{ "uniprot_canonical_ac": "A0A096MJS9-1", "uniprot_ac": "A0A096MJS9", "uniprot_id": "A0A096MJS9_RAT", "mass": { "chemical_mass": 67698.0, "monoisotopic_mass": 67698.0 }, "refseq": { "ac": "XP_003751543", "name": "N-acetyltransferase ESCO2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543" }, "gene_names": [ { "name": "Esco2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9" }, { "name": "Esco2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543", "id": "XP_003751543" }, { "name": "rCG_52137", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9" } ], "protein_names": [ { "name": "Establishment of sister chromatid cohesion N-acetyltransferase 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJS9#names_and_taxonomy", "id": "A0A096MJS9" }, { "name": "N-acetyltransferase ESCO2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543", "id": "XP_003751543" }, { "name": "RCG52137, isoform CRA_a", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A096MJS9#names_and_taxonomy", "id": "A0A096MJS9" } ], "function": [], "disease": [ { "disease_id": "DOID:5325", "recommended_name": { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "Roberts syndrome", "description": "A syndrome characterized by tetraphocomelia, craniofacial anomalies, growth retardation, intellectual disability, and cardiac and renal abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in ESCO2 on chromosome 8p21.1." }, "synonyms": [ { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "SC phocomelia syndrome", "description": "" }, { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "RBS", "description": "" }, { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "LONG BONE DEFICIENCIES ASSOCIATED WITH CLEFT LIP-PALATE", "description": "" }, { "id": "MONDO:0010009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010009", "name": "SC phocomelia syndrome", "description": "A rare genetic syndrome with an autosomal recessive pattern of inheritance. It is caused by a mutation in the ESCO2 gene. Clinical signs at birth include multiple limb and facial abnormalities. It is considered to be a mild variant of Roberts syndrome." }, { "id": "MONDO:0010009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010009", "name": "pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0010009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010009", "name": "hypomelia hypotrichosis Facial hemangioma syndrome", "description": "" }, { "id": "MONDO:0010009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010009", "name": "SC phocomelia syndrome", "description": "" }, { "id": "MONDO:0010009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010009", "name": "SC pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0010009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010009", "name": "Roberts-SC phocomelia syndrome", "description": "" }, { "id": "MONDO:0010009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010009", "name": "phocomelia-pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "Roberts syndrome", "description": "Roberts syndrome (RBS) is characterized by pre- and postnatal growth retardation, severe symmetric limb reduction defects, craniofacial anomalies and severe intellectual deficit. SC phocomelia is a milder form of RBS." }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "SC pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "Roberts syndrome/SC phocomelia", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "SC phocomelia", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "SC phocomelia syndrome (mild variant of Roberts syndrome)", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "long bone deficiencies associated with cleft LIP-palate", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "Roberts syndrome", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "Roberts tetraphocomelia syndrome", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "ROBERTS syndrome; RBS", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "RBS", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "Roberts-SC phocomelia syndrome", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "Tetraphocomelia-cleft palate syndrome", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "Appelt-Gerken-Lenz syndrome", "description": "" }, { "id": "MONDO:0009997", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009997", "name": "long bone deficiencies associated with cleft Lip-palate", "description": "" }, { "id": "MIM:269000", "resource": "MIM", "url": "https://www.omim.org/entry/269000", "name": "SC phocomelia syndrome", "description": "SC phocomelia syndrome" }, { "id": "MIM:268300", "resource": "MIM", "url": "https://www.omim.org/entry/268300", "name": "Roberts syndrome", "description": "Roberts syndrome" } ], "evidence": [ { "id": "5325", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5325" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "common_name": "Rat" } ], "gene": [ { "name": "Esco2", "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "locus": { "chromosome": "15", "start_pos": 42518855, "end_pos": 42500929, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000015921", "url": "https://www.ensembl.org/id/ENSRNOG00000015921" } ] } } ], "crossref": [ { "id": "ENSRNOG00000015921", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015921", "database": "Bgee" }, { "id": "691979", "url": "https://www.ncbi.nlm.nih.gov/gene/691979", "database": "GeneID" }, { "id": "IPR028005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028005", "database": "InterPro" }, { "id": "IPR028009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028009", "database": "InterPro" }, { "id": "rno:691979", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:691979", "database": "KEGG Pathway" }, { "id": "VPRCPNK", "url": "https://omabrowser.org/oma/group/VPRCPNK/", "database": "OMA" }, { "id": "1024179at2759", "url": "http://www.orthodb.org/?query=1024179at2759", "database": "OrthoDB" }, { "id": "PF13878", "url": "http://pfam.xfam.org/family/PF13878", "database": "Pfam" }, { "id": "PF13880", "url": "http://pfam.xfam.org/family/PF13880", "database": "Pfam" }, { "id": "R-RNO-2468052", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "database": "Reactome" }, { "id": "XP_003751543", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543", "database": "RefSeq" }, { "id": "1593313", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593313", "database": "RGD" }, { "id": "45948", "url": "https://www.rhea-db.org/rhea/45948", "database": "Rhea" }, { "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "database": "UniProtKB" }, { "id": "A0A096MJS9-1", "url": "https://www.uniprot.org/uniprot/A0A096MJS9-1", "database": "UniProtKB" }, { "id": "A0A0G2K4A1", "url": "https://www.uniprot.org/uniprot/A0A0G2K4A1", "database": "UniProtKB" }, { "id": "A0A0G2K4A1-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K4A1-1", "database": "UniProtKB" }, { "id": "D4ABF1", "url": "https://www.uniprot.org/uniprot/D4ABF1", "database": "UniProtKB" }, { "id": "D4ABF1-1", "url": "https://www.uniprot.org/uniprot/D4ABF1-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS", "length": 595, "header": "tr|A0A096MJS9-1|A0A096MJS9_RAT Isoform 1 of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1" }, "isoforms": [ { "isoform_ac": "A0A096MJS9-1", "url": "https://www.uniprot.org/uniprot/A0A096MJS9#A0A096MJS9-1", "sequence": { "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS", "length": 595, "header": "tr|A0A096MJS9-1|A0A096MJS9_RAT Isoform 1 of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1" }, "locus": { "chromosome": "15", "start_pos": 42517559, "end_pos": 42502450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076451", "url": "https://www.ensembl.org/id/ENSRNOT00000076451" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068247", "url": "https://www.ensembl.org/id/ENSRNOP00000068247" } ] } }, { "isoform_ac": "A0A0G2K4A1-1", "url": "https://www.uniprot.org/uniprot/A0A096MJS9#A0A0G2K4A1-1", "sequence": { "sequence": "MATFTPRKRKRHTLKADNDDSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTNKPMSSSVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS", "length": 587, "header": "tr|A0A0G2K4A1-1|A0A096MJS9_RAT Computationally mapped isoform of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1" }, "locus": { "chromosome": "15", "start_pos": 42517553, "end_pos": 42502450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000081500", "url": "https://www.ensembl.org/id/ENSRNOT00000081500" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072962", "url": "https://www.ensembl.org/id/ENSRNOP00000072962" } ] } }, { "isoform_ac": "D4ABF1-1", "url": "https://www.uniprot.org/uniprot/A0A096MJS9#D4ABF1-1", "sequence": { "sequence": "MMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS", "length": 594, "header": "tr|D4ABF1-1|D4ABF1_RAT Computationally mapped isoform of Establishment of sister chromatid cohesion N-acetyltransferase 2 OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1" }, "locus": { "chromosome": "15", "start_pos": 42517556, "end_pos": 42502450, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000021320", "url": "https://www.ensembl.org/id/ENSRNOT00000021320" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000021320", "url": "https://www.ensembl.org/id/ENSRNOP00000021320" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:691979", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:691979", "resource": "KEGG Pathway" }, { "id": "R-RNO-2468052", "name": "Establishment of Sister Chromatid Cohesion", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "resource": "Reactome", "description": "Establishment of Sister Chromatid Cohesion" } ], "orthologs": [ { "uniprot_canonical_ac": "Q56NI9-1", "protein_name": "N-acetyltransferase ESCO2", "gene_name": "ESCO2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS", "length": 601 }, "evidence": [ { "id": "12432", "url": "http://www.informatics.jax.org/homology/12432", "database": "MGI" }, { "id": "A0A096MJS9", "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CIB9-1", "protein_name": "N-acetyltransferase ESCO2", "gene_name": "Esco2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMATCTPRKRKRYTLNADNDDSLLTDISSSKLRCAENLFPSPNKKHNYQSSVQKEDKSCSHQLHFPSSPLKTTENSRFSFANHSSLFKPAMSTVSFYSKEKYYLNPLERKLIRECRSICLATESGDKPIPSVTENIQRKPVCTKKNKKKQKSLTAKYQPNYKHIKSKSRNLKNSKPNQVTYKPVVDQENSCFPAKNYPNSPPRVLSQKIKPQVTLQGGAAFFVRKRNSLKKLPLEDKPLLLQKNLPEVPEGAPEAKQIPKSLLVDEKSSVKVQNARSKNEEKLRKNPSGAVVSSKECNLDKHDFPSENSLDENKTISPESVYPIFNVSSVNTKRPEEQSSVGSTACTNFLKQTNVPKNINSRDTNKGGKDQLVIDAGQKHFGTTVCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKFVGWKRERVVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQTVPVCPDKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSASKECSRAWRCSDVPEPAICGISRIWVFRLKRRKRIARRLVDTVRNCFMFGCFLSTNEIAFSDPTPDGKLFATKYCNTPNFLVYNFHN", "length": 592 }, "evidence": [ { "id": "12432", "url": "http://www.informatics.jax.org/homology/12432", "database": "MGI" }, { "id": "A0A096MJS9", "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "chromocenter", "id": "GO:0010369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010369", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "pericentric heterochromatin", "id": "GO:0005721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005721", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "XY body", "id": "GO:0001741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001741", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "regulation of DNA replication", "id": "GO:0006275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "sister chromatid cohesion", "id": "GO:0007062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007062", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "21873635" }, { "name": "protein localization to chromatin", "id": "GO:0071168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "post-translational protein acetylation", "id": "GO:0034421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034421", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "acetyltransferase activity", "id": "GO:0016407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016407", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" }, { "name": "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "id": "GO:0004468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004468", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprot/A0A096MJS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "45948", "name": "", "equation": "acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P62916-1", "Q5TKR9-1", "M0R4T9-1", "Q5XI06-1", "Q99MK2-1", "Q9WVS9-1", "Q3MHC1-1", "Q9EPU2-1", "Q9QXS4-1", "D4ACX5-1", "Q6JHU9-1", "Q5M939-1", "Q9Y6F8-1", "O15516-1", "Q00403-1", "Q8WYB5-1", "Q9H9T3-1", "Q9H7Z6-1", "Q9Y6F7-1", "Q15788-1", "Q9H7X0-1", "Q56NI9-1", "P21675-1", "Q9UKN8-1", "Q92993-1", "Q92793-1", "Q92794-1", "Q92831-1", "Q9Y6Q9-1", "Q5FWF5-1", "Q09472-1", "Q92830-1", "O14929-1", "P62915-1", "P70365-1", "Q9DBU2-1", "O09000-1", "Q9D1P2-1", "Q8BY71-1", "Q8BRB7-1", "Q9JHD1-1", "Q5SVQ0-1", "O08785-1", "Q9WTK2-1", "Q9JIY8-1", "Q8BZ21-1", "E0CYR6-1", "Q9JHD2-1", "Q80UV9-1", "Q8BMQ2-1", "P45481-1", "Q69Z69-1", "Q9CZX0-1", "Q8CHK4-1", "Q8CIB9-1", "B2RWS6-1", "Q95SX8-1", "Q960X4-1", "Q0KIB3-1", "Q9VAV6-1", "O02193-1" ], "evidence": [ { "id": "45948", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45948" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "B2RWS6", "gene_name": "Ep300", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] } ] }, { "uniprot_ac": "D4ACX5", "gene_name": "Kat2a", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "D4ACX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACX5" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "D4ACX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACX5" } ] } ] }, { "uniprot_ac": "E0CYR6", "gene_name": "Nat8f7", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "E0CYR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E0CYR6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "E0CYR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E0CYR6" } ] } ] }, { "uniprot_ac": "M0R4T9", "gene_name": "Kat6b", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "M0R4T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4T9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "M0R4T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4T9" } ] } ] }, { "uniprot_ac": "O02193", "gene_name": "mof", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "O02193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O02193" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O02193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O02193" } ] } ] }, { "uniprot_ac": "O08785", "gene_name": "Clock", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "O08785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08785" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O08785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08785" } ] } ] }, { "uniprot_ac": "O09000", "gene_name": "Ncoa3", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "O09000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09000" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O09000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09000" } ] } ] }, { "uniprot_ac": "O14929", "gene_name": "HAT1", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "O14929", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14929" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O14929", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14929" } ] } ] }, { "uniprot_ac": "O15516", "gene_name": "CLOCK", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "O15516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15516" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "O15516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15516" } ] } ] }, { "uniprot_ac": "P21675", "gene_name": "TAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein.", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] } ] }, { "uniprot_ac": "P45481", "gene_name": "Crebbp", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "P45481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45481" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P45481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45481" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P45481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45481" } ] } ] }, { "uniprot_ac": "P62915", "gene_name": "Gtf2b", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "P62915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62915" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P62915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62915" } ] } ] }, { "uniprot_ac": "P62916", "gene_name": "Gtf2b", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "P62916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62916" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P62916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62916" } ] } ] }, { "uniprot_ac": "P70365", "gene_name": "Ncoa1", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "P70365", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70365" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P70365", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70365" } ] } ] }, { "uniprot_ac": "Q00403", "gene_name": "GTF2B", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "Q00403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00403" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q00403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00403" } ] } ] }, { "uniprot_ac": "Q09472", "gene_name": "EP300", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "Q09472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09472" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q09472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09472" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q09472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09472" } ] } ] }, { "uniprot_ac": "Q0KIB3", "gene_name": "Hat1", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "Q0KIB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KIB3" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q0KIB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KIB3" } ] } ] }, { "uniprot_ac": "Q15788", "gene_name": "NCOA1", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "Q15788", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15788" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q15788", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15788" } ] } ] }, { "uniprot_ac": "Q3MHC1", "gene_name": "Naa60", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MHC1" } ] }, { "ec_number": "2.3.1.259", "activity": "Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA.", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MHC1" } ] }, { "ec_number": "2.3.1.259", "activity": "", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MHC1" } ] } ] }, { "uniprot_ac": "Q56NI9", "gene_name": "ESCO2", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q56NI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56NI9" } ] } ] }, { "uniprot_ac": "Q5FWF5", "gene_name": "ESCO1", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q5FWF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FWF5" } ] } ] }, { "uniprot_ac": "Q5M939", "gene_name": "Hat1", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "Q5M939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M939" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q5M939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M939" } ] } ] }, { "uniprot_ac": "Q5SVQ0", "gene_name": "Kat7", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "Q5SVQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SVQ0" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q5SVQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SVQ0" } ] } ] }, { "uniprot_ac": "Q5TKR9", "gene_name": "Kat6a", "activity": [ { "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.", "evidence": [ { "id": "Q5TKR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TKR9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q5TKR9", "database": "UniProtKB", "url": 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