{
    "uniprot_canonical_ac": "A0A0G2JVC4-1",
    "uniprot_ac": "A0A0G2JVC4",
    "uniprot_id": "A0A0G2JVC4_RAT",
    "mass": {
        "chemical_mass": 58497.0,
        "monoisotopic_mass": 58497.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Cgas",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4",
            "id": "A0A0G2JVC4"
        }
    ],
    "protein_names": [
        {
            "name": "Cyclic GMP-AMP synthase",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4#names_and_taxonomy",
            "id": "A0A0G2JVC4"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JVC4",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Cgas",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4",
            "locus": {
                "chromosome": "8",
                "start_pos": 85803433,
                "end_pos": 85789763,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000046191",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000046191"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000046191",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000046191",
            "database": "Bgee"
        },
        {
            "id": "IPR024810",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024810",
            "database": "InterPro"
        },
        {
            "id": "ACCSRTK",
            "url": "https://omabrowser.org/oma/group/ACCSRTK/",
            "database": "OMA"
        },
        {
            "id": "PF03281",
            "url": "http://pfam.xfam.org/family/PF03281",
            "database": "Pfam"
        },
        {
            "id": "1586939",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1586939",
            "database": "RGD"
        },
        {
            "id": "A0A0G2JVC4",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4",
            "database": "UniProtKB"
        },
        {
            "id": "A0A0G2JVC4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4-1",
            "database": "UniProtKB"
        },
        {
            "id": "M0R8I6",
            "url": "https://www.uniprot.org/uniprot/M0R8I6",
            "database": "UniProtKB"
        },
        {
            "id": "M0R8I6-1",
            "url": "https://www.uniprot.org/uniprot/M0R8I6-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MEDPRRRTTAPRAKKPSAKRAPTRPSGTRATVSHAGSCGPQRGARSRRVERDGDTTEKPHTPAPRVRPRRAAERTEDAQPLATDAAGASERPAVREPQRQVILDPEPPAVPEPQAPEDPEAPTVARGPVRRRGARSIRQPRASQGSRKEPDKLKKVLDKLRLKRKEISAAAETVNKVVDQLLRRMQRRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELEEYYETGAFYRVKFKRIPRGNPLSHFLEGEVLSATKVLSKFRELIKEEVKEIKDTDVTVEEEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKGGLPIQDWLGTKVRTNLRREPFYLVPKNAKDGNRFQGYDVECVFGLGVLYILCGHGQGRVLYEKSGIQCCVKECLKLMKYLLEQLKREFQELDAFCSYHVKTAIFHMWTKDPQDSQWDPRNLSTCFDKFLTFFLECLRTEKLDHYFIPKFNLFSQELIDKKSKEFLSEKIEYERNNGFPIFNKF",
        "length": 510,
        "header": "tr|A0A0G2JVC4-1|A0A0G2JVC4_RAT Isoform 1 of Cyclic GMP-AMP synthase  OS=Rattus norvegicus OX=10116 GN=Cgas PE=1 SV=1 CANONICAL=A0A0G2JVC4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JVC4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4#A0A0G2JVC4-1",
            "sequence": {
                "sequence": "MEDPRRRTTAPRAKKPSAKRAPTRPSGTRATVSHAGSCGPQRGARSRRVERDGDTTEKPHTPAPRVRPRRAAERTEDAQPLATDAAGASERPAVREPQRQVILDPEPPAVPEPQAPEDPEAPTVARGPVRRRGARSIRQPRASQGSRKEPDKLKKVLDKLRLKRKEISAAAETVNKVVDQLLRRMQRRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELEEYYETGAFYRVKFKRIPRGNPLSHFLEGEVLSATKVLSKFRELIKEEVKEIKDTDVTVEEEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKGGLPIQDWLGTKVRTNLRREPFYLVPKNAKDGNRFQGYDVECVFGLGVLYILCGHGQGRVLYEKSGIQCCVKECLKLMKYLLEQLKREFQELDAFCSYHVKTAIFHMWTKDPQDSQWDPRNLSTCFDKFLTFFLECLRTEKLDHYFIPKFNLFSQELIDKKSKEFLSEKIEYERNNGFPIFNKF",
                "length": 510,
                "header": "tr|A0A0G2JVC4-1|A0A0G2JVC4_RAT Isoform 1 of Cyclic GMP-AMP synthase  OS=Rattus norvegicus OX=10116 GN=Cgas PE=1 SV=1 CANONICAL=A0A0G2JVC4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 85803433,
                "end_pos": 85789766,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000081544",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000081544"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000069428",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069428"
                    }
                ]
            }
        },
        {
            "isoform_ac": "M0R8I6-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4#M0R8I6-1",
            "sequence": {
                "sequence": "MEDPRRRTTAPRAKKPSAKRAPTRPSGTRATVSHAGSCGPQRGARSRRVERDGDTTEKPHTPAPRVRPRRAAERTEDAQPLATDAAGASERPAVREPQRQVILDPEPPAVPEPQAPEDPEAPTVARGPVRRRGARSIRQPRASQGSRKEPDKLKKVLDKLRLKRKEISAAAETVNKVVDQLLRRMQRRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELEEYYETGAFYRVKFKRIPRGNPLSHFLEGEVLSATKVLSKFRELIKEEVKEIKDTDVTVEEEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKGGLPIQDWLGTKVRTNLRRAVLSCTQECKRWK",
                "length": 358,
                "header": "tr|M0R8I6-1|M0R8I6_RAT Computationally mapped isoform of Cyclic GMP-AMP synthase  OS=Rattus norvegicus OX=10116 GN=Cgas PE=1 SV=1 CANONICAL=A0A0G2JVC4-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 85803433,
                "end_pos": 85795523,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000073286",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000073286"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000065782",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000065782"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8C6L5-1",
            "protein_name": "Cyclic GMP-AMP synthase",
            "gene_name": "Cgas",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MEDPRRRTTAPRAKKPSAKRAPTQPSRTRAHAESCGPQRGARSRRAERDGDTTEKPRAPGPRVHPARATELTKDAQPSAMDAAGATARPAVRVPQQQAILDPELPAVREPQPPADPEARKVVRGPSHRRGARSTGQPRAPRGSRKEPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL",
                "length": 507
            },
            "evidence": [
                {
                    "id": "A0A0G2JVC4",
                    "url": "https://omabrowser.org/oma/group/A0A0G2JVC4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8N884-1",
            "protein_name": "Cyclic GMP-AMP synthase",
            "gene_name": "CGAS",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSRQKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGSCRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF",
                "length": 522
            },
            "evidence": [
                {
                    "id": "A0A0G2JVC4",
                    "url": "https://omabrowser.org/oma/group/A0A0G2JVC4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 16,
                "go_terms": [
                    {
                        "name": "cellular response to exogenous dsRNA",
                        "id": "GO:0071360",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071360",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of double-strand break repair via homologous recombination",
                        "id": "GO:2000042",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of immunoglobulin production",
                        "id": "GO:0002637",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002637",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "defense response to virus",
                        "id": "GO:0051607",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of immune response",
                        "id": "GO:0050776",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to DNA damage stimulus",
                        "id": "GO:0006974",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of defense response to virus by host",
                        "id": "GO:0002230",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002230",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cAMP-mediated signaling",
                        "id": "GO:0043950",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043950",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "activation of innate immune response",
                        "id": "GO:0002218",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002218",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cellular senescence",
                        "id": "GO:2000774",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000774",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of type I interferon production",
                        "id": "GO:0032481",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "paracrine signaling",
                        "id": "GO:0038001",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038001",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "determination of adult lifespan",
                        "id": "GO:0008340",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of T cell activation",
                        "id": "GO:0050863",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050863",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of type I interferon production",
                        "id": "GO:0032479",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032479",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cGMP-mediated signaling",
                        "id": "GO:0010753",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010753",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cyclic-GMP-AMP synthase activity",
                        "id": "GO:0061501",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061501",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chromatin binding",
                        "id": "GO:0003682",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphatidylinositol-4,5-bisphosphate binding",
                        "id": "GO:0005546",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "double-stranded DNA binding",
                        "id": "GO:0003690",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "site of double-strand break",
                        "id": "GO:0035861",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC4",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 447,
            "end_pos": 449,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}