{ "uniprot_canonical_ac": "A2A7F4-1", "uniprot_ac": "A2A7F4", "uniprot_id": "A2A7F4_MOUSE", "mass": { "chemical_mass": 217389.0, "monoisotopic_mass": 217389.0 }, "refseq": { "ac": "NP_001333589", "name": "zinc finger protein Rlf", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589" }, "gene_names": [ { "name": "Rlf", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A7F4", "id": "A2A7F4" }, { "name": "9230110M18Rik; AI195322; MommeD8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589", "id": "NP_001333589" }, { "name": "Rlf", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589", "id": "NP_001333589" } ], "protein_names": [ { "name": "Rearranged L-myc fusion sequence", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A7F4#names_and_taxonomy", "id": "A2A7F4" }, { "name": "zinc finger protein Rlf", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589", "id": "NP_001333589" } ], "function": [ { "annotation": "Our study highlights the importance of RLF-dependent epigenetic modifications to DNA for maintaining correct gene regulatory network and intercellular signalling interactions during heart chamber and septal development.", "evidence": [ { "database": "RefSeq", "id": "NP_001333589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589" }, { "database": "PubMed", "id": "27930960", "url": "https://glygen.org/publication/PubMed/27930960" } ] }, { "annotation": "This study provides the first evidence that the epigenetic modifier Rlf is involved in the maintenance of DNA methylation at enhancers and CpG island shores across the genome. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001333589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589" }, { "database": "PubMed", "id": "25857663", "url": "https://glygen.org/publication/PubMed/25857663" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A7F4", "url": "https://www.uniprot.org/uniprot/A2A7F4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Rlf", "url": "https://www.uniprot.org/uniprot/A2A7F4", "locus": { "chromosome": "4", "start_pos": 121215084, "end_pos": 121145373, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000049878", "url": "https://www.ensembl.org/id/ENSMUSG00000049878" } ] } } ], "crossref": [ { "id": "ENSMUSG00000049878", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000049878", "database": "Bgee" }, { "id": "109263", "url": "https://www.ncbi.nlm.nih.gov/gene/109263", "database": "GeneID" }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro" }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro" }, { "id": "mmu:109263", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:109263", "database": "KEGG Pathway" }, { "id": "1924705", "url": "http://www.informatics.jax.org/marker/MGI:1924705", "database": "MGI" }, { "id": "SMFQHRY", "url": "https://omabrowser.org/oma/group/SMFQHRY/", "database": "OMA" }, { "id": "1318335at2759", "url": "http://www.orthodb.org/?query=1318335at2759", "database": "OrthoDB" }, { "id": "PF00096", "url": "http://pfam.xfam.org/family/PF00096", "database": "Pfam" }, { "id": "NP_001333589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589", "database": "RefSeq" }, { "id": "A2A7F4", "url": "https://www.uniprot.org/uniprot/A2A7F4", "database": "UniProtKB" }, { "id": "A2A7F4-1", "url": "https://www.uniprot.org/uniprot/A2A7F4-1", "database": "UniProtKB" }, { "id": "E9Q532", "url": "https://www.uniprot.org/uniprot/E9Q532", "database": "UniProtKB" }, { "id": "E9Q532-1", "url": "https://www.uniprot.org/uniprot/E9Q532-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MADGKGDATAAAGAGAGAEAPAVAGAEVETESMARGHRPASPASGAPGLRPCLWQLETELREQEVSEVSSLSYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIQSFASARPFLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEVWVPFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPILLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKELAQVSCFQQAYITCLCSMLPSEEAIQEIAKVDCKDVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLETFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGIGVSILLCVRALQLRSSEDEEMKASVCKTISCLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDDGKEDKQYRRSLTDQNKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKELFVPHVMEHVKMPPSRSHRSRKKLLLKSAQRGIYPKSPTGSLEQNPEQARGESHEYVTFSKLEDRRLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNVLGCKKFYYSKIEYQNHLSMHNVESPDGELKKSVKLEEPGAGGKQDCVDQSHLLDETEKSHSLEDHHLCPGSASAHIDTTETLKDNSDSNSSDQLSHSSSTSITEELIDTLDHSETMQDLLLSHEKVFVPSSLKDKCSNVAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHCKPRKIKTKDLFNCLDDKHNEADKFDAEPKPSSDTNSDSPDEGPDHSIHTKCKREHQGYSPEPSICASKRPCTEDTMLELLLRLKHLSLKNSIAHGSFSGSLQGCPSSGAKSLQSVPSSISDVNLQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFRCHICQRSFTRKTHLRIHYKNKHQIGSDRATHRLLDSEKCDHEGPCSVDRLKGDCSTELGPNSNSETTQCHSKKDECSSETDLESSCEETESKISGISSPIGSHREEGEEKEGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKLFACKYKDCNKRFLCSKALAKHCSDSHNLDHIEESKVLSETESAARFSCNQPQCPAVFYSFSKLKHHLLEQHNIEGEIHSDYEIHCTLNGCGQIFSHRSNYFQHVYYRHKDYYDNLFSSQKVANERLLRSEKVCQTTQAQGLTQTQGQTQGQTQGQEQQAAKRPFNTKAKKCGLLKDKKAPITFKTRAEAIHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMNSAYLEQQLENLVVCVKYGTKIKDEPPSEVEPCVKKEESTSCESVHTENGAPGDSSVPLPNTDSTCPAEQDVGQKGCSERNPVFDTHSLLYRGTLKCNHSSETTSLEQCNIAQSSPCKIESPIPNPSGTESGTYFTDFQLPLPRIKEEPGQHSSGQENTVKNATQVPKENIRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKDDDFDDWEPSEHLTLNNSSHPSNDLTGNVVADTIVNESAPQVDIPHSSSDPPVSENLTAVPPLVVAEATAVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1918, "header": "tr|A2A7F4-1|A2A7F4_MOUSE Isoform 1 of Rearranged L-myc fusion sequence OS=Mus musculus OX=10090 GN=Rlf PE=1 SV=1 CANONICAL=A2A7F4-1" }, "isoforms": [ { "isoform_ac": "A2A7F4-1", "url": "https://www.uniprot.org/uniprot/A2A7F4#A2A7F4-1", "sequence": { "sequence": "MADGKGDATAAAGAGAGAEAPAVAGAEVETESMARGHRPASPASGAPGLRPCLWQLETELREQEVSEVSSLSYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIQSFASARPFLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEVWVPFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPILLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKELAQVSCFQQAYITCLCSMLPSEEAIQEIAKVDCKDVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLETFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGIGVSILLCVRALQLRSSEDEEMKASVCKTISCLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDDGKEDKQYRRSLTDQNKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKELFVPHVMEHVKMPPSRSHRSRKKLLLKSAQRGIYPKSPTGSLEQNPEQARGESHEYVTFSKLEDRRLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNVLGCKKFYYSKIEYQNHLSMHNVESPDGELKKSVKLEEPGAGGKQDCVDQSHLLDETEKSHSLEDHHLCPGSASAHIDTTETLKDNSDSNSSDQLSHSSSTSITEELIDTLDHSETMQDLLLSHEKVFVPSSLKDKCSNVAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHCKPRKIKTKDLFNCLDDKHNEADKFDAEPKPSSDTNSDSPDEGPDHSIHTKCKREHQGYSPEPSICASKRPCTEDTMLELLLRLKHLSLKNSIAHGSFSGSLQGCPSSGAKSLQSVPSSISDVNLQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFRCHICQRSFTRKTHLRIHYKNKHQIGSDRATHRLLDSEKCDHEGPCSVDRLKGDCSTELGPNSNSETTQCHSKKDECSSETDLESSCEETESKISGISSPIGSHREEGEEKEGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKLFACKYKDCNKRFLCSKALAKHCSDSHNLDHIEESKVLSETESAARFSCNQPQCPAVFYSFSKLKHHLLEQHNIEGEIHSDYEIHCTLNGCGQIFSHRSNYFQHVYYRHKDYYDNLFSSQKVANERLLRSEKVCQTTQAQGLTQTQGQTQGQTQGQEQQAAKRPFNTKAKKCGLLKDKKAPITFKTRAEAIHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMNSAYLEQQLENLVVCVKYGTKIKDEPPSEVEPCVKKEESTSCESVHTENGAPGDSSVPLPNTDSTCPAEQDVGQKGCSERNPVFDTHSLLYRGTLKCNHSSETTSLEQCNIAQSSPCKIESPIPNPSGTESGTYFTDFQLPLPRIKEEPGQHSSGQENTVKNATQVPKENIRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKDDDFDDWEPSEHLTLNNSSHPSNDLTGNVVADTIVNESAPQVDIPHSSSDPPVSENLTAVPPLVVAEATAVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1918, "header": "tr|A2A7F4-1|A2A7F4_MOUSE Isoform 1 of Rearranged L-myc fusion sequence OS=Mus musculus OX=10090 GN=Rlf PE=1 SV=1 CANONICAL=A2A7F4-1" }, "locus": { "chromosome": "4", "start_pos": 121072268, "end_pos": 121003555, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000056635", "url": "https://www.ensembl.org/id/ENSMUST00000056635" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000050825", "url": "https://www.ensembl.org/id/ENSMUSP00000050825" } ] } }, { "isoform_ac": "E9Q532-1", "url": "https://www.uniprot.org/uniprot/A2A7F4#E9Q532-1", "sequence": { "sequence": "MWHLIYYSNFITYLHSYLHCRSCFELLLSVSESELPCEVWVPFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPILLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKELAQVSCFQQAYITCLCSMLPSEEAIQEIAKVDCKDVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLETFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGIGVSILLCVRALQLRSSEDEEMKASVCKTISCLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDDGKEDKQYRRSLTDQNKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKELFVPHVMEHVKMPPSRSHRSRKKLLLKSAQRGIYPKSPTGSLEQNPEQARGESHEYVTFSKLEDRRLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNVLGCKKFYYSKIEYQNHLSMHNVESPDGELKKSVKLEEPGAGGKQDCVDQSHLLDETEKSHSLEDHHLCPGSASAHIDTTETLKDNSDSNSSDQLSHSSSTSITEELIDTLDHSETMQDLLLSHEKVFVPSSLKDKCSNVAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHCKPRKIKTKDLFNCLDDKHNEADKFDAEPKPSSDTNSDSPDEGPDHSIHTKCKREHQGYSPEPSICASKRPCTEDTMLELLLRLKHLSLKNSIAHGSFSGSLQGCPSSGAKSLQSVPSSISDVNLQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFRCHICQRSFTRKTHLRIHYKNKHQIGSDRATHRLLDSEKCDHEGPCSVDRLKGDCSTELGPNSNSETTQCHSKKDECSSETDLESSCEETESKISGISSPIGSHREEGEEKEGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKLFACKYKDCNKRFLCSKALAKHCSDSHNLDHIEESKVLSETESAARFSCNQPQCPAVFYSFSKLKHHLLEQHNIEGEIHSDYEIHCTLNGCGQIFSHRSNYFQHVYYRHKDYYDNLFSSQKVANERLLRSEKVCQTTQAQGLTQTQGQTQGQTQGQEQQAAKRPFNTKAKKCGLLKDKKAPITFKTRAEAIHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMNSAYLEQQLENLVVCVKYGTKIKDEPPSEVEPCVKKEESTSCESVHTENGAPGDSSVPLPNTDSTCPAEQDVGQKGCSERNPVFDTHSLLYRGTLKCNHSSETTSLEQCNIAQSSPCKIESPIPNPSGTESGTYFTDFQLPLPRIKEEPGQHSSGQENTVKNATQVPKENIRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKDDDFDDWEPSEHLTLNNSSHPSNDLTGNVVADTIVNESAPQVDIPHSSSDPPVSENLTAVPPLVVAEATAVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1808, "header": "tr|E9Q532-1|A2A7F4_MOUSE Computationally mapped isoform of Rearranged L-myc fusion sequence OS=Mus musculus OX=10090 GN=Rlf PE=1 SV=1 CANONICAL=A2A7F4-1" }, "locus": { "chromosome": "4", "start_pos": 121045555, "end_pos": 121003555, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000168615", "url": "https://www.ensembl.org/id/ENSMUST00000168615" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000127068", "url": "https://www.ensembl.org/id/ENSMUSP00000127068" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers.", "journal": "BMC biology", "date": "2015", "authors": "Harten SK, Oey H, Bourke LM, Bharti V, Isbel L, Daxinger L, Faou P, Robertson N, Matthews JM, Whitelaw E", "evidence": [ { "database": "RefSeq", "id": "NP_001333589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589" } ], "reference": [ { "type": "PubMed", "id": "25857663", "url": "https://glygen.org/publication/PubMed/25857663" } ] }, { "title": "Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.", "journal": "Differentiation; research in biological diversity", "date": "2017", "authors": "Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK", "evidence": [ { "database": "RefSeq", "id": "NP_001333589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333589" } ], "reference": [ { "type": "PubMed", "id": "27930960", "url": "https://glygen.org/publication/PubMed/27930960" } ] } ], "pathway": [ { "id": "mmu:109263", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:109263", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13129-1", "protein_name": "Zinc finger protein Rlf", "gene_name": "RLF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADGKGDAAAVAGAGAEAPAVAGAGDGVETESMVRGHRPVSPAPGASGLRPCLWQLETELREQEVSEVSSLNYCRSFCQTLLQYASNKNASEHIVYLLEVYRLAIQSFASARPYLTTECEDVLLVLGRLVLSCFELLLSVSESELPCEVWLPFLQSLQESHDALLEFGNNNLQILVHVTKEGVWKNPVLLKILSQQPVETEEVNKLIAQEGPSFLQMRIKHLLKSNCIPQATALSKLCAESKEISNVSSFQQAYITCLCSMLPNEDAIKEIAKVDCKEVLDIICNLESEGQDNTAFVLCTTYLTQQLQTASVYCSWELTLFWSKLQRRIDPSLDTFLERCRQFGVIAKTQQHLFCLIRVIQTEAQDAGLGVSILLCVRALQLRSSEDEEMKASVCKTIACLLPEDLEVRRACQLTEFLIEPSLDGFNMLEELYLQPDQKFDEENAPVPNSLRCELLLALKAHWPFDPEFWDWKTLKRHCHQLLGQEASDSDDDLSGYEMSINDTDVLESFLSDYDEGKEDKQYRRRDLTDQHKEKRDKKPIGSSERYQRWLQYKFFCLLCKRECIEARILHHSKMHMEDGIYTCPVCIKKFKRKEMFVPHVMEHVKMPPSRRDRSKKKLLLKGSQKGICPKSPSAIPEQNHSLNDQAKGESHEYVTFSKLEDCHLQDRDLYPCPGTDCSRVFKQFKYLSVHLKAEHQNNDENAKHYLDMKNRREKCTYCRRHFMSAFHLREHEQVHCGPQPYMCVSIDCYARFGSVNELLNHKQKHDDLRYKCELNGCNIVFSDLGQLYHHEAQHFRDASYTCNFLGCKKFYYSKIEYQNHLSMHNVENSNGDIKKSVKLEESATGEKQDCINQPHLLNQTDKSHLPEDLFCAESANSQIDTETAENLKENSDSNSSDQLSHSSSASMNEELIDTLDHSETMQDVLLSNEKVFGPSSLKEKCSSMAVCFDGTKFTCGFDGCGSTYKNARGMQKHLRKVHPYHFKPKKIKTKDLFPSLGNEHNQTTEKLDAEPKPCSDTNSDSPDEGLDHNIHIKCKREHQGYSSESSICASKRPCTEDTMLELLLRLKHLSLKNSITHGSFSGSLQGYPSSGAKSLQSVSSISDLNFQNQDENMPSQYLAQLAAKPFFCELQGCKYEFVTREALLMHYLKKHNYSKEKVLQLTMFQHRYSPFQCHICQRSFTRKTHLRIHYKNKHQIGSDRATHKLLDNEKCDHEGPCSVDRLKGDCSAELGGDPSSNSEKPHCHPKKDECSSETDLESSCEETESKTSDISSPIGSHREEQEGREGRGSRRTVAKGNLCYILNKYHKPFHCIHKTCNSSFTNLKGLIRHYRTVHQYNKEQLCLEKDKARTKRELVKCKKIFACKYKECNKRFLCSKALAKHCSDSHNLDHIEEPKVLSEAGSAARFSCNQPQCPAVFYTFNKLKHHLMEQHNIEGEIHSDYEIHCDLNGCGQIFTHRSNYSQHVYYRHKDYYDDLFRSQKVANERLLRSEKVCQTADTQGHEHQTTRRSFNAKSKKCGLIKEKKAPISFKTRAEALHMCVEHSEHTQYPCMVQGCLSVVKLESSIVRHYKRTHQMSSAYLEQQMENLVVCVKYGTKIKEEPPSEADPCIKKEENRSCESERTEHSHSPGDSSAPIQNTDCCHSSERDGGQKGCIESSSVFDADTLLYRGTLKCNHSSKTTSLEQCNIVQPPPPCKIENSIPNPNGTESGTYFTSFQLPLPRIKESETRQHSSGQENTVKNPTHVPKENFRKHSQPRSFDLKTYKPMGFESSFLKFIQESEEKEDDFDDWEPSEHLTLSNSSQSSNDLTGNVVANNMVNDSEPEVDIPHSSSDSTIHENLTAIPPLIVAETTTVPSLENLRVVLDKALTDCGELALKQLHYLRPVVVLERSKFSTPILDLFPTKKTDELCVGSS", "length": 1914 }, "evidence": [ { "id": "8243", "url": "http://www.informatics.jax.org/homology/8243", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A2A7F4", "url": "https://www.uniprot.org/uniprot/A2A7F4" } ], "pmid": "21873635" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A2A7F4", "url": "https://www.uniprot.org/uniprot/A2A7F4" } ], "pmid": "21873635" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2A7F4", "url": "https://www.uniprot.org/uniprot/A2A7F4" } ], "pmid": "21873635" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A2A7F4", "url": "https://www.uniprot.org/uniprot/A2A7F4" } ], "pmid": "21873635" }, { "name": "regulation of DNA methylation", "id": "GO:0044030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044030", "evidence": [ { "database": "UniProtKB", "id": "A2A7F4", "url": "https://www.uniprot.org/uniprot/A2A7F4" } ], "pmid": "25857663" }, { "name": "histone H3-K4 monomethylation", "id": "GO:0097692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097692", "evidence": [ { "database": "UniProtKB", "id": "A2A7F4", "url": "https://www.uniprot.org/uniprot/A2A7F4" } ], "pmid": "25857663" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1148, "end_pos": 1150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1311, "end_pos": 1313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1681, "end_pos": 1683, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1745, "end_pos": 1747, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1803, "end_pos": 1805, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1804, "end_pos": 1806, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1823, "end_pos": 1825, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1843, "end_pos": 1845, "annotation": "n_glycosylation_sequon" }, { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" }, { "start_pos": 890, "end_pos": 892, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }