{ "uniprot_canonical_ac": "A2A259-1", "uniprot_ac": "A2A259", "uniprot_id": "PK2L1_MOUSE", "mass": { "chemical_mass": 87234.0, "monoisotopic_mass": 87234.0 }, "refseq": { "ac": "NP_852087", "name": "polycystic kidney disease 2-like 1 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" }, "gene_names": [ { "name": "Pkd2l1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A259", "id": "A2A259" }, { "name": "B830002B15; BC046386; PCL; PKD2L; Pkdl; TRPP3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087", "id": "NP_852087" }, { "name": "Pkd2l1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087", "id": "NP_852087" }, { "name": "Trpp3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A259", "id": "A2A259" } ], "protein_names": [ { "name": "Polycystic kidney disease 2-like 1 protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A2A259#names_and_taxonomy", "id": "A2A259" }, { "name": "Polycystin-2 homolog", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A2A259#names_and_taxonomy", "id": "A2A259" }, { "name": "polycystic kidney disease 2-like 1 protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087", "id": "NP_852087" }, { "name": "polycystin-L; polycystin-2 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087", "id": "NP_852087" } ], "function": [ { "annotation": "PKD2L1 deficiency increased p300-mediated acetylation of histone 3 lysine 27 on the promoter of sodium/calcium exchange 1 (NCX1) by repressing AMP-activated protein kinase (AMPK) activity, resulting in NCX1 overexpression and mitochondrial Ca(2+) overload.", "evidence": [ { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" }, { "database": "PubMed", "id": "30089272", "url": "https://glygen.org/publication/PubMed/30089272" } ] }, { "annotation": "PKD2L1 forms functional cation channels on the plasma membrane by interacting with PKD1", "evidence": [ { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" }, { "database": "PubMed", "id": "15548533", "url": "https://glygen.org/publication/PubMed/15548533" } ] }, { "annotation": "Pkd1l3 and Pkd2l1 are co-expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer.", "evidence": [ { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" }, { "database": "PubMed", "id": "16805797", "url": "https://glygen.org/publication/PubMed/16805797" } ] }, { "annotation": "Pore-forming subunit of a heteromeric, non-selective cation channel that is permeable to Ca(2+) (PubMed:16891422, PubMed:15548533, PubMed:19464260, PubMed:20538909, PubMed:21185261, PubMed:22420714, PubMed:25820328, PubMed:28904867, PubMed:29567962). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336288, PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336288). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:16891422, PubMed:16929298, PubMed:20406802, PubMed:21098668, PubMed:21625513). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:18535624, PubMed:19464260, PubMed:20538909, PubMed:20406802, PubMed:22420714, PubMed:28904867, PubMed:29567962). May play a role in the perception of carbonation taste (PubMed:19833970). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (PubMed:28553944).", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259#function" }, { "database": "PubMed", "id": "19464260", "url": "https://glygen.org/publication/PubMed/19464260" }, { "database": "PubMed", "id": "25820328", "url": "https://glygen.org/publication/PubMed/25820328" }, { "database": "PubMed", "id": "24336289", "url": "https://glygen.org/publication/PubMed/24336289" }, { "database": "PubMed", "id": "22420714", "url": "https://glygen.org/publication/PubMed/22420714" }, { "database": "PubMed", "id": "18535624", "url": "https://glygen.org/publication/PubMed/18535624" }, { "database": "PubMed", "id": "16891422", "url": "https://glygen.org/publication/PubMed/16891422" }, { "database": "PubMed", "id": "20406802", "url": "https://glygen.org/publication/PubMed/20406802" }, { "database": "PubMed", "id": "20538909", "url": "https://glygen.org/publication/PubMed/20538909" }, { "database": "PubMed", "id": "28904867", "url": "https://glygen.org/publication/PubMed/28904867" }, { "database": "PubMed", "id": "21185261", "url": "https://glygen.org/publication/PubMed/21185261" }, { "database": "PubMed", "id": "29567962", "url": "https://glygen.org/publication/PubMed/29567962" }, { "database": "PubMed", "id": "15548533", "url": "https://glygen.org/publication/PubMed/15548533" }, { "database": "PubMed", "id": "21625513", "url": "https://glygen.org/publication/PubMed/21625513" }, { "database": "PubMed", "id": "21098668", "url": "https://glygen.org/publication/PubMed/21098668" }, { "database": "PubMed", "id": "28553944", "url": "https://glygen.org/publication/PubMed/28553944" }, { "database": "PubMed", "id": "24336288", "url": "https://glygen.org/publication/PubMed/24336288" }, { "database": "PubMed", "id": "19833970", "url": "https://glygen.org/publication/PubMed/19833970" }, { "database": "PubMed", "id": "16929298", "url": "https://glygen.org/publication/PubMed/16929298" } ] }, { "annotation": "The pore helix and transmembrane segment 6 of PKD2L1 are involved in upper and lower-gate opening, adopt an open conformation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" }, { "database": "PubMed", "id": "29567962", "url": "https://glygen.org/publication/PubMed/29567962" } ] }, { "annotation": "These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors.", "evidence": [ { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" }, { "database": "PubMed", "id": "16891422", "url": "https://glygen.org/publication/PubMed/16891422" } ] } ], "disease": [ { "disease_id": "DOID:0110859", "recommended_name": { "id": "DOID:0110859", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110859", "name": "polycystic kidney disease 2", "description": "A autosomal dominant polycystic kidney disease that has_material_basis_in autosomal dominant inheritance of mutation in the PKD2 gene on chromosome 4q22.1." }, "synonyms": [ { "id": "DOID:0110859", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110859", "name": "Apkd2", "description": "" }, { "id": "DOID:0110859", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110859", "name": "Pkd2", "description": "" }, { "id": "DOID:0110859", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110859", "name": "Polycystic Kidney Disease, Adult, Type II", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "polycystic kidney disease 2", "description": "Autosomal dominant polycystic kidney disease caused by a mutation in PKD2." }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "Autosomal dominant polycystic kidney disease type 2", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "APKD2", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "autosomal dominant polycystic kidney disease caused by mutation in PKD2", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "PKD2 autosomal dominant polycystic kidney disease", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "polycystic kidney disease, adult, type II", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "polycystic kidney disease type 2", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "PKD2", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "polycystic kidney disease 2 with or without polycystic liver disease", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "polycystic kidney disease 2", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "polycystic kidney disease, adult, type 2", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "polycystic kidney disease 2 with or without polycystic liver disease; PKD2", "description": "" }, { "id": "MONDO:0013131", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013131", "name": "polycystic kidney disease 2; PKD2", "description": "" }, { "id": "MIM:613095", "resource": "MIM", "url": "https://www.omim.org/entry/613095", "name": "Polycystic kidney disease 2 with or without polycystic liver disease", "description": "Polycystic kidney disease 2 with or without polycystic liver disease" } ], "evidence": [ { "id": "0110859", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110859" } ] }, { "disease_id": "DOID:898", "recommended_name": { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "autosomal dominant polycystic kidney disease", "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal dominant fashion." }, "synonyms": [ { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "Congenital biliary ectasias", "description": "" }, { "id": "DOID:898", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:898", "name": "POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1", "description": "" } ], "evidence": [ { "id": "898", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:898" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 522, "end_pos": 522, "sequence_org": "G", "sequence_mut": "L", "comment": "Loss of channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "29567962", "url": "https://glygen.org/publication/PubMed/29567962" } ] }, { "start_pos": 523, "end_pos": 523, "sequence_org": "D", "sequence_mut": "E", "comment": "Little or no effect on calcium channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "21185261", "url": "https://glygen.org/publication/PubMed/21185261" } ] }, { "start_pos": 523, "end_pos": 523, "sequence_org": "D", "sequence_mut": "N", "comment": "Impaired calcium channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "21185261", "url": "https://glygen.org/publication/PubMed/21185261" } ] }, { "start_pos": 525, "end_pos": 525, "sequence_org": "D", "sequence_mut": "N", "comment": "Little or no effect on calcium channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "21185261", "url": "https://glygen.org/publication/PubMed/21185261" } ] }, { "start_pos": 530, "end_pos": 530, "sequence_org": "D", "sequence_mut": "N", "comment": "Little or no effect on calcium channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "21185261", "url": "https://glygen.org/publication/PubMed/21185261" } ] }, { "start_pos": 531, "end_pos": 531, "sequence_org": "N", "sequence_mut": "Q", "comment": "No effect on activation by low pH.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "28904867", "url": "https://glygen.org/publication/PubMed/28904867" } ] }, { "start_pos": 533, "end_pos": 533, "sequence_org": "N", "sequence_mut": "Q", "comment": "Loss of activation by low pH.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "28904867", "url": "https://glygen.org/publication/PubMed/28904867" } ] }, { "start_pos": 560, "end_pos": 560, "sequence_org": "I", "sequence_mut": "F", "comment": "Loss of channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "29567962", "url": "https://glygen.org/publication/PubMed/29567962" } ] }, { "start_pos": 568, "end_pos": 568, "sequence_org": "K", "sequence_mut": "A", "comment": "Increases localization at the cell surface when expressed in absence of PKD1.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "15548533", "url": "https://glygen.org/publication/PubMed/15548533" } ] }, { "start_pos": 576, "end_pos": 576, "sequence_org": "D", "sequence_mut": "A", "comment": "Induces localization to the endoplasmic reticulum when expressed in absence of PKD1.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "PubMed", "id": "15548533", "url": "https://glygen.org/publication/PubMed/15548533" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Pkd2l1", "url": "https://www.uniprot.org/uniprot/A2A259", "locus": { "chromosome": "19", "start_pos": 44192442, "end_pos": 44147637, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000037578", "url": "https://www.ensembl.org/id/ENSMUSG00000037578" } ] } } ], "crossref": [ { "id": "ENSMUSG00000037578", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037578", "database": "Bgee" }, { "id": "329064", "url": "https://www.ncbi.nlm.nih.gov/gene/329064", "database": "GeneID" }, { "id": "A2A259", "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A259*", "database": "IntAct" }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro" }, { "id": "IPR003915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003915", "database": "InterPro" }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro" }, { "id": "IPR013122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013122", "database": "InterPro" }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro" }, { "id": "mmu:329064", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:329064", "database": "KEGG Pathway" }, { "id": "1352448", "url": "http://www.informatics.jax.org/marker/MGI:1352448", "database": "MGI" }, { "id": "PDPWGVQ", "url": "https://omabrowser.org/oma/group/PDPWGVQ/", "database": "OMA" }, { "id": "426073at2759", "url": "http://www.orthodb.org/?query=426073at2759", "database": "OrthoDB" }, { "id": "5Z1W", "url": "https://www.rcsb.org/structure/5Z1W", "database": "PDB" }, { "id": "PF08016", "url": "http://pfam.xfam.org/family/PF08016", "database": "Pfam" }, { "id": "PR_A2A259", "url": "http://purl.obolibrary.org/obo/PR_A2A259", "database": "PRO" }, { "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087", "database": "RefSeq" }, { "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259", "database": "UniProtKB" }, { "id": "A2A259-1", "url": "https://www.uniprot.org/uniprot/A2A259-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MNSMESPKNQELQTLGNRAWDNPAYSDPPSPNRTLRICTVSSVALPETQPKKPEVRCQEKTQRTLVSSCCLHICRSIRGLWGTTLTENTAENRELYVKTTLRELVVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDSGVSFQTISSMSDFWDFAQGPLLDSLYWTKWYNNQSLGRGSHSFIYYENLLLGAPRLRQLRVRNDSCVVHEDFREDILNCYDVYSPDKEDQLPFGPQNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHRLRYLSSVWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDQLQLSDFLKQSYNKTLLRLRLRKERVSDVQKVLKGGEPEIQFEDFTSTLRELGHEEHEITAAFTRFDQDGDHILDEEEQEQMRQGLEEERVTLNAEIENLGRSVGHSPPGELGAEAARGQSWVSGEEFDMLTRRVLQLQCVLEGVVSQIDAVGSKLKMLERKGELAPSPGMGEPAVWENLYNPS", "length": 760, "header": "sp|A2A259-1|PK2L1_MOUSE Isoform 1 of Polycystic kidney disease 2-like 1 protein OS=Mus musculus OX=10090 GN=Pkd2l1 PE=1 SV=1 CANONICAL=A2A259-1" }, "isoforms": [ { "isoform_ac": "A2A259-1", "url": "https://www.uniprot.org/uniprot/A2A259#A2A259-1", "sequence": { "sequence": "MNSMESPKNQELQTLGNRAWDNPAYSDPPSPNRTLRICTVSSVALPETQPKKPEVRCQEKTQRTLVSSCCLHICRSIRGLWGTTLTENTAENRELYVKTTLRELVVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDSGVSFQTISSMSDFWDFAQGPLLDSLYWTKWYNNQSLGRGSHSFIYYENLLLGAPRLRQLRVRNDSCVVHEDFREDILNCYDVYSPDKEDQLPFGPQNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHRLRYLSSVWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDQLQLSDFLKQSYNKTLLRLRLRKERVSDVQKVLKGGEPEIQFEDFTSTLRELGHEEHEITAAFTRFDQDGDHILDEEEQEQMRQGLEEERVTLNAEIENLGRSVGHSPPGELGAEAARGQSWVSGEEFDMLTRRVLQLQCVLEGVVSQIDAVGSKLKMLERKGELAPSPGMGEPAVWENLYNPS", "length": 760, "header": "sp|A2A259-1|PK2L1_MOUSE Isoform 1 of Polycystic kidney disease 2-like 1 protein OS=Mus musculus OX=10090 GN=Pkd2l1 PE=1 SV=1 CANONICAL=A2A259-1" }, "locus": { "chromosome": "19", "start_pos": 44180713, "end_pos": 44136949, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000042026", "url": "https://www.ensembl.org/id/ENSMUST00000042026" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000045675", "url": "https://www.ensembl.org/id/ENSMUSP00000045675" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 177, "start_aa": "Asn", "end_pos": 177, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A259", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A259#ptm_processing" }, { "id": "29567962", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29567962" }, { "id": "5Z1W", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/5Z1W" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 207, "start_aa": "Asn", "end_pos": 207, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A259", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A259#ptm_processing" }, { "id": "29567962", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29567962" }, { "id": "5Z1W", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/5Z1W" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 241, "start_aa": "Asn", "end_pos": 241, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A259", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A259#ptm_processing" }, { "id": "29567962", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29567962" }, { "id": "5Z1W", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/5Z1W" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 505, "start_aa": "Asn", "end_pos": 505, "end_aa": "Asn", "residue": "Asn", "evidence": [ { "id": "A2A259", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A259#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted" ], "publication": [ { "title": "Genomic organization and functional analysis of murine PKD2L1.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Ito H., Watanabe H., Murakami M., Ono K., Xu F., Miyoshi I., Iijima T., Ohba T., Shida S., Satoh E.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" } ], "reference": [ { "type": "PubMed", "id": "15548533", "url": "https://glygen.org/publication/PubMed/15548533" } ] }, { "title": "Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.", "journal": "Journal of neurochemistry", "date": "2006", "authors": "LopezJimenez ND, Cavenagh MM, Sainz E, Cruz-Ithier MA, Battey JF, Sullivan SL", "evidence": [ { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" } ], "reference": [ { "type": "PubMed", "id": "16805797", "url": "https://glygen.org/publication/PubMed/16805797" } ] }, { "title": "Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Kubota M., Tominaga M., Inada H., Zhuang H., Matsunami H., Ishimaru Y.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" } ], "reference": [ { "type": "PubMed", "id": "16891422", "url": "https://glygen.org/publication/PubMed/16891422" } ] }, { "title": "The cells and logic for mammalian sour taste detection.", "journal": "Nature", "date": "2006", "authors": "Chen X., Guo W., Huang A.L., Chandrashekar J., Hoon M.A., Ryba N.J., Zuker C.S., Trankner D.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "16929298", "url": "https://glygen.org/publication/PubMed/16929298" } ] }, { "title": "The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse.", "journal": "Chem. Senses", "date": "2008", "authors": "Yang R., Kataoka S., Sevigny J., Matsunami H., Ishimaru Y., Finger T.E., Kinnamon J.C.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "18156604", "url": "https://glygen.org/publication/PubMed/18156604" } ] }, { "title": "Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1.", "journal": "EMBO Rep.", "date": "2008", "authors": "Tominaga M., Inada H., Fushiki T., Matsunami H., Ishimaru Y., Kawabata F.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "18535624", "url": "https://glygen.org/publication/PubMed/18535624" } ] }, { "title": "Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste receptor.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2009", "authors": "Abe K., Ishii S., Misaka T., Kishi M., Ishimaru Y., Kaga T.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "19464260", "url": "https://glygen.org/publication/PubMed/19464260" } ] }, { "title": "The taste of carbonation.", "journal": "Science", "date": "2009", "authors": "Oka Y., Sly W., Chandrashekar J., Ryba N.J., Zuker C.S., Yarmolinsky D., von Buchholtz L.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "19833970", "url": "https://glygen.org/publication/PubMed/19833970" } ] }, { "title": "Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells.", "journal": "J. Biol. Chem.", "date": "2010", "authors": "Maruyama Y., Yanagawa Y., Murakami S., Kawaguchi H., Uchida K., Tominaga M., Yamanaka A., Sokabe T., Shibasaki K.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "20406802", "url": "https://glygen.org/publication/PubMed/20406802" } ] }, { "title": "Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae.", "journal": "FASEB J.", "date": "2010", "authors": "Abe K., Yamamoto K., Misaka T., Asakura T., Matsunami H., Akiba M., Ishimaru Y., Katano Y., Roberts R.W.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "20538909", "url": "https://glygen.org/publication/PubMed/20538909" } ] }, { "title": "A proton current drives action potentials in genetically identified sour taste cells.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2010", "authors": "Liman E.R., Chang R.B., Waters H.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "21098668", "url": "https://glygen.org/publication/PubMed/21098668" } ] }, { "title": "The single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2011", "authors": "Abe K., Misaka T., Asakura T., Ishimaru Y., Katano Y., Fujimoto C., Yamasoba T.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "21185261", "url": "https://glygen.org/publication/PubMed/21185261" } ] }, { "title": "Sour taste responses in mice lacking PKD channels.", "journal": "PLoS ONE", "date": "2011", "authors": "Yanagawa Y., Ninomiya Y., Yoshida R., Matsunami H., Ishimaru Y., Horio N., Yasumatsu K.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "21625513", "url": "https://glygen.org/publication/PubMed/21625513" } ] }, { "title": "The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs.", "journal": "FEBS J.", "date": "2012", "authors": "Ishii S., Misaka T., Kishi M., Okada S., Ishimaru Y., Kurokawa A., Yamagami K.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "22420714", "url": "https://glygen.org/publication/PubMed/22420714" } ] }, { "title": "Primary cilia are specialized calcium signalling organelles.", "journal": "Nature", "date": "2013", "authors": "Clapham D.E., Delling M., DeCaen P.G., Doerner J.F., Febvay S.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "24336288", "url": "https://glygen.org/publication/PubMed/24336288" } ] }, { "title": "Direct recording and molecular identification of the calcium channel of primary cilia.", "journal": "Nature", "date": "2013", "authors": "Clapham D.E., Delling M., DeCaen P.G., Vien T.N.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "24336289", "url": "https://glygen.org/publication/PubMed/24336289" } ] }, { "title": "A novel PKD2L1 C-terminal domain critical for trimerization and channel function.", "journal": "Sci. Rep.", "date": "2015", "authors": "Huang J., Tang J., Yang J., Zhang F., Cao Y., Zeng H., Zheng W., Chen X.Z., Hussein S., Fernandez-Patron C., Hernandez-Anzaldo S.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "25820328", "url": "https://glygen.org/publication/PubMed/25820328" } ] }, { "title": "The cellular mechanism for water detection in the mammalian taste system.", "journal": "Nat. Neurosci.", "date": "2017", "authors": "Oka Y., Wennemuth G., Zocchi D.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "28553944", "url": "https://glygen.org/publication/PubMed/28553944" } ] }, { "title": "The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation.", "journal": "FEBS Open Bio", "date": "2017", "authors": "Shimizu T., Higuchi T., Fujii T., Sakai H., Nilius B., Ohno C., Toba T.", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "reference": [ { "type": "PubMed", "id": "28904867", "url": "https://glygen.org/publication/PubMed/28904867" } ] }, { "title": "Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1.", "journal": "Nature communications", "date": "2018", "authors": "Su Q, Hu F, Liu Y, Ge X, Mei C, Yu S, Shen A, Zhou Q, Yan C, Lei J, Zhang Y, Liu X, Wang T", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259#ptm_processing" }, { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" }, { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" } ], "reference": [ { "type": "PubMed", "id": "29567962", "url": "https://glygen.org/publication/PubMed/29567962" } ] }, { "title": "Deficiency of PKD2L1 (TRPP3) Exacerbates Pathological Cardiac Hypertrophy by Augmenting NCX1-Mediated Mitochondrial Calcium Overload.", "journal": "Cell reports", "date": "2018", "authors": "Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z", "evidence": [ { "database": "RefSeq", "id": "NP_852087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852087" } ], "reference": [ { "type": "PubMed", "id": "30089272", "url": "https://glygen.org/publication/PubMed/30089272" } ] } ], "pathway": [ { "id": "mmu:329064", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:329064", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZDT6-1", "protein_name": "Polycystin 2-like 1, transient receptor potential cation channel", "gene_name": "Pkd2l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNIMENSKEQELQTLGSRVWDNPAYSSPPSPNGTPRICTVSSVALPETQPKKPEVRRQEKTPRVPVSGCCLLICRGIRGLWGTTLTENTAENRELYVKTTLRELVVYIVFLVDVCLLTYGMTSSSAYYYTKVMSELFLHTPSESAVSFQTISSMSDFWDGPLLDSLYWTKWYNNQSLGSSSHSFIYYENLLLGVPRLRQLRVRNDSCVVHEDFREDILNCYDVYSPDKEDQLPFGPLNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGAIPSWQIRTVKLIRYVNNWDFFIVGCEVIFCIFIFYYVVEEILEIRVHRFRYLSSVWNILDLVVILLSIVAVGFHVFRTLEVNRLMGELLQQPDTYPDFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVESFSTFVKCIFTQFRIILGDFDYNAIDNANRILGPVYFITYVFFVFFVLLNMFLAIINDTYSEVKEELAGQRDQLQLSDLLKQSYSKTLQRLRLRKERVSDVQKVLKGGEPEIQFEDFTNTLRELTRRVLQLQRVLEGVVSQVDALSSKLKMLERKGELAPSPGMARGASCLGEPL", "length": 676 }, "evidence": [ { "id": "22946", "url": "http://www.informatics.jax.org/homology/22946", "database": "MGI" }, { "id": "A2A259", "url": "https://omabrowser.org/oma/group/A2A259/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9P0L9-1", "protein_name": "Polycystic kidney disease 2-like 1 protein", "gene_name": "PKD2L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQETAYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETVLEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEVPYKREEEALEERRLSRGEIPTLQRS", "length": 805 }, "evidence": [ { "id": "22946", "url": "http://www.informatics.jax.org/homology/22946", "database": "MGI" }, { "id": "A2A259", "url": "https://omabrowser.org/oma/group/A2A259/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "muscle alpha-actinin binding", "id": "GO:0051371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051371", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "24336288" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "16891422" }, { "name": "alpha-actinin binding", "id": "GO:0051393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051393", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "20408813" }, { "name": "cytoskeletal protein binding", "id": "GO:0008092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "calcium activated cation channel activity", "id": "GO:0005227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005227", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "cation channel activity", "id": "GO:0005261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005261", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "28904867" }, { "name": "sodium channel activity", "id": "GO:0005272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005272", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "calcium-activated potassium channel activity", "id": "GO:0015269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015269", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "cation channel complex", "id": "GO:0034703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034703", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": 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"https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "16891422" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "non-motile cilium", "id": "GO:0097730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "calcium channel complex", "id": "GO:0034704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034704", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "29567962" }, { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "inorganic cation transmembrane transport", "id": "GO:0098662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098662", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "28904867" }, { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "29567962" }, { "name": "protein homotetramerization", "id": "GO:0051289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051289", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "cation transport", "id": "GO:0006812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006812", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "16891422" }, { "name": "sodium ion transmembrane transport", "id": "GO:0035725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035725", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": "https://www.uniprot.org/uniprot/A2A259" } ], "pmid": "" }, { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "A2A259", "url": 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