{ "uniprot_canonical_ac": "A0MZ67-1", "uniprot_ac": "A0MZ67", "uniprot_id": "SHOT1_RAT", "mass": { "chemical_mass": 71446.0, "monoisotopic_mass": 71446.0 }, "refseq": { "ac": "NP_001073173", "name": "shootin-1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" }, "gene_names": [ { "name": "Shtn1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0MZ67", "id": "A0MZ67" }, { "name": "RGD1311558; Shootin1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173", "id": "NP_001073173" }, { "name": "RGD1311558", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0MZ67", "id": "A0MZ67" }, { "name": "Shtn1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173", "id": "NP_001073173" } ], "protein_names": [ { "name": "Shootin-1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0MZ67#names_and_taxonomy", "id": "A0MZ67" }, { "name": "Shootin1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0MZ67#names_and_taxonomy", "id": "A0MZ67" }, { "name": "shootin-1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173", "id": "NP_001073173" } ], "function": [ { "annotation": "Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth (PubMed:17030985, PubMed:17439943, PubMed:18519736, PubMed:20664640). Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth (PubMed:18519736, PubMed:23453953). Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone (PubMed:17030985). Plays also a role in regenerative neurite outgrowth (PubMed:20664640). In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67#function" }, { "database": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" }, { "database": "PubMed", "id": "Q8K2Q9", "url": "https://glygen.org/publication/PubMed/Q8K2Q9" }, { "database": "PubMed", "id": "18519736", "url": "https://glygen.org/publication/PubMed/18519736" }, { "database": "PubMed", "id": "17030985", "url": "https://glygen.org/publication/PubMed/17030985" }, { "database": "PubMed", "id": "17439943", "url": "https://glygen.org/publication/PubMed/17439943" }, { "database": "PubMed", "id": "20664640", "url": "https://glygen.org/publication/PubMed/20664640" } ] }, { "annotation": "Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth", "evidence": [ { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" }, { "database": "PubMed", "id": "18519736", "url": "https://glygen.org/publication/PubMed/18519736" } ] }, { "annotation": "Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization.", "evidence": [ { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" }, { "database": "PubMed", "id": "17030985", "url": "https://glygen.org/publication/PubMed/17030985" } ] }, { "annotation": "Shootin1 is located at a critical interface, transducing a chemical signal into traction forces for axon outgrowth. A chemoattractant, netrin-1, positively regulates traction forces at axonal growth cones via Pak1-mediated shootin1 phosphorylation.", "evidence": [ { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" }, { "database": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" } ] }, { "annotation": "The shootin1-cortactin interaction participates in netrin-1-induced F-actin adhesion coupling and in the promotion of traction forces for axon outgrowth.", "evidence": [ { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" }, { "database": "PubMed", "id": "26261183", "url": "https://glygen.org/publication/PubMed/26261183" } ] }, { "annotation": "These results suggest that shootin1b may function in various peripheral tissues including epithelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" }, { "database": "PubMed", "id": "27177867", "url": "https://glygen.org/publication/PubMed/27177867" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 101, "end_pos": 101, "sequence_org": "S", "sequence_mut": "A", "comment": "Inhibits F-actin retrograde flow at the peripheral region of growth cones; when associated with A-249.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" } ] }, { "start_pos": 101, "end_pos": 101, "sequence_org": "S", "sequence_mut": "D", "comment": "Does not inhibit F-actin retrograde flow at the peripheral region of growth cones; when associated with D-249.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" } ] }, { "start_pos": 249, "end_pos": 249, "sequence_org": "S", "sequence_mut": "A", "comment": "Inhibits F-actin retrograde flow at the peripheral region of growth cones; when associated with A-101.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" } ] }, { "start_pos": 249, "end_pos": 249, "sequence_org": "S", "sequence_mut": "D", "comment": "Does not inhibit F-actin retrograde flow at the peripheral region of growth cones; when associated with D-101.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ], "common_name": "Rat" } ], "gene": [ { "name": "Shtn1", "url": "https://www.uniprot.org/uniprot/A0MZ67", "locus": { "chromosome": "1", "start_pos": 280233929, "end_pos": 280130504, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000018350", "url": "https://www.ensembl.org/id/ENSRNOG00000018350" } ] } } ], "crossref": [ { "id": "ENSRNOG00000018350", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000018350", "database": "Bgee" }, { "id": "292139", "url": "https://www.ncbi.nlm.nih.gov/gene/292139", "database": "GeneID" }, { "id": "A0MZ67", "url": "https://www.ebi.ac.uk/intact/interactors/id:A0MZ67*", "database": "IntAct" }, { "id": "IPR024849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024849", "database": "InterPro" }, { "id": "rno:292139", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:292139", "database": "KEGG Pathway" }, { "id": "NLMDAAI", "url": "https://omabrowser.org/oma/group/NLMDAAI/", "database": "OMA" }, { "id": "744654at2759", "url": "http://www.orthodb.org/?query=744654at2759", "database": "OrthoDB" }, { "id": "PTHR46606", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46606", "database": "PANTHER" }, { "id": "PR_A0MZ67", "url": "http://purl.obolibrary.org/obo/PR_A0MZ67", "database": "PRO" }, { "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173", "database": "RefSeq" }, { "id": "1311558", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311558", "database": "RGD" }, { "id": "A0A0G2K9C4", "url": "https://www.uniprot.org/uniprot/A0A0G2K9C4", "database": "UniProtKB" }, { "id": "A0A0G2K9C4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K9C4-1", "database": "UniProtKB" }, { "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67", "database": "UniProtKB" }, { "id": "A0MZ67-1", "url": "https://www.uniprot.org/uniprot/A0MZ67-1", "database": "UniProtKB" }, { "id": "A0MZ67-2", "url": "https://www.uniprot.org/uniprot/A0MZ67-2", "database": "UniProtKB" }, { "id": "D4A6P3", "url": "https://www.uniprot.org/uniprot/D4A6P3", "database": "UniProtKB" }, { "id": "D4A6P3-1", "url": "https://www.uniprot.org/uniprot/D4A6P3-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKETCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDDPGTDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKVLAIELESLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSVLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQLEEERIQHQQKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGGSTKKEKATQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELKGILGTLNKSTSSRSLKSLGPENSETELERILRRRKLTAEADSSSPTGILATSESKSMPVLGSVSSVTKSALNKKTLEAEFNNPCPLTPEPGEGPRKLEGCTNSKVTFQPPSKGGYRRKCVGSENQSEPVVVLDPVSTHEPQTKDQAAEKDPTQCKEEERGETQPEFKEDSSGGKTGETDSSNC", "length": 633, "header": "sp|A0MZ67-1|SHOT1_RAT Isoform 1 of Shootin-1 OS=Rattus norvegicus OX=10116 GN=Shtn1 PE=1 SV=1 CANONICAL=A0MZ67-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K9C4-1", "url": "https://www.uniprot.org/uniprot/A0MZ67#A0A0G2K9C4-1", "sequence": { "sequence": "MKTFEQRTRKQRRRVTRLGKNEMKLLRNWKSFRKCSHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDDPGTDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKVLAIELESLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSVLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQLEEERIQHQQKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGGSTKKEKATQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELKGILGTLNKSTSSRSLKSLGPENSETELERILRRRKLTAEADSSSPTGILATSESKSMPVLGSVSSVTKSALNKKTLEAEFNNPCPLTPEPGEGPRKLEGCTNSKVTFQPPSKGGYRRKCVGSENQSEPVVVLDPVSTHEPQTKDQAAEKDPTQCKEEERGETQPEFKEDSSGGKTGETDSSNC", "length": 610, "header": "tr|A0A0G2K9C4-1|A0A0G2K9C4_RAT Computationally mapped isoform of Shootin-1 OS=Rattus norvegicus OX=10116 GN=Shtn1 PE=1 SV=1 CANONICAL=A0MZ67-1" }, "locus": { "chromosome": "1", "start_pos": 280218026, "end_pos": 280130706, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085778", "url": "https://www.ensembl.org/id/ENSRNOT00000085778" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074944", "url": "https://www.ensembl.org/id/ENSRNOP00000074944" } ] } }, { "isoform_ac": "A0MZ67-1", "url": "https://www.uniprot.org/uniprot/A0MZ67#A0MZ67-1", "sequence": { "sequence": "MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKETCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDDPGTDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKVLAIELESLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSVLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQLEEERIQHQQKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGGSTKKEKATQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELKGILGTLNKSTSSRSLKSLGPENSETELERILRRRKLTAEADSSSPTGILATSESKSMPVLGSVSSVTKSALNKKTLEAEFNNPCPLTPEPGEGPRKLEGCTNSKVTFQPPSKGGYRRKCVGSENQSEPVVVLDPVSTHEPQTKDQAAEKDPTQCKEEERGETQPEFKEDSSGGKTGETDSSNC", "length": 633, "header": "sp|A0MZ67-1|SHOT1_RAT Isoform 1 of Shootin-1 OS=Rattus norvegicus OX=10116 GN=Shtn1 PE=1 SV=1 CANONICAL=A0MZ67-1" }, "locus": {} }, { "isoform_ac": "A0MZ67-2", "url": "https://www.uniprot.org/uniprot/A0MZ67#A0MZ67-2", "sequence": { "sequence": "MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKETCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDDPGTDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKVLAIELESLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSVLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQLEEERIQHQQKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGGSTKKEKATQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELKGILASQ", "length": 456, "header": "sp|A0MZ67-2|SHOT1_RAT Isoform 2 of Shootin-1 OS=Rattus norvegicus OX=10116 GN=Shtn1 PE=1 SV=1 CANONICAL=A0MZ67-1" }, "locus": {} }, { "isoform_ac": "D4A6P3-1", "url": "https://www.uniprot.org/uniprot/A0MZ67#D4A6P3-1", "sequence": { "sequence": "MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKETCDKIRQERDEAVKKLEEFQKCSHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDDDPGTDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKVLAIELESLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSVLAVEEYEELQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQLEEERIQHQQKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGGSTKKEKATQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELKGILGTLNKSTSSRSLKSLGPENSETELERILRRRKLTAEADSSSPTGILATSESKSMPVLGSVSSVTKSALNKKTLEAEFNNPCPLTPEPGEGPRKLEGCTNSKVTFQPPSKGGYRRKCVGSENQSEPVVVLDPVSTHEPQTKDQAAEKDPTQCKEEERGETQPEFKEDSSGGKTGETDSSNC", "length": 633, "header": "tr|D4A6P3-1|D4A6P3_RAT Computationally mapped isoform of Shootin-1 OS=Rattus norvegicus OX=10116 GN=Shtn1 PE=1 SV=3 CANONICAL=A0MZ67-1" }, "locus": { "chromosome": "1", "start_pos": 280233755, "end_pos": 280130706, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000064463", "url": "https://www.ensembl.org/id/ENSRNOT00000064463" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000061843", "url": "https://www.ensembl.org/id/ENSRNOP00000061843" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "Q703I1-1", "kinase_gene_name": "Oser1", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "iPTMnet", "id": "A0MZ67", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0MZ67" }, { "database": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" } ] }, { "start_pos": 101, "end_pos": 101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PAK1", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 249, "end_pos": 249, "kinase_uniprot_canonical_ac": "Q703I1-1", "kinase_gene_name": "Oser1", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "iPTMnet", "id": "A0MZ67", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0MZ67" }, { "database": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" } ] }, { "start_pos": 249, "end_pos": 249, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PAK1", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 375, "end_pos": 375, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 3, "end_pos": 3, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 473, "end_pos": 473, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 487, "end_pos": 487, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 494, "end_pos": 494, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 496, "end_pos": 496, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 506, "end_pos": 506, "kinase_uniprot_canonical_ac": "Q703I1-1", "kinase_gene_name": "Oser1", "residue": "Ser", "comment": "", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "iPTMnet", "id": "A0MZ67", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0MZ67" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "start_pos": 506, "end_pos": 506, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "start_pos": 515, "end_pos": 515, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] }, { "start_pos": 537, "end_pos": 537, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ] } ], "glycation": [], "keywords": [], "publication": [ { "title": "Shootin1: a protein involved in the organization of an asymmetric signal for neuronal polarization.", "journal": "J. Cell Biol.", "date": "2006", "authors": "Inagaki N., Roepstorff P., Shimada T., Toriyama M., Nomura E., Katsuta K., Kim K.B., Mitsuba M., Sakumura Y.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" } ], "reference": [ { "type": "PubMed", "id": "17030985", "url": "https://glygen.org/publication/PubMed/17030985" } ] }, { "title": "Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity.", "journal": "J. Biol. Chem.", "date": "2007", "authors": "Suzuki T., Inagaki N., Mori T., Wada T., Kubota Y.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ], "reference": [ { "type": "PubMed", "id": "17439943", "url": "https://glygen.org/publication/PubMed/17439943" } ] }, { "title": "Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth.", "journal": "J. Cell Biol.", "date": "2008", "authors": "Watanabe N., Inagaki N., Sugiura T., Shimada T., Toriyama M., Kamiguchi H., Uemura K.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" } ], "reference": [ { "type": "PubMed", "id": "18519736", "url": "https://glygen.org/publication/PubMed/18519736" } ] }, { "title": "A diffusion-based neurite length-sensing mechanism involved in neuronal symmetry breaking.", "journal": "Mol. Syst. Biol.", "date": "2010", "authors": "Ishii S., Inagaki N., Shimada T., Toriyama M., Sakumura Y.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ], "reference": [ { "type": "PubMed", "id": "20664640", "url": "https://glygen.org/publication/PubMed/20664640" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "UniProtKB", "id": "D4A6P3", "url": "https://www.uniprot.org/uniprot/D4A6P3" }, { "database": "UniProtKB", "id": "A0A0G2K9C4", "url": "https://www.uniprot.org/uniprot/A0A0G2K9C4" }, { "database": "iPTMnet", "id": "A0MZ67", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0MZ67" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Synchronous symmetry breaking in neurons with different neurite counts.", "journal": "PLoS ONE", "date": "2013", "authors": "Scott M.A., Steinmeyer J.D., Wissner-Gross Z.D., Yanik M.F.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ], "reference": [ { "type": "PubMed", "id": "23408951", "url": "https://glygen.org/publication/PubMed/23408951" } ] }, { "title": "Conversion of a signal into forces for axon outgrowth through Pak1-mediated shootin1 phosphorylation.", "journal": "Curr. Biol.", "date": "2013", "authors": "Inagaki N., Toriyama M., Sakumura Y., Kozawa S.", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" }, { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" }, { "database": "iPTMnet", "id": "A0MZ67", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0MZ67" } ], "reference": [ { "type": "PubMed", "id": "23453953", "url": "https://glygen.org/publication/PubMed/23453953" } ] }, { "title": "Shootin1-cortactin interaction mediates signal-force transduction for axon outgrowth.", "journal": "The Journal of cell biology", "date": "2015", "authors": "Kubo Y, Baba K, Toriyama M, Minegishi T, Sugiura T, Kozawa S, Ikeda K, Inagaki N", "evidence": [ { "database": "RefSeq", "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173" } ], "reference": [ { "type": "PubMed", "id": "26261183", "url": 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regulation of neuron migration", "id": "GO:2001224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001224", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 14, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0MZ67", "url": "https://www.uniprot.org/uniprot/A0MZ67" } ], "pmid": "18519736" }, { "name": "axon", "id": 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