{ "uniprot_canonical_ac": "A2A472-1", "uniprot_ac": "A2A472", "uniprot_id": "A2A472_MOUSE", "mass": { "chemical_mass": 57797.0, "monoisotopic_mass": 57797.0 }, "refseq": { "ac": "NP_001092269", "name": "TOX high mobility group box family member 2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269" }, "gene_names": [ { "name": "Tox2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472" }, { "name": "AI851523; AV026525; BI987407; Gcx1; RxHMG1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269", "id": "NP_001092269" }, { "name": "Tox2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269", "id": "NP_001092269" } ], "protein_names": [ { "name": "TOX high mobility group box family member 2 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269", "id": "NP_001092269" }, { "name": "TOX high mobility group box family member 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A472#names_and_taxonomy", "id": "A2A472" }, { "name": "granulosa cell HMG-box protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269", "id": "NP_001092269" } ], "function": [ { "annotation": "Identification and functional analysis of the rat Gcx1 ortholog.", "evidence": [ { "database": "RefSeq", "id": "NP_001092269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269" }, { "database": "PubMed", "id": "14764631", "url": "https://glygen.org/publication/PubMed/14764631" } ] }, { "annotation": "Tox2(-/-) mice exhibited defective Tfh differentiation, and inhibition of both Tox2 and the related transcription factor Tox abolished Tfh differentiation. Thus, a Tox2-Bcl6 axis establishes a transcriptional feed-forward loop that promotes the Tfh program.", "evidence": [ { "database": "RefSeq", "id": "NP_001092269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269" }, { "database": "PubMed", "id": "31732165", "url": "https://glygen.org/publication/PubMed/31732165" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Tox2", "url": "https://www.uniprot.org/uniprot/A2A472", "locus": { "chromosome": "2", "start_pos": 163203125, "end_pos": 163324170, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000074607", "url": "https://www.ensembl.org/id/ENSMUSG00000074607" } ] } } ], "crossref": [ { "id": "ENSMUSG00000074607", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074607", "database": "Bgee" }, { "id": "269389", "url": "https://www.ncbi.nlm.nih.gov/gene/269389", "database": "GeneID" }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro" }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro" }, { "id": "mmu:269389", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269389", "database": "KEGG Pathway" }, { "id": "3611233", "url": "http://www.informatics.jax.org/marker/MGI:3611233", "database": "MGI" }, { "id": "HLDYYHG", "url": "https://omabrowser.org/oma/group/HLDYYHG/", "database": "OMA" }, { "id": "818359at2759", "url": "http://www.orthodb.org/?query=818359at2759", "database": "OrthoDB" }, { "id": "PF00505", "url": "http://pfam.xfam.org/family/PF00505", "database": "Pfam" }, { "id": "NP_001092269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269", "database": "RefSeq" }, { "id": "XP_006499675", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006499675", "database": "RefSeq" }, { "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472", "database": "UniProtKB" }, { "id": "A2A472-1", "url": "https://www.uniprot.org/uniprot/A2A472-1", "database": "UniProtKB" }, { "id": "A2A473", "url": "https://www.uniprot.org/uniprot/A2A473", "database": "UniProtKB" }, { "id": "A2A473-1", "url": "https://www.uniprot.org/uniprot/A2A473-1", "database": "UniProtKB" }, { "id": "A2A474", "url": "https://www.uniprot.org/uniprot/A2A474", "database": "UniProtKB" }, { "id": "A2A474-1", "url": "https://www.uniprot.org/uniprot/A2A474-1", "database": "UniProtKB" }, { "id": "E9Q0B9", "url": "https://www.uniprot.org/uniprot/E9Q0B9", "database": "UniProtKB" }, { "id": "E9Q0B9-1", "url": "https://www.uniprot.org/uniprot/E9Q0B9-1", "database": "UniProtKB" }, { "id": "F6XVL5", "url": "https://www.uniprot.org/uniprot/F6XVL5", "database": "UniProtKB" }, { "id": "F6XVL5-1", "url": "https://www.uniprot.org/uniprot/F6XVL5-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MGGGGAGPPANRGPRVVGRLIKLLFLAFFSLSVLIMQQHLTEAVAGAFSRCLGFRGMRLRLLTRHWCIAGASLQKFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHGSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSVDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCSLLPRDKSLYLT", "length": 547, "header": "tr|A2A472-1|A2A472_MOUSE Isoform 1 of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1" }, "isoforms": [ { "isoform_ac": "A2A472-1", "url": "https://www.uniprot.org/uniprot/A2A472#A2A472-1", "sequence": { "sequence": "MGGGGAGPPANRGPRVVGRLIKLLFLAFFSLSVLIMQQHLTEAVAGAFSRCLGFRGMRLRLLTRHWCIAGASLQKFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHGSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSVDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCSLLPRDKSLYLT", "length": 547, "header": "tr|A2A472-1|A2A472_MOUSE Isoform 1 of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1" }, "locus": { "chromosome": "2", "start_pos": 163164697, "end_pos": 163067283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000099110", "url": "https://www.ensembl.org/id/ENSMUST00000099110" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000096710", "url": "https://www.ensembl.org/id/ENSMUSP00000096710" } ] } }, { "isoform_ac": "A2A473-1", "url": "https://www.uniprot.org/uniprot/A2A472#A2A473-1", "sequence": { "sequence": "MDVRLYPSAPAVGARPGAEPAGLAHLDYYHCGKFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHGSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSVDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCSLLPRDKSLYLT", "length": 505, "header": "tr|A2A473-1|A2A472_MOUSE Computationally mapped isoform of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1" }, "locus": { "chromosome": "2", "start_pos": 163164697, "end_pos": 163045084, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000109428", "url": "https://www.ensembl.org/id/ENSMUST00000109428" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000105055", "url": "https://www.ensembl.org/id/ENSMUSP00000105055" } ] } }, { "isoform_ac": "A2A474-1", "url": "https://www.uniprot.org/uniprot/A2A472#A2A474-1", "sequence": { "sequence": "MLSGCCSSRASGRSLGLRGWASLQVHPQALRERLRPGALCSSPWSGRRGPRRPGRPGAEFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHG", "length": 124, "header": "tr|A2A474-1|A2A472_MOUSE Computationally mapped isoform of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1" }, "locus": { "chromosome": "2", "start_pos": 163118017, "end_pos": 163046525, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000128999", "url": "https://www.ensembl.org/id/ENSMUST00000128999" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122344", "url": "https://www.ensembl.org/id/ENSMUSP00000122344" } ] } }, { "isoform_ac": "E9Q0B9-1", "url": "https://www.uniprot.org/uniprot/A2A472#E9Q0B9-1", "sequence": { "sequence": "MQQHLTEAVAGAFSRCLGFRGMRLRLLTRHWCIAGASLQKFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHGSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSVDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRGSPPPTTSPKNLQEPSAR", "length": 522, "header": "tr|E9Q0B9-1|E9Q0B9_MOUSE Computationally mapped isoform of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1" }, "locus": { "chromosome": "2", "start_pos": 163164927, "end_pos": 163067388, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000165937", "url": "https://www.ensembl.org/id/ENSMUST00000165937" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000126243", "url": "https://www.ensembl.org/id/ENSMUSP00000126243" } ] } }, { "isoform_ac": "F6XVL5-1", "url": "https://www.uniprot.org/uniprot/A2A472#F6XVL5-1", "sequence": { "sequence": "XAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRGSPPPTTSPKNLQEPSAR", "length": 169, "header": "tr|F6XVL5-1|F6XVL5_MOUSE Computationally mapped isoform of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1" }, "locus": { "chromosome": "2", "start_pos": 163164929, "end_pos": 163162298, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000148599", "url": "https://www.ensembl.org/id/ENSMUST00000148599" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118219", "url": "https://www.ensembl.org/id/ENSMUSP00000118219" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells.", "journal": "Endocrinology", "date": "2004", "authors": "Kajitani T, Mizutani T, Yamada K, Yazawa T, Sekiguchi T, Yoshino M, Kawata H, Miyamoto K", "evidence": [ { "database": "RefSeq", "id": "NP_001092269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269" } ], "reference": [ { "type": "PubMed", "id": "14764631", "url": "https://glygen.org/publication/PubMed/14764631" } ] }, { "title": "The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.", "journal": "Immunity", "date": "2019", "authors": "Xu W, Zhao X, Wang X, Feng H, Gou M, Jin W, Wang X, Liu X, Dong C", "evidence": [ { "database": "RefSeq", "id": "NP_001092269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269" } ], "reference": [ { "type": "PubMed", "id": "31732165", "url": "https://glygen.org/publication/PubMed/31732165" } ] } ], "pathway": [ { "id": "mmu:269389", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269389", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q76IQ7-1", "protein_name": "TOX high mobility group box family member 2", "gene_name": "Tox2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGLRSGIAHSSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSTDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNAQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSAASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPAPMALQVQLAMSPSPPGPQDFPHISDFPSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRSSPPPTTSPKNLQEPSAR", "length": 473 }, "evidence": [ { "id": "13155", "url": "http://www.informatics.jax.org/homology/13155", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96NM4-1", "protein_name": "TOX high mobility group box family member 2", "gene_name": "TOX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQQTRTEAVAGAFSRCLGFCGMRLGLLLLARHWCIAGVFPQKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSSIAHSSPSPPGSKSATPSPSSSTQEEESEVHFKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSPPVSMSPAPQPPVLPTPMALQVQLAMSPSPPGPQDFPHISEFPSSSGSCSPGPSNPTSSGDWDSSYPSGECGISTCSLLPRDKSLYLT", "length": 488 }, "evidence": [ { "id": "13155", "url": "http://www.informatics.jax.org/homology/13155", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472" } ], "pmid": "21873635" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472" } ], "pmid": "21873635" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A2A472", "url": "https://www.uniprot.org/uniprot/A2A472" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }