{ "uniprot_canonical_ac": "A2A5R2-1", "uniprot_ac": "A2A5R2", "uniprot_id": "BIG2_MOUSE", "mass": { "chemical_mass": 202240.0, "monoisotopic_mass": 202240.0 }, "refseq": { "ac": "NP_001078964", "name": "brefeldin A-inhibited guanine nucleotide-exchange protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964" }, "gene_names": [ { "name": "Arfgef2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2" }, { "name": "AI463430; AW493672; BIG2; E230011G24Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964", "id": "NP_001078964" }, { "name": "Arfgef2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964", "id": "NP_001078964" }, { "name": "Arfgep2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2" }, { "name": "Big2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2" } ], "protein_names": [ { "name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A5R2#names_and_taxonomy", "id": "A2A5R2" }, { "name": "ADP-ribosylation factor guanine nucleotide-exchange factor 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A5R2#names_and_taxonomy", "id": "A2A5R2" }, { "name": "Brefeldin A-inhibited GEP 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A5R2#names_and_taxonomy", "id": "A2A5R2" }, { "name": "brefeldin A-inhibited GEP 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964", "id": "NP_001078964" }, { "name": "brefeldin A-inhibited guanine nucleotide-exchange protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964", "id": "NP_001078964" } ], "function": [ { "annotation": "An early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum.", "evidence": [ { "database": "RefSeq", "id": "NP_001078964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964" }, { "database": "PubMed", "id": "23386609", "url": "https://glygen.org/publication/PubMed/23386609" } ] }, { "annotation": "Coordinated interactions between actin (through FlnA) and vesicle trafficking (through Big2-Arf) direct the assembly and disassembly of membrane protein complexes required for neuronal migration and neuroependymal integrity.", "evidence": [ { "database": "RefSeq", "id": "NP_001078964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964" }, { "database": "PubMed", "id": "24089482", "url": "https://glygen.org/publication/PubMed/24089482" } ] }, { "annotation": "Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2#function" } ] }, { "annotation": "Results indicate that murine BIG2 is essential for early embryonic development.", "evidence": [ { "database": "RefSeq", "id": "NP_001078964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964" }, { "database": "PubMed", "id": "20857375", "url": "https://glygen.org/publication/PubMed/20857375" } ] } ], "disease": [ { "disease_id": "DOID:0050454", "recommended_name": { "id": "DOID:0050454", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050454", "name": "periventricular nodular heterotopia", "description": "A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain." }, "synonyms": [ { "id": "DOID:0050454", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050454", "name": "periventricular heterotopia", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "heterotopia, periventricular, X-linked dominant", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "heterotopia, periventricular nodular, with Frontometaphyseal dysplasia", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "heterotopia periventricular X-linked dominant", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "heterotopia, periventricular, Ehlers-Danlos variant", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "heterotopia, periventricular, X-linked dominant", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "periventricular nodular heterotopia 4, formerly", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "X-linked periventricular heterotopia", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "periventricular nodular heterotopia 4", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "nodular heterotopia bilateral periventricular", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "PVNH1", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "nodular heterotopia, bilateral periventricular", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "bilateral periventricular nodular heterotopia", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "periventricular nodular heterotopia 1", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "heterotopia, familial nodular", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "periventricular nodular heterotopia 1; PVNH1", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "heterotopia familial nodular", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "BPNH", "description": "" }, { "id": "MONDO:0010233", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010233", "name": "NHBP", "description": "" }, { "id": "MONDO:0011966", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011966", "name": "periventricular heterotopia with microcephaly, autosomal recessive", "description": "" }, { "id": "MONDO:0011966", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011966", "name": "periventricular heterotopia with microcephaly, autosomal recessive; ARPHM", "description": "" }, { "id": "MONDO:0011966", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011966", "name": "periventricular nodular heterotopia 2", "description": "" }, { "id": "MONDO:0011966", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011966", "name": "heterotopia, periventricular, autosomal recessive", "description": "" }, { "id": "MONDO:0011966", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011966", "name": "ARPHM", "description": "" }, { "id": "MONDO:0011966", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011966", "name": "periventricular heterotopia with microcephaly, autosomal recessive", "description": "" }, { "id": "MONDO:0011967", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011967", "name": "heterotopia, periventricular, associated with chromosome 5P anomalies", "description": "" }, { "id": "MONDO:0011967", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011967", "name": "heterotopia, periventricular, associated with chromosome 5P anomalies", "description": "" }, { "id": "MONDO:0011967", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011967", "name": "periventricular nodular heterotopia 3", "description": "" }, { "id": "MONDO:0013031", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013031", "name": "chromosome 5Q14.3 deletion syndrome, distal", "description": "" }, { "id": "MONDO:0013031", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013031", "name": "chromosome 5Q14.3 deletion syndrome, distal", "description": "" }, { "id": "MONDO:0013031", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013031", "name": "periventricular nodular heterotopia 5", "description": "" }, { "id": "MONDO:0013031", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013031", "name": "heterotopia, periventricular, associated with chromosome 5Q deletion", "description": "" }, { "id": "MONDO:0014240", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014240", "name": "periventricular nodular heterotopia 6", "description": "Any periventricular nodular heterotopia in which the cause of the disease is a mutation in the ERMARD gene." }, { "id": "MONDO:0014240", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014240", "name": "periventricular nodular heterotopia type 6", "description": "" }, { "id": "MONDO:0014240", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014240", "name": "ERMARD periventricular nodular heterotopia", "description": "" }, { "id": "MONDO:0014240", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014240", "name": "periventricular nodular heterotopia 6", "description": "" }, { "id": "MONDO:0014240", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014240", "name": "periventricular nodular heterotopia caused by mutation in ERMARD", "description": "" }, { "id": "MONDO:0014240", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014240", "name": "PVNH6", "description": "" }, { "id": "MONDO:0014240", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014240", "name": "periventricular nodular heterotopia 6; PVNH6", "description": "" }, { "id": "MIM:300049", "resource": "MIM", "url": "https://www.omim.org/entry/300049", "name": "Periventricular nodular heterotopia 1", "description": "Periventricular nodular heterotopia 1" }, { "id": "MIM:608097", "resource": "MIM", "url": "https://www.omim.org/entry/608097", "name": "Periventricular nodular heterotopia 2", "description": "Periventricular nodular heterotopia 2" }, { "id": "MIM:615544", "resource": "MIM", "url": "https://www.omim.org/entry/615544", "name": "Periventricular nodular heterotopia 6", "description": "Periventricular nodular heterotopia 6" } ], "evidence": [ { "id": "0050454", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050454" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Arfgef2", "url": "https://www.uniprot.org/uniprot/A2A5R2", "locus": { "chromosome": "2", "start_pos": 166805588, "end_pos": 166898052, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000074582", "url": "https://www.ensembl.org/id/ENSMUSG00000074582" } ] } } ], "crossref": [ { "id": "ENSMUSG00000074582", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074582", "database": "Bgee" }, { "id": "cd00171", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00171", "database": "CDD" }, { "id": "99371", "url": "https://www.ncbi.nlm.nih.gov/gene/99371", "database": "GeneID" }, { "id": "A2A5R2", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A5R2*", "database": "IntAct" }, { "id": "IPR000904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000904", "database": "InterPro" }, { "id": "IPR015403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015403", "database": "InterPro" }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro" }, { "id": "IPR023394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023394", "database": "InterPro" }, { "id": "IPR032629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032629", "database": "InterPro" }, { "id": "IPR032691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032691", "database": "InterPro" }, { "id": "IPR035999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035999", "database": "InterPro" }, { "id": "mmu:99371", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99371", "database": "KEGG Pathway" }, { "id": "2139354", "url": "http://www.informatics.jax.org/marker/MGI:2139354", "database": "MGI" }, { "id": "DLYITFF", "url": "https://omabrowser.org/oma/group/DLYITFF/", "database": "OMA" }, { "id": "815698at2759", "url": "http://www.orthodb.org/?query=815698at2759", "database": "OrthoDB" }, { "id": "PF01369", "url": "http://pfam.xfam.org/family/PF01369", "database": "Pfam" }, { "id": "PF09324", "url": "http://pfam.xfam.org/family/PF09324", "database": "Pfam" }, { "id": "PF12783", "url": "http://pfam.xfam.org/family/PF12783", "database": "Pfam" }, { "id": "PF16213", "url": "http://pfam.xfam.org/family/PF16213", "database": "Pfam" }, { "id": "PR_A2A5R2", "url": "http://purl.obolibrary.org/obo/PR_A2A5R2", "database": "PRO" }, { "id": "NP_001078964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964", "database": "RefSeq" }, { "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2", "database": "UniProtKB" }, { "id": "A2A5R2-1", "url": "https://www.uniprot.org/uniprot/A2A5R2-1", "database": "UniProtKB" }, { "id": "F6YCJ0", "url": "https://www.uniprot.org/uniprot/F6YCJ0", "database": "UniProtKB" }, { "id": "F6YCJ0-1", "url": "https://www.uniprot.org/uniprot/F6YCJ0-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPMQSKPQSPVIQATAGSPKFSRLKQSQAQSKPTTPEKAELPNGDHAQSGLGKVSLENGEAPRERGSPVSGRAEPSRGTDSGAQEVVKDILEDVVTSAVKEAAEKHGLPEPDRALGALECQECAVPPGVDENSQTNGIADDRQSLSSADNLEPDVQGHQVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHSLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYEALHEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWRPAGMEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYAHQKLLASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDAEIHIETENQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKISDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGLVYKIWIPEEPSQVPAALSSTW", "length": 1792, "header": "sp|A2A5R2-1|BIG2_MOUSE Isoform 1 of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Mus musculus OX=10090 GN=Arfgef2 PE=1 SV=1 CANONICAL=A2A5R2-1" }, "isoforms": [ { "isoform_ac": "A2A5R2-1", "url": "https://www.uniprot.org/uniprot/A2A5R2#A2A5R2-1", "sequence": { "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPMQSKPQSPVIQATAGSPKFSRLKQSQAQSKPTTPEKAELPNGDHAQSGLGKVSLENGEAPRERGSPVSGRAEPSRGTDSGAQEVVKDILEDVVTSAVKEAAEKHGLPEPDRALGALECQECAVPPGVDENSQTNGIADDRQSLSSADNLEPDVQGHQVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHSLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYEALHEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWRPAGMEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYAHQKLLASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDAEIHIETENQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKISDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGLVYKIWIPEEPSQVPAALSSTW", 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"https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1535, "end_pos": 1535, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 1541, "end_pos": 1541, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ] }, { "start_pos": 1789, "end_pos": 1789, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ] }, { "start_pos": 214, "end_pos": 214, "kinase_uniprot_canonical_ac": "", 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"database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 244, "end_pos": 244, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ] }, { "start_pos": 355, "end_pos": 355, "kinase_uniprot_canonical_ac": "", 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} ] }, { "start_pos": 621, "end_pos": 621, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 623, "end_pos": 623, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Thr", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "iPTMnet", "id": "A2A5R2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A5R2" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 623, "end_pos": 623, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 624, "end_pos": 624, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "iPTMnet", "id": "A2A5R2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A5R2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 624, "end_pos": 624, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 633, "end_pos": 633, "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b", "residue": "Thr", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "iPTMnet", "id": "A2A5R2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A5R2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 633, "end_pos": 633, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "start_pos": 707, "end_pos": 707, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "UniProtKB", "id": "F6YCJ0", "url": "https://www.uniprot.org/uniprot/F6YCJ0" }, { "database": "iPTMnet", "id": "A2A5R2", "url": 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Proteome Res.", "date": "2008", "authors": "Dong J., Han G., Jiang X., Ye M., Zhou H., Zou H., Wu R.", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "UniProtKB", "id": "F6YCJ0", "url": "https://www.uniprot.org/uniprot/F6YCJ0" } ], "reference": [ { "type": "PubMed", "id": "18630941", "url": "https://glygen.org/publication/PubMed/18630941" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "iPTMnet", "id": "A2A5R2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A5R2" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.", "journal": "The International journal of developmental biology", "date": "2010", "authors": "Grzmil P, Enkhbaatar Z, Gundsambuu B, Oidovsambuu O, Yalcin S, Wolf S, Engel W, Neesen J", "evidence": [ { "database": "RefSeq", "id": "NP_001078964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964" } ], "reference": [ { "type": "PubMed", "id": "20857375", "url": "https://glygen.org/publication/PubMed/20857375" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" }, { "database": "iPTMnet", "id": "A2A5R2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A5R2" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Lowery J, Szul T, Styers M, Holloway Z, Oorschot V, Klumperman J, Sztul E", "evidence": [ { "database": "RefSeq", "id": "NP_001078964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964" } ], "reference": [ { "type": "PubMed", "id": "23386609", "url": "https://glygen.org/publication/PubMed/23386609" } ] }, { "title": "Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2013", "authors": "Zhang J, Neal J, Lian G, Hu J, Lu J, Sheen V", "evidence": [ { "database": "RefSeq", "id": "NP_001078964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964" } ], "reference": [ { "type": "PubMed", "id": "24089482", "url": "https://glygen.org/publication/PubMed/24089482" } ] } ], "pathway": [ { "id": "mmu:99371", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99371", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q7TSU1-1", "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2", "gene_name": "Arfgef2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETVCNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQATAGSPKFSRLKQSQAQSKPTTPEKTELPNGDHARSSLGKVNSENGEAHRERGSSISGRAEPSGGSDNGAQEVVKDILEDVVTSAVKEAAEKQGLPEPDQAPGVPECQECTVPPAVDENSQTNGIADDRQSLSSADNLEPDAQGHPVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIPDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKEHTMATKSTKQNVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHSLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYEALHEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFRTTIPHVLLTWRPAGMEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYANQKLLASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETENQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWGEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASVYYPYLCEMMQFDLIPELRAVLRKFFLRIGLVYKIWVPEEPSQVPAASTAW", "length": 1791 }, "evidence": [ { "id": "111880", "url": "http://www.informatics.jax.org/homology/111880", "database": "MGI" }, { "id": "A2A5R2", "url": "https://omabrowser.org/oma/group/A2A5R2/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y6D5-1", "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2", "gene_name": "ARFGEF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGHQVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW", "length": 1785 }, "evidence": [ { "id": "111880", "url": "http://www.informatics.jax.org/homology/111880", "database": "MGI" }, { "id": "A2A5R2", "url": "https://omabrowser.org/oma/group/A2A5R2/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 15, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "asymmetric synapse", "id": "GO:0032279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032279", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "symmetric synapse", "id": "GO:0032280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032280", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "axonemal microtubule", "id": "GO:0005879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005879", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "endosome organization", "id": "GO:0007032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "receptor recycling", "id": "GO:0001881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001881", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "Golgi to plasma membrane transport", "id": "GO:0006893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006893", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "endomembrane system organization", "id": "GO:0010256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010256", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "regulation of ARF protein signal transduction", "id": "GO:0032012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "myosin binding", "id": "GO:0017022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017022", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "protein kinase A regulatory subunit binding", "id": "GO:0034237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034237", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" }, { "name": "GABA receptor binding", "id": "GO:0050811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050811", "evidence": [ { "database": "UniProtKB", "id": "A2A5R2", "url": "https://www.uniprot.org/uniprot/A2A5R2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1201, "end_pos": 1203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1525, "end_pos": 1527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 812, "end_pos": 814, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }