "end_pos": 1071, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1121, "end_pos": 1121, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ] }, { "start_pos": 1451, "end_pos": 1451, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ] }, { "start_pos": 1454, "end_pos": 1454, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ] }, { "start_pos": 1470, "end_pos": 1470, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" }, { "database": "iPTMnet", "id": "A2A863", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A863" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1470, "end_pos": 1470, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1483, "end_pos": 1483, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ] }, { "start_pos": 1490, "end_pos": 1490, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ] }, { "start_pos": 1526, "end_pos": 1526, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ] }, { "start_pos": 1787, "end_pos": 1787, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ] }, { "start_pos": 773, "end_pos": 773, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ] } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" }, { "database": "iPTMnet", "id": "A2A863", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A863" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Airway epithelial integrin beta4 suppresses allergic inflammation by decreasing CCL17 production.", "journal": "Clinical science (London, England : 1979)", "date": "2020", "authors": "Yuan L, Zhang X, Yang M, Du X, Wang L, Wu S, Wu M, Duan Z, Xiao G, Zou Y, Xiang Y, Qu X, Liu H, Qin L, Qin Q, Qin X, Liu C", "evidence": [ { "database": "RefSeq", "id": "NP_001005608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608" } ], "reference": [ { "type": "PubMed", "id": "32608482", "url": "https://glygen.org/publication/PubMed/32608482" } ] }, { "title": "DNA methylation down-regulates integrin beta4 expression in asthmatic airway epithelial cells.", "journal": "Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology", "date": "2020", "authors": "Wu M, Yang Y, Yuan L, Yang M, Wang L, Du X, Qin L, Wu S, Xiang Y, Qu X, Liu H, Qin X, Liu C", "evidence": [ { "database": "RefSeq", "id": "NP_001005608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608" } ], "reference": [ { "type": "PubMed", "id": "32618381", "url": "https://glygen.org/publication/PubMed/32618381" } ] }, { "title": "Airway epithelial integrin beta4-deficiency exacerbates lipopolysaccharide-induced acute lung injury.", "journal": "Journal of cellular physiology", "date": "2021", "authors": "Jiang W, Wang JM, Luo JH, Chen Y, Pi J, Ma XD, Liu CX, Zhou Y, Qu XP, Liu C, Liu HJ, Qin XQ, Xiang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001005608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005608" } ], "reference": [ { "type": "PubMed", "id": "34018612", "url": "https://glygen.org/publication/PubMed/34018612" } ] }, { "title": "Sequence of a cDNA encoding the beta 4 subunit of murine integrin.", "journal": "Gene", "date": "1993", "authors": "Chang L.Y., Sacchi A., Rizzo M.G., Cimino L., Foote L.J., Kennel S.J.", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "reference": [ { "type": "PubMed", "id": "8359687", "url": "https://glygen.org/publication/PubMed/8359687" } ] } ], "pathway": [ { "id": "mmu:192897", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:192897", "resource": "KEGG Pathway" }, { "id": "R-MMU-2022090", "name": "Assembly of collagen fibrils and other multimeric structures", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022090", "resource": "Reactome", "description": "Assembly of collagen fibrils and other multimeric structures" }, { "id": "R-MMU-3000157", "name": "Laminin interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000157", "resource": "Reactome", "description": "Laminin interactions" }, { "id": "R-MMU-3000170", "name": "Syndecan interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000170", "resource": "Reactome", "description": "Syndecan interactions" }, { "id": "R-MMU-446107", "name": "Type I hemidesmosome assembly", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-446107", "resource": "Reactome", "description": "Type I hemidesmosome assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "P16144-1", "protein_name": "Integrin beta-4", "gene_name": "ITGB4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTSGTLSTHMDQQFFQT", "length": 1822 }, "evidence": [ { "id": "179", "url": "http://www.informatics.jax.org/homology/179", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q64632-1", "protein_name": "Integrin beta-4", "gene_name": "Itgb4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGLCSSPWVKLLLAVVLSAGLPGNMANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQADVLAAGCRGESVLVMESSLEITENIQIDTSLHRSQVSPQGLQVRLRPGEERNFVFKVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWDKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDATGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQRGNIHLKPSFSDGLRMDASVICDMCACELQKEVQSARCHYRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGLGFCECGRCHCNQRSSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYTVEGDGSPGPNSTVLVHKKKDCLPAPSWWLIPLLIFLLLLLVLLLLLCWKYCACCKACLGLLPCCNQGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASISPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVNGVHKLQQTKFRQQPNAGKKQDHTIVDTVLLAPRSAKQSLLKLTEKQVEQGSFHELKVAPGYYTLTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGIVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFYPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPNTATVIIGEQDETDRSLINEISASPPLPRGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWVQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAHGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHQTHRMLSTSSTLTRDYHSLTRTDHSQSGTLPRDYSTLTSLSSQGLPPIWEDGRSRLPLSWTLGSWSRAQMKGVPASRGSPDSIILAGQSAAPSWGTDSRGAMGVPDTPTRLVFSALGPTSLKVSWQEPQCDRALLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGGPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSHSGLFQNPLQSEYSTVTSTHSTTTTEPFLIDGLTLGTQRLEAGGSLTRHVTQEFVSRTLTTSGSLSTHMDQQFFQT", "length": 1807 }, "evidence": [ { "id": "179", "url": "http://www.informatics.jax.org/homology/179", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "neuregulin binding", "id": "GO:0038132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038132", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "21873635" }, { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "insulin-like growth factor I binding", "id": "GO:0031994", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031994", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 15, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "21873635" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "16436605" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "23382219" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "17011173" }, { "name": "basal plasma membrane", "id": "GO:0009925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009925", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "11891657" }, { "name": "hemidesmosome", "id": "GO:0030056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030056", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "22274697" }, { "name": "integrin complex", "id": "GO:0008305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008305", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "8707838" } ] }, { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "8707838" }, { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "21873635" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "21873635" }, { "name": "filopodium assembly", "id": "GO:0046847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046847", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "16365040" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "cell adhesion mediated by integrin", "id": "GO:0033627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033627", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "21873635" }, { "name": "response to wounding", "id": "GO:0009611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "nail development", "id": "GO:0035878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035878", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "myelination in peripheral nervous system", "id": "GO:0022011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022011", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "29315582" }, { "name": "cell motility", "id": "GO:0048870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048870", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "skin morphogenesis", "id": "GO:0043589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043589", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "hemidesmosome assembly", "id": "GO:0031581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031581", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" }, { "name": "peripheral nervous system myelin formation", "id": "GO:0032290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032290", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "29315582" }, { "name": "trophoblast cell migration", "id": "GO:0061450", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061450", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "21606200" }, { "name": "mesodermal cell differentiation", "id": "GO:0048333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048333", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1116, "end_pos": 1118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1589, "end_pos": 1591, "annotation": "n_glycosylation_sequon" }, { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 619, "end_pos": 621, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" }, { "start_pos": 982, "end_pos": 984, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secondary association with tertaspanins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2A863", "url": "https://www.uniprot.org/uniprot/A2A863" }, { "database": "PubMed", "id": "P16144", "url": "https://glygen.org/publication/PubMed/P16144" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }