{
    "uniprot_canonical_ac": "A2A761-1",
    "uniprot_ac": "A2A761",
    "uniprot_id": "ZFP69_MOUSE",
    "mass": {
        "chemical_mass": 65725.0,
        "monoisotopic_mass": 65725.0
    },
    "refseq": {
        "ac": "NP_001005788",
        "name": "zinc finger protein 69 isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788"
    },
    "gene_names": [
        {
            "name": "Zfp69",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2A761",
            "id": "A2A761"
        },
        {
            "name": "Gm1029; Krab2; Zfp63",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788",
            "id": "NP_001005788"
        },
        {
            "name": "Zfp69",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788",
            "id": "NP_001005788"
        },
        {
            "name": "Znf642",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2A761",
            "id": "A2A761"
        }
    ],
    "protein_names": [
        {
            "name": "Zinc finger protein 69",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A2A761#names_and_taxonomy",
            "id": "A2A761"
        },
        {
            "name": "Zfp63p; zinc finger protein 642",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788",
            "id": "NP_001005788"
        },
        {
            "name": "Zinc finger protein 642",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A2A761#names_and_taxonomy",
            "id": "A2A761"
        },
        {
            "name": "zinc finger protein 69 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788",
            "id": "NP_001005788"
        }
    ],
    "function": [
        {
            "annotation": "Putative transcription factor that appears to regulate lipid metabolism.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A761",
                    "url": "https://www.uniprot.org/uniprot/A2A761#function"
                },
                {
                    "database": "PubMed",
                    "id": "19578398",
                    "url": "https://glygen.org/publication/PubMed/19578398"
                },
                {
                    "database": "PubMed",
                    "id": "26232096",
                    "url": "https://glygen.org/publication/PubMed/26232096"
                }
            ]
        },
        {
            "annotation": "Zfp69 is the most likely candidate for the diabetogenic effect of Nidd/SJL locus.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001005788",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788"
                },
                {
                    "database": "PubMed",
                    "id": "19578398",
                    "url": "https://glygen.org/publication/PubMed/19578398"
                }
            ]
        },
        {
            "annotation": "Zfp69 mRNA-expression was significantly higher in diabetic subjects than in unaffected controls. Review article",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001005788",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788"
                },
                {
                    "database": "PubMed",
                    "id": "20865372",
                    "url": "https://glygen.org/publication/PubMed/20865372"
                }
            ]
        },
        {
            "annotation": "Zfp69 mediates hyperlipidaemia, liver fat accumulation and mild insulin resistance. However, it does not induce type 2 diabetes, suggesting that the diabetogenic effect of the Zfp69 locus requires synergy with other as yet unidentified genes.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001005788",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788"
                },
                {
                    "database": "PubMed",
                    "id": "26232096",
                    "url": "https://glygen.org/publication/PubMed/26232096"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A761",
                    "url": "https://www.uniprot.org/uniprot/A2A761"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Zfp69",
            "url": "https://www.uniprot.org/uniprot/A2A761",
            "locus": {
                "chromosome": "4",
                "start_pos": 120951699,
                "end_pos": 120930137,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000064141",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000064141"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000064141",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000064141",
            "database": "Bgee"
        },
        {
            "id": "cd07765",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765",
            "database": "CDD"
        },
        {
            "id": "381549",
            "url": "https://www.ncbi.nlm.nih.gov/gene/381549",
            "database": "GeneID"
        },
        {
            "id": "IPR001909",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909",
            "database": "InterPro"
        },
        {
            "id": "IPR013087",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087",
            "database": "InterPro"
        },
        {
            "id": "IPR036051",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051",
            "database": "InterPro"
        },
        {
            "id": "IPR036236",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236",
            "database": "InterPro"
        },
        {
            "id": "mmu:381549",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381549",
            "database": "KEGG Pathway"
        },
        {
            "id": "107794",
            "url": "http://www.informatics.jax.org/marker/MGI:107794",
            "database": "MGI"
        },
        {
            "id": "1318335at2759",
            "url": "http://www.orthodb.org/?query=1318335at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00096",
            "url": "http://pfam.xfam.org/family/PF00096",
            "database": "Pfam"
        },
        {
            "id": "PF01352",
            "url": "http://pfam.xfam.org/family/PF01352",
            "database": "Pfam"
        },
        {
            "id": "PR_A2A761",
            "url": "http://purl.obolibrary.org/obo/PR_A2A761",
            "database": "PRO"
        },
        {
            "id": "R-MMU-212436",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436",
            "database": "Reactome"
        },
        {
            "id": "NP_001005788",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788",
            "database": "RefSeq"
        },
        {
            "id": "A2A761",
            "url": "https://www.uniprot.org/uniprot/A2A761",
            "database": "UniProtKB"
        },
        {
            "id": "A2A761-1",
            "url": "https://www.uniprot.org/uniprot/A2A761-1",
            "database": "UniProtKB"
        },
        {
            "id": "G3UWJ2",
            "url": "https://www.uniprot.org/uniprot/G3UWJ2",
            "database": "UniProtKB"
        },
        {
            "id": "G3UWJ2-1",
            "url": "https://www.uniprot.org/uniprot/G3UWJ2-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MPQQLLITPATEATWVKLKEVSLWEDVTKMFGGEALLSHDANGTQQESLADGTTPGTPAAGSHDGATPGTTATGSHDEATPGTPAAGSHDGETPGIPAAGSHDGETPGTPTAGSHDGVTPGTTAAGSQESLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVAGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWTHKKKRQEGNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCMRARRYPCNVCEKMFKQPIHLVEHMRTHTGEKPFRCKECGRAFSQSASLNTHQRIHTGEKPFACEECGKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHRTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSRHQKIHRRNTFRDDPGHENKRQL",
        "length": 587,
        "header": "sp|A2A761-1|ZFP69_MOUSE Isoform 1 of Zinc finger protein 69  OS=Mus musculus OX=10090 GN=Zfp69 PE=3 SV=1 CANONICAL=A2A761-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A2A761-1",
            "url": "https://www.uniprot.org/uniprot/A2A761#A2A761-1",
            "sequence": {
                "sequence": "MPQQLLITPATEATWVKLKEVSLWEDVTKMFGGEALLSHDANGTQQESLADGTTPGTPAAGSHDGATPGTTATGSHDEATPGTPAAGSHDGETPGIPAAGSHDGETPGTPTAGSHDGVTPGTTAAGSQESLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVAGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWTHKKKRQEGNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCMRARRYPCNVCEKMFKQPIHLVEHMRTHTGEKPFRCKECGRAFSQSASLNTHQRIHTGEKPFACEECGKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHRTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSRHQKIHRRNTFRDDPGHENKRQL",
                "length": 587,
                "header": "sp|A2A761-1|ZFP69_MOUSE Isoform 1 of Zinc finger protein 69  OS=Mus musculus OX=10090 GN=Zfp69 PE=3 SV=1 CANONICAL=A2A761-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 120806631,
                "end_pos": 120787553,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000106280",
                        "url": "https://www.ensembl.org/id/ENSMUST00000106280"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000101887",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000101887"
                    }
                ]
            }
        },
        {
            "isoform_ac": "G3UWJ2-1",
            "url": "https://www.uniprot.org/uniprot/A2A761#G3UWJ2-1",
            "sequence": {
                "sequence": "MLENYRNLVSVGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWT",
                "length": 110,
                "header": "tr|G3UWJ2-1|G3UWJ2_MOUSE Computationally mapped isoform of Zinc finger protein 69  OS=Mus musculus OX=10090 GN=Zfp69 PE=4 SV=1 CANONICAL=A2A761-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 120792297,
                "end_pos": 120788504,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000130702",
                        "url": "https://www.ensembl.org/id/ENSMUST00000130702"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000133312",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000133312"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL.",
            "journal": "PLoS Genet.",
            "date": "2009",
            "authors": "Al-Hasani H., Schuermann A., Vogel H., Scherneck S., Teichert M., Blueher M., Joost H.G., Nestler M., Kluge R., Herzig S., Schulz N., Berriel Diaz M., Block M.D., Tischer S.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A761",
                    "url": "https://www.uniprot.org/uniprot/A2A761"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001005788",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19578398",
                    "url": "https://glygen.org/publication/PubMed/19578398"
                }
            ]
        },
        {
            "title": "Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.",
            "journal": "Results and problems in cell differentiation",
            "date": "2010",
            "authors": "Scherneck S, Vogel H, Nestler M, Kluge R, Schurmann A, Joost HG",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001005788",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20865372",
                    "url": "https://glygen.org/publication/PubMed/20865372"
                }
            ]
        },
        {
            "title": "The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.",
            "journal": "Diabetologia",
            "date": "2015",
            "authors": "Jain D., Schuermann A., Scherneck S., Chung B., Joost H.G., Schulz N., Stadion M.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A2A761",
                    "url": "https://www.uniprot.org/uniprot/A2A761"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_001005788",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26232096",
                    "url": "https://glygen.org/publication/PubMed/26232096"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:381549",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381549",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-212436",
            "name": "Generic Transcription Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436",
            "resource": "Reactome",
            "description": "Generic Transcription Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q49AA0-1",
            "protein_name": "Zinc finger protein 69 homolog",
            "gene_name": "ZFP69",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MPQQLLITLPTEASTWVKLQHPKKAVEGAPLWEDVTKMFEGEALLSQDAEDVKTQRESLEDEVTPGLPTAESQELLTFKDISIDFTQEEWGQLAPAHQNLYREVMLENYSNLVSVGYQLSKPSVISQLEKGEEPWMAEKEGPGDPSSDLKSKIETIESTAKSTISQERLYHGIMMESFMRDDIIYSTLRKVSTYDDVLERHQETCMRDVRQAILTHKKRVQETNKFGENIIVHSNVIIEQRHHKYDTPTKRNTYKLDLINHPTSYIRTKTYECNICEKIFKQPIHLTEHMRIHTGEKPFRCKECGRAFSQSASLSTHQRIHTGEKPFECEECGKAFRHRSSLNQHHRTHTGEKPYVCDKCQKAFSQNISLVQHLRTHSGEKPFTCNECGKTFRQIRHLSEHIRIHTGEKPYACTACCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHKTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECNECGKAFSYNSSLSRHHEIHRRNAFRNKV",
                "length": 526
            },
            "evidence": [
                {
                    "id": "45693",
                    "url": "http://www.informatics.jax.org/homology/45693",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "negative regulation of transcription by RNA polymerase II",
                        "id": "GO:0000122",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "lipid metabolic process",
                        "id": "GO:0006629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of lipid metabolic process",
                        "id": "GO:0019216",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019216",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": "26232096"
                    },
                    {
                        "name": "regulation of transcription, DNA-templated",
                        "id": "GO:0006355",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": "26232096"
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 4,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding",
                        "id": "GO:0000977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific",
                        "id": "GO:0001227",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "DNA-binding transcription factor activity, RNA polymerase II-specific",
                        "id": "GO:0000981",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A2A761",
                                "url": "https://www.uniprot.org/uniprot/A2A761"
                            }
                        ],
                        "pmid": "21873635"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 420,
            "end_pos": 422,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 42,
            "end_pos": 44,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 560,
            "end_pos": 562,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}