{
    "uniprot_canonical_ac": "A0A0G2JVC1-1",
    "uniprot_ac": "A0A0G2JVC1",
    "uniprot_id": "A0A0G2JVC1_RAT",
    "mass": {
        "chemical_mass": 53902.0,
        "monoisotopic_mass": 53902.0
    },
    "refseq": {
        "ac": "XP_006241444",
        "name": "E3 ubiquitin-protein ligase Mdm2 isoform X2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241444"
    },
    "gene_names": [
        {
            "name": "Mdm2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1",
            "id": "A0A0G2JVC1"
        },
        {
            "name": "Mdm2_predicted",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1",
            "id": "A0A0G2JVC1"
        },
        {
            "name": "Mdm2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241444",
            "id": "XP_006241444"
        },
        {
            "name": "rCG_48669",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1",
            "id": "A0A0G2JVC1"
        }
    ],
    "protein_names": [
        {
            "name": "E3 ubiquitin-protein ligase Mdm2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1#names_and_taxonomy",
            "id": "A0A0G2JVC1"
        },
        {
            "name": "2.3.2.27",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1#names_and_taxonomy",
            "id": "A0A0G2JVC1"
        },
        {
            "name": "E3 ubiquitin-protein ligase Mdm2 isoform X2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241444",
            "id": "XP_006241444"
        },
        {
            "name": "E3 ubiquitin-protein ligase Mdm2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569",
            "id": "NP_001101569"
        },
        {
            "name": "double minute 2; MDM2 proto-oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; p53 E3 ubiquitin protein ligase; MDM2 oncogene, E3 ubiquitin protein ligase; transformed mouse 3T3 cell double minute 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569",
            "id": "NP_001101569"
        }
    ],
    "function": [
        {
            "annotation": "LncRNA UCA1 protects cardiomyocytes against hypoxia/reoxygenation induced apoptosis through inhibiting miR-143/MDM2/p53 axis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                },
                {
                    "database": "PubMed",
                    "id": "30998966",
                    "url": "https://glygen.org/publication/PubMed/30998966"
                }
            ]
        },
        {
            "annotation": "Murine double minute-2-forkhead box O1-thrombospondin-1 pathway plays an important role in angio-regulation of the skeletal muscle in the pathophysiological context of type 1 diabetes.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                },
                {
                    "database": "PubMed",
                    "id": "30360646",
                    "url": "https://glygen.org/publication/PubMed/30360646"
                }
            ]
        },
        {
            "annotation": "Only MDM2/FRS2 low-grade osteosarcoma was dedifferentiated parosteal osteosarcoma",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                },
                {
                    "database": "PubMed",
                    "id": "30001240",
                    "url": "https://glygen.org/publication/PubMed/30001240"
                }
            ]
        },
        {
            "annotation": "Tempo-spatial alternative polyadenylation analysis reveals that 3' UTR lengthening of Mdm2 regulates p53 expression and cellular senescence in aged rat testis.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                },
                {
                    "database": "PubMed",
                    "id": "31973811",
                    "url": "https://glygen.org/publication/PubMed/31973811"
                }
            ]
        },
        {
            "annotation": "The results indicate that the miR-188-3p-MDM2-p53 axis may have a critical role in sevoflurane-induced cognitive dysfunction.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                },
                {
                    "database": "PubMed",
                    "id": "29344658",
                    "url": "https://glygen.org/publication/PubMed/29344658"
                }
            ]
        }
    ],
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        {
            "disease_id": "DOID:0050625",
            "recommended_name": {
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                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050625",
                "name": "biliary tract benign neoplasm",
                "description": "A hepatobiliary benign neoplasm located_in the biliary tract."
            },
            "synonyms": [
                {
                    "id": "DOID:0050625",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050625",
                    "name": "extrahepatic bile duct neoplasm",
                    "description": ""
                },
                {
                    "id": "DOID:0050625",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050625",
                    "name": "neoplasm of extrahepatic bile ducts",
                    "description": ""
                },
                {
                    "id": "DOID:0050625",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050625",
                    "name": "tumor of the extrahepatic bile duct",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0050625",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050625"
                }
            ]
        },
        {
            "disease_id": "DOID:11054",
            "recommended_name": {
                "id": "DOID:11054",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:11054",
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                "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
            },
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                {
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                    "resource": "Disease Ontology",
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                    "name": "bladder cancer",
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                },
                {
                    "id": "DOID:11054",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11054",
                    "name": "tumor of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder cancer",
                    "description": "A primary or metastatic malignant neoplasm involving the bladder."
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "bladder cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant bladder neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of the urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
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                    "name": "malignant bladder tumor",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant urinary bladder neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder malignant neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm, urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "cancer of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
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                },
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                    "resource": "MONDO",
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                    "name": "tumor of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
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                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm, bladder",
                    "description": ""
                },
                {
                    "id": "MIM:109800",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/109800",
                    "name": "Bladder cancer",
                    "description": "Bladder cancer"
                }
            ],
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                {
                    "id": "11054",
                    "database": "Alliance of Genome Resources",
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                }
            ]
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        {
            "disease_id": "DOID:1115",
            "recommended_name": {
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                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1115",
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            },
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1115",
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                    "description": ""
                },
                {
                    "id": "DOID:1115",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1115",
                    "name": "tumor of soft tissue and skeleton",
                    "description": ""
                }
            ],
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                    "url": "https://www.alliancegenome.org/disease/DOID:1115"
                }
            ]
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        {
            "disease_id": "DOID:1612",
            "recommended_name": {
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                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1612",
                "name": "breast cancer",
                "description": "A thoracic cancer that originates in the mammary gland."
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                {
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "breast tumor",
                    "description": ""
                },
                {
                    "id": "DOID:1612",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "malignant neoplasm of breast",
                    "description": ""
                },
                {
                    "id": "DOID:1612",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "malignant tumor of the breast",
                    "description": ""
                },
                {
                    "id": "DOID:1612",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "mammary cancer",
                    "description": ""
                },
                {
                    "id": "DOID:1612",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "mammary tumor",
                    "description": ""
                },
                {
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1612",
                    "name": "primary breast cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0016419",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "hereditary breast carcinoma",
                    "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                },
                {
                    "id": "MONDO:0016419",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "familial breast carcinoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0016419",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "familial breast cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0016419",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "hereditary breast cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0016419",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "familial cancer of breast",
                    "description": ""
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                {
                    "id": "MONDO:0016419",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "familial cancer of the breast",
                    "description": ""
                },
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                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "breast cancer, familial Male",
                    "description": ""
                },
                {
                    "id": "MONDO:0016419",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "hereditary breast carcinoma",
                    "description": ""
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                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                    "name": "breast cancer, familial",
                    "description": ""
                },
                {
                    "id": "MIM:114480",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/114480",
                    "name": "Breast cancer",
                    "description": "Breast cancer"
                }
            ],
            "evidence": [
                {
                    "id": "1612",
                    "database": "Alliance of Genome Resources",
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                }
            ]
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        {
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                "id": "DOID:1697",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1697",
                "name": "ichthyosis",
                "description": "A skin disease characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed."
            },
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1697",
                    "name": "ichthyoses",
                    "description": ""
                },
                {
                    "id": "DOID:1697",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1697",
                    "name": "non-syndromic ichthyosis",
                    "description": ""
                }
            ],
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                {
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                    "url": "https://www.alliancegenome.org/disease/DOID:1697"
                }
            ]
        },
        {
            "disease_id": "DOID:2055",
            "recommended_name": {
                "id": "DOID:2055",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:2055",
                "name": "post-traumatic stress disorder",
                "description": "An anxiety disorder which results from a traumatic experience that results in psychological trauma."
            },
            "synonyms": [
                {
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2055",
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                    "description": ""
                },
                {
                    "id": "DOID:2055",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:2055",
                    "name": "PTSD",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "2055",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:2055"
                }
            ]
        },
        {
            "disease_id": "DOID:224",
            "recommended_name": {
                "id": "DOID:224",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:224",
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                "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death."
            },
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                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "TIA",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "TIA - Transient ischaemic attack",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "TRANSIENT ISCHEMIC ATTACK",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "Transient cerebral ischaemia",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "Transient cerebral ischemia",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "Transient ischemic attacks",
                    "description": ""
                },
                {
                    "id": "DOID:224",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:224",
                    "name": "transient ischemic attack",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "224",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:224"
                }
            ]
        },
        {
            "disease_id": "DOID:3068",
            "recommended_name": {
                "id": "DOID:3068",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:3068",
                "name": "glioblastoma",
                "description": "An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes."
            },
            "synonyms": [
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "glioblastoma multiforme",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "GBM",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "adult glioblastoma multiforme",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "grade IV adult Astrocytic tumor",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "primary glioblastoma multiforme",
                    "description": ""
                },
                {
                    "id": "DOID:3068",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3068",
                    "name": "spongioblastoma multiforme",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "3068",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:3068"
                }
            ]
        },
        {
            "disease_id": "DOID:3587",
            "recommended_name": {
                "id": "DOID:3587",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:3587",
                "name": "pancreatic ductal carcinoma",
                "description": "A pancreatic carcinoma located_in the pancreatic duct."
            },
            "synonyms": [
                {
                    "id": "DOID:3587",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3587",
                    "name": "malignant neoplasm of duct of Wirsung",
                    "description": ""
                },
                {
                    "id": "DOID:3587",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3587",
                    "name": "pancreatic duct cancer",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "3587",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:3587"
                }
            ]
        },
        {
            "disease_id": "DOID:3669",
            "recommended_name": {
                "id": "DOID:3669",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:3669",
                "name": "intermittent claudication",
                "description": ""
            },
            "synonyms": [
                {
                    "id": "DOID:3669",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3669",
                    "name": "Charcot's syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:3669",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3669",
                    "name": "Intermittent claudication",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "3669",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:3669"
                }
            ]
        },
        {
            "disease_id": "DOID:409",
            "recommended_name": {
                "id": "DOID:409",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:409",
                "name": "liver disease",
                "description": ""
            },
            "synonyms": [
                {
                    "id": "DOID:409",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:409",
                    "name": "disorder of liver",
                    "description": ""
                },
                {
                    "id": "DOID:409",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:409",
                    "name": "hepatic disorder",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "409",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:409"
                }
            ]
        },
        {
            "disease_id": "DOID:4947",
            "recommended_name": {
                "id": "DOID:4947",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:4947",
                "name": "cholangiocarcinoma",
                "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells."
            },
            "synonyms": [
                {
                    "id": "DOID:4947",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4947",
                    "name": "adult primary Cholangiocarcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:4947",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4947",
                    "name": "adult primary cholangiocellular carcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:4947",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4947",
                    "name": "cholangiosarcoma",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "4947",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:4947"
                }
            ]
        },
        {
            "disease_id": "DOID:4989",
            "recommended_name": {
                "id": "DOID:4989",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:4989",
                "name": "pancreatitis",
                "description": ""
            },
            "synonyms": [
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "hereditary chronic pancreatitis",
                    "description": "Hereditary chronic pancreatitis (HCP), a rare inherited form of pancreatitis is defined as recurrent acute pancreatitis and/or chronic pancreatitis in two first-degree relatives or 3 or more second-degree relatives in 2 or more generations, for which no predisposing factors are identified. HCP is characterized by irreversible damage to both exocrine and endocrine components of the pancreas."
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "PCTT",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, chronic, protection against",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "HPC",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "autosomal dominant hereditary pancreatitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, chronic pancreatitis, chronic, susceptibility to, included",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "Hp",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, chronic, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, hereditary",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "hereditary pancreatitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, hereditary; PCTT",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "familial pancreatitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, calcific, included",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "hereditary chronic pancreatitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, chronic, protection against, included",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, calcific",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, chronic",
                    "description": ""
                },
                {
                    "id": "MIM:167800",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/167800",
                    "name": "Pancreatitis, hereditary",
                    "description": "Pancreatitis, hereditary"
                }
            ],
            "evidence": [
                {
                    "id": "4989",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:4989"
                }
            ]
        },
        {
            "disease_id": "DOID:684",
            "recommended_name": {
                "id": "DOID:684",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:684",
                "name": "hepatocellular carcinoma",
                "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver."
            },
            "synonyms": [
                {
                    "id": "DOID:684",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:684",
                    "name": "Hepatoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "hepatocellular carcinoma",
                    "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation."
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "HCC",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "hepatoblastoma caused by somatic mutation",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "liver cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "liver carcinoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "carcinoma, hepatocellular, malignant",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "liver and intrahepatic bile duct carcinoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "hepatocellular carcinoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "adult primary hepatocellular carcinoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "hepatoblastoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "carcinoma of the liver cells",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "carcinoma of liver cells",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "hepatocellular adenocarcinoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "primary carcinoma of the liver cells",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "carcinoma of liver",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "hepatoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "hepatocellular cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "primary carcinoma of liver cells",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "liver cell carcinoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "liver cell cancer (hepatocellular carcinoma)",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "cancer, hepatocellular",
                    "description": ""
                },
                {
                    "id": "MONDO:0007256",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256",
                    "name": "adult hepatoma",
                    "description": ""
                },
                {
                    "id": "MIM:114550",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/114550",
                    "name": "Hepatocellular carcinoma",
                    "description": "Hepatocellular carcinoma"
                }
            ],
            "evidence": [
                {
                    "id": "684",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:684"
                }
            ]
        },
        {
            "disease_id": "DOID:8552",
            "recommended_name": {
                "id": "DOID:8552",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:8552",
                "name": "chronic myeloid leukemia",
                "description": "A myeloid leukemia that is characterized by over production of white blood cells."
            },
            "synonyms": [
                {
                    "id": "DOID:8552",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8552",
                    "name": "CML",
                    "description": ""
                },
                {
                    "id": "DOID:8552",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8552",
                    "name": "CML - chronic Myelogenous Leukemia",
                    "description": ""
                },
                {
                    "id": "DOID:8552",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8552",
                    "name": "Myeloid Leukemia, chronic",
                    "description": ""
                },
                {
                    "id": "DOID:8552",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8552",
                    "name": "chronic granulocytic leukaemia",
                    "description": ""
                },
                {
                    "id": "DOID:8552",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8552",
                    "name": "chronic granulocytic leukemia",
                    "description": ""
                },
                {
                    "id": "DOID:8552",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8552",
                    "name": "chronic myelogenous leukaemia",
                    "description": ""
                },
                {
                    "id": "DOID:8552",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8552",
                    "name": "chronic myelogenous leukemia",
                    "description": ""
                },
                {
                    "id": "DOID:8552",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:8552",
                    "name": "chronic myeloid leukaemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "chronic myelogenous leukemia, BCR-ABL1 positive",
                    "description": "A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival."
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "chronic granulocytic leukemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "myeloid leukemia, chronic",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "chronic myeloid leukemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "chronic myelocytic leukemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "leukemia, chronic myeloid",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "CML - chronic myelogenous leukemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "leukemia, chronic myeloid; CML",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "BCR-ABL Positive chronic myelogenous leukemia",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "hematopoeitic - chronic myelocytic leukemia (CML)",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "chronic myelogenous leukemia, BCR-ABL1 Positive",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "chronic myelogenous leukemias",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "CML",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "leukemia, chronic myeloid, atypical",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "leukemia, chronic myelogenous",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "chronic myelogenous leukemia (CML)",
                    "description": ""
                },
                {
                    "id": "MONDO:0011996",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996",
                    "name": "chronic myelogenous leukemia",
                    "description": ""
                },
                {
                    "id": "MIM:608232",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/608232",
                    "name": "Leukemia, chronic myeloid, atypical",
                    "description": "Leukemia, chronic myeloid, atypical"
                }
            ],
            "evidence": [
                {
                    "id": "8552",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:8552"
                }
            ]
        },
        {
            "disease_id": "DOID:9119",
            "recommended_name": {
                "id": "DOID:9119",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:9119",
                "name": "acute myeloid leukemia",
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            },
            "synonyms": [
                {
                    "id": "DOID:9119",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9119",
                    "name": "AML - acute Myeloid Leukemia",
                    "description": ""
                },
                {
                    "id": "DOID:9119",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9119",
                    "name": "Leukemia, Myelocytic, acute",
                    "description": ""
                },
                {
                    "id": "DOID:9119",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9119",
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                    "description": ""
                },
                {
                    "id": "DOID:9119",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9119",
                    "name": "acute myeloblastic leukemia",
                    "description": ""
                },
                {
                    "id": "DOID:9119",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9119",
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                    "description": ""
                },
                {
                    "id": "DOID:9119",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9119",
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                    "description": ""
                },
                {
                    "id": "DOID:9119",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:9119",
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                    "description": ""
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                {
                    "id": "MONDO:0018874",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874",
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                {
                    "id": "MONDO:0018874",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874",
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                {
                    "id": "MONDO:0018874",
                    "resource": "MONDO",
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                {
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                    "resource": "MONDO",
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                {
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                {
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            "id": "1329283at2759",
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        },
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        {
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        {
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        {
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        {
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        "length": 483,
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                "length": 483,
                "header": "tr|A0A0G2JVC1-1|A0A0G2JVC1_RAT Isoform 1 of E3 ubiquitin-protein ligase Mdm2  OS=Rattus norvegicus OX=10116 GN=Mdm2 PE=1 SV=1 CANONICAL=A0A0G2JVC1-1"
            },
            "locus": {
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                "start_pos": 60742415,
                "end_pos": 60720300,
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                "evidence": [
                    {
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                        "id": "ENSRNOT00000086116",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000086116"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000069425",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069425"
                    }
                ]
            }
        },
        {
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                "length": 458,
                "header": "tr|D3ZVH5-1|D3ZVH5_RAT Computationally mapped isoform of E3 ubiquitin-protein ligase Mdm2  OS=Rattus norvegicus OX=10116 GN=Mdm2 PE=1 SV=1 CANONICAL=A0A0G2JVC1-1"
            },
            "locus": {
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                "start_pos": 60742415,
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                "evidence": [
                    {
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                        "id": "ENSRNOT00000066767",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000066767"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000063449",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000063449"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A0G2JVC1",
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
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                {
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                    "id": "D3ZVH5",
                    "url": "https://www.uniprot.org/uniprot/D3ZVH5"
                }
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                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        },
        {
            "title": "MicroRNA-188-3p is involved in sevoflurane anesthesia-induced neuroapoptosis by targeting MDM2.",
            "journal": "Molecular medicine reports",
            "date": "2018",
            "authors": "Wang L, Zheng M, Wu S, Niu Z",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
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            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29344658",
                    "url": "https://glygen.org/publication/PubMed/29344658"
                }
            ]
        },
        {
            "title": "Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis.",
            "journal": "The American journal of surgical pathology",
            "date": "2018",
            "authors": "He X, Pang Z, Zhang X, Lan T, Chen H, Chen M, Yang H, Huang J, Chen Y, Zhang Z, Jing W, Peng R, Zhang H",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30001240",
                    "url": "https://glygen.org/publication/PubMed/30001240"
                }
            ]
        },
        {
            "title": "Hyperglycaemia correlates with skeletal muscle capillary regression and is associated with alterations in the murine double minute-2/forkhead box O1/thrombospondin-1 pathway in type 1 diabetic BioBreeding rats.",
            "journal": "Diabetes &amp; vascular disease research",
            "date": "2019",
            "authors": "Aiken J, Mandel ER, Riddell MC, Birot O",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30360646",
                    "url": "https://glygen.org/publication/PubMed/30360646"
                }
            ]
        },
        {
            "title": "LncRNA UCA1 protects cardiomyocytes against hypoxia/reoxygenation induced apoptosis through inhibiting miR-143/MDM2/p53 axis.",
            "journal": "Genomics",
            "date": "2020",
            "authors": "Wang QS, Zhou J, Li X",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30998966",
                    "url": "https://glygen.org/publication/PubMed/30998966"
                }
            ]
        },
        {
            "title": "Tempo-spatial alternative polyadenylation analysis reveals that 3' UTR lengthening of Mdm2 regulates p53 expression and cellular senescence in aged rat testis.",
            "journal": "Biochemical and biophysical research communications",
            "date": "2020",
            "authors": "Wang L, Chen M, Fu H, Ni T, Wei G",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001101569",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31973811",
                    "url": "https://glygen.org/publication/PubMed/31973811"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:314856",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314856",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-198323",
            "name": "AKT phosphorylates targets in the cytosol",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198323",
            "resource": "Reactome",
            "description": "AKT phosphorylates targets in the cytosol"
        },
        {
            "id": "R-RNO-2559580",
            "name": "Oxidative Stress Induced Senescence",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559580",
            "resource": "Reactome",
            "description": "Oxidative Stress Induced Senescence"
        },
        {
            "id": "R-RNO-2559585",
            "name": "Oncogene Induced Senescence",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559585",
            "resource": "Reactome",
            "description": "Oncogene Induced Senescence"
        },
        {
            "id": "R-RNO-3232142",
            "name": "SUMOylation of ubiquitinylation proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3232142",
            "resource": "Reactome",
            "description": "SUMOylation of ubiquitinylation proteins"
        },
        {
            "id": "R-RNO-5689880",
            "name": "Ub-specific processing proteases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880",
            "resource": "Reactome",
            "description": "Ub-specific processing proteases"
        },
        {
            "id": "R-RNO-6804756",
            "name": "Regulation of TP53 Activity through Phosphorylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756",
            "resource": "Reactome",
            "description": "Regulation of TP53 Activity through Phosphorylation"
        },
        {
            "id": "R-RNO-6804757",
            "name": "Regulation of TP53 Degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804757",
            "resource": "Reactome",
            "description": "Regulation of TP53 Degradation"
        },
        {
            "id": "R-RNO-6804760",
            "name": "Regulation of TP53 Activity through Methylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804760",
            "resource": "Reactome",
            "description": "Regulation of TP53 Activity through Methylation"
        },
        {
            "id": "R-RNO-69541",
            "name": "Stabilization of p53",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69541",
            "resource": "Reactome",
            "description": "Stabilization of p53"
        },
        {
            "id": "R-RNO-8941858",
            "name": "Regulation of RUNX3 expression and activity",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8941858",
            "resource": "Reactome",
            "description": "Regulation of RUNX3 expression and activity"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P23804-1",
            "protein_name": "E3 ubiquitin-protein ligase Mdm2",
            "gene_name": "Mdm2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MCNTNMSVSTEGAASTSQIPASEQETLVRPKPLLLKLLKSVGAQNDTYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVAVSQQDSGTSLSESRRQPEGGSDLKDPLQAPPEEKPSSSDLISRLSTSSRRRSISETEENTDELPGERHRKRRRSLSFDPSLGLCELREMCSGGSSSSSSSSSESTETPSHQDLDDGVSEHSGDCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQTGESDTDSFEGDPEISLADYWKCTSCNEMNPPLPSHCKRCWTLRENWLPDDKGKDKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPLSQESDDYSQPSTSSSIVYSSQESVKELKEETQDKDESVESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN",
                "length": 489
            },
            "evidence": [
                {
                    "id": "1793",
                    "url": "http://www.informatics.jax.org/homology/1793",
                    "database": "MGI"
                },
                {
                    "id": "A0A0G2JVC1",
                    "url": "https://omabrowser.org/oma/group/A0A0G2JVC1/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q00987-1",
            "protein_name": "E3 ubiquitin-protein ligase Mdm2",
            "gene_name": "MDM2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP",
                "length": 491
            },
            "evidence": [
                {
                    "id": "1793",
                    "url": "http://www.informatics.jax.org/homology/1793",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 69,
                "go_terms": [
                    {
                        "name": "heart valve development",
                        "id": "GO:0003170",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003170",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of transcription by RNA polymerase II",
                        "id": "GO:0000122",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "21873635"
                    },
                    {
                        "name": "heart development",
                        "id": "GO:0007507",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of gene expression",
                        "id": "GO:0010629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19850968"
                    },
                    {
                        "name": "positive regulation of gene expression",
                        "id": "GO:0010628",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19103650"
                    },
                    {
                        "name": "response to drug",
                        "id": "GO:0042493",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042493",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19136059"
                    },
                    {
                        "name": "negative regulation of apoptotic process",
                        "id": "GO:0043066",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "17881359"
                    },
                    {
                        "name": "positive regulation of mitotic cell cycle",
                        "id": "GO:0045931",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045931",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "amyloid fibril formation",
                        "id": "GO:1990000",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990000",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "blood vessel remodeling",
                        "id": "GO:0001974",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "apoptotic process",
                        "id": "GO:0006915",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic process",
                        "id": "GO:0043154",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043154",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19850968"
                    },
                    {
                        "name": "negative regulation of transcription, DNA-templated",
                        "id": "GO:0045892",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19103650"
                    },
                    {
                        "name": "positive regulation of protein export from nucleus",
                        "id": "GO:0046827",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046827",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "17881359"
                    },
                    {
                        "name": "negative regulation of neuron projection development",
                        "id": "GO:0010977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "23051735"
                    },
                    {
                        "name": "cellular response to hypoxia",
                        "id": "GO:0071456",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest",
                        "id": "GO:0006977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to morphine",
                        "id": "GO:0043278",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043278",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "14625023"
                    },
                    {
                        "name": "response to steroid hormone",
                        "id": "GO:0048545",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048545",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "17000718"
                    },
                    {
                        "name": "cellular response to growth factor stimulus",
                        "id": "GO:0071363",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071363",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "16091747"
                    },
                    {
                        "name": "blood vessel development",
                        "id": "GO:0001568",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001568",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to toxic substance",
                        "id": "GO:0009636",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "16598789"
                    },
                    {
                        "name": "response to cocaine",
                        "id": "GO:0042220",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042220",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "14625023"
                    },
                    {
                        "name": "establishment of protein localization",
                        "id": "GO:0045184",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of muscle cell differentiation",
                        "id": "GO:0051149",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051149",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to hydrogen peroxide",
                        "id": "GO:0070301",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19638633"
                    },
                    {
                        "name": "cellular response to alkaloid",
                        "id": "GO:0071312",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071312",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19136059"
                    },
                    {
                        "name": "positive regulation of vascular associated smooth muscle cell proliferation",
                        "id": "GO:1904707",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904707",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "21498419"
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "16330492"
                    },
                    {
                        "name": "response to antibiotic",
                        "id": "GO:0046677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to organic substance",
                        "id": "GO:0071310",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071310",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19950214"
                    },
                    {
                        "name": "endocardial cushion morphogenesis",
                        "id": "GO:0003203",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003203",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein localization to nucleus",
                        "id": "GO:0034504",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034504",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ventricular septum development",
                        "id": "GO:0003281",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003281",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cell cycle",
                        "id": "GO:0045787",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045787",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to peptide hormone stimulus",
                        "id": "GO:0071375",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071375",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19850968"
                    },
                    {
                        "name": "atrioventricular valve morphogenesis",
                        "id": "GO:0003181",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003181",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process",
                        "id": "GO:0032436",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of gene expression",
                        "id": "GO:0010468",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-dependent protein catabolic process",
                        "id": "GO:0006511",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein autoubiquitination",
                        "id": "GO:0051865",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to organic cyclic compound",
                        "id": "GO:0071407",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071407",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19819240"
                    },
                    {
                        "name": "regulation of heart rate",
                        "id": "GO:0002027",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002027",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "atrial septum development",
                        "id": "GO:0003283",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003283",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to iron ion",
                        "id": "GO:0010039",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010039",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "20019189"
                    },
                    {
                        "name": "positive regulation of vascular associated smooth muscle cell migration",
                        "id": "GO:1904754",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904754",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "21498419"
                    },
                    {
                        "name": "negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator",
                        "id": "GO:1902254",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902254",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein destabilization",
                        "id": "GO:0031648",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to antibiotic",
                        "id": "GO:0071236",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071236",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "18469520"
                    },
                    {
                        "name": "cellular response to estrogen stimulus",
                        "id": "GO:0071391",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071391",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "14667141"
                    },
                    {
                        "name": "proteolysis involved in cellular protein catabolic process",
                        "id": "GO:0051603",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of DNA damage response, signal transduction by p53 class mediator",
                        "id": "GO:0043518",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043518",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to ether",
                        "id": "GO:0045472",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045472",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "16790648"
                    },
                    {
                        "name": "traversing start control point of mitotic cell cycle",
                        "id": "GO:0007089",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007089",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to gamma radiation",
                        "id": "GO:0071480",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071480",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell cycle",
                        "id": "GO:0051726",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to magnesium ion",
                        "id": "GO:0032026",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032026",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "15165363"
                    },
                    {
                        "name": "cardiac septum morphogenesis",
                        "id": "GO:0060411",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060411",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of protein catabolic process",
                        "id": "GO:0042176",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042176",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to UV-C",
                        "id": "GO:0071494",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071494",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "14558917"
                    },
                    {
                        "name": "negative regulation of protein processing",
                        "id": "GO:0010955",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010955",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19638633"
                    },
                    {
                        "name": "response to water-immersion restraint stress",
                        "id": "GO:1990785",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990785",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "23174211"
                    },
                    {
                        "name": "protein-containing complex assembly",
                        "id": "GO:0065003",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to vitamin B1",
                        "id": "GO:0071301",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071301",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "15656374"
                    },
                    {
                        "name": "response to formaldehyde",
                        "id": "GO:1904404",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904404",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "18045764"
                    },
                    {
                        "name": "cellular response to actinomycin D",
                        "id": "GO:0072717",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072717",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of signal transduction by p53 class mediator",
                        "id": "GO:1901797",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901797",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 9,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "17107963"
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleolus",
                        "id": "GO:0005730",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19819240"
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "14642282"
                    },
                    {
                        "name": "synapse",
                        "id": "GO:0045202",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "14642282"
                    },
                    {
                        "name": "nuclear body",
                        "id": "GO:0016604",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein-containing complex",
                        "id": "GO:0032991",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 18,
                "go_terms": [
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "enzyme binding",
                        "id": "GO:0019899",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein domain specific binding",
                        "id": "GO:0019904",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ribonucleoprotein complex binding",
                        "id": "GO:0043021",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043021",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase binding",
                        "id": "GO:0031625",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase activity",
                        "id": "GO:0061630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein N-terminus binding",
                        "id": "GO:0047485",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047485",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-protein transferase activity",
                        "id": "GO:0004842",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "16330492"
                    },
                    {
                        "name": "peroxisome proliferator activated receptor binding",
                        "id": "GO:0042975",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042975",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "19103650"
                    },
                    {
                        "name": "ubiquitin binding",
                        "id": "GO:0043130",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "p53 binding",
                        "id": "GO:0002039",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "16330492"
                    },
                    {
                        "name": "SUMO transferase activity",
                        "id": "GO:0019789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "disordered domain specific binding",
                        "id": "GO:0097718",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097718",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ligase activity",
                        "id": "GO:0016874",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "5S rRNA binding",
                        "id": "GO:0008097",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008097",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "receptor serine/threonine kinase binding",
                        "id": "GO:0033612",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033612",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": "26228571"
                    },
                    {
                        "name": "NEDD8 ligase activity",
                        "id": "GO:0061663",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061663",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A0G2JVC1",
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 5,
            "end_pos": 7,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "R-RNO-198599",
            "name": "AKT phosphorylates MDM2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [
                "R-RNO-198644"
            ],
            "output_participant_list": [
                "R-RNO-198638"
            ],
            "enzyme_list": [
                "P47196-1",
                "A0A0G2JVC1-1",
                "P47197-1",
                "Q63484-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-198599",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198599"
                }
            ]
        },
        {
            "id": "R-RNO-3000434",
            "name": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1",
                "P63281-1",
                "Q6AZ28-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-3000434",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3000434"
                }
            ]
        },
        {
            "id": "R-RNO-3215295",
            "name": "USP7 deubiquitinates MDM2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [
                "R-RNO-3215278",
                "R-RNO-3222068"
            ],
            "enzyme_list": [
                "Q4VSI4-1",
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-3215295",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3215295"
                }
            ]
        },
        {
            "id": "R-RNO-3222072",
            "name": "DAXX binds Ub-MDM2 and USP7",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q4VSI4-1",
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-3222072",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3222072"
                }
            ]
        },
        {
            "id": "R-RNO-349426",
            "name": "Phosphorylation of MDM4 by CHEK2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-349426",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349426"
                }
            ]
        },
        {
            "id": "R-RNO-349455",
            "name": "Phosphorylation of MDM4 by ATM",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1",
                "D4ACL8-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-349455",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349455"
                }
            ]
        },
        {
            "id": "R-RNO-5228523",
            "name": "RANBP2 SUMOylates MDM2 with SUMO1",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nuclear envelope, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1",
                "P49793-1",
                "P63281-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5228523",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5228523"
                }
            ]
        },
        {
            "id": "R-RNO-5633460",
            "name": "MDM2 binds TP53",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5633460",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5633460"
                }
            ]
        },
        {
            "id": "R-RNO-5689950",
            "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q4VSI4-1",
                "A0A0G2JVC1-1",
                "O54857-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5689950",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689950"
                }
            ]
        },
        {
            "id": "R-RNO-5689972",
            "name": "USP2 deubiquitinates MDM2,MDM4",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [
                "R-RNO-5689946"
            ],
            "enzyme_list": [
                "Q5U349-1",
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-5689972",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689972"
                }
            ]
        },
        {
            "id": "R-RNO-6792863",
            "name": "PP2A-PP2R5C dephosphorylates MDM2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [
                "R-RNO-6792489"
            ],
            "enzyme_list": [
                "P63331-1",
                "A0A0G2JVC1-1",
                "P62716-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6792863",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6792863"
                }
            ]
        },
        {
            "id": "R-RNO-6792871",
            "name": "CCNG1 recruits PP2A-PPP2R5C to MDM2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P63331-1",
                "A0A0G2JVC1-1",
                "P62716-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6792871",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6792871"
                }
            ]
        },
        {
            "id": "R-RNO-6793661",
            "name": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [
                "R-RNO-6793669"
            ],
            "output_participant_list": [
                "R-RNO-6792862"
            ],
            "enzyme_list": [
                "Q63699-1",
                "A0A0G2JVC1-1",
                "P39951-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6793661",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6793661"
                }
            ]
        },
        {
            "id": "R-RNO-6793666",
            "name": "MDM2 translocates to the nucleus",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6793666",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6793666"
                }
            ]
        },
        {
            "id": "R-RNO-6795460",
            "name": "SGK1 phosphorylates MDM2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q06226-1",
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6795460",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6795460"
                }
            ]
        },
        {
            "id": "R-RNO-6795667",
            "name": "MDM2 translocates to the cytosol",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, nucleoplasm",
            "input_participant_list": [
                "R-RNO-69486"
            ],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6795667",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6795667"
                }
            ]
        },
        {
            "id": "R-RNO-6798373",
            "name": "MDM2 ubiquitinates DYRK2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [
                "R-RNO-6798383"
            ],
            "enzyme_list": [
                "A0A0G2JVC1-1",
                "F1LYY7-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6798373",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798373"
                }
            ]
        },
        {
            "id": "R-RNO-6804253",
            "name": "MDM2 ubiquitinates JMY",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [
                "R-RNO-6804234"
            ],
            "output_participant_list": [
                "R-RNO-6804247"
            ],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6804253",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804253"
                }
            ]
        },
        {
            "id": "R-RNO-6804724",
            "name": "MDM2 ubiquitinates phosphorylated MDM4",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6804724",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804724"
                }
            ]
        },
        {
            "id": "R-RNO-6804741",
            "name": "MDM2 forms homo- or heterodimers",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1",
                "D4ACL8-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6804741",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804741"
                }
            ]
        },
        {
            "id": "R-RNO-6804879",
            "name": "MDM2 ubiquitinates TP53",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6804879",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804879"
                }
            ]
        },
        {
            "id": "R-RNO-6804942",
            "name": "MDM2 homodimers auto-ubiquitinate",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6804942",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804942"
                }
            ]
        },
        {
            "id": "R-RNO-6804955",
            "name": "ATM phosphorylates MDM2",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [
                "R-RNO-6804954"
            ],
            "enzyme_list": [
                "A0A0G2JVC1-1",
                "D4ACL8-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6804955",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804955"
                }
            ]
        },
        {
            "id": "R-RNO-6805022",
            "name": "USP2 binds the heterodimer of MDM2 and MDM4",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q5U349-1",
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-6805022",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6805022"
                }
            ]
        },
        {
            "id": "R-RNO-8952371",
            "name": "MDM2 binds RUNX3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-8952371",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8952371"
                }
            ]
        },
        {
            "id": "R-RNO-8952382",
            "name": "MDM2 polyubiquitinates RUNX3",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ],
            "evidence": [
                {
                    "id": "R-RNO-8952382",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8952382"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-RNO-198638",
            "participant_name": "phospho-Mdm2 [cytosol]",
            "crossref": [
                {
                    "id": "ENSRNOG00000006304",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000086116",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "XP_006241444.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "1305332",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000069425",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "A0A0G2JVC1",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "XP_006241445.1",
                    "database": "RefSeq",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-198644",
            "participant_name": "Mdm2 [cytosol]",
            "crossref": [
                {
                    "id": "A0A0G2JVC1",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000086116",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000069425",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "XP_006241444.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "XP_006241445.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000006304",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "1305332",
                    "database": "RGD",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-3215278",
            "participant_name": "Usp7 [nucleoplasm]",
            "crossref": [
                {
                    "id": "Q4VSI4",
                    "database": "PRO",
                    "url": ""
                },
                {
                    "id": "NP_001019961.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "1306915",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "Q4VSI4",
                    "database": "UniProt",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-3222068",
            "participant_name": "Daxx [nucleoplasm]",
            "crossref": [
                {
                    "id": "Q8VIB2",
                    "database": "PRO",
                    "url": ""
                },
                {
                    "id": "Q8VIB2",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "621227",
                    "database": "RGD",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-5689946",
            "participant_name": "Usp2 [nucleoplasm]",
            "crossref": [
                {
                    "id": "621073",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "XP_006242923.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000030257",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "3.4.19.12",
                    "database": "IntEnz",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000009975",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "NP_446226.2",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "Q5U349",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000006663",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "Q5U349",
                    "database": "PRO",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000036051",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "XP_006242925.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000009975",
                    "database": "Ensembl",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-6792489",
            "participant_name": "Ccng1 [nucleoplasm]",
            "crossref": [
                {
                    "id": "ENSRNOG00000003256",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "NP_037055.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000065633",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "P39950",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "2295",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000063905",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "P39950",
                    "database": "PRO",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-6792862",
            "participant_name": "phospho-Mdm2 [nucleoplasm]",
            "crossref": [
                {
                    "id": "1305332",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000069425",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "XP_006241445.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "A0A0G2JVC1",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000086116",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000006304",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "XP_006241444.1",
                    "database": "RefSeq",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-6793669",
            "participant_name": "phospho-Mdm2 [nucleoplasm]",
            "crossref": [
                {
                    "id": "A0A0G2JVC1",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000086116",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000069425",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "XP_006241444.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "XP_006241445.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000006304",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "1305332",
                    "database": "RGD",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-6798383",
            "participant_name": "Dyrk2 [nucleoplasm]",
            "crossref": [
                {
                    "id": "ENSRNOP00000010283",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000010283",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "1312039",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "F1LYY7",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "XP_006241453.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "XP_017450342.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "NP_001101570.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000007821",
                    "database": "Ensembl",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-6804234",
            "participant_name": "Jmy [nucleoplasm]",
            "crossref": [
                {
                    "id": "M0R8J3",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "1585601",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000065789",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000050343",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000075286",
                    "database": "Ensembl",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-6804247",
            "participant_name": "Jmy [nucleoplasm]",
            "crossref": [
                {
                    "id": "M0R8J3",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000065789",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000075286",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000050343",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "1585601",
                    "database": "RGD",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-6804954",
            "participant_name": "phospho-Mdm2 [nucleoplasm]",
            "crossref": [
                {
                    "id": "XP_006241445.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "1305332",
                    "database": "RGD",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000069425",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "A0A0G2JVC1",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "XP_006241444.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000006304",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000086116",
                    "database": "Ensembl",
                    "url": ""
                }
            ]
        },
        {
            "participant_id": "R-RNO-69486",
            "participant_name": "Mdm2 [nucleoplasm]",
            "crossref": [
                {
                    "id": "A0A0G2JVC1",
                    "database": "UniProt",
                    "url": ""
                },
                {
                    "id": "ENSRNOT00000086116",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "ENSRNOP00000069425",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "XP_006241444.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "XP_006241445.1",
                    "database": "RefSeq",
                    "url": ""
                },
                {
                    "id": "ENSRNOG00000006304",
                    "database": "Ensembl",
                    "url": ""
                },
                {
                    "id": "1305332",
                    "database": "RGD",
                    "url": ""
                }
            ]
        }
    ],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A0A0G2JVC1",
            "gene_name": "Mdm2",
            "activity": [
                {
                    "ec_number": "2.3.2.27",
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
                    "evidence": [
                        {
                            "id": "A0A0G2JVC1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                        }
                    ]
                },
                {
                    "ec_number": "2.3.2.27",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A0G2JVC1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "D4ACL8",
            "gene_name": "Atm",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + a protein = ADP + a phosphoprotein.",
                    "evidence": [
                        {
                            "id": "D4ACL8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D4ACL8"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "D4ACL8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/D4ACL8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "F1LYY7",
            "gene_name": "Dyrk2",
            "activity": [
                {
                    "ec_number": "2.7.12.1",
                    "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein].",
                    "evidence": [
                        {
                            "id": "F1LYY7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/F1LYY7"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.12.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "F1LYY7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/F1LYY7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O54857",
            "gene_name": "Pten",
            "activity": [
                {
                    "ec_number": "3.1.3.67",
                    "activity": "Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.",
                    "evidence": [
                        {
                            "id": "O54857",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O54857"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.3.16",
                    "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.",
                    "evidence": [
                        {
                            "id": "O54857",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O54857"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.3.48",
                    "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.",
                    "evidence": [
                        {
                            "id": "O54857",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O54857"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.3.16",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O54857",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O54857"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.3.48",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O54857",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O54857"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.3.67",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O54857",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O54857"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P39951",
            "gene_name": "Cdk1",
            "activity": [
                {
                    "ec_number": "2.7.11.22",
                    "activity": "ATP + a protein = ADP + a phosphoprotein.",
                    "evidence": [
                        {
                            "id": "P39951",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39951"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.23",
                    "activity": "ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.",
                    "evidence": [
                        {
                            "id": "P39951",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39951"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.23",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P39951",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39951"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.22",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P39951",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39951"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P47196",
            "gene_name": "Akt1",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + a protein = ADP + a phosphoprotein.",
                    "evidence": [
                        {
                            "id": "P47196",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P47196"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P47196",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P47196"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P47197",
            "gene_name": "Akt2",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + a protein = ADP + a phosphoprotein.",
                    "evidence": [
                        {
                            "id": "P47197",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P47197"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P47197",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P47197"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P49793",
            "gene_name": "Nup98",
            "activity": [
                {
                    "ec_number": "3.4.21.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P49793",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49793"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P62716",
            "gene_name": "Ppp2cb",
            "activity": [
                {
                    "ec_number": "3.1.3.16",
                    "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.",
                    "evidence": [
                        {
                            "id": "P62716",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62716"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.3.16",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P62716",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P62716"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P63281",
            "gene_name": "Ube2i",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P63281",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P63281"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P63331",
            "gene_name": "Ppp2ca",
            "activity": [
                {
                    "ec_number": "3.1.3.16",
                    "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.",
                    "evidence": [
                        {
                            "id": "P63331",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P63331"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.3.16",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P63331",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P63331"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q06226",
            "gene_name": "Sgk1",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + a protein = ADP + a phosphoprotein.",
                    "evidence": [
                        {
                            "id": "Q06226",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q06226"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q06226",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q06226"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q4VSI4",
            "gene_name": "Usp7",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "Q4VSI4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q4VSI4"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q4VSI4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q4VSI4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5U349",
            "gene_name": "Usp2",
            "activity": [
                {
                    "ec_number": "3.4.19.12",
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).",
                    "evidence": [
                        {
                            "id": "Q5U349",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5U349"
                        }
                    ]
                },
                {
                    "ec_number": "3.4.19.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5U349",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5U349"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q63484",
            "gene_name": "Akt3",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + a protein = ADP + a phosphoprotein.",
                    "evidence": [
                        {
                            "id": "Q63484",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63484"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q63484",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63484"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q63699",
            "gene_name": "Cdk2",
            "activity": [
                {
                    "ec_number": "2.7.11.22",
                    "activity": "ATP + a protein = ADP + a phosphoprotein.",
                    "evidence": [
                        {
                            "id": "Q63699",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63699"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.22",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q63699",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63699"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6AZ28",
            "gene_name": "Pias2",
            "activity": [
                {
                    "ec_number": "2.3.2.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6AZ28",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AZ28"
                        }
                    ]
                }
            ]
        }
    ],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ]
}
