{ "uniprot_canonical_ac": "A0A0G2JUI2-1", "uniprot_ac": "A0A0G2JUI2", "uniprot_id": "A0A0G2JUI2_RAT", "mass": { "chemical_mass": 63844.0, "monoisotopic_mass": 63844.0 }, "refseq": {}, "gene_names": [ { "name": "Rufy4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "id": "A0A0G2JUI2" } ], "protein_names": [ { "name": "RUN and FYVE domain-containing 4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2#names_and_taxonomy", "id": "A0A0G2JUI2" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUI2", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Rufy4", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "locus": { "chromosome": "9", "start_pos": 81402124, "end_pos": 81421990, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000032991", "url": "https://www.ensembl.org/id/ENSRNOG00000032991" } ] } } ], "crossref": [ { "id": "ENSRNOG00000032991", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032991", "database": "Bgee" }, { "id": "301510", "url": "https://www.ncbi.nlm.nih.gov/gene/301510", "database": "GeneID" }, { "id": "IPR004012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004012", "database": "InterPro" }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro" }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro" }, { "id": "IPR017455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "database": "InterPro" }, { "id": "IPR037213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037213", "database": "InterPro" }, { "id": "IPR042939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042939", "database": "InterPro" }, { "id": "rno:301510", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301510", "database": "KEGG Pathway" }, { "id": "PMFSESH", "url": "https://omabrowser.org/oma/group/PMFSESH/", "database": "OMA" }, { "id": "962969at2759", "url": "http://www.orthodb.org/?query=962969at2759", "database": "OrthoDB" }, { "id": "PTHR47732", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47732", "database": "PANTHER" }, { "id": "PF02759", "url": "http://pfam.xfam.org/family/PF02759", "database": "Pfam" }, { "id": "XP_006226938", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006226938", "database": "RefSeq" }, { "id": "1560678", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1560678", "database": "RGD" }, { "id": "A0A0G2JUI2", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "database": "UniProtKB" }, { "id": "A0A0G2JUI2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2-1", "database": "UniProtKB" }, { "id": "F1M513", "url": "https://www.uniprot.org/uniprot/F1M513", "database": "UniProtKB" }, { "id": "F1M513-1", "url": "https://www.uniprot.org/uniprot/F1M513-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MAEKETILKISRNLKNAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQRSFLGARKDYWDFLFTALRRQRGYTEQMNFICSQDKLKTSLGKGRAFIRLCLAHGQLAESMQLCLLNPQLTREWYGPRSPLLCPELQGDILDSLYTLNGVAFNLDLQRPDLDEAWPMFSESHYSSPSRTRERRPRKPKGFPEEVRCSKGQQLQGPEAGGTSCLQDATTEDLPPDLRTPLQQDHLPTFLEEKREDSRSLSCPQSIWETGREGFRLDQEGGPKTRKLLENSTASIQQQKGGAKDVQMQLTGRKDEGKGSLPGTEGRKTTEGIQERATDWNHAQELLAPSLQGREEDAELGYRHGWDQPGALGQSWVLGSKKGPTTGKPQEWTGVTRATVQKDQTEVPLQQEVIKEPGYGLQLTEVQAQCQEQLQAQEGELQALQEQLSRCQEERALLQAMLEQKQQEAERRAAMYEKELEGQRDLVQAMKRRVLELIQEKDHQWQRLQQLSTVTPGHCMGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPACAQQEEIQVT", "length": 563, "header": "tr|A0A0G2JUI2-1|A0A0G2JUI2_RAT Isoform 1 of RUN and FYVE domain-containing 4 OS=Rattus norvegicus OX=10116 GN=Rufy4 PE=4 SV=1 CANONICAL=A0A0G2JUI2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JUI2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2#A0A0G2JUI2-1", "sequence": { "sequence": "MAEKETILKISRNLKNAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQRSFLGARKDYWDFLFTALRRQRGYTEQMNFICSQDKLKTSLGKGRAFIRLCLAHGQLAESMQLCLLNPQLTREWYGPRSPLLCPELQGDILDSLYTLNGVAFNLDLQRPDLDEAWPMFSESHYSSPSRTRERRPRKPKGFPEEVRCSKGQQLQGPEAGGTSCLQDATTEDLPPDLRTPLQQDHLPTFLEEKREDSRSLSCPQSIWETGREGFRLDQEGGPKTRKLLENSTASIQQQKGGAKDVQMQLTGRKDEGKGSLPGTEGRKTTEGIQERATDWNHAQELLAPSLQGREEDAELGYRHGWDQPGALGQSWVLGSKKGPTTGKPQEWTGVTRATVQKDQTEVPLQQEVIKEPGYGLQLTEVQAQCQEQLQAQEGELQALQEQLSRCQEERALLQAMLEQKQQEAERRAAMYEKELEGQRDLVQAMKRRVLELIQEKDHQWQRLQQLSTVTPGHCMGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPACAQQEEIQVT", "length": 563, "header": "tr|A0A0G2JUI2-1|A0A0G2JUI2_RAT Isoform 1 of RUN and FYVE domain-containing 4 OS=Rattus norvegicus OX=10116 GN=Rufy4 PE=4 SV=1 CANONICAL=A0A0G2JUI2-1" }, "locus": { "chromosome": "9", "start_pos": 81421274, "end_pos": 81403598, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000083595", "url": "https://www.ensembl.org/id/ENSRNOT00000083595" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069107", "url": "https://www.ensembl.org/id/ENSRNOP00000069107" } ] } }, { "isoform_ac": "F1M513-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2#F1M513-1", "sequence": { "sequence": "MNFICSQDKLKTSLGKGRAFIRLCLAHGQLAESMQLCLLNPQLTREWYGPRSPLLCPELQGDILDSLYTLNGVAFNLDLQRPDLDEAWPMFSESHYSSPSRTRERRPRKPKGFPEEVRCSKGQQLQGPEAGGTSCLQDATTEDLPPDLRTPLQQDHLPTFLEEKREDSRSLSCPQSIWETGREGFRLDQEGGPKTRKLLENSTASIQQQKGGAKDVQMQLTGRKDEGKGSLPGTEGRKTTEGIQERATDWNHAQELLAPSLQGREEDAELGYRHGWDQPGALGQSWVLGSKKGPTTGKPQEWTGVTRATVQKDQTEVPLQQEVIKEPGYGLQLTEVQAQCQEQLQAQEGELQALQEQLSRCQEERALLQAMLEQKQQEAERRAAMYEKELEGQRDLVQAMKRRVLELIQEKDHQWQRLQQLSTVTPGHCMGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPACAQQEEIQVT", "length": 479, "header": "tr|F1M513-1|F1M513_RAT Computationally mapped isoform of RUN and FYVE domain-containing 4 OS=Rattus norvegicus OX=10116 GN=Rufy4 PE=4 SV=3 CANONICAL=A0A0G2JUI2-1" }, "locus": { "chromosome": "9", "start_pos": 81421274, "end_pos": 81405184, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000046019", "url": "https://www.ensembl.org/id/ENSRNOT00000046019" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000042319", "url": "https://www.ensembl.org/id/ENSRNOP00000042319" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:301510", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301510", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TYX8-1", "protein_name": "RUN and FYVE domain-containing protein 4", "gene_name": "Rufy4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANNGTILKISRSLKNAVSAILQGYGDGQEPVTETSAELHRLCGCLELLLQFDQKEQRSFLGARKDYWDFLFTALRRHRGYTEQMSFICSQDKLKTSLGKGRAFIRLCLARGQLAESMQLCLLNPQLTREWYGPRSPLLCAELQEDILDSLYALNGVAFNLDLQRPDLDEAWPMFSESRCSSPSRTGKRRPGKPKGFPEEVRCSRGEQLQEPDTGGTSCLQDATREDRTPDLCKPLQPSHLPTFLEEKREDSRSLSCPQSTWETEREGFQLDQKDGGPKPRKFLENSTASIQQQRSRAKDVKMQLTGRKVEGKGSLSGTEDQRTTEGIQKRAADWDLGQGLMAPGLQGREDAELGYRCEWNQPDVLRQSWVLGTKKSSPTEKPQEWTGVTSGTMQEDGSEVPLQQEVIKDPGYGLQLAKEQAQCQEQLRAQEAELQALQEQLSRCQKERALLQVKLEQKQQEAERRDAMYQTELEGQRDLVQAMKRRVLELIHEKDLQWQRLQQLSTVAPGHCIGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPTCAQQEEIQDT", "length": 563 }, "evidence": [ { "id": "52359", "url": "http://www.informatics.jax.org/homology/52359", "database": "MGI" }, { "id": "A0A0G2JUI2", "url": "https://omabrowser.org/oma/group/A0A0G2JUI2/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZNE9-2", "protein_name": "RUN and FYVE domain-containing protein 4", "gene_name": "RUFY4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEEGAILKVTKDLRAAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQKSFLGPRKDYWDFLCTALRRQRGNMEPIHFVRSQDKLKTPLGKGRAFIRFCLARGQLAEALQLCLLNSELTREWYGPRSPLLCPERQEDILDSLYALNGVAFELDLQQPDLDGAWPMFSESRCSSSTQTQGRRPRKNKDAPKKIPAAYGGPENVQIEDSHTSQAICLQDAPSGQQLAGLPRSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRFSRRYPCRLCGGLLCHACSMDYKKRDRCCPPCAQGREAQVT", "length": 571 }, "evidence": [ { "id": "52359", "url": "http://www.informatics.jax.org/homology/52359", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUI2", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2" } ], "pmid": "" }, { "name": "positive regulation of macroautophagy", "id": "GO:0016239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016239", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUI2", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2" } ], "pmid": "" }, { "name": "cellular response to interleukin-4", "id": "GO:0071353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071353", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUI2", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUI2", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUI2", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JUI2", "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ] }