{ "uniprot_canonical_ac": "A2A559-1", "uniprot_ac": "A2A559", "uniprot_id": "PGAP3_MOUSE", "mass": { "chemical_mass": 36528.0, "monoisotopic_mass": 36528.0 }, "refseq": { "ac": "NP_001028709", "name": "post-GPI attachment to proteins factor 3 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709" }, "gene_names": [ { "name": "Pgap3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559" }, { "name": "CAB2; D430035D22Rik; Perld1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709", "id": "NP_001028709" }, { "name": "Perld1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A559", "id": "A2A559" }, { "name": "Pgap3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709", "id": "NP_001028709" } ], "protein_names": [ { "name": "Post-GPI attachment to proteins factor 3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A559#names_and_taxonomy", "id": "A2A559" }, { "name": "PER1-like domain-containing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A559#names_and_taxonomy", "id": "A2A559" }, { "name": "per1-like domain containing 1; post-GPI attachment to proteins factor 3; PER1-like domain-containing protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709", "id": "NP_001028709" }, { "name": "post-GPI attachment to proteins factor 3 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709", "id": "NP_001028709" } ], "function": [ { "annotation": "Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559#function" } ] }, { "annotation": "The response of T cells was enhanced in Pgap3 knockout mice in both in vitro and in vivo studies, including alloreactive response, antigen-specific immune response, and experimental autoimmune encephalomyelitis.", "evidence": [ { "database": "RefSeq", "id": "NP_001028709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709" }, { "database": "PubMed", "id": "22227195", "url": "https://glygen.org/publication/PubMed/22227195" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Pgap3", "url": "https://www.uniprot.org/uniprot/A2A559", "locus": { "chromosome": "11", "start_pos": 98400490, "end_pos": 98388677, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000038208", "url": "https://www.ensembl.org/id/ENSMUSG00000038208" } ] } } ], "crossref": [ { "id": "ENSMUSG00000038208", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038208", "database": "Bgee" }, { "id": "320655", "url": "https://www.ncbi.nlm.nih.gov/gene/320655", "database": "GeneID" }, { "id": "IPR007217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007217", "database": "InterPro" }, { "id": "mmu:320655", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320655", "database": "KEGG Pathway" }, { "id": "2444461", "url": "http://www.informatics.jax.org/marker/MGI:2444461", "database": "MGI" }, { "id": "FMIEDCR", "url": "https://omabrowser.org/oma/group/FMIEDCR/", "database": "OMA" }, { "id": "828384at2759", "url": "http://www.orthodb.org/?query=828384at2759", "database": "OrthoDB" }, { "id": "PTHR13148", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13148", "database": "PANTHER" }, { "id": "PF04080", "url": "http://pfam.xfam.org/family/PF04080", "database": "Pfam" }, { "id": "PR_A2A559", "url": "http://purl.obolibrary.org/obo/PR_A2A559", "database": "PRO" }, { "id": "NP_001028709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709", "database": "RefSeq" }, { "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559", "database": "UniProtKB" }, { "id": "A2A559-1", "url": "https://www.uniprot.org/uniprot/A2A559-1", "database": "UniProtKB" }, { "id": "A2A559-2", "url": "https://www.uniprot.org/uniprot/A2A559-2", "database": "UniProtKB" } ], "sequence": { "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD", "length": 320, "header": "sp|A2A559-1|PGAP3_MOUSE Isoform 1 of Post-GPI attachment to proteins factor 3 OS=Mus musculus OX=10090 GN=Pgap3 PE=2 SV=1 CANONICAL=A2A559-1" }, "isoforms": [ { "isoform_ac": "A2A559-1", "url": "https://www.uniprot.org/uniprot/A2A559#A2A559-1", "sequence": { "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD", "length": 320, "header": "sp|A2A559-1|PGAP3_MOUSE Isoform 1 of Post-GPI attachment to proteins factor 3 OS=Mus musculus OX=10090 GN=Pgap3 PE=2 SV=1 CANONICAL=A2A559-1" }, "locus": { "chromosome": "11", "start_pos": 98291221, "end_pos": 98280867, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000090827", "url": "https://www.ensembl.org/id/ENSMUST00000090827" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000088337", "url": "https://www.ensembl.org/id/ENSMUSP00000088337" } ] } }, { "isoform_ac": "A2A559-2", "url": "https://www.uniprot.org/uniprot/A2A559#A2A559-2", "sequence": { "sequence": "MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD", "length": 269, "header": "sp|A2A559-2|PGAP3_MOUSE Isoform 2 of Post-GPI attachment to proteins factor 3 OS=Mus musculus OX=10090 GN=Pgap3 PE=2 SV=1 CANONICAL=A2A559-1" }, "locus": { "chromosome": "11", "start_pos": 98291221, "end_pos": 98280867, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000128897", "url": "https://www.ensembl.org/id/ENSMUST00000128897" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119668", "url": "https://www.ensembl.org/id/ENSMUSP00000119668" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 40, "start_aa": "Asn", "end_pos": 40, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A559#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Murakami H, Wang Y, Hasuwa H, Maeda Y, Kinoshita T, Murakami Y", "evidence": [ { "database": "RefSeq", "id": "NP_001028709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028709" } ], "reference": [ { "type": "PubMed", "id": "22227195", "url": "https://glygen.org/publication/PubMed/22227195" } ] } ], "pathway": [ { "id": "mmu:320655", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:320655", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B1WBW5-1", "protein_name": "Post-GPI attachment to proteins factor 3", "gene_name": "Pgap3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARRTAPLLLLTLAVGLAGSSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWLTVGLYLQEGYRVPQFHGKWPFSRFLFIQEPASALASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPTVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNHRRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESEAMFKLD", "length": 320 }, "evidence": [ { "id": "5484", "url": "http://www.informatics.jax.org/homology/5484", "database": "MGI" }, { "id": "A2A559", "url": "https://omabrowser.org/oma/group/A2A559/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96FM1-1", "protein_name": "Post-GPI attachment to proteins factor 3", "gene_name": "PGAP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVRTVGLQHPAVVSAFRALLLLMLTVHVSYLSLIRFDYGYNLVANVAIGLVNVVWWLAWCLWNQRRLPHVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEDKFKLD", "length": 320 }, "evidence": [ { "id": "5484", "url": "http://www.informatics.jax.org/homology/5484", "database": "MGI" }, { "id": "A2A559", "url": "https://omabrowser.org/oma/group/A2A559/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "intrinsic component of endoplasmic reticulum membrane", "id": "GO:0031227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031227", "evidence": [ { "database": "UniProtKB", "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559" } ], "pmid": "" }, { "name": "integral component of membrane", "id": "GO:0016021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "evidence": [ { "database": "UniProtKB", "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hydrolase activity, acting on ester bonds", "id": "GO:0016788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016788", "evidence": [ { "database": "UniProtKB", "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "GPI anchor metabolic process", "id": "GO:0006505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006505", "evidence": [ { "database": "UniProtKB", "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559" } ], "pmid": "" }, { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "A2A559", "url": "https://www.uniprot.org/uniprot/A2A559" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }